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The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical decisions involve answering open-ended questions without pre-set options. To better understand LLMs in the clinic, we construct a benchmark ClinicBench. We first collect eleven existing datasets covering diverse clinical language generation, understanding, and reasoning tasks. Furthermore, we construct six novel datasets and complex clinical tasks that are close to real-world practice, i.e., referral QA, treatment recommendation, hospitalization (long document) summarization, patient education, pharmacology QA and drug interaction for emerging drugs. We conduct an extensive evaluation of twenty-two LLMs under both zero-shot and few-shot settings. Finally, we invite medical experts to evaluate the clinical usefulness of LLMs.

We present a simple variable quantization approach that quantizes different layers of a large language model (LLM) at different bit levels. Specifically, we quantize the most important layers to higher bit precision and less important layers to lower bits to achieve floating point quantization levels. We propose two effective strategies to measure the importance of layers within LLMs: the first measures the importance of a layer based on how different its output embeddings are from the input embeddings (the higher the better); the second estimates the importance of a layer using the number of layer weights that are much larger than average (the smaller the better). We show that quantizing different layers at varying bits according to our importance scores results in minimal performance drop with a far more compressed model size. Finally, we present several practical key takeaways from our variable layer-wise quantization experiments: (a) LLM performance under variable quantization remains close to the original model until 25-50% of layers are moved in lower quantization using our proposed ordering but only until 5-10% if moved using no specific ordering; (b) Quantizing LLMs to lower bits performs substantially better than pruning unless extreme quantization (2-bit) is used; and (c) Layer-wise quantization to lower bits works better in the case of larger LLMs with more layers compared to smaller LLMs with fewer layers. The code used to run the experiments is available at: //github.com/RazvanDu/LayerwiseQuant.

Recent advancements in general-purpose or domain-specific multimodal large language models (LLMs) have witnessed remarkable progress for medical decision-making. However, they are designated for specific classification or generative tasks, and require model training or finetuning on large-scale datasets with sizeable parameters and tremendous computing, hindering their clinical utility across diverse resource-constrained scenarios in practice. In this paper, we propose a novel and lightweight framework Med-MoE (Mixture-of-Experts) that tackles both discriminative and generative multimodal medical tasks. The learning of Med-MoE consists of three steps: multimodal medical alignment, instruction tuning and routing, and domain-specific MoE tuning. After aligning multimodal medical images with LLM tokens, we then enable the model for different multimodal medical tasks with instruction tuning, together with a trainable router tailored for expert selection across input modalities. Finally, the model is tuned by integrating the router with multiple domain-specific experts, which are selectively activated and further empowered by meta expert. Comprehensive experiments on both open- and close-end medical question answering (Med-VQA) and image classification tasks across datasets such as VQA-RAD, SLAKE and Path-VQA demonstrate that our model can achieve performance superior to or on par with state-of-the-art baselines, while only requiring approximately 30\%-50\% of activated model parameters. Extensive analysis and ablations corroborate the effectiveness and practical utility of our method.

To improve the ability of the large language model (LLMs) to tackle complex reasoning problems, chain-of-thoughts (CoT) methods were proposed to guide LLMs to reason step-by-step, enabling problem solving from simple to complex. State-of-the-art methods for generating such a chain involve interactive collaboration, where the learner generates candidate intermediate thoughts, evaluated by the LLM, guiding the generation of subsequent thoughts. However, a widespread yet understudied problem is that the evaluation from the LLM is typically noisy and unreliable, potentially misleading the generation process in selecting promising intermediate thoughts. In this paper, motivated by Vapnik's principle, we use pairwise-comparison evaluation instead of point-wise scoring to search for promising intermediate thoughts with the noisy feedback from the LLM. In each round, we randomly pair intermediate thoughts and directly prompt the LLM to select the more promising one from each pair, allowing us to identify the most promising thoughts through an iterative process. To further alleviate the noise in the comparison, we incorporate techniques from ensemble learning and dueling bandits, proposing two variants of the algorithm. Experiments on three real-world tasks demonstrate the effectiveness of our proposed algorithm and verify the rationale of the pairwise comparison mechanism.

The integration of experiment technologies with large language models (LLMs) is transforming scientific research, offering AI capabilities beyond specialized problem-solving to becoming research assistants for human scientists. In power systems, simulations are essential for research. However, LLMs face significant challenges in power system simulations due to limited pre-existing knowledge and the complexity of power grids. To address this issue, this work proposes a modular framework that integrates expertise from both the power system and LLM domains. This framework enhances LLMs' ability to perform power system simulations on previously unseen tools. Validated using 34 simulation tasks in Daline, a (optimal) power flow simulation and linearization toolbox not yet exposed to LLMs, the proposed framework improved GPT-4o's simulation coding accuracy from 0% to 96.07%, also outperforming the ChatGPT-4o web interface's 33.8% accuracy (with the entire knowledge base uploaded). These results highlight the potential of LLMs as research assistants in power systems.

