This article explores the critical role of statistical analysis in precision medicine. It discusses how personalized healthcare is enhanced by statistical methods that interpret complex, multidimensional datasets, focusing on predictive modeling, machine learning algorithms, and data visualization techniques. The paper addresses challenges in data integration and interpretation, particularly with diverse data sources like electronic health records (EHRs) and genomic data. It also delves into ethical considerations such as patient privacy and data security. In addition, the paper highlights the evolution of statistical analysis in medicine, core statistical methodologies in precision medicine, and future directions in the field, emphasizing the integration of artificial intelligence (AI) and machine learning (ML).
The recently emerging molecular communication (MC) paradigm intents to leverage communication engineering tools for the design of synthetic chemical communication systems. These systems are envisioned to operate on nanoscale and in biological environments, such as the human body, and catalyze the emergence of revolutionary applications in the context of early disease monitoring and drug targeting. However, while a plethora of theoretical (and more recently also more and more practical) MC system designs have been proposed over the past years, some fundamental questions remain open, hindering the breakthrough of MC in real-world applications. One of these questions is: What is a useful measure of information in the context of MC-based applications? While most existing works in MC build upon the concept of syntactic information as introduced by Shannon, in this paper, we explore the framework of semantic information as introduced by Kolchinsky and Wolpert for the information theoretical analysis of a natural MC system, namely bacterial chemotaxis. Exploiting the computational modeling tool of agent-based modeling (ABM), we are able to demonstrate that the semantic information framework can provide a useful information theoretical framework for quantifying the information exchange of chemotactic bacteria with their environment. In particular, we show that the measured semantic information provides a useful measure of the ability of the bacteria to adapt to and survive in a changing environment. Encouraged by our results, we envision that the semantic information framework can open new avenues for developing theoretical and practical MC system designs and in this way help to unleash the full potential of MC for complex adaptive systems-based nanoscale applications.
Problematic smartphone use negatively affects physical and mental health. Despite the wide range of prior research, existing persuasive techniques are not flexible enough to provide dynamic persuasion content based on users' physical contexts and mental states. We first conducted a Wizard-of-Oz study (N=12) and an interview study (N=10) to summarize the mental states behind problematic smartphone use: boredom, stress, and inertia. This informs our design of four persuasion strategies: understanding, comforting, evoking, and scaffolding habits. We leveraged large language models (LLMs) to enable the automatic and dynamic generation of effective persuasion content. We developed MindShift, a novel LLM-powered problematic smartphone use intervention technique. MindShift takes users' in-the-moment app usage behaviors, physical contexts, mental states, goals \& habits as input, and generates personalized and dynamic persuasive content with appropriate persuasion strategies. We conducted a 5-week field experiment (N=25) to compare MindShift with its simplified version (remove mental states) and baseline techniques (fixed reminder). The results show that MindShift improves intervention acceptance rates by 4.7-22.5% and reduces smartphone usage duration by 7.4-9.8%. Moreover, users have a significant drop in smartphone addiction scale scores and a rise in self-efficacy scale scores. Our study sheds light on the potential of leveraging LLMs for context-aware persuasion in other behavior change domains.
With the explosive growth of medical data and the rapid development of artificial intelligence technology, precision medicine has emerged as a key to enhancing the quality and efficiency of healthcare services. In this context, Large Language Models (LLMs) play an increasingly vital role in medical knowledge acquisition and question-answering systems. To further improve the performance of these systems in the medical domain, we introduce an innovative method that jointly trains an Information Retrieval (IR) system and an LLM during the fine-tuning phase. This approach, which we call Joint Medical LLM and Retrieval Training (JMLR), is designed to overcome the challenges faced by traditional models in handling medical question-answering tasks. By employing a synchronized training mechanism, JMLR reduces the demand for computational resources and enhances the model's ability to leverage medical knowledge for reasoning and answering questions. Our experimental results demonstrate that JMLR-13B (81.2% on Amboos, 61.3% on MedQA) outperforms models using conventional pre-training and fine-tuning Meditron-70B (76.4% on AMBOSS, 60.3% on MedQA). For models of the same 7B scale, JMLR-7B(68.7% on Amboos, 51.7% on MedQA) significantly outperforms other public models (Meditron-7B: 50.1%, 47.9%), proving its superiority in terms of cost (our training time: 37 hours, traditional method: 144 hours), efficiency, and effectiveness in medical question-answering tasks. Through this work, we provide a new and efficient knowledge enhancement tool for healthcare, demonstrating the great potential of integrating IR and LLM training in precision medical information retrieval and question-answering systems.
Advances in large language models (LLMs) provide new opportunities in healthcare for improved patient care, clinical decision-making, and enhancement of physician and administrator workflows. However, the potential of these models importantly depends on their ability to generalize effectively across clinical environments and populations, a challenge often underestimated in early development. To better understand reasons for these challenges and inform mitigation approaches, we evaluated ClinicLLM, an LLM trained on [HOSPITAL]'s clinical notes, analyzing its performance on 30-day all-cause readmission prediction focusing on variability across hospitals and patient characteristics. We found poorer generalization particularly in hospitals with fewer samples, among patients with government and unspecified insurance, the elderly, and those with high comorbidities. To understand reasons for lack of generalization, we investigated sample sizes for fine-tuning, note content (number of words per note), patient characteristics (comorbidity level, age, insurance type, borough), and health system aspects (hospital, all-cause 30-day readmission, and mortality rates). We used descriptive statistics and supervised classification to identify features. We found that, along with sample size, patient age, number of comorbidities, and the number of words in notes are all important factors related to generalization. Finally, we compared local fine-tuning (hospital specific), instance-based augmented fine-tuning and cluster-based fine-tuning for improving generalization. Among these, local fine-tuning proved most effective, increasing AUC by 0.25% to 11.74% (most helpful in settings with limited data). Overall, this study provides new insights for enhancing the deployment of large language models in the societally important domain of healthcare, and improving their performance for broader populations.
