Deep Learning-based image synthesis techniques have been applied in healthcare research for generating medical images to support open research and augment medical datasets. Training generative adversarial neural networks (GANs) usually require large amounts of training data. Federated learning (FL) provides a way of training a central model using distributed data while keeping raw data locally. However, given that the FL server cannot access the raw data, it is vulnerable to backdoor attacks, an adversarial by poisoning training data. Most backdoor attack strategies focus on classification models and centralized domains. It is still an open question if the existing backdoor attacks can affect GAN training and, if so, how to defend against the attack in the FL setting. In this work, we investigate the overlooked issue of backdoor attacks in federated GANs (FedGANs). The success of this attack is subsequently determined to be the result of some local discriminators overfitting the poisoned data and corrupting the local GAN equilibrium, which then further contaminates other clients when averaging the generator's parameters and yields high generator loss. Therefore, we proposed FedDetect, an efficient and effective way of defending against the backdoor attack in the FL setting, which allows the server to detect the client's adversarial behavior based on their losses and block the malicious clients. Our extensive experiments on two medical datasets with different modalities demonstrate the backdoor attack on FedGANs can result in synthetic images with low fidelity. After detecting and suppressing the detected malicious clients using the proposed defense strategy, we show that FedGANs can synthesize high-quality medical datasets (with labels) for data augmentation to improve classification models' performance.
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Vision-language models (VLMs) have recently demonstrated strong efficacy as visual assistants that can parse natural queries about the visual content and generate human-like outputs. In this work, we explore the ability of these models to demonstrate human-like reasoning based on the perceived information. To address a crucial concern regarding the extent to which their reasoning capabilities are fully consistent and grounded, we also measure the reasoning consistency of these models. We achieve this by proposing a chain-of-thought (CoT) based consistency measure. However, such an evaluation requires a benchmark that encompasses both high-level inference and detailed reasoning chains, which is costly. We tackle this challenge by proposing a LLM-Human-in-the-Loop pipeline, which notably reduces cost while simultaneously ensuring the generation of a high-quality dataset. Based on this pipeline and the existing coarse-grained annotated dataset, we build the CURE benchmark to measure both the zero-shot reasoning performance and consistency of VLMs. We evaluate existing state-of-the-art VLMs, and find that even the best-performing model is unable to demonstrate strong visual reasoning capabilities and consistency, indicating that substantial efforts are required to enable VLMs to perform visual reasoning as systematically and consistently as humans. As an early step, we propose a two-stage training framework aimed at improving both the reasoning performance and consistency of VLMs. The first stage involves employing supervised fine-tuning of VLMs using step-by-step reasoning samples automatically generated by LLMs. In the second stage, we further augment the training process by incorporating feedback provided by LLMs to produce reasoning chains that are highly consistent and grounded. We empirically highlight the effectiveness of our framework in both reasoning performance and consistency.
Generalization capabilities of learning-based medical image segmentation across domains are currently limited by the performance degradation caused by the domain shift, particularly for ultrasound (US) imaging. The quality of US images heavily relies on carefully tuned acoustic parameters, which vary across sonographers, machines, and settings. To improve the generalizability on US images across domains, we propose MI-SegNet, a novel mutual information (MI) based framework to explicitly disentangle the anatomical and domain feature representations; therefore, robust domain-independent segmentation can be expected. Two encoders are employed to extract the relevant features for the disentanglement. The segmentation only uses the anatomical feature map for its prediction. In order to force the encoders to learn meaningful feature representations a cross-reconstruction method is used during training. Transformations, specific to either domain or anatomy are applied to guide the encoders in their respective feature extraction task. Additionally, any MI present in both feature maps is punished to further promote separate feature spaces. We validate the generalizability of the proposed domain-independent segmentation approach on several datasets with varying parameters and machines. Furthermore, we demonstrate the effectiveness of the proposed MI-SegNet serving as a pre-trained model by comparing it with state-of-the-art networks.
Despite significant research effort in the development of automatic dialogue evaluation metrics, little thought is given to evaluating dialogues other than in English. At the same time, ensuring metrics are invariant to semantically similar responses is also an overlooked topic. In order to achieve the desired properties of robustness and multilinguality for dialogue evaluation metrics, we propose a novel framework that takes advantage of the strengths of current evaluation models with the newly-established paradigm of prompting Large Language Models (LLMs). Empirical results show our framework achieves state of the art results in terms of mean Spearman correlation scores across several benchmarks and ranks first place on both the Robust and Multilingual tasks of the DSTC11 Track 4 "Automatic Evaluation Metrics for Open-Domain Dialogue Systems", proving the evaluation capabilities of prompted LLMs.
Speech synthesis systems powered by neural networks hold promise for multimedia production, but frequently face issues with producing expressive speech and seamless editing. In response, we present the Cross-Utterance Conditioned Variational Autoencoder speech synthesis (CUC-VAE S2) framework to enhance prosody and ensure natural speech generation. This framework leverages the powerful representational capabilities of pre-trained language models and the re-expression abilities of variational autoencoders (VAEs). The core component of the CUC-VAE S2 framework is the cross-utterance CVAE, which extracts acoustic, speaker, and textual features from surrounding sentences to generate context-sensitive prosodic features, more accurately emulating human prosody generation. We further propose two practical algorithms tailored for distinct speech synthesis applications: CUC-VAE TTS for text-to-speech and CUC-VAE SE for speech editing. The CUC-VAE TTS is a direct application of the framework, designed to generate audio with contextual prosody derived from surrounding texts. On the other hand, the CUC-VAE SE algorithm leverages real mel spectrogram sampling conditioned on contextual information, producing audio that closely mirrors real sound and thereby facilitating flexible speech editing based on text such as deletion, insertion, and replacement. Experimental results on the LibriTTS datasets demonstrate that our proposed models significantly enhance speech synthesis and editing, producing more natural and expressive speech.
Performance metrics for medical image segmentation models are used to measure the agreement between the reference annotation and the predicted segmentation. Usually, overlap metrics, such as the Dice, are used as a metric to evaluate the performance of these models in order for results to be comparable. However, there is a mismatch between the distributions of cases and difficulty level of segmentation tasks in public data sets compared to clinical practice. Common metrics fail to measure the impact of this mismatch, especially for clinical data sets that include low signal pathologies, a difficult segmentation task, and uncertain, small, or empty reference annotations. This limitation may result in ineffective research of machine learning practitioners in designing and optimizing models. Dimensions of evaluating clinical value include consideration of the uncertainty of reference annotations, independence from reference annotation volume size, and evaluation of classification of empty reference annotations. We study how uncertain, small, and empty reference annotations influence the value of metrics for medical image segmentation on an in-house data set regardless of the model. We examine metrics behavior on the predictions of a standard deep learning framework in order to identify metrics with clinical value. We compare to a public benchmark data set (BraTS 2019) with a high-signal pathology and certain, larger, and no empty reference annotations. We may show machine learning practitioners, how uncertain, small, or empty reference annotations require a rethinking of the evaluation and optimizing procedures. The evaluation code was released to encourage further analysis of this topic. //github.com/SophieOstmeier/UncertainSmallEmpty.git
Most self-supervised methods for representation learning leverage a cross-view consistency objective i.e., they maximize the representation similarity of a given image's augmented views. Recent work NNCLR goes beyond the cross-view paradigm and uses positive pairs from different images obtained via nearest neighbor bootstrapping in a contrastive setting. We empirically show that as opposed to the contrastive learning setting which relies on negative samples, incorporating nearest neighbor bootstrapping in a self-distillation scheme can lead to a performance drop or even collapse. We scrutinize the reason for this unexpected behavior and provide a solution. We propose to adaptively bootstrap neighbors based on the estimated quality of the latent space. We report consistent improvements compared to the naive bootstrapping approach and the original baselines. Our approach leads to performance improvements for various self-distillation method/backbone combinations and standard downstream tasks. Our code is publicly available at //github.com/tileb1/AdaSim.
The recent proliferation of knowledge graphs (KGs) coupled with incomplete or partial information, in the form of missing relations (links) between entities, has fueled a lot of research on knowledge base completion (also known as relation prediction). Several recent works suggest that convolutional neural network (CNN) based models generate richer and more expressive feature embeddings and hence also perform well on relation prediction. However, we observe that these KG embeddings treat triples independently and thus fail to cover the complex and hidden information that is inherently implicit in the local neighborhood surrounding a triple. To this effect, our paper proposes a novel attention based feature embedding that captures both entity and relation features in any given entity's neighborhood. Additionally, we also encapsulate relation clusters and multihop relations in our model. Our empirical study offers insights into the efficacy of our attention based model and we show marked performance gains in comparison to state of the art methods on all datasets.
We propose a novel attention gate (AG) model for medical imaging that automatically learns to focus on target structures of varying shapes and sizes. Models trained with AGs implicitly learn to suppress irrelevant regions in an input image while highlighting salient features useful for a specific task. This enables us to eliminate the necessity of using explicit external tissue/organ localisation modules of cascaded convolutional neural networks (CNNs). AGs can be easily integrated into standard CNN architectures such as the U-Net model with minimal computational overhead while increasing the model sensitivity and prediction accuracy. The proposed Attention U-Net architecture is evaluated on two large CT abdominal datasets for multi-class image segmentation. Experimental results show that AGs consistently improve the prediction performance of U-Net across different datasets and training sizes while preserving computational efficiency. The code for the proposed architecture is publicly available.
Deep learning (DL) based semantic segmentation methods have been providing state-of-the-art performance in the last few years. More specifically, these techniques have been successfully applied to medical image classification, segmentation, and detection tasks. One deep learning technique, U-Net, has become one of the most popular for these applications. In this paper, we propose a Recurrent Convolutional Neural Network (RCNN) based on U-Net as well as a Recurrent Residual Convolutional Neural Network (RRCNN) based on U-Net models, which are named RU-Net and R2U-Net respectively. The proposed models utilize the power of U-Net, Residual Network, as well as RCNN. There are several advantages of these proposed architectures for segmentation tasks. First, a residual unit helps when training deep architecture. Second, feature accumulation with recurrent residual convolutional layers ensures better feature representation for segmentation tasks. Third, it allows us to design better U-Net architecture with same number of network parameters with better performance for medical image segmentation. The proposed models are tested on three benchmark datasets such as blood vessel segmentation in retina images, skin cancer segmentation, and lung lesion segmentation. The experimental results show superior performance on segmentation tasks compared to equivalent models including U-Net and residual U-Net (ResU-Net).
Recently, ensemble has been applied to deep metric learning to yield state-of-the-art results. Deep metric learning aims to learn deep neural networks for feature embeddings, distances of which satisfy given constraint. In deep metric learning, ensemble takes average of distances learned by multiple learners. As one important aspect of ensemble, the learners should be diverse in their feature embeddings. To this end, we propose an attention-based ensemble, which uses multiple attention masks, so that each learner can attend to different parts of the object. We also propose a divergence loss, which encourages diversity among the learners. The proposed method is applied to the standard benchmarks of deep metric learning and experimental results show that it outperforms the state-of-the-art methods by a significant margin on image retrieval tasks.
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