Outbreaks of hand-foot-and-mouth disease(HFMD) have been associated with significant morbidity and, in severe cases, mortality. Accurate forecasting of daily admissions of pediatric HFMD patients is therefore crucial for aiding the hospital in preparing for potential outbreaks and mitigating nosocomial transmissions. To address this pressing need, we propose a novel transformer-based model with a U-net shape, utilizing the patching strategy and the joint prediction strategy that capitalizes on insights from herpangina, a disease closely correlated with HFMD. This model also integrates representation learning by introducing reconstruction loss as an auxiliary loss. The results show that our U-net Patching Time Series Transformer (UPTST) model outperforms existing approaches in both long- and short-arm prediction accuracy of HFMD at hospital-level. Furthermore, the exploratory extension experiments show that the model's capabilities extend beyond prediction of infectious disease, suggesting broader applicability in various domains.
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Medical image segmentation, which is essential for many clinical applications, has achieved almost human-level performance via data-driven deep learning techniques. Nevertheless, its performance is predicated on the costly process of manually annotating a large amount of medical images. To this end, we propose a novel framework for robust semi-supervised medical image segmentation using diagonal hierarchical consistency (DiHC-Net). First, it is composed of multiple sub-models with identical multi-scale architecture but with distinct sub-layers, such as up-sampling and normalisation layers. Second, a novel diagonal hierarchical consistency is enforced between one model's intermediate and final prediction and other models' soft pseudo labels in a diagonal hierarchical fashion. Experimental results verify the efficacy of our simple framework, outperforming all previous approaches on public Left Atrium (LA) dataset.
Optical Coherence Tomography Angiography (OCTA) is a promising tool for detecting Alzheimer's disease (AD) by imaging the retinal microvasculature. Ophthalmologists commonly use region-based analysis, such as the ETDRS grid, to study OCTA image biomarkers and understand the correlation with AD. However, existing studies have used general deep computer vision methods, which present challenges in providing interpretable results and leveraging clinical prior knowledge. To address these challenges, we propose a novel deep-learning framework called Polar-Net. Our approach involves mapping OCTA images from Cartesian coordinates to polar coordinates, which allows for the use of approximate sector convolution and enables the implementation of the ETDRS grid-based regional analysis method commonly used in clinical practice. Furthermore, Polar-Net incorporates clinical prior information of each sector region into the training process, which further enhances its performance. Additionally, our framework adapts to acquire the importance of the corresponding retinal region, which helps researchers and clinicians understand the model's decision-making process in detecting AD and assess its conformity to clinical observations. Through evaluations on private and public datasets, we have demonstrated that Polar-Net outperforms existing state-of-the-art methods and provides more valuable pathological evidence for the association between retinal vascular changes and AD. In addition, we also show that the two innovative modules introduced in our framework have a significant impact on improving overall performance.
Exploiting cognates for transfer learning in under-resourced languages is an exciting opportunity for language understanding tasks, including unsupervised machine translation, named entity recognition and information retrieval. Previous approaches mainly focused on supervised cognate detection tasks based on orthographic, phonetic or state-of-the-art contextual language models, which under-perform for most under-resourced languages. This paper proposes a novel language-agnostic weakly-supervised deep cognate detection framework for under-resourced languages using morphological knowledge from closely related languages. We train an encoder to gain morphological knowledge of a language and transfer the knowledge to perform unsupervised and weakly-supervised cognate detection tasks with and without the pivot language for the closely-related languages. While unsupervised, it overcomes the need for hand-crafted annotation of cognates. We performed experiments on different published cognate detection datasets across language families and observed not only significant improvement over the state-of-the-art but also our method outperformed the state-of-the-art supervised and unsupervised methods. Our model can be extended to a wide range of languages from any language family as it overcomes the requirement of the annotation of the cognate pairs for training. The code and dataset building scripts can be found at //github.com/koustavagoswami/Weakly_supervised-Cognate_Detection
Ultrasound (US) imaging is widely used in diagnosing and staging abdominal diseases due to its lack of non-ionizing radiation and prevalent availability. However, significant inter-operator variability and inconsistent image acquisition hinder the widespread adoption of extensive screening programs. Robotic ultrasound systems have emerged as a promising solution, offering standardized acquisition protocols and the possibility of automated acquisition. Additionally, these systems enable access to 3D data via robotic tracking, enhancing volumetric reconstruction for improved ultrasound interpretation and precise disease diagnosis. However, the interpretability of 3D US reconstruction of abdominal images can be affected by the patient's breathing motion. This study introduces a method to compensate for breathing motion in 3D US compounding by leveraging implicit neural representations. Our approach employs a robotic ultrasound system for automated screenings. To demonstrate the method's effectiveness, we evaluate our proposed method for the diagnosis and monitoring of abdominal aorta aneurysms as a representative use case. Our experiments demonstrate that our proposed pipeline facilitates robust automated robotic acquisition, mitigating artifacts from breathing motion, and yields smoother 3D reconstructions for enhanced screening and medical diagnosis.
