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We propose a new concept of lifts of reversible diffusion processes and show that various well-known non-reversible Markov processes arising in applications are lifts in this sense of simple reversible diffusions. Furthermore, we introduce a concept of non-asymptotic relaxation times and show that these can at most be reduced by a square root through lifting, generalising a related result in discrete time. Finally, we demonstrate how the recently developed approach to quantitative hypocoercivity based on space-time Poincar\'e inequalities can be rephrased and simplified in the language of lifts and how it can be applied to find optimal lifts.

Several mixed-effects models for longitudinal data have been proposed to accommodate the non-linearity of late-life cognitive trajectories and assess the putative influence of covariates on it. No prior research provides a side-by-side examination of these models to offer guidance on their proper application and interpretation. In this work, we examined five statistical approaches previously used to answer research questions related to non-linear changes in cognitive aging: the linear mixed model (LMM) with a quadratic term, LMM with splines, the functional mixed model, the piecewise linear mixed model, and the sigmoidal mixed model. We first theoretically describe the models. Next, using data from two prospective cohorts with annual cognitive testing, we compared the interpretation of the models by investigating associations of education on cognitive change before death. Lastly, we performed a simulation study to empirically evaluate the models and provide practical recommendations. Except for the LMM-quadratic, the fit of all models was generally adequate to capture non-linearity of cognitive change and models were relatively robust. Although spline-based models have no interpretable nonlinearity parameters, their convergence was easier to achieve, and they allow graphical interpretation. In contrast, piecewise and sigmoidal models, with interpretable non-linear parameters, may require more data to achieve convergence.

Chemical and biochemical reactions can exhibit surprisingly different behaviours from multiple steady-state solutions to oscillatory solutions and chaotic behaviours. Such behaviour has been of great interest to researchers for many decades. The Briggs-Rauscher, Belousov-Zhabotinskii and Bray-Liebhafsky reactions, for which periodic variations in concentrations can be visualized by changes in colour, are experimental examples of oscillating behaviour in chemical systems. These type of systems are modelled by a system of partial differential equations coupled by a nonlinearity. However, analysing the pattern, one may suspect that the dynamic is only generated by a finite number of spatial Fourier modes. In fluid dynamics, it is shown that for large times, the solution is determined by a finite number of spatial Fourier modes, called determining modes. In the article, we first introduce the concept of determining modes and show that, indeed, it is sufficient to characterise the dynamic by only a finite number of spatial Fourier modes. In particular, we analyse the exact number of the determining modes of $u$ and $v$, where the couple $(u,v)$ solves the following stochastic system \begin{equation*} \partial_t{u}(t) = r_1\Delta u(t) -\alpha_1u(t)- \gamma_1u(t)v^2(t) + f(1 - u(t)) + g(t),\quad \partial_t{v}(t) = r_2\Delta v(t) -\alpha_2v(t) + \gamma_2 u(t)v^2(t) + h(t),\quad u(0) = u_0,\;v(0) = v_0, \end{equation*} where $r_1,r_2,\gamma_1,\gamma_2>0$, $\alpha_1,\alpha_2 \ge 0$ and $g,h$ are time depending mappings specified later.

A component-splitting method is proposed to improve convergence characteristics for implicit time integration of compressible multicomponent reactive flows. The characteristic decomposition of flux jacobian of multicomponent Navier-Stokes equations yields a large sparse eigensystem, presenting challenges of slow convergence and high computational costs for implicit methods. To addresses this issue, the component-splitting method segregates the implicit operator into two parts: one for the flow equations (density/momentum/energy) and the other for the component equations. Each part's implicit operator employs flux-vector splitting based on their respective spectral radii to achieve accelerated convergence. This approach improves the computational efficiency of implicit iteration, mitigating the quadratic increase in time cost with the number of species. Two consistence corrections are developed to reduce the introduced component-splitting error and ensure the numerical consistency of mass fraction. Importantly, the impact of component-splitting method on accuracy is minimal as the residual approaches convergence. The accuracy, efficiency, and robustness of component-splitting method are thoroughly investigated and compared with the coupled implicit scheme through several numerical cases involving thermo-chemical nonequilibrium hypersonic flows. The results demonstrate that the component-splitting method decreases the required number of iteration steps for convergence of residual and wall heat flux, decreases the computation time per iteration step, and diminishes the residual to lower magnitude. The acceleration efficiency is enhanced with increases in CFL number and number of species.

