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In recent years, explainable methods for artificial intelligence (XAI) have tried to reveal and describe models' decision mechanisms in the case of classification tasks. However, XAI for semantic segmentation and in particular for single instances has been little studied to date. Understanding the process underlying automatic segmentation of single instances is crucial to reveal what information was used to detect and segment a given object of interest. In this study, we proposed two instance-level explanation maps for semantic segmentation based on SmoothGrad and Grad-CAM++ methods. Then, we investigated their relevance for the detection and segmentation of white matter lesions (WML), a magnetic resonance imaging (MRI) biomarker in multiple sclerosis (MS). 687 patients diagnosed with MS for a total of 4043 FLAIR and MPRAGE MRI scans were collected at the University Hospital of Basel, Switzerland. Data were randomly split into training, validation and test sets to train a 3D U-Net for MS lesion segmentation. We observed 3050 true positive (TP), 1818 false positive (FP), and 789 false negative (FN) cases. We generated instance-level explanation maps for semantic segmentation, by developing two XAI methods based on SmoothGrad and Grad-CAM++. We investigated: 1) the distribution of gradients in saliency maps with respect to both input MRI sequences; 2) the model's response in the case of synthetic lesions; 3) the amount of perilesional tissue needed by the model to segment a lesion. Saliency maps (based on SmoothGrad) in FLAIR showed positive values inside a lesion and negative in its neighborhood. Peak values of saliency maps generated for these four groups of volumes presented distributions that differ significantly from one another, suggesting a quantitative nature of the proposed saliency. Contextual information of 7mm around the lesion border was required for their segmentation.

We consider discontinuous Galerkin methods for an elliptic distributed optimal control problem constrained by a convection-dominated problem. We prove global optimal convergence rates using an inf-sup condition, with the diffusion parameter $\varepsilon$ and regularization parameter $\beta$ explicitly tracked. We then propose a multilevel preconditioner based on downwind ordering to solve the discretized system. The preconditioner only requires two approximate solves of single convection-dominated equations using multigrid methods. Moreover, for the strongly convection-dominated case, only two sweeps of block Gauss-Seidel iterations are needed. We also derive a simple bound indicating the role played by the multigrid preconditioner. Numerical results are shown to support our findings.

We present the first formulation of the optimal polynomial approximation of the solution of linear non-autonomous systems of ODEs in the framework of the so-called $\star$-product. This product is the basis of new approaches for the solution of such ODEs, both in the analytical and the numerical sense. The paper shows how to formally state the problem and derives upper bounds for its error.

This paper presents an analysis of properties of two hybrid discretization methods for Gaussian derivatives, based on convolutions with either the normalized sampled Gaussian kernel or the integrated Gaussian kernel followed by central differences. The motivation for studying these discretization methods is that in situations when multiple spatial derivatives of different order are needed at the same scale level, they can be computed significantly more efficiently compared to more direct derivative approximations based on explicit convolutions with either sampled Gaussian kernels or integrated Gaussian kernels. While these computational benefits do also hold for the genuinely discrete approach for computing discrete analogues of Gaussian derivatives, based on convolution with the discrete analogue of the Gaussian kernel followed by central differences, the underlying mathematical primitives for the discrete analogue of the Gaussian kernel, in terms of modified Bessel functions of integer order, may not be available in certain frameworks for image processing, such as when performing deep learning based on scale-parameterized filters in terms of Gaussian derivatives, with learning of the scale levels. In this paper, we present a characterization of the properties of these hybrid discretization methods, in terms of quantitative performance measures concerning the amount of spatial smoothing that they imply, as well as the relative consistency of scale estimates obtained from scale-invariant feature detectors with automatic scale selection, with an emphasis on the behaviour for very small values of the scale parameter, which may differ significantly from corresponding results obtained from the fully continuous scale-space theory, as well as between different types of discretization methods.

Recently, addressing spatial confounding has become a major topic in spatial statistics. However, the literature has provided conflicting definitions, and many proposed definitions do not address the issue of confounding as it is understood in causal inference. We define spatial confounding as the existence of an unmeasured causal confounder with a spatial structure. We present a causal inference framework for nonparametric identification of the causal effect of a continuous exposure on an outcome in the presence of spatial confounding. We propose double machine learning (DML), a procedure in which flexible models are used to regress both the exposure and outcome variables on confounders to arrive at a causal estimator with favorable robustness properties and convergence rates, and we prove that this approach is consistent and asymptotically normal under spatial dependence. As far as we are aware, this is the first approach to spatial confounding that does not rely on restrictive parametric assumptions (such as linearity, effect homogeneity, or Gaussianity) for both identification and estimation. We demonstrate the advantages of the DML approach analytically and in simulations. We apply our methods and reasoning to a study of the effect of fine particulate matter exposure during pregnancy on birthweight in California.

