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The past few years have seen an increasing number of initiatives aimed at integrating information generated outside of confirmatory randomised clinical trials (RCTs) into drug development. However, data generated non-concurrently and through observational studies can provide results that are difficult to compare with randomised trial data. Moreover, the scientific questions these data can serve to answer often remain vague. Our starting point is to use clearly defined objectives for evidence generation, which are formulated towards early discussion with health technology assessment (HTA) bodies and are additional to regulatory requirements for authorisation of a new treatment. We propose FACTIVE (Flexible Augmented Clinical Trial for Improved eVidencE generation), a new class of study designs enabling flexible augmentation of confirmatory randomised controlled trials with concurrent and close-to-real-world elements. These enabling designs facilitate estimation of certain treatment effects in the confirmatory part and other, complementary treatment effects in a concurrent real-world part. Each stakeholder should use the evidence that is relevant within their own decision-making framework. High quality data are generated under one single protocol and the use of randomisation ensures rigorous statistical inference and interpretation within and between the different parts of the experiment. Evidence for the decision-making of HTA bodies could be available earlier than is currently the case.

Knowledge Graphs are repositories of information that gather data from a multitude of domains and sources in the form of semantic triples, serving as a source of structured data for various crucial applications in the modern web landscape, from Wikipedia infoboxes to search engines. Such graphs mainly serve as secondary sources of information and depend on well-documented and verifiable provenance to ensure their trustworthiness and usability. However, their ability to systematically assess and assure the quality of this provenance, most crucially whether it properly supports the graph's information, relies mainly on manual processes that do not scale with size. ProVe aims at remedying this, consisting of a pipelined approach that automatically verifies whether a Knowledge Graph triple is supported by text extracted from its documented provenance. ProVe is intended to assist information curators and consists of four main steps involving rule-based methods and machine learning models: text extraction, triple verbalisation, sentence selection, and claim verification. ProVe is evaluated on a Wikidata dataset, achieving promising results overall and excellent performance on the binary classification task of detecting support from provenance, with 87.5% accuracy and 82.9% F1-macro on text-rich sources. The evaluation data and scripts used in this paper are available on GitHub and Figshare.

Spiking neural networks, also often referred to as the third generation of neural networks, carry the potential for a massive reduction in memory and energy consumption over traditional, second-generation neural networks. Inspired by the undisputed efficiency of the human brain, they introduce temporal and neuronal sparsity, which can be exploited by next-generation neuromorphic hardware. To open the pathway toward engineering applications, we introduce this exciting technology in the context of continuum mechanics. However, the nature of spiking neural networks poses a challenge for regression problems, which frequently arise in the modeling of engineering sciences. To overcome this problem, a framework for regression using spiking neural networks is proposed. In particular, a network topology for decoding binary spike trains to real numbers is introduced, utilizing the membrane potential of spiking neurons. As the aim of this contribution is a concise introduction to this new methodology, several different spiking neural architectures, ranging from simple spiking feed-forward to complex spiking long short-term memory neural networks, are derived. Several numerical experiments directed towards regression of linear and nonlinear, history-dependent material models are carried out. A direct comparison with counterparts of traditional neural networks shows that the proposed framework is much more efficient while retaining precision and generalizability. All code has been made publicly available in the interest of reproducibility and to promote continued enhancement in this new domain.

Recent advances in Transformer-based large language models (LLMs) have led to significant performance improvements across many tasks. These gains come with a drastic increase in the models' size, potentially leading to slow and costly use at inference time. In practice, however, the series of generations made by LLMs is composed of varying levels of difficulty. While certain predictions truly benefit from the models' full capacity, other continuations are more trivial and can be solved with reduced compute. In this work, we introduce Confident Adaptive Language Modeling (CALM), a framework for dynamically allocating different amounts of compute per input and generation timestep. Early exit decoding involves several challenges that we address here, such as: (1) what confidence measure to use; (2) connecting sequence-level constraints to local per-token exit decisions; and (3) attending back to missing hidden representations due to early exits in previous tokens. Through theoretical analysis and empirical experiments on three diverse text generation tasks, we demonstrate the efficacy of our framework in reducing compute -- potential speedup of up to $\times 3$ -- while provably maintaining high performance.

Deep neural networks (DNNs) have achieved unprecedented success in the field of artificial intelligence (AI), including computer vision, natural language processing and speech recognition. However, their superior performance comes at the considerable cost of computational complexity, which greatly hinders their applications in many resource-constrained devices, such as mobile phones and Internet of Things (IoT) devices. Therefore, methods and techniques that are able to lift the efficiency bottleneck while preserving the high accuracy of DNNs are in great demand in order to enable numerous edge AI applications. This paper provides an overview of efficient deep learning methods, systems and applications. We start from introducing popular model compression methods, including pruning, factorization, quantization as well as compact model design. To reduce the large design cost of these manual solutions, we discuss the AutoML framework for each of them, such as neural architecture search (NAS) and automated pruning and quantization. We then cover efficient on-device training to enable user customization based on the local data on mobile devices. Apart from general acceleration techniques, we also showcase several task-specific accelerations for point cloud, video and natural language processing by exploiting their spatial sparsity and temporal/token redundancy. Finally, to support all these algorithmic advancements, we introduce the efficient deep learning system design from both software and hardware perspectives.

