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Recent advancements in Artificial Intelligence (AI) have profoundly influenced medical fields, by providing tools to reduce clinical workloads. However, most AI models are constrained to execute uni-modal tasks, in stark contrast to the comprehensive approaches utilized by medical professionals. To address this, here we present RO-LLaMA, a versatile generalist large language model (LLM) tailored for the field of radiation oncology. This model seamlessly covers a wide range of the workflow of radiation oncologists, adept at various tasks such as clinical report summarization, radiation therapy plan suggestion, and plan-guided therapy target volume segmentation. In particular, to maximize the end-to-end performance, we further present a novel Consistency Embedding Fine-Tuning (CEFTune) technique, which boosts LLM's robustness to additional errors at the intermediates while preserving the capability of handling clean inputs, and creatively transform this concept into LLM-driven segmentation framework as Consistency Embedding Segmentation (CESEG). Experimental results on multi-centre cohort sets demonstrate our proposed RO-LLaMA's promising performance for diverse tasks with generalization capabilities.

Emissions of nitric oxide and nitrogen dioxide, which are named as NOx, are a major environmental and health concern.To react to the climate crisis, the South Korean government has strengthened NOx emission regulations. An accurate NOx prediction model can help companies to meet their NOx emission quotas and achieve cost savings. This study focuses on developing a model which forecasts the amount of NOx emissions in Pohang, a heavy industrial city in South Korea with serious air pollution problems.In this study, the Long-short term memory (LSTM) modeling is applied to predict the amount of NOx emissions, with missing data imputation using stochastic regression. Two parameters (i.e., time windows and learning rates) necessary to run the LSTM model are tested and selected using the Adam optimizer, one of the popular optimization methods in LSTM. I found that the model that I applied achieved the acceptable prediction performance since its Mean Absolute Scaled Error (MASE), the most important evaluation criterion, is less than 1. This means that applying the model that I developed in predicting future NOx emissions will perform better than a naive prediction, a model that simply predicts them based on the last observed data point.

In the realm of medical research, the intricate interplay of epidemiological risk, genomic activity, adverse events, and clinical response necessitates a nuanced consideration of multiple variables. Clinical trials, designed to meticulously assess the efficacy and safety of interventions, routinely incorporate a diverse array of endpoints. While a primary endpoint is customary, supplemented by key secondary endpoints, the statistical significance is typically evaluated independently for each. To address the inherent challenges in studying multiple endpoints, diverse strategies, including composite endpoints and global testing, have been proposed. This work stands apart by focusing on the evaluation of a clinical trial, deviating from the conventional approach to underscore the efficacy of a multiple-endpoint procedure. A double-blind study was conducted to gauge the treatment efficacy in adults infected with human immunodeficiency virus type 1 (HIV-1), featuring CD4 cell counts ranging from 200 to 500 per cubic millimeter. A total of 2467 HIV-1-infected patients (43 percent without prior antiretroviral treatment) were randomly assigned to one of four daily regimens: 600 mg of zidovudine; 600 mg of zidovudine plus 400 mg of didanosine; 600 mg of zidovudine plus 2.25 mg of zalcitabine; or 400 mg of didanosine. The primary endpoint comprised a >50 percent decline in CD4 cell count, development of acquired immunodeficiency syndrome (AIDS), or death. This study sought to determine the efficacy and safety of zidovudine (AZT) versus didanosine (ddI), AZT plus ddI, and AZT plus zalcitabine (ddC) in preventing disease progression in HIV-infected patients with CD4 counts of 200-500 cells/mm3. By jointly considering all endpoints, the multiple-endpoints approach yields results of greater significance than a single-endpoint approach.

Quantification of cardiac motion with cine Cardiac Magnetic Resonance Imaging (CMRI) is an integral part of arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis. Yet, the expert evaluation of motion abnormalities with CMRI is a challenging task. To automatically assess cardiac motion, we register CMRIs from different time points of the cardiac cycle using Implicit Neural Representations (INRs) and perform a biomechanically informed regularization inspired by the myocardial incompressibility assumption. To enhance the registration performance, our method first rectifies the inter-slice misalignment inherent to CMRI by performing a rigid registration guided by the long-axis views, and then increases the through-plane resolution using an unsupervised deep learning super-resolution approach. Finally, we propose to synergically combine information from short-axis and 4-chamber long-axis views, along with an initialization to incorporate information from multiple cardiac time points. Thereafter, to quantify cardiac motion, we calculate global and segmental strain over a cardiac cycle and compute the peak strain. The evaluation of the method is performed on a dataset of cine CMRI scans from 47 ARVC patients and 67 controls. Our results show that inter-slice alignment and generation of super-resolved volumes combined with joint analysis of the two cardiac views, notably improves registration performance. Furthermore, the proposed initialization yields more physiologically plausible registrations. The significant differences in the peak strain, discerned between the ARVC patients and healthy controls suggest that automated motion quantification methods may assist in diagnosis and provide further understanding of disease-specific alterations of cardiac motion.