This article proposes a method to uncover opportunities for exploitation and exploration from consumer IoT interaction data. We develop a unique decomposition of cosine similarity that quantifies exploitation through functional similarity of interactions, exploration through cross-capacity similarity of counterfactual interactions, and differentiation of the two opportunities through within-similarity. We propose a topological data analysis method that incorporates these components of similarity and provides for their visualization. Functionally similar automations reveal exploitation opportunities for substitutes-in-use or complements-in-use, while exploration opportunities extend functionality into new use cases. This data-driven approach provides marketers with a powerful capability to discover possibilities for refining existing automation features while exploring new innovations. More generally, our approach can aid marketing efforts to balance these strategic opportunities in high technology contexts.
Intensive care unit (ICU) patients often develop new health-related problems in their long-term recovery. Health care professionals keeping a diary of a patient's stay is a proven strategy to tackle this but faces several adoption barriers, such as lack of time and difficulty in knowing what to write. Large language models (LLMs), with their ability to generate human-like text and adaptability, could solve these challenges. However, realizing this vision involves addressing several socio-technical and practical research challenges. This paper discusses these challenges and proposes future research directions to utilize the potential of LLMs in ICU diary writing, ultimately improving the long-term recovery outcomes for ICU patients.
Graph neural networks generalize conventional neural networks to graph-structured data and have received widespread attention due to their impressive representation ability. In spite of the remarkable achievements, the performance of Euclidean models in graph-related learning is still bounded and limited by the representation ability of Euclidean geometry, especially for datasets with highly non-Euclidean latent anatomy. Recently, hyperbolic space has gained increasing popularity in processing graph data with tree-like structure and power-law distribution, owing to its exponential growth property. In this survey, we comprehensively revisit the technical details of the current hyperbolic graph neural networks, unifying them into a general framework and summarizing the variants of each component. More importantly, we present various HGNN-related applications. Last, we also identify several challenges, which potentially serve as guidelines for further flourishing the achievements of graph learning in hyperbolic spaces.
The recent advancements in artificial intelligence (AI) combined with the extensive amount of data generated by today's clinical systems, has led to the development of imaging AI solutions across the whole value chain of medical imaging, including image reconstruction, medical image segmentation, image-based diagnosis and treatment planning. Notwithstanding the successes and future potential of AI in medical imaging, many stakeholders are concerned of the potential risks and ethical implications of imaging AI solutions, which are perceived as complex, opaque, and difficult to comprehend, utilise, and trust in critical clinical applications. Despite these concerns and risks, there are currently no concrete guidelines and best practices for guiding future AI developments in medical imaging towards increased trust, safety and adoption. To bridge this gap, this paper introduces a careful selection of guiding principles drawn from the accumulated experiences, consensus, and best practices from five large European projects on AI in Health Imaging. These guiding principles are named FUTURE-AI and its building blocks consist of (i) Fairness, (ii) Universality, (iii) Traceability, (iv) Usability, (v) Robustness and (vi) Explainability. In a step-by-step approach, these guidelines are further translated into a framework of concrete recommendations for specifying, developing, evaluating, and deploying technically, clinically and ethically trustworthy AI solutions into clinical practice.
A fundamental goal of scientific research is to learn about causal relationships. However, despite its critical role in the life and social sciences, causality has not had the same importance in Natural Language Processing (NLP), which has traditionally placed more emphasis on predictive tasks. This distinction is beginning to fade, with an emerging area of interdisciplinary research at the convergence of causal inference and language processing. Still, research on causality in NLP remains scattered across domains without unified definitions, benchmark datasets and clear articulations of the remaining challenges. In this survey, we consolidate research across academic areas and situate it in the broader NLP landscape. We introduce the statistical challenge of estimating causal effects, encompassing settings where text is used as an outcome, treatment, or as a means to address confounding. In addition, we explore potential uses of causal inference to improve the performance, robustness, fairness, and interpretability of NLP models. We thus provide a unified overview of causal inference for the computational linguistics community.
With the advent of deep neural networks, learning-based approaches for 3D reconstruction have gained popularity. However, unlike for images, in 3D there is no canonical representation which is both computationally and memory efficient yet allows for representing high-resolution geometry of arbitrary topology. Many of the state-of-the-art learning-based 3D reconstruction approaches can hence only represent very coarse 3D geometry or are limited to a restricted domain. In this paper, we propose occupancy networks, a new representation for learning-based 3D reconstruction methods. Occupancy networks implicitly represent the 3D surface as the continuous decision boundary of a deep neural network classifier. In contrast to existing approaches, our representation encodes a description of the 3D output at infinite resolution without excessive memory footprint. We validate that our representation can efficiently encode 3D structure and can be inferred from various kinds of input. Our experiments demonstrate competitive results, both qualitatively and quantitatively, for the challenging tasks of 3D reconstruction from single images, noisy point clouds and coarse discrete voxel grids. We believe that occupancy networks will become a useful tool in a wide variety of learning-based 3D tasks.