BRCA genes, comprising BRCA1 and BRCA2 play indispensable roles in preserving genomic stability and facilitating DNA repair mechanisms. The presence of germline mutations in these genes has been associated with increased susceptibility to various cancers, notably breast and ovarian cancers. Recent advancements in cost-effective sequencing technologies have revolutionized the landscape of cancer genomics, leading to a notable rise in the number of sequenced cancer patient genomes, enabling large-scale computational studies. In this study, we delve into the BRCA mutations in the dbSNP, housing an extensive repository of 41,177 and 44,205 genetic mutations for BRCA1 and BRCA2, respectively. Employing meticulous computational analysis from an umbrella perspective, our research unveils intriguing findings pertaining to a number of critical aspects. Namely, we discover that the majority of BRCA mutations in dbSNP have unknown clinical significance. We find that, although exon 11 for both genes contains the majority of the mutations and may seem as if it is a mutation hot spot, upon analyzing mutations per base pair, we find that all exons exhibit similar levels of mutations. Investigating mutations within introns, while we observe that the recorded mutations are generally uniformly distributed, almost all of the pathogenic mutations in introns are located close to splicing regions (at the beginning or the end). In addition to the findings mentioned earlier, we have also made other discoveries concerning mutation types and the level of confidence in observations within the dbSNP database.
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Over the last years, Unmanned Aerial Vehicles (UAVs) have seen significant advancements in sensor capabilities and computational abilities, allowing for efficient autonomous navigation and visual tracking applications. However, the demand for computationally complex tasks has increased faster than advances in battery technology. This opens up possibilities for improvements using edge computing. In edge computing, edge servers can achieve lower latency responses compared to traditional cloud servers through strategic geographic deployments. Furthermore, these servers can maintain superior computational performance compared to UAVs, as they are not limited by battery constraints. Combining these technologies by aiding UAVs with edge servers, research finds measurable improvements in task completion speed, energy efficiency, and reliability across multiple applications and industries. This systematic literature review aims to analyze the current state of research and collect, select, and extract the key areas where UAV activities can be supported and improved through edge computing.
Distributed algorithms, particularly Diffusion Least Mean Square, are widely favored for their reliability, robustness, and fast convergence in various industries. However, limited observability of the target can compromise the integrity of the algorithm. To address this issue, this paper proposes a framework for analyzing combination strategies by drawing inspiration from signal flow analysis. A thresholding-based algorithm is also presented to identify and utilize the support vector in scenarios with missing information about the target vector's support. The proposed approach is demonstrated in two combination scenarios, showcasing the effectiveness of the algorithm in situations characterized by sparse observations in the time and transform domains.
In the field of Artificial (General) Intelligence (AI), the several recent advancements in Natural language processing (NLP) activities relying on Large Language Models (LLMs) have come to encourage the adoption of LLMs as scientific models of language. While the terminology employed for the characterization of LLMs favors their embracing as such, it is not clear that they are in a place to offer insights into the target system they seek to represent. After identifying the most important theoretical and empirical risks brought about by the adoption of scientific models that lack transparency, we discuss LLMs relating them to every scientific model's fundamental components: the object, the medium, the meaning and the user. We conclude that, at their current stage of development, LLMs hardly offer any explanations for language, and then we provide an outlook for more informative future research directions on this topic.
Vision Transformers (ViTs) are becoming more popular and dominating technique for various vision tasks, compare to Convolutional Neural Networks (CNNs). As a demanding technique in computer vision, ViTs have been successfully solved various vision problems while focusing on long-range relationships. In this paper, we begin by introducing the fundamental concepts and background of the self-attention mechanism. Next, we provide a comprehensive overview of recent top-performing ViT methods describing in terms of strength and weakness, computational cost as well as training and testing dataset. We thoroughly compare the performance of various ViT algorithms and most representative CNN methods on popular benchmark datasets. Finally, we explore some limitations with insightful observations and provide further research direction. The project page along with the collections of papers are available at //github.com/khawar512/ViT-Survey
Hallucination plagues even frontier LLMs--but how bad is it really for summarizing academic papers? We evaluate Factored Verification, a simple automated method for detecting hallucinations in abstractive summaries. This method sets a new SotA on hallucination detection in the summarization task of the HaluEval benchmark, achieving 76.2% accuracy. We then use this method to estimate how often language models hallucinate when summarizing across multiple academic papers and find 0.62 hallucinations in the average ChatGPT (16k) summary, 0.84 for GPT-4, and 1.55 for Claude 2. We ask models to self-correct using Factored Critiques and find that this lowers the number of hallucinations to 0.49 for ChatGPT, 0.46 for GPT-4, and 0.95 for Claude 2. The hallucinations we find are often subtle, so we advise caution when using models to synthesize academic papers.