We consider Maxwell eigenvalue problems on uncertain shapes with perfectly conducting TESLA cavities being the driving example. Due to the shape uncertainty the resulting eigenvalues and eigenmodes are also uncertain and it is well known that the eigenvalues may exhibit crossings or bifurcations under perturbation. We discuss how the shape uncertainties can be modelled using the domain mapping approach and how the deformation mapping can be expressed as coefficients in Maxwell's equations. Using derivatives of these coefficients and derivatives of the eigenpairs, we follow a perturbation approach to compute approximations of mean and covariance of the eigenpairs. For small perturbations these approximations are faster and more accurate than sampling or surrogate model strategies. For the implementation we use an approach based on isogeometric analysis, which allows for straightforward modelling of the domain deformations and computation of the required derivatives. Numerical experiments for a three-dimensional 9-cell TESLA cavity are presented.

Nonparametric estimators for the mean and the covariance functions of functional data are proposed. The setup covers a wide range of practical situations. The random trajectories are, not necessarily differentiable, have unknown regularity, and are measured with error at discrete design points. The measurement error could be heteroscedastic. The design points could be either randomly drawn or common for all curves. The estimators depend on the local regularity of the stochastic process generating the functional data. We consider a simple estimator of this local regularity which exploits the replication and regularization features of functional data. Next, we use the ``smoothing first, then estimate'' approach for the mean and the covariance functions. They can be applied with both sparsely or densely sampled curves, are easy to calculate and to update, and perform well in simulations. Simulations built upon an example of real data set, illustrate the effectiveness of the new approach.

This work considers two boundary correction techniques to mitigate the reduction in the temporal order of convergence in PDE sense (i.e., when both the space and time resolutions tend to zero independently of each other) of $d$ dimension space-discretized parabolic problems on a rectangular domain subject to time dependent boundary conditions. We make use of the MoL approach (method of lines) where the space discretization is made with central differences of order four and the time integration is carried out with $s$-stage AMF-W-methods. The time integrators are of ADI-type (alternating direction implicit by using a directional splitting) and of higher order than the usual ones appearing in the literature which only reach order 2. Besides, the techniques here explained also work for most of splitting methods, when directional splitting is used. A remarkable fact is that with these techniques, the time integrators recover the temporal order of PDE-convergence at the level of time-independent boundary conditions.

We study the performance of stochastic first-order methods for finding saddle points of convex-concave functions. A notorious challenge faced by such methods is that the gradients can grow arbitrarily large during optimization, which may result in instability and divergence. In this paper, we propose a simple and effective regularization technique that stabilizes the iterates and yields meaningful performance guarantees even if the domain and the gradient noise scales linearly with the size of the iterates (and is thus potentially unbounded). Besides providing a set of general results, we also apply our algorithm to a specific problem in reinforcement learning, where it leads to performance guarantees for finding near-optimal policies in an average-reward MDP without prior knowledge of the bias span.

We study an interacting particle method (IPM) for computing the large deviation rate function of entropy production for diffusion processes, with emphasis on the vanishing-noise limit and high dimensions. The crucial ingredient to obtain the rate function is the computation of the principal eigenvalue $\lambda$ of elliptic, non-self-adjoint operators. We show that this principal eigenvalue can be approximated in terms of the spectral radius of a discretized evolution operator obtained from an operator splitting scheme and an Euler--Maruyama scheme with a small time step size, and we show that this spectral radius can be accessed through a large number of iterations of this discretized semigroup, suitable for the IPM. The IPM applies naturally to problems in unbounded domains, scales easily to high dimensions, and adapts to singular behaviors in the vanishing-noise limit. We show numerical examples in dimensions up to 16. The numerical results show that our numerical approximation of $\lambda$ converges to the analytical vanishing-noise limit within visual tolerance with a fixed number of particles and a fixed time step size. Our paper appears to be the first one to obtain numerical results of principal eigenvalue problems for non-self-adjoint operators in such high dimensions.