Large language models (LLMs) are transforming the landscape of chemistry and materials science. Recent examples of LLM-accelerated experimental research include virtual assistants for parsing synthesis recipes from the literature, or using the extracted knowledge to guide synthesis and characterization. Despite these advancements, their application is constrained to labs with automated instruments and control software, leaving much of materials science reliant on manual processes. Here, we demonstrate the rapid deployment of a Python-based control module for a Keithley 2400 electrical source measure unit using ChatGPT-4. Through iterative refinement, we achieved effective instrument management with minimal human intervention. Additionally, a user-friendly graphical user interface (GUI) was created, effectively linking all instrument controls to interactive screen elements. Finally, we integrated this AI-crafted instrument control software with a high-performance stochastic optimization algorithm to facilitate rapid and automated extraction of electronic device parameters related to semiconductor charge transport mechanisms from current-voltage (IV) measurement data. This integration resulted in a comprehensive open-source toolkit for semiconductor device characterization and analysis using IV curve measurements. We demonstrate the application of these tools by acquiring, analyzing, and parameterizing IV data from a Pt/Cr$_2$O$_3$:Mg/$\beta$-Ga$_2$O$_3$ heterojunction diode, a novel stack for high-power and high-temperature electronic devices. This approach underscores the powerful synergy between LLMs and the development of instruments for scientific inquiry, showcasing a path for further acceleration in materials science.

The strong capability of large language models (LLMs) has been applied to information extraction (IE) through either retrieval augmented prompting or instruction tuning (IT). However, the best way to incorporate information with LLMs for IE remains an open question. In this paper, we explore Retrieval Augmented Instruction Tuning (RA-IT) for IE, focusing on the task of open named entity recognition (NER). Specifically, for each training sample, we retrieve semantically similar examples from the training dataset as the context and prepend them to the input of the original instruction. To evaluate our RA-IT approach more thoroughly, we construct a Chinese IT dataset for open NER and evaluate RA-IT in both English and Chinese scenarios. Experimental results verify the effectiveness of RA-IT across various data sizes and in both English and Chinese scenarios. We also conduct thorough studies to explore the impacts of various retrieval strategies in the proposed RA-IT framework. Code and data are available at: //github.com/Emma1066/Retrieval-Augmented-IT-OpenNER

Large language models have achieved remarkable success on general NLP tasks, but they may fall short for domain-specific problems. Recently, various Retrieval-Augmented Large Language Models (RALLMs) are proposed to address this shortcoming. However, existing evaluation tools only provide a few baselines and evaluate them on various domains without mining the depth of domain knowledge. In this paper, we address the challenges of evaluating RALLMs by introducing the R-Eval toolkit, a Python toolkit designed to streamline the evaluation of different RAG workflows in conjunction with LLMs. Our toolkit, which supports popular built-in RAG workflows and allows for the incorporation of customized testing data on the specific domain, is designed to be user-friendly, modular, and extensible. We conduct an evaluation of 21 RALLMs across three task levels and two representative domains, revealing significant variations in the effectiveness of RALLMs across different tasks and domains. Our analysis emphasizes the importance of considering both task and domain requirements when choosing a RAG workflow and LLM combination. We are committed to continuously maintaining our platform at //github.com/THU-KEG/R-Eval to facilitate both the industry and the researchers.

While large language models (LLMs) have demonstrated remarkable capabilities across a range of downstream tasks, a significant concern revolves around their propensity to exhibit hallucinations: LLMs occasionally generate content that diverges from the user input, contradicts previously generated context, or misaligns with established world knowledge. This phenomenon poses a substantial challenge to the reliability of LLMs in real-world scenarios. In this paper, we survey recent efforts on the detection, explanation, and mitigation of hallucination, with an emphasis on the unique challenges posed by LLMs. We present taxonomies of the LLM hallucination phenomena and evaluation benchmarks, analyze existing approaches aiming at mitigating LLM hallucination, and discuss potential directions for future research.

Large language models (LLMs) have significantly advanced the field of natural language processing (NLP), providing a highly useful, task-agnostic foundation for a wide range of applications. The great promise of LLMs as general task solvers motivated people to extend their functionality largely beyond just a ``chatbot'', and use it as an assistant or even replacement for domain experts and tools in specific domains such as healthcare, finance, and education. However, directly applying LLMs to solve sophisticated problems in specific domains meets many hurdles, caused by the heterogeneity of domain data, the sophistication of domain knowledge, the uniqueness of domain objectives, and the diversity of the constraints (e.g., various social norms, cultural conformity, religious beliefs, and ethical standards in the domain applications). To fill such a gap, explosively-increase research, and practices have been conducted in very recent years on the domain specialization of LLMs, which, however, calls for a comprehensive and systematic review to better summarizes and guide this promising domain. In this survey paper, first, we propose a systematic taxonomy that categorizes the LLM domain-specialization techniques based on the accessibility to LLMs and summarizes the framework for all the subcategories as well as their relations and differences to each other. We also present a comprehensive taxonomy of critical application domains that can benefit from specialized LLMs, discussing their practical significance and open challenges. Furthermore, we offer insights into the current research status and future trends in this area.