ChatGPT and other Generative Artificial Intelligence (GAI) models tend to inherit and even amplify prevailing societal biases as they are trained on large amounts of existing data. Given the increasing usage of ChatGPT and other GAI by students, faculty members, and staff in higher education institutions (HEIs), there is an urgent need to examine the ethical issues involved such as its potential biases. In this scoping review, we clarify the ways in which biases related to GAI in higher education settings have been discussed in recent academic publications and identify what type of potential biases are commonly reported in this body of literature. We searched for academic articles written in English, Chinese, and Japanese across four main databases concerned with GAI usage in higher education and bias. Our findings show that while there is an awareness of potential biases around large language models (LLMs) and GAI, the majority of articles touch on ``bias'' at a relatively superficial level. Few identify what types of bias may occur under what circumstances. Neither do they discuss the possible implications for the higher education, staff, faculty members, or students. There is a notable lack of empirical work at this point, and we call for higher education researchers and AI experts to conduct more research in this area.

Concept-based models naturally lend themselves to the development of inherently interpretable skin lesion diagnosis, as medical experts make decisions based on a set of visual patterns of the lesion. Nevertheless, the development of these models depends on the existence of concept-annotated datasets, whose availability is scarce due to the specialized knowledge and expertise required in the annotation process. In this work, we show that vision-language models can be used to alleviate the dependence on a large number of concept-annotated samples. In particular, we propose an embedding learning strategy to adapt CLIP to the downstream task of skin lesion classification using concept-based descriptions as textual embeddings. Our experiments reveal that vision-language models not only attain better accuracy when using concepts as textual embeddings, but also require a smaller number of concept-annotated samples to attain comparable performance to approaches specifically devised for automatic concept generation.

Monkeypox (MPox) is a zoonotic infectious disease induced by the MPox Virus, part of the poxviridae orthopoxvirus group initially discovered in Africa and gained global attention in mid-2022 with cases reported outside endemic areas. Symptoms include headaches, chills, fever, smallpox, measles, and chickenpox-like skin manifestations and the WHO officially announced MPox as a global public health pandemic, in July 2022.Traditionally, PCR testing of skin lesions is considered a benchmark for the primary diagnosis by WHO, with symptom management as the primary treatment and antiviral drugs like tecovirimat for severe cases. However, manual analysis within hospitals poses a substantial challenge including the substantial burden on healthcare professionals, limited facilities, availability and fatigue among doctors, and human error during public health emergencies. Therefore, this survey paper provides an extensive and efficient analysis of deep learning (DL) methods for the automatic detection of MPox in skin lesion images. These DL techniques are broadly grouped into categories, including deep CNN, Deep CNNs ensemble, deep hybrid learning, the newly developed, and Vision transformer for diagnosing MPox. Moreover, this study offers a systematic exploration of the evolutionary progression of DL techniques and identifies, and addresses limitations in previous methods while highlighting the valuable contributions and innovation. Additionally, the paper addresses benchmark datasets and their collection from various authentic sources, pre-processing techniques, and evaluation metrics. The survey also briefly delves into emerging concepts, identifies research gaps, limitations, and applications, and outlines challenges in the diagnosis process. This survey furnishes valuable insights into the prospective areas of DL innovative ideas and is anticipated to serve as a path for researchers.

Interactive segmentation is a crucial research area in medical image analysis aiming to boost the efficiency of costly annotations by incorporating human feedback. This feedback takes the form of clicks, scribbles, or masks and allows for iterative refinement of the model output so as to efficiently guide the system towards the desired behavior. In recent years, deep learning-based approaches have propelled results to a new level causing a rapid growth in the field with 121 methods proposed in the medical imaging domain alone. In this review, we provide a structured overview of this emerging field featuring a comprehensive taxonomy, a systematic review of existing methods, and an in-depth analysis of current practices. Based on these contributions, we discuss the challenges and opportunities in the field. For instance, we find that there is a severe lack of comparison across methods which needs to be tackled by standardized baselines and benchmarks.

There is growing concern that the potential of black box AI may exacerbate health-related disparities and biases such as gender and ethnicity in clinical decision-making. Biased decisions can arise from data availability and collection processes, as well as from the underlying confounding effects of the protected attributes themselves. This work proposes a machine learning-based orthogonal approach aiming to analyze and suppress the effect of the confounder through discriminant dimensionality reduction and orthogonalization of the protected attributes against the primary attribute information. By doing so, the impact of the protected attributes on disease diagnosis can be realized, undesirable feature correlations can be mitigated, and the model prediction performance can be enhanced.

Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.