The field of causal discovery develops model selection methods to infer cause-effect relations among a set of random variables. For this purpose, different modelling assumptions have been proposed to render cause-effect relations identifiable. One prominent assumption is that the joint distribution of the observed variables follows a linear non-Gaussian structural equation model. In this paper, we develop novel goodness-of-fit tests that assess the validity of this assumption in the basic setting without latent confounders as well as in extension to linear models that incorporate latent confounders. Our approach involves testing algebraic relations among second and higher moments that hold as a consequence of the linearity of the structural equations. Specifically, we show that the linearity implies rank constraints on matrices and tensors derived from moments. For a practical implementation of our tests, we consider a multiplier bootstrap method that uses incomplete U-statistics to estimate subdeterminants, as well as asymptotic approximations to the null distribution of singular values. The methods are illustrated, in particular, for the T\"ubingen collection of benchmark data sets on cause-effect pairs.
Binarization is a powerful compression technique for neural networks, significantly reducing FLOPs, but often results in a significant drop in model performance. To address this issue, partial binarization techniques have been developed, but a systematic approach to mixing binary and full-precision parameters in a single network is still lacking. In this paper, we propose a controlled approach to partial binarization, creating a budgeted binary neural network (B2NN) with our MixBin strategy. This method optimizes the mixing of binary and full-precision components, allowing for explicit selection of the fraction of the network to remain binary. Our experiments show that B2NNs created using MixBin outperform those from random or iterative searches and state-of-the-art layer selection methods by up to 3% on the ImageNet-1K dataset. We also show that B2NNs outperform the structured pruning baseline by approximately 23% at the extreme FLOP budget of 15%, and perform well in object tracking, with up to a 12.4% relative improvement over other baselines. Additionally, we demonstrate that B2NNs developed by MixBin can be transferred across datasets, with some cases showing improved performance over directly applying MixBin on the downstream data.
Despite recent attention and exploration of depth for various tasks, it is still an unexplored modality for weakly-supervised object detection (WSOD). We propose an amplifier method for enhancing the performance of WSOD by integrating depth information. Our approach can be applied to any WSOD method based on multiple-instance learning, without necessitating additional annotations or inducing large computational expenses. Our proposed method employs a monocular depth estimation technique to obtain hallucinated depth information, which is then incorporated into a Siamese WSOD network using contrastive loss and fusion. By analyzing the relationship between language context and depth, we calculate depth priors to identify the bounding box proposals that may contain an object of interest. These depth priors are then utilized to update the list of pseudo ground-truth boxes, or adjust the confidence of per-box predictions. Our proposed method is evaluated on six datasets (COCO, PASCAL VOC, Conceptual Captions, Clipart1k, Watercolor2k, and Comic2k) by implementing it on top of two state-of-the-art WSOD methods, and we demonstrate a substantial enhancement in performance.
Laparoscopic surgery has been shown through a number of randomized trials to be an effective form of treatment for cholecystitis. Given this evidence, one natural question for clinical practice is: does the effectiveness of laparoscopic surgery vary among patients? It might be the case that, while the overall effect is positive, some patients treated with laparoscopic surgery may respond positively to the intervention while others do not or may be harmed. In our study, we focus on conditional average treatment effects to understand whether treatment effects vary systematically with patient characteristics. Recent methodological work has developed a meta-learner framework for flexible estimation of conditional causal effects. In this framework, nonparametric estimation methods can be used to avoid bias from model misspecification while preserving statistical efficiency. In addition, researchers can flexibly and effectively explore whether treatment effects vary with a large number of possible effect modifiers. However, these methods have certain limitations. For example, conducting inference can be challenging if black-box models are used. Further, interpreting and visualizing the effect estimates can be difficult when there are multi-valued effect modifiers. In this paper, we develop new methods that allow for interpretable results and inference from the meta-learner framework for heterogeneous treatment effects estimation. We also demonstrate methods that allow for an exploratory analysis to identify possible effect modifiers. We apply our methods to a large database for the use of laparoscopic surgery in treating cholecystitis. We also conduct a series of simulation studies to understand the relative performance of the methods we develop. Our study provides key guidelines for the interpretation of conditional causal effects from the meta-learner framework.
In neurosurgical procedures maximizing the resection of tumor tissue while avoiding healthy tissue is of paramount importance and a difficult task due to many factors, such as surrounding eloquent brain. Swiftly identifying tumor tissue for removal could increase surgical outcomes. The TumorID is a laser-induced fluorescence spectroscopy device that utilizes endogenous fluorophores such as NADH and FAD to detect tumor regions. With the goal of creating an endoscopic tool for intraoperative tumor detection in mind, a study of the TumorID was conducted to assess how the angle of incidence (AoI) affects the collected spectral response of the scanned tumor. For this study, flat and convex NADH/FAD gellan gum phantoms were scanned at various AoI (a range of 36 degrees) to observe the spectral behavior. Results showed that spectral signature did not change significantly across flat and convex phantoms, and the Area under Curve (AUC) values calculated for each spectrum had a standard deviation of 0.02 and 0.01 for flat and convex phantoms, respectively. Therefore, the study showed that AoI will affect the intensity of the spectral response, but the peaks representative of the endogenous fluorophores are still observable and similar. Future work includes conducting an AoI study with a longer working-distance lens, then incorporating said lens to design an endoscopic, intraoperative tumor detection device for minimally invasive surgery, with first applications in endonasal endoscopic approaches for pituitary tumors.
Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.
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