Semi-competing risks refers to the survival analysis setting where the occurrence of a non-terminal event is subject to whether a terminal event has occurred, but not vice versa. Semi-competing risks arise in a broad range of clinical contexts, with a novel example being the pregnancy condition preeclampsia, which can only occur before the `terminal' event of giving birth. Models that acknowledge semi-competing risks enable investigation of relationships between covariates and the joint timing of the outcomes, but methods for model selection and prediction of semi-competing risks in high dimensions are lacking. Instead, researchers commonly analyze only a single or composite outcome, losing valuable information and limiting clinical utility -- in the obstetric setting, this means ignoring valuable insight into timing of delivery after preeclampsia has onset. To address this gap we propose a novel penalized estimation framework for frailty-based illness-death multi-state modeling of semi-competing risks. Our approach combines non-convex and structured fusion penalization, inducing global sparsity as well as parsimony across submodels. We perform estimation and model selection via a pathwise routine for non-convex optimization, and prove the first statistical error bound results in this setting. We present a simulation study investigating estimation error and model selection performance, and a comprehensive application of the method to joint risk modeling of preeclampsia and timing of delivery using pregnancy data from an electronic health record.
相關內容
We derive a new parallel-in-time approach for solving large-scale optimization problems constrained by time-dependent partial differential equations arising from fluid dynamics. The solver involves the use of a block circulant approximation of the original matrices, enabling parallelization-in-time via the use of fast Fourier transforms, and we devise bespoke matrix approximations which may be applied within this framework. These make use of permutations, saddle-point approximations, commutator arguments, as well as inner solvers such as the Uzawa method, Chebyshev semi-iteration, and multigrid. Theoretical results underpin our strategy of applying a block circulant strategy, and numerical experiments demonstrate the effectiveness and robustness of our approach on Stokes and Oseen problems. Noteably, satisfying results for the strong and weak scaling of our methods are provided within a fully parallel architecture.
Semi-supervised anomaly detection, which aims to improve the performance of the anomaly detector by using a small amount of anomaly data in addition to unlabeled data, has attracted attention. Existing semi-supervised approaches assume that unlabeled data are mostly normal. They train the anomaly detector to minimize the anomaly scores for the unlabeled data, and to maximize those for the anomaly data. However, in practice, the unlabeled data are often contaminated with anomalies. This weakens the effect of maximizing the anomaly scores for anomalies, and prevents us from improving the detection performance. To solve this problem, we propose the positive-unlabeled autoencoder, which is based on positive-unlabeled learning and the anomaly detector such as the autoencoder. With our approach, we can approximate the anomaly scores for normal data using the unlabeled and anomaly data. Therefore, without the labeled normal data, we can train the anomaly detector to minimize the anomaly scores for normal data, and to maximize those for the anomaly data. In addition, our approach is applicable to various anomaly detectors such as the DeepSVDD. Experiments on various datasets show that our approach achieves better detection performance than existing approaches.
The problem of finding the optimal placement of emergency exits in an indoor environment to facilitate the rapid and orderly evacuation of crowds is addressed in this work. A cellular-automaton model is used to simulate the behavior of pedestrians in such scenarios, taking into account factors such as the environment, the pedestrians themselves, and the interactions among them. A metric is proposed to determine how successful or satisfactory an evacuation was. Subsequently, two metaheuristic algorithms, namely an iterated greedy heuristic and an evolutionary algorithm (EA) are proposed to solve the optimization problem. A comparative analysis shows that the proposed EA is able to find effective solutions for different scenarios, and that an island-based version of it outperforms the other two algorithms in terms of solution quality.
Near-Term Enforcement of AI Chip Export Controls Using A Firmware-Based Design for Offline Licensing
Offline Licensing is a mechanism for compute governance that could be used to prevent unregulated training of potentially dangerous frontier AI models. The mechanism works by disabling AI chips unless they have an unused license from a regulator. In this report, we present a design for a minimal version of Offline Licensing that could be delivered via a firmware update. Existing AI chips could potentially support Offline Licensing within a year if they have the following (relatively common) hardware security features: firmware verification, firmware rollback protection, and secure non-volatile memory. Public documentation suggests that NVIDIA's H100 AI chip already has these security features. Without additional hardware modifications, the system is susceptible to physical hardware attacks. However, these attacks might require expensive equipment and could be difficult to reliably apply to thousands of AI chips. A firmware-based Offline Licensing design shares the same legal requirements and license approval mechanism as a hardware-based solution. Implementing a firmware-based solution now could accelerate the eventual deployment of a more secure hardware-based solution in the future. For AI chip manufacturers, implementing this security mechanism might allow chips to be sold to customers that would otherwise be prohibited by export restrictions. For governments, it may be important to be able to prevent unsafe or malicious actors from training frontier AI models in the next few years. Based on this initial analysis, firmware-based Offline Licensing could partially solve urgent security and trade problems and is technically feasible for AI chips that have common hardware security features.
