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Background: An early diagnosis together with an accurate disease progression monitoring of multiple sclerosis is an important component of successful disease management. Prior studies have established that multiple sclerosis is correlated with speech discrepancies. Early research using objective acoustic measurements has discovered measurable dysarthria. Objective: To determine the potential clinical utility of machine learning and deep learning/AI approaches for the aiding of diagnosis, biomarker extraction and progression monitoring of multiple sclerosis using speech recordings. Methods: A corpus of 65 MS-positive and 66 healthy individuals reading the same text aloud was used for targeted acoustic feature extraction utilizing automatic phoneme segmentation. A series of binary classification models was trained, tuned, and evaluated regarding their Accuracy and area-under-curve. Results: The Random Forest model performed best, achieving an Accuracy of 0.82 on the validation dataset and an area-under-curve of 0.76 across 5 k-fold cycles on the training dataset. 5 out of 7 acoustic features were statistically significant. Conclusion: Machine learning and artificial intelligence in automatic analyses of voice recordings for aiding MS diagnosis and progression tracking seems promising. Further clinical validation of these methods and their mapping onto multiple sclerosis progression is needed, as well as a validating utility for English-speaking populations.

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機(ji)器(qi)學(xue)(xue)習(xi)(xi)(xi)(Machine Learning)是一個研(yan)(yan)究(jiu)(jiu)計算學(xue)(xue)習(xi)(xi)(xi)方(fang)法(fa)的(de)(de)(de)國際論(lun)(lun)壇。該雜志發表文(wen)(wen)(wen)(wen)章,報告廣泛的(de)(de)(de)學(xue)(xue)習(xi)(xi)(xi)方(fang)法(fa)應用(yong)(yong)于各種學(xue)(xue)習(xi)(xi)(xi)問(wen)題(ti)(ti)的(de)(de)(de)實(shi)質性結果。該雜志的(de)(de)(de)特(te)色論(lun)(lun)文(wen)(wen)(wen)(wen)描述(shu)研(yan)(yan)究(jiu)(jiu)的(de)(de)(de)問(wen)題(ti)(ti)和(he)方(fang)法(fa),應用(yong)(yong)研(yan)(yan)究(jiu)(jiu)和(he)研(yan)(yan)究(jiu)(jiu)方(fang)法(fa)的(de)(de)(de)問(wen)題(ti)(ti)。有關學(xue)(xue)習(xi)(xi)(xi)問(wen)題(ti)(ti)或方(fang)法(fa)的(de)(de)(de)論(lun)(lun)文(wen)(wen)(wen)(wen)通過實(shi)證(zheng)研(yan)(yan)究(jiu)(jiu)、理論(lun)(lun)分(fen)析或與(yu)心理現(xian)象的(de)(de)(de)比較提供了(le)堅實(shi)的(de)(de)(de)支(zhi)持(chi)。應用(yong)(yong)論(lun)(lun)文(wen)(wen)(wen)(wen)展示了(le)如何(he)應用(yong)(yong)學(xue)(xue)習(xi)(xi)(xi)方(fang)法(fa)來解(jie)決(jue)重(zhong)要(yao)的(de)(de)(de)應用(yong)(yong)問(wen)題(ti)(ti)。研(yan)(yan)究(jiu)(jiu)方(fang)法(fa)論(lun)(lun)文(wen)(wen)(wen)(wen)改進了(le)機(ji)器(qi)學(xue)(xue)習(xi)(xi)(xi)的(de)(de)(de)研(yan)(yan)究(jiu)(jiu)方(fang)法(fa)。所有的(de)(de)(de)論(lun)(lun)文(wen)(wen)(wen)(wen)都以其他(ta)研(yan)(yan)究(jiu)(jiu)人員可以驗證(zheng)或復制的(de)(de)(de)方(fang)式描述(shu)了(le)支(zhi)持(chi)證(zheng)據。論(lun)(lun)文(wen)(wen)(wen)(wen)還詳細說(shuo)明(ming)了(le)學(xue)(xue)習(xi)(xi)(xi)的(de)(de)(de)組成部(bu)分(fen),并討論(lun)(lun)了(le)關于知(zhi)識表示和(he)性能任務的(de)(de)(de)假設。 官網地址:

In December 2019, a novel virus called COVID-19 had caused an enormous number of causalities to date. The battle with the novel Coronavirus is baffling and horrifying after the Spanish Flu 2019. While the front-line doctors and medical researchers have made significant progress in controlling the spread of the highly contiguous virus, technology has also proved its significance in the battle. Moreover, Artificial Intelligence has been adopted in many medical applications to diagnose many diseases, even baffling experienced doctors. Therefore, this survey paper explores the methodologies proposed that can aid doctors and researchers in early and inexpensive methods of diagnosis of the disease. Most developing countries have difficulties carrying out tests using the conventional manner, but a significant way can be adopted with Machine and Deep Learning. On the other hand, the access to different types of medical images has motivated the researchers. As a result, a mammoth number of techniques are proposed. This paper first details the background knowledge of the conventional methods in the Artificial Intelligence domain. Following that, we gather the commonly used datasets and their use cases to date. In addition, we also show the percentage of researchers adopting Machine Learning over Deep Learning. Thus we provide a thorough analysis of this scenario. Lastly, in the research challenges, we elaborate on the problems faced in COVID-19 research, and we address the issues with our understanding to build a bright and healthy environment.

The People's Speech is a free-to-download 30,000-hour and growing supervised conversational English speech recognition dataset licensed for academic and commercial usage under CC-BY-SA (with a CC-BY subset). The data is collected via searching the Internet for appropriately licensed audio data with existing transcriptions. We describe our data collection methodology and release our data collection system under the Apache 2.0 license. We show that a model trained on this dataset achieves a 9.98% word error rate on Librispeech's test-clean test set.Finally, we discuss the legal and ethical issues surrounding the creation of a sizable machine learning corpora and plans for continued maintenance of the project under MLCommons's sponsorship.

Floyd and Knuth investigated in 1990 register machines which can add, subtract and compare integers as primitive operations. They asked whether their current bound on the number of registers for multiplying and dividing fast (running in time linear in the size of the input) can be improved and whether one can output fast the powers of two summing up to a positive integer in subquadratic time. Both questions are answered positively. Furthermore, it is shown that every function computed by only one register is automatic and that automatic functions with one input can be computed with four registers in linear time; automatic functions with a larger number of inputs can be computed with 5 registers in linear time. There is a nonautomatic function with one input which can be computed with two registers in linear time.

In this article, an original data-driven approach is proposed to detect both linear and nonlinear damage in structures using output-only responses. The method deploys variational mode decomposition (VMD) and a generalised autoregressive conditional heteroscedasticity (GARCH) model for signal processing and feature extraction. To this end, VMD decomposes the response signals into intrinsic mode functions (IMFs). Afterwards, the GARCH model is utilised to represent the statistics of IMFs. The model coefficients of IMFs construct the primary feature vector. Kernel-based principal component analysis (PCA) and linear discriminant analysis (LDA) are utilised to reduce the redundancy of the primary features by mapping them to the new feature space. The informative features are then fed separately into three supervised classifiers, namely support vector machine (SVM), k-nearest neighbour (kNN), and fine tree. The performance of the proposed method is evaluated on two experimentally scaled models in terms of linear and nonlinear damage assessment. Kurtosis and ARCH tests proved the compatibility of the GARCH model.

In this paper, five different deep learning models are being compared for predicting travel time. These models are autoregressive integrated moving average (ARIMA) model, recurrent neural network (RNN) model, autoregressive (AR) model, Long-short term memory (LSTM) model, and gated recurrent units (GRU) model. The aim of this study is to investigate the performance of each developed model for forecasting travel time. The dataset used in this paper consists of travel time and travel speed information from the state of Missouri. The learning rate used for building each model was varied from 0.0001-0.01. The best learning rate was found to be 0.001. The study concluded that the ARIMA model was the best model architecture for travel time prediction and forecasting.

Treatment decisions for brain metastatic disease rely on knowledge of the primary organ site, and currently made with biopsy and histology. Here we develop a novel deep learning approach for accurate non-invasive digital histology with whole-brain MRI data. Our IRB-approved single-site retrospective study was comprised of patients (n=1,399) referred for MRI treatment-planning and gamma knife radiosurgery over 19 years. Contrast-enhanced T1-weighted and T2-weighted Fluid-Attenuated Inversion Recovery brain MRI exams (n=1,582) were preprocessed and input to the proposed deep learning workflow for tumor segmentation, modality transfer, and primary site classification into one of five classes (lung, breast, melanoma, renal, and others). Ten-fold cross-validation generated overall AUC of 0.947 (95%CI:0.938,0.955), lung class AUC of 0.899 (95%CI:0.884,0.915), breast class AUC of 0.990 (95%CI:0.983,0.997), melanoma class AUC of 0.882 (95%CI:0.858,0.906), renal class AUC of 0.870 (95%CI:0.823,0.918), and other class AUC of 0.885 (95%CI:0.843,0.949). These data establish that whole-brain imaging features are discriminative to allow accurate diagnosis of the primary organ site of malignancy. Our end-to-end deep radiomic approach has great potential for classifying metastatic tumor types from whole-brain MRI images. Further refinement may offer an invaluable clinical tool to expedite primary cancer site identification for precision treatment and improved outcomes.

It is well-known that an algorithm exists which approximates the NP-complete problem of Set Cover within a factor of ln(n), and it was recently proven that this approximation ratio is optimal unless P = NP. This optimality result is the product of many advances in characterizations of NP, in terms of interactive proof systems and probabilistically checkable proofs (PCP), and improvements to the analyses thereof. However, as a result, it is difficult to extract the development of Set Cover approximation bounds from the greater scope of proof system analysis. This paper attempts to present a chronological progression of results on lower-bounding the approximation ratio of Set Cover. We analyze a series of proofs of progressively better bounds and unify the results under similar terminologies and frameworks to provide an accurate comparison of proof techniques and their results. We also treat many preliminary results as black-boxes to better focus our analysis on the core reductions to Set Cover instances. The result is alternative versions of several hardness proofs, beginning with initial inapproximability results and culminating in a version of the proof that ln(n) is a tight lower bound.

We present a continuous formulation of machine learning, as a problem in the calculus of variations and differential-integral equations, very much in the spirit of classical numerical analysis and statistical physics. We demonstrate that conventional machine learning models and algorithms, such as the random feature model, the shallow neural network model and the residual neural network model, can all be recovered as particular discretizations of different continuous formulations. We also present examples of new models, such as the flow-based random feature model, and new algorithms, such as the smoothed particle method and spectral method, that arise naturally from this continuous formulation. We discuss how the issues of generalization error and implicit regularization can be studied under this framework.

This paper surveys the machine learning literature and presents machine learning as optimization models. Such models can benefit from the advancement of numerical optimization techniques which have already played a distinctive role in several machine learning settings. Particularly, mathematical optimization models are presented for commonly used machine learning approaches for regression, classification, clustering, and deep neural networks as well new emerging applications in machine teaching and empirical model learning. The strengths and the shortcomings of these models are discussed and potential research directions are highlighted.

We study the use of the Wave-U-Net architecture for speech enhancement, a model introduced by Stoller et al for the separation of music vocals and accompaniment. This end-to-end learning method for audio source separation operates directly in the time domain, permitting the integrated modelling of phase information and being able to take large temporal contexts into account. Our experiments show that the proposed method improves several metrics, namely PESQ, CSIG, CBAK, COVL and SSNR, over the state-of-the-art with respect to the speech enhancement task on the Voice Bank corpus (VCTK) dataset. We find that a reduced number of hidden layers is sufficient for speech enhancement in comparison to the original system designed for singing voice separation in music. We see this initial result as an encouraging signal to further explore speech enhancement in the time-domain, both as an end in itself and as a pre-processing step to speech recognition systems.

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