This study addresses a class of linear mixed-integer programming (MILP) problems that involve uncertainty in the objective function parameters. The parameters are assumed to form a random vector, whose probability distribution can only be observed through a finite training data set. Unlike most of the related studies in the literature, we also consider uncertainty in the underlying data set. The data uncertainty is described by a set of linear constraints for each random sample, and the uncertainty in the distribution (for a fixed realization of data) is defined using a type-1 Wasserstein ball centered at the empirical distribution of the data. The overall problem is formulated as a three-level distributionally robust optimization (DRO) problem. First, we prove that the three-level problem admits a single-level MILP reformulation, if the class of loss functions is restricted to biaffine functions. Secondly, it turns out that for several particular forms of data uncertainty, the outlined problem can be solved reasonably fast by leveraging the nominal MILP problem. Finally, we conduct a computational study, where the out-of-sample performance of our model and computational complexity of the proposed MILP reformulation are explored numerically for several application domains.

As the development of formal proofs is a time-consuming task, it is important to devise ways of sharing the already written proofs to prevent wasting time redoing them. One of the challenges in this domain is to translate proofs written in proof assistants based on impredicative logics to proof assistants based on predicative logics, whenever impredicativity is not used in an essential way. In this paper we present a transformation for sharing proofs with a core predicative system supporting prenex universe polymorphism (like in Agda). It consists in trying to elaborate each term into a predicative universe polymorphic term as general as possible. The use of universe polymorphism is justified by the fact that mapping each universe to a fixed one in the target theory is not sufficient in most cases. During the elaboration, we need to solve unification problems in the equational theory of universe levels. In order to do this, we give a complete characterization of when a single equation admits a most general unifier. This characterization is then employed in a partial algorithm which uses a constraint-postponement strategy for trying to solve unification problems. The proposed translation is of course partial, but in practice allows one to translate many proofs that do not use impredicativity in an essential way. Indeed, it was implemented in the tool Predicativize and then used to translate semi-automatically many non-trivial developments from Matita's library to Agda, including proofs of Bertrand's Postulate and Fermat's Little Theorem, which (as far as we know) were not available in Agda yet.

We introduce a single-set axiomatisation of cubical $\omega$-categories, including connections and inverses. We justify these axioms by establishing a series of equivalences between the category of single-set cubical $\omega$-categories, and their variants with connections and inverses, and the corresponding cubical $\omega$-categories. We also report on the formalisation of cubical $\omega$-categories with the Isabelle/HOL proof assistant, which has been instrumental in finding the single-set axioms.

We introduce a novel quantum programming language featuring higher-order programs and quantum controlflow which ensures that all qubit transformations are unitary. Our language boasts a type system guaranteeingboth unitarity and polynomial-time normalization. Unitarity is achieved by using a special modality forsuperpositions while requiring orthogonality among superposed terms. Polynomial-time normalization isachieved using a linear-logic-based type discipline employing Barber and Plotkin duality along with a specificmodality to account for potential duplications. This type discipline also guarantees that derived values havepolynomial size. Our language seamlessly combines the two modalities: quantum circuit programs upholdunitarity, and all programs are evaluated in polynomial time, ensuring their feasibility.

C-based interpreters such as CPython make extensive use of C "extension" code, which is opaque to static analysis tools and faster runtimes with JIT compilers, such as PyPy. Not only are the extensions opaque, but the interface between the dynamic language types and the C types can introduce impedance. We hypothesise that frequent calls to C extension code introduce significant overhead that is often unnecessary. We validate this hypothesis by introducing a simple technique, "typed methods", which allow selected C extension functions to have additional metadata attached to them in a backward-compatible way. This additional metadata makes it much easier for a JIT compiler (and as we show, even an interpreter!) to significantly reduce the call and return overhead. Although we have prototyped typed methods in PyPy, we suspect that the same technique is applicable to a wider variety of language runtimes and that the information can also be consumed by static analysis tooling.

Iterated conditional expectation (ICE) g-computation is an estimation approach for addressing time-varying confounding for both longitudinal and time-to-event data. Unlike other g-computation implementations, ICE avoids the need to specify models for each time-varying covariate. For variance estimation, previous work has suggested the bootstrap. However, bootstrapping can be computationally intense and sensitive to the number of resamples used. Here, we present ICE g-computation as a set of stacked estimating equations. Therefore, the variance for the ICE g-computation estimator can be consistently estimated using the empirical sandwich variance estimator. Performance of the variance estimator was evaluated empirically with a simulation study. The proposed approach is also demonstrated with an illustrative example on the effect of cigarette smoking on the prevalence of hypertension. In the simulation study, the empirical sandwich variance estimator appropriately estimated the variance. When comparing runtimes between the sandwich variance estimator and the bootstrap for the applied example, the sandwich estimator was substantially faster, even when bootstraps were run in parallel. The empirical sandwich variance estimator is a viable option for variance estimation with ICE g-computation.