We study the data-generating mechanism for reconstructive SSL to shed light on its effectiveness. With an infinite amount of labeled samples, we provide a sufficient and necessary condition for perfect linear approximation. The condition reveals a full-rank component that preserves the label classes of Y, along with a redundant component. Motivated by the condition, we propose to approximate the redundant component by a low-rank factorization and measure the approximation quality by introducing a new quantity $\epsilon_s$, parameterized by the rank of factorization s. We incorporate $\epsilon_s$ into the excess risk analysis under both linear regression and ridge regression settings, where the latter regularization approach is to handle scenarios when the dimension of the learned features is much larger than the number of labeled samples n for downstream tasks. We design three stylized experiments to compare SSL with supervised learning under different settings to support our theoretical findings.
Principal stratification provides a causal inference framework that allows adjustment for confounded post-treatment variables when comparing treatments. Although the literature has focused mainly on binary post-treatment variables, there is a growing interest in principal stratification involving continuous post-treatment variables. However, characterizing the latent principal strata with a continuous post-treatment presents a significant challenge, which is further complicated in observational studies where the treatment is not randomized. In this paper, we introduce the Confounders-Aware SHared atoms BAyesian mixture (CASBAH), a novel approach for principal stratification with continuous post-treatment variables that can be directly applied to observational studies. CASBAH leverages a dependent Dirichlet process, utilizing shared atoms across treatment levels, to effectively control for measured confounders and facilitate information sharing between treatment groups in the identification of principal strata membership. CASBAH also offers a comprehensive quantification of uncertainty surrounding the membership of the principal strata. Through Monte Carlo simulations, we show that the proposed methodology has excellent performance in characterizing the latent principal strata and estimating the effects of treatment on post-treatment variables and outcomes. Finally, CASBAH is applied to a case study in which we estimate the causal effects of US national air quality regulations on pollution levels and health outcomes.
3D object detection aims to recover the 3D information of concerning objects and serves as the fundamental task of autonomous driving perception. Its performance greatly depends on the scale of labeled training data, yet it is costly to obtain high-quality annotations for point cloud data. While conventional methods focus on generating pseudo-labels for unlabeled samples as supplements for training, the structural nature of 3D point cloud data facilitates the composition of objects and backgrounds to synthesize realistic scenes. Motivated by this, we propose a hardness-aware scene synthesis (HASS) method to generate adaptive synthetic scenes to improve the generalization of the detection models. We obtain pseudo-labels for unlabeled objects and generate diverse scenes with different compositions of objects and backgrounds. As the scene synthesis is sensitive to the quality of pseudo-labels, we further propose a hardness-aware strategy to reduce the effect of low-quality pseudo-labels and maintain a dynamic pseudo-database to ensure the diversity and quality of synthetic scenes. Extensive experimental results on the widely used KITTI and Waymo datasets demonstrate the superiority of the proposed HASS method, which outperforms existing semi-supervised learning methods on 3D object detection. Code: //github.com/wzzheng/HASS.
Simplicity bias, the propensity of deep models to over-rely on simple features, has been identified as a potential reason for limited out-of-distribution generalization of neural networks (Shah et al., 2020). Despite the important implications, this phenomenon has been theoretically confirmed and characterized only under strong dataset assumptions, such as linear separability (Lyu et al., 2021). In this work, we characterize simplicity bias for general datasets in the context of two-layer neural networks initialized with small weights and trained with gradient flow. Specifically, we prove that in the early training phases, network features cluster around a few directions that do not depend on the size of the hidden layer. Furthermore, for datasets with an XOR-like pattern, we precisely identify the learned features and demonstrate that simplicity bias intensifies during later training stages. These results indicate that features learned in the middle stages of training may be more useful for OOD transfer. We support this hypothesis with experiments on image data.
Quantum computing holds the potential to solve problems that are practically unsolvable by classical computers due to its ability to significantly reduce time complexity. We aim to harness this potential to enhance ray casting, a pivotal technique in computer graphics for simplifying the rendering of 3D objects. To perform ray casting in a quantum computer, we need to encode the defining parameters of primitives into qubits. However, during the current noisy intermediate-scale quantum (NISQ) era, challenges arise from the limited number of qubits and the impact of noise when executing multiple gates. Through logic optimization, we reduced the depth of quantum circuits as well as the number of gates and qubits. As a result, the event count of correct measurements from an IBM quantum computer significantly exceeded that of incorrect measurements.
Object detection typically assumes that training and test data are drawn from an identical distribution, which, however, does not always hold in practice. Such a distribution mismatch will lead to a significant performance drop. In this work, we aim to improve the cross-domain robustness of object detection. We tackle the domain shift on two levels: 1) the image-level shift, such as image style, illumination, etc, and 2) the instance-level shift, such as object appearance, size, etc. We build our approach based on the recent state-of-the-art Faster R-CNN model, and design two domain adaptation components, on image level and instance level, to reduce the domain discrepancy. The two domain adaptation components are based on H-divergence theory, and are implemented by learning a domain classifier in adversarial training manner. The domain classifiers on different levels are further reinforced with a consistency regularization to learn a domain-invariant region proposal network (RPN) in the Faster R-CNN model. We evaluate our newly proposed approach using multiple datasets including Cityscapes, KITTI, SIM10K, etc. The results demonstrate the effectiveness of our proposed approach for robust object detection in various domain shift scenarios.
小貼士
登錄享
相關主題
注冊地址： 北京市海淀區羊坊店路18號2幢3層301-191