Unsupervised domain adaptation has recently emerged as an effective paradigm for generalizing deep neural networks to new target domains. However, there is still enormous potential to be tapped to reach the fully supervised performance. In this paper, we present a novel active learning strategy to assist knowledge transfer in the target domain, dubbed active domain adaptation. We start from an observation that energy-based models exhibit free energy biases when training (source) and test (target) data come from different distributions. Inspired by this inherent mechanism, we empirically reveal that a simple yet efficient energy-based sampling strategy sheds light on selecting the most valuable target samples than existing approaches requiring particular architectures or computation of the distances. Our algorithm, Energy-based Active Domain Adaptation (EADA), queries groups of targe data that incorporate both domain characteristic and instance uncertainty into every selection round. Meanwhile, by aligning the free energy of target data compact around the source domain via a regularization term, domain gap can be implicitly diminished. Through extensive experiments, we show that EADA surpasses state-of-the-art methods on well-known challenging benchmarks with substantial improvements, making it a useful option in the open world. Code is available at //github.com/BIT-DA/EADA.

Domain generalization (DG), i.e., out-of-distribution generalization, has attracted increased interests in recent years. Domain generalization deals with a challenging setting where one or several different but related domain(s) are given, and the goal is to learn a model that can generalize to an unseen test domain. For years, great progress has been achieved. This paper presents the first review for recent advances in domain generalization. First, we provide a formal definition of domain generalization and discuss several related fields. Next, we thoroughly review the theories related to domain generalization and carefully analyze the theory behind generalization. Then, we categorize recent algorithms into three classes and present them in detail: data manipulation, representation learning, and learning strategy, each of which contains several popular algorithms. Third, we introduce the commonly used datasets and applications. Finally, we summarize existing literature and present some potential research topics for the future.

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing research direction owing to the large amount of available data and low budget requirement, compared with randomized controlled trials. Embraced with the rapidly developed machine learning area, various causal effect estimation methods for observational data have sprung up. In this survey, we provide a comprehensive review of causal inference methods under the potential outcome framework, one of the well known causal inference framework. The methods are divided into two categories depending on whether they require all three assumptions of the potential outcome framework or not. For each category, both the traditional statistical methods and the recent machine learning enhanced methods are discussed and compared. The plausible applications of these methods are also presented, including the applications in advertising, recommendation, medicine and so on. Moreover, the commonly used benchmark datasets as well as the open-source codes are also summarized, which facilitate researchers and practitioners to explore, evaluate and apply the causal inference methods.

Human knowledge provides a formal understanding of the world. Knowledge graphs that represent structural relations between entities have become an increasingly popular research direction towards cognition and human-level intelligence. In this survey, we provide a comprehensive review on knowledge graph covering overall research topics about 1) knowledge graph representation learning, 2) knowledge acquisition and completion, 3) temporal knowledge graph, and 4) knowledge-aware applications, and summarize recent breakthroughs and perspective directions to facilitate future research. We propose a full-view categorization and new taxonomies on these topics. Knowledge graph embedding is organized from four aspects of representation space, scoring function, encoding models and auxiliary information. For knowledge acquisition, especially knowledge graph completion, embedding methods, path inference and logical rule reasoning are reviewed. We further explore several emerging topics including meta relational learning, commonsense reasoning, and temporal knowledge graphs. To facilitate future research on knowledge graphs, we also provide a curated collection of datasets and open-source libraries on different tasks. In the end, we have a thorough outlook on several promising research directions.

Transfer learning aims at improving the performance of target learners on target domains by transferring the knowledge contained in different but related source domains. In this way, the dependence on a large number of target domain data can be reduced for constructing target learners. Due to the wide application prospects, transfer learning has become a popular and promising area in machine learning. Although there are already some valuable and impressive surveys on transfer learning, these surveys introduce approaches in a relatively isolated way and lack the recent advances in transfer learning. As the rapid expansion of the transfer learning area, it is both necessary and challenging to comprehensively review the relevant studies. This survey attempts to connect and systematize the existing transfer learning researches, as well as to summarize and interpret the mechanisms and the strategies in a comprehensive way, which may help readers have a better understanding of the current research status and ideas. Different from previous surveys, this survey paper reviews over forty representative transfer learning approaches from the perspectives of data and model. The applications of transfer learning are also briefly introduced. In order to show the performance of different transfer learning models, twenty representative transfer learning models are used for experiments. The models are performed on three different datasets, i.e., Amazon Reviews, Reuters-21578, and Office-31. And the experimental results demonstrate the importance of selecting appropriate transfer learning models for different applications in practice.