High Resolution (HR) medical images provide rich anatomical structure details to facilitate early and accurate diagnosis. In MRI, restricted by hardware capacity, scan time, and patient cooperation ability, isotropic 3D HR image acquisition typically requests long scan time and, results in small spatial coverage and low SNR. Recent studies showed that, with deep convolutional neural networks, isotropic HR MR images could be recovered from low-resolution (LR) input via single image super-resolution (SISR) algorithms. However, most existing SISR methods tend to approach a scale-specific projection between LR and HR images, thus these methods can only deal with a fixed up-sampling rate. For achieving different up-sampling rates, multiple SR networks have to be built up respectively, which is very time-consuming and resource-intensive. In this paper, we propose ArSSR, an Arbitrary Scale Super-Resolution approach for recovering 3D HR MR images. In the ArSSR model, the reconstruction of HR images with different up-scaling rates is defined as learning a continuous implicit voxel function from the observed LR images. Then the SR task is converted to represent the implicit voxel function via deep neural networks from a set of paired HR-LR training examples. The ArSSR model consists of an encoder network and a decoder network. Specifically, the convolutional encoder network is to extract feature maps from the LR input images and the fully-connected decoder network is to approximate the implicit voxel function. Due to the continuity of the learned function, a single ArSSR model can achieve arbitrary up-sampling rate reconstruction of HR images from any input LR image after training. Experimental results on three datasets show that the ArSSR model can achieve state-of-the-art SR performance for 3D HR MR image reconstruction while using a single trained model to achieve arbitrary up-sampling scales.
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Deep convolutional neural networks have been demonstrated to be effective for SISR in recent years. On the one hand, residual connections and dense connections have been used widely to ease forward information and backward gradient flows to boost performance. However, current methods use residual connections and dense connections separately in most network layers in a sub-optimal way. On the other hand, although various networks and methods have been designed to improve computation efficiency, save parameters, or utilize training data of multiple scale factors for each other to boost performance, it either do super-resolution in HR space to have a high computation cost or can not share parameters between models of different scale factors to save parameters and inference time. To tackle these challenges, we propose an efficient single image super-resolution network using dual path connections with multiple scale learning named as EMSRDPN. By introducing dual path connections inspired by Dual Path Networks into EMSRDPN, it uses residual connections and dense connections in an integrated way in most network layers. Dual path connections have the benefits of both reusing common features of residual connections and exploring new features of dense connections to learn a good representation for SISR. To utilize the feature correlation of multiple scale factors, EMSRDPN shares all network units in LR space between different scale factors to learn shared features and only uses a separate reconstruction unit for each scale factor, which can utilize training data of multiple scale factors to help each other to boost performance, meanwhile which can save parameters and support shared inference for multiple scale factors to improve efficiency. Experiments show EMSRDPN achieves better performance and comparable or even better parameter and inference efficiency over SOTA methods.
Image registration is a fundamental task for medical imaging. Resampling of the intensity values is required during registration and better spatial resolution with finer and sharper structures can improve the resampling performance and hence the registration accuracy. Super-resolution (SR) is an algorithmic technique targeting at spatial resolution enhancement which can achieve an image resolution beyond the hardware limitation. In this work, we consider SR as a preprocessing technique and present a CNN-based resolution enhancement module (REM) which can be easily plugged into the registration network in a cascaded manner. Different residual schemes and network configurations of REM are investigated to obtain an effective architecture design of REM. In fact, REM is not confined to image registration, it can also be straightforwardly integrated into other vision tasks for enhanced resolution. The proposed REM is thoroughly evaluated for deformable registration on medical images quantitatively and qualitatively at different upscaling factors. Experiments on LPBA40 brain MRI dataset demonstrate that REM not only improves the registration accuracy, especially when the input images suffer from degraded spatial resolution, but also generates resolution enhanced images which can be exploited for successive diagnosis.
Kidney DCE-MRI aims at both qualitative assessment of kidney anatomy and quantitative assessment of kidney function by estimating the tracer kinetic (TK) model parameters. Accurate estimation of TK model parameters requires an accurate measurement of the arterial input function (AIF) with high temporal resolution. Accelerated imaging is used to achieve high temporal resolution, which yields under-sampling artifacts in the reconstructed images. Compressed sensing (CS) methods offer a variety of reconstruction options. Most commonly, sparsity of temporal differences is encouraged for regularization to reduce artifacts. Increasing regularization in CS methods removes the ambient artifacts but also over-smooths the signal temporally which reduces the parameter estimation accuracy. In this work, we propose a single image trained deep neural network to reduce MRI under-sampling artifacts without reducing the accuracy of functional imaging markers. Instead of regularizing with a penalty term in optimization, we promote regularization by generating images from a lower dimensional representation. In this manuscript we motivate and explain the lower dimensional input design. We compare our approach to CS reconstructions with multiple regularization weights. Proposed approach results in kidney biomarkers that are highly correlated with the ground truth markers estimated using the CS reconstruction which was optimized for functional analysis. At the same time, the proposed approach reduces the artifacts in the reconstructed images.
We consider the single image super-resolution (SISR) problem, where a high-resolution (HR) image is generated based on a low-resolution (LR) input. Recently, generative adversarial networks (GANs) become popular to hallucinate details. Most methods along this line rely on a predefined single-LR-single-HR mapping, which is not flexible enough for the SISR task. Also, GAN-generated fake details may often undermine the realism of the whole image. We address these issues by proposing best-buddy GANs (Beby-GAN) for rich-detail SISR. Relaxing the immutable one-to-one constraint, we allow the estimated patches to dynamically seek the best supervision during training, which is beneficial to producing more reasonable details. Besides, we propose a region-aware adversarial learning strategy that directs our model to focus on generating details for textured areas adaptively. Extensive experiments justify the effectiveness of our method. An ultra-high-resolution 4K dataset is also constructed to facilitate future super-resolution research.
