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With the development and application of deep learning in signal detection tasks, the vulnerability of neural networks to adversarial attacks has also become a security threat to signal detection networks. This paper defines a signal adversarial examples generation model for signal detection network from the perspective of adding perturbations to the signal. The model uses the inequality relationship of L2-norm between time domain and time-frequency domain to constrain the energy of signal perturbations. Building upon this model, we propose a method for generating signal adversarial examples utilizing gradient-based attacks and Short-Time Fourier Transform. The experimental results show that under the constraint of signal perturbation energy ratio less than 3%, our adversarial attack resulted in a 28.1% reduction in the mean Average Precision (mAP), a 24.7% reduction in recall, and a 30.4% reduction in precision of the signal detection network. Compared to random noise perturbation of equivalent intensity, our adversarial attack demonstrates a significant attack effect.

Continuous glucose monitoring (CGM) data has revolutionized the management of type 1 diabetes, particularly when integrated with insulin pumps to mitigate clinical events such as hypoglycemia. Recently, there has been growing interest in utilizing CGM devices in clinical studies involving healthy and diabetes populations. However, efficiently exploiting the high temporal resolution of CGM profiles remains a significant challenge. Numerous indices -- such as time-in-range metrics and glucose variability measures -- have been proposed, but evidence suggests these metrics overlook critical aspects of glucose dynamic homeostasis. As an alternative method, this paper explores the clinical value of glucodensity metrics in capturing glucose dynamics -- specifically the speed and acceleration of CGM time series -- as new biomarkers for predicting long-term glucose outcomes. Our results demonstrate significant information gains, exceeding 20\% in terms of adjusted $R^2$, in forecasting glycosylated hemoglobin (HbA1c) and fasting plasma glucose (FPG) at five and eight years from baseline AEGIS data, compared to traditional non-CGM and CGM glucose biomarkers. These findings underscore the importance of incorporating more complex CGM functional metrics, such as the glucodensity approach, to fully capture continuous glucose fluctuations across different time-scale resolutions.

Human motion prediction is crucial for human-centric multimedia understanding and interacting. Current methods typically rely on ground truth human poses as observed input, which is not practical for real-world scenarios where only raw visual sensor data is available. To implement these methods in practice, a pre-phrase of pose estimation is essential. However, such two-stage approaches often lead to performance degradation due to the accumulation of errors. Moreover, reducing raw visual data to sparse keypoint representations significantly diminishes the density of information, resulting in the loss of fine-grained features. In this paper, we propose \textit{LiDAR-HMP}, the first single-LiDAR-based 3D human motion prediction approach, which receives the raw LiDAR point cloud as input and forecasts future 3D human poses directly. Building upon our novel structure-aware body feature descriptor, LiDAR-HMP adaptively maps the observed motion manifold to future poses and effectively models the spatial-temporal correlations of human motions for further refinement of prediction results. Extensive experiments show that our method achieves state-of-the-art performance on two public benchmarks and demonstrates remarkable robustness and efficacy in real-world deployments.

The tolerance of an element of a combinatorial optimization problem with respect to a given optimal solution is the maximum change, i.e., decrease or increase, of its cost, such that this solution remains optimal. The bottleneck path problem, for given an edge-capacitated graph, a source, and a target, is to find the $\max$-$\min$ value of edge capacities on paths between the source and the target. For any given sample of this problem with $n$ vertices and $m$ edges, there is known the Ramaswamy-Orlin-Chakravarty's algorithm to compute an optimal path and all tolerances with respect to it in $O(m+n\log n)$ time. In this paper, for any in advance given $(n,m)$-network with distinct edge capacities and $k$ source-target pairs, we propose an $O\Big(m \alpha(m,n)+\min\big((n+k)\log n,km\big)\Big)$-time preprocessing, where $\alpha(\cdot,\cdot)$ is the inverse Ackermann function, to find in $O(k)$ time all $2k$ tolerances of an arbitrary edge with respect to some $\max\min$ paths between the paired sources and targets. To find both tolerances of all edges with respect to those optