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The electron microscope (EM) remains the predominant technique for elucidating intricate details of the animal nervous system at the nanometer scale. However, accurately reconstructing the complex morphology of axons and myelin sheaths poses a significant challenge. Furthermore, the absence of publicly available, large-scale EM datasets encompassing complete cross sections of the corpus callosum, with dense ground truth segmentation for axons and myelin sheaths, hinders the advancement and evaluation of holistic corpus callosum reconstructions. To surmount these obstacles, we introduce the AxonCallosumEM dataset, comprising a 1.83 times 5.76mm EM image captured from the corpus callosum of the Rett Syndrome (RTT) mouse model, which entail extensive axon bundles. We meticulously proofread over 600,000 patches at a resolution of 1024 times 1024, thus providing a comprehensive ground truth for myelinated axons and myelin sheaths. Additionally, we extensively annotated three distinct regions within the dataset for the purposes of training, testing, and validation. Utilizing this dataset, we develop a fine-tuning methodology that adapts Segment Anything Model (SAM) to EM images segmentation tasks, called EM-SAM, enabling outperforms other state-of-the-art methods. Furthermore, we present the evaluation results of EM-SAM as a baseline.

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iOS 8 提供的應用間和應用跟系統的功能交互特性。
  • Today (iOS and OS X): widgets for the Today view of Notification Center
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  • Actions (iOS and OS X): app extensions to view or manipulate inside another app
  • Photo Editing (iOS): edit a photo or video in Apple's Photos app with extensions from a third-party apps
  • Finder Sync (OS X): remote file storage in the Finder with support for Finder content annotation
  • Storage Provider (iOS): an interface between files inside an app and other apps on a user's device
  • Custom Keyboard (iOS): system-wide alternative keyboards

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We study the composite convex optimization problems with a Quasi-Self-Concordant smooth component. This problem class naturally interpolates between classic Self-Concordant functions and functions with Lipschitz continuous Hessian. Previously, the best complexity bounds for this problem class were associated with trust-region schemes and implementations of a ball-minimization oracle. In this paper, we show that for minimizing Quasi-Self-Concordant functions we can use instead the basic Newton Method with Gradient Regularization. For unconstrained minimization, it only involves a simple matrix inversion operation (solving a linear system) at each step. We prove a fast global linear rate for this algorithm, matching the complexity bound of the trust-region scheme, while our method remains especially simple to implement. Then, we introduce the Dual Newton Method, and based on it, develop the corresponding Accelerated Newton Scheme for this problem class, which further improves the complexity factor of the basic method. As a direct consequence of our results, we establish fast global linear rates of simple variants of the Newton Method applied to several practical problems, including Logistic Regression, Soft Maximum, and Matrix Scaling, without requiring additional assumptions on strong or uniform convexity for the target objective.

Unsupervised anomaly detection (UAD) is a widely adopted approach in industry due to rare anomaly occurrences and data imbalance. A desirable characteristic of an UAD model is contained generalization ability which excels in the reconstruction of seen normal patterns but struggles with unseen anomalies. Recent studies have pursued to contain the generalization capability of their UAD models in reconstruction from different perspectives, such as design of neural network (NN) structure and training strategy. In contrast, we note that containing of generalization ability in reconstruction can also be obtained simply from steep-shaped loss landscape. Motivated by this, we propose a loss landscape sharpening method by amplifying the reconstruction loss, dubbed Loss AMPlification (LAMP). LAMP deforms the loss landscape into a steep shape so the reconstruction error on unseen anomalies becomes greater. Accordingly, the anomaly detection performance is improved without any change of the NN architecture. Our findings suggest that LAMP can be easily applied to any reconstruction error metrics in UAD settings where the reconstruction model is trained with anomaly-free samples only.

This paper studies the discretization of a homogenization and dimension reduction model for the elastic deformation of microstructured thin plates proposed by Hornung, Neukamm, and Vel\v{c}i\'c in 2014. Thereby, a nonlinear bending energy is based on a homogenized quadratic form which acts on the second fundamental form associated with the elastic deformation. Convergence is proven for a multi-affine finite element discretization of the involved three-dimensional microscopic cell problems and a discrete Kirchhoff triangle discretization of the two-dimensional isometry-constrained macroscopic problem. Finally, the convergence properties are numerically verified in selected test cases and qualitatively compared with deformation experiments for microstructured sheets of paper.

Whole slide image (WSI) analysis has become increasingly important in the medical imaging community, enabling automated and objective diagnosis, prognosis, and therapeutic-response prediction. However, in clinical practice, the ever-evolving environment hamper the utility of WSI analysis models. In this paper, we propose the FIRST continual learning framework for WSI analysis, named ConSlide, to tackle the challenges of enormous image size, utilization of hierarchical structure, and catastrophic forgetting by progressive model updating on multiple sequential datasets. Our framework contains three key components. The Hierarchical Interaction Transformer (HIT) is proposed to model and utilize the hierarchical structural knowledge of WSI. The Breakup-Reorganize (BuRo) rehearsal method is developed for WSI data replay with efficient region storing buffer and WSI reorganizing operation. The asynchronous updating mechanism is devised to encourage the network to learn generic and specific knowledge respectively during the replay stage, based on a nested cross-scale similarity learning (CSSL) module. We evaluated the proposed ConSlide on four public WSI datasets from TCGA projects. It performs best over other state-of-the-art methods with a fair WSI-based continual learning setting and achieves a better trade-off of the overall performance and forgetting on previous task

The bistatic integrated sensing and communication (ISAC) system model avoids the strong self-interference in a monostatic ISAC system by employing a pair of physically separated sensing transceiver and maintaining the merit of co-designing radar sensing and communications on shared spectrum and hardware. Inspired by the appealing benefits of bistatic radar, we study bistatic ISAC, where a transmitter sends a message to a communication receiver and a sensing receiver at another location carries out a decoding-and-estimation(DnE) operation to obtain the state of the communication receiver. In this paper, both communication and sensing channels are modelled as state-dependent memoryless channels with independent and identically distributed time-varying state sequences. We consider a rate of reliable communication for the message at the communication receiver as communication metric. The objective of this model is to characterize the capacity-distortion region, i.e., the set of all the achievable rate while simultaneously allowing the sensing receiver to sense the state sequence with a given distortion threshold. In terms of the decoding degree on this message at the sensing receiver, we propose three achievable DnE strategies, the blind estimation, the partial-decoding-based estimation, and the full-decoding-based estimation, respectively. Based on the three strategies, we derive the three achievable rate-distortion regions. In addition, under the constraint of the degraded broadcast channel, i.e., the communication receiver is statistically stronger than the sensing receiver, and the partial-decoding-based estimation, we characterize the capacity region. Examples in both non-degraded and degraded cases are provided to compare the achievable rate-distortion regions under three DnE strategies and demonstrate the advantages of ISAC over independent communication and sensing.

Spurred by the recent rapid increase in the development and distribution of large language models (LLMs) across industry and academia, much recent work has drawn attention to safety- and security-related threats and vulnerabilities of LLMs, including in the context of potentially criminal activities. Specifically, it has been shown that LLMs can be misused for fraud, impersonation, and the generation of malware; while other authors have considered the more general problem of AI alignment. It is important that developers and practitioners alike are aware of security-related problems with such models. In this paper, we provide an overview of existing - predominantly scientific - efforts on identifying and mitigating threats and vulnerabilities arising from LLMs. We present a taxonomy describing the relationship between threats caused by the generative capabilities of LLMs, prevention measures intended to address such threats, and vulnerabilities arising from imperfect prevention measures. With our work, we hope to raise awareness of the limitations of LLMs in light of such security concerns, among both experienced developers and novel users of such technologies.

We develop a novel asymptotic theory for local polynomial (quasi-) maximum-likelihood estimators of time-varying parameters in a broad class of nonlinear time series models. Under weak regularity conditions, we show the proposed estimators are consistent and follow normal distributions in large samples. Our conditions impose weaker smoothness and moment conditions on the data-generating process and its likelihood compared to existing theories. Furthermore, the bias terms of the estimators take a simpler form. We demonstrate the usefulness of our general results by applying our theory to local (quasi-)maximum-likelihood estimators of a time-varying VAR's, ARCH and GARCH, and Poisson autogressions. For the first three models, we are able to substantially weaken the conditions found in the existing literature. For the Poisson autogression, existing theories cannot be be applied while our novel approach allows us to analyze it.

We propose a novel-view augmentation (NOVA) strategy to train NeRFs for photo-realistic 3D composition of dynamic objects in a static scene. Compared to prior work, our framework significantly reduces blending artifacts when inserting multiple dynamic objects into a 3D scene at novel views and times; achieves comparable PSNR without the need for additional ground truth modalities like optical flow; and overall provides ease, flexibility, and scalability in neural composition. Our codebase is on GitHub.

Humans and animals have the ability to continually acquire, fine-tune, and transfer knowledge and skills throughout their lifespan. This ability, referred to as lifelong learning, is mediated by a rich set of neurocognitive mechanisms that together contribute to the development and specialization of our sensorimotor skills as well as to long-term memory consolidation and retrieval. Consequently, lifelong learning capabilities are crucial for autonomous agents interacting in the real world and processing continuous streams of information. However, lifelong learning remains a long-standing challenge for machine learning and neural network models since the continual acquisition of incrementally available information from non-stationary data distributions generally leads to catastrophic forgetting or interference. This limitation represents a major drawback for state-of-the-art deep neural network models that typically learn representations from stationary batches of training data, thus without accounting for situations in which information becomes incrementally available over time. In this review, we critically summarize the main challenges linked to lifelong learning for artificial learning systems and compare existing neural network approaches that alleviate, to different extents, catastrophic forgetting. We discuss well-established and emerging research motivated by lifelong learning factors in biological systems such as structural plasticity, memory replay, curriculum and transfer learning, intrinsic motivation, and multisensory integration.

We introduce a multi-task setup of identifying and classifying entities, relations, and coreference clusters in scientific articles. We create SciERC, a dataset that includes annotations for all three tasks and develop a unified framework called Scientific Information Extractor (SciIE) for with shared span representations. The multi-task setup reduces cascading errors between tasks and leverages cross-sentence relations through coreference links. Experiments show that our multi-task model outperforms previous models in scientific information extraction without using any domain-specific features. We further show that the framework supports construction of a scientific knowledge graph, which we use to analyze information in scientific literature.

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