Normalizing flows have recently demonstrated promising results for low-level vision tasks. For image super-resolution (SR), it learns to predict diverse photo-realistic high-resolution (HR) images from the low-resolution (LR) image rather than learning a deterministic mapping. For image rescaling, it achieves high accuracy by jointly modelling the downscaling and upscaling processes. While existing approaches employ specialized techniques for these two tasks, we set out to unify them in a single formulation. In this paper, we propose the hierarchical conditional flow (HCFlow) as a unified framework for image SR and image rescaling. More specifically, HCFlow learns a bijective mapping between HR and LR image pairs by modelling the distribution of the LR image and the rest high-frequency component simultaneously. In particular, the high-frequency component is conditional on the LR image in a hierarchical manner. To further enhance the performance, other losses such as perceptual loss and GAN loss are combined with the commonly used negative log-likelihood loss in training. Extensive experiments on general image SR, face image SR and image rescaling have demonstrated that the proposed HCFlow achieves state-of-the-art performance in terms of both quantitative metrics and visual quality.
Recent advances in single image super-resolution (SISR) explored the power of convolutional neural network (CNN) to achieve a better performance. Despite the great success of CNN-based methods, it is not easy to apply these methods to edge devices due to the requirement of heavy computation. To solve this problem, various fast and lightweight CNN models have been proposed. The information distillation network is one of the state-of-the-art methods, which adopts the channel splitting operation to extract distilled features. However, it is not clear enough how this operation helps in the design of efficient SISR models. In this paper, we propose the feature distillation connection (FDC) that is functionally equivalent to the channel splitting operation while being more lightweight and flexible. Thanks to FDC, we can rethink the information multi-distillation network (IMDN) and propose a lightweight and accurate SISR model called residual feature distillation network (RFDN). RFDN uses multiple feature distillation connections to learn more discriminative feature representations. We also propose a shallow residual block (SRB) as the main building block of RFDN so that the network can benefit most from residual learning while still being lightweight enough. Extensive experimental results show that the proposed RFDN achieve a better trade-off against the state-of-the-art methods in terms of performance and model complexity. Moreover, we propose an enhanced RFDN (E-RFDN) and won the first place in the AIM 2020 efficient super-resolution challenge. Code will be available at //github.com/njulj/RFDN.
Human pose estimation - the process of recognizing human keypoints in a given image - is one of the most important tasks in computer vision and has a wide range of applications including movement diagnostics, surveillance, or self-driving vehicle. The accuracy of human keypoint prediction is increasingly improved thanks to the burgeoning development of deep learning. Most existing methods solved human pose estimation by generating heatmaps in which the ith heatmap indicates the location confidence of the ith keypoint. In this paper, we introduce novel network structures referred to as multiresolution representation learning for human keypoint prediction. At different resolutions in the learning process, our networks branch off and use extra layers to learn heatmap generation. We firstly consider the architectures for generating the multiresolution heatmaps after obtaining the lowest-resolution feature maps. Our second approach allows learning during the process of feature extraction in which the heatmaps are generated at each resolution of the feature extractor. The first and second approaches are referred to as multi-resolution heatmap learning and multi-resolution feature map learning respectively. Our architectures are simple yet effective, achieving good performance. We conducted experiments on two common benchmarks for human pose estimation: MS-COCO and MPII dataset.
This is an official pytorch implementation of Deep High-Resolution Representation Learning for Human Pose Estimation. In this work, we are interested in the human pose estimation problem with a focus on learning reliable high-resolution representations. Most existing methods recover high-resolution representations from low-resolution representations produced by a high-to-low resolution network. Instead, our proposed network maintains high-resolution representations through the whole process. We start from a high-resolution subnetwork as the first stage, gradually add high-to-low resolution subnetworks one by one to form more stages, and connect the mutli-resolution subnetworks in parallel. We conduct repeated multi-scale fusions such that each of the high-to-low resolution representations receives information from other parallel representations over and over, leading to rich high-resolution representations. As a result, the predicted keypoint heatmap is potentially more accurate and spatially more precise. We empirically demonstrate the effectiveness of our network through the superior pose estimation results over two benchmark datasets: the COCO keypoint detection dataset and the MPII Human Pose dataset. The code and models have been publicly available at \url{//github.com/leoxiaobin/deep-high-resolution-net.pytorch}.
In this paper, we focus on three problems in deep learning based medical image segmentation. Firstly, U-net, as a popular model for medical image segmentation, is difficult to train when convolutional layers increase even though a deeper network usually has a better generalization ability because of more learnable parameters. Secondly, the exponential ReLU (ELU), as an alternative of ReLU, is not much different from ReLU when the network of interest gets deep. Thirdly, the Dice loss, as one of the pervasive loss functions for medical image segmentation, is not effective when the prediction is close to ground truth and will cause oscillation during training. To address the aforementioned three problems, we propose and validate a deeper network that can fit medical image datasets that are usually small in the sample size. Meanwhile, we propose a new loss function to accelerate the learning process and a combination of different activation functions to improve the network performance. Our experimental results suggest that our network is comparable or superior to state-of-the-art methods.
Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ~10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results. Our code and trained models are available for download: //github.com/holgerroth/3Dunet_abdomen_cascade.
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