Multilingual Neural Machine Translation (MNMT) facilitates knowledge sharing but often suffers from poor zero-shot (ZS) translation qualities. While prior work has explored the causes of overall low ZS performance, our work introduces a fresh perspective: the presence of high variations in ZS performance. This suggests that MNMT does not uniformly exhibit poor ZS capability; instead, certain translation directions yield reasonable results. Through systematic experimentation involving 1,560 language directions spanning 40 languages, we identify three key factors contributing to high variations in ZS NMT performance: 1) target side translation capability 2) vocabulary overlap 3) linguistic properties. Our findings highlight that the target side translation quality is the most influential factor, with vocabulary overlap consistently impacting ZS performance. Additionally, linguistic properties, such as language family and writing system, play a role, particularly with smaller models. Furthermore, we suggest that the off-target issue is a symptom of inadequate ZS performance, emphasizing that zero-shot translation challenges extend beyond addressing the off-target problem. We release the data and models serving as a benchmark to study zero-shot for future research at //github.com/Smu-Tan/ZS-NMT-Variations
We study a sender-receiver model where the receiver can commit to a decision rule before the sender determines the information policy. The decision rule can depend on the signal structure and the signal realization that the sender adopts. This framework captures applications where a decision-maker (the receiver) solicit advice from an interested party (sender). In these applications, the receiver faces uncertainty regarding the sender's preferences and the set of feasible signal structures. Consequently, we adopt a unified robust analysis framework that includes max-min utility, min-max regret, and min-max approximation ratio as special cases. We show that it is optimal for the receiver to sacrifice ex-post optimality to perfectly align the sender's incentive. The optimal decision rule is a quota rule, i.e., the decision rule maximizes the receiver's ex-ante payoff subject to the constraint that the marginal distribution over actions adheres to a consistent quota, regardless of the sender's chosen signal structure.
Large Language Models (LLMs), like ChatGPT, are fundamentally tools trained on vast data, reflecting diverse societal impressions. This paper aims to investigate LLMs' self-perceived bias concerning indigeneity when simulating scenarios of indigenous people performing various roles. Through generating and analyzing multiple scenarios, this work offers a unique perspective on how technology perceives and potentially amplifies societal biases related to indigeneity in social computing. The findings offer insights into the broader implications of indigeneity in critical computing.
The globally convergent convexification numerical method is constructed for a Coefficient Inverse Problem for the Mean Field Games System. A coefficient characterizing the global interaction term is recovered from the single measurement data. In particular, a new Carleman estimate for the Volterra integral operator is proven, and it stronger than the previously known one. Numerical results demonstrate accurate reconstructions from noisy data.
The advent of large language models marks a revolutionary breakthrough in artificial intelligence. With the unprecedented scale of training and model parameters, the capability of large language models has been dramatically improved, leading to human-like performances in understanding, language synthesizing, and common-sense reasoning, etc. Such a major leap-forward in general AI capacity will change the pattern of how personalization is conducted. For one thing, it will reform the way of interaction between humans and personalization systems. Instead of being a passive medium of information filtering, large language models present the foundation for active user engagement. On top of such a new foundation, user requests can be proactively explored, and user's required information can be delivered in a natural and explainable way. For another thing, it will also considerably expand the scope of personalization, making it grow from the sole function of collecting personalized information to the compound function of providing personalized services. By leveraging large language models as general-purpose interface, the personalization systems may compile user requests into plans, calls the functions of external tools to execute the plans, and integrate the tools' outputs to complete the end-to-end personalization tasks. Today, large language models are still being developed, whereas the application in personalization is largely unexplored. Therefore, we consider it to be the right time to review the challenges in personalization and the opportunities to address them with LLMs. In particular, we dedicate this perspective paper to the discussion of the following aspects: the development and challenges for the existing personalization system, the newly emerged capabilities of large language models, and the potential ways of making use of large language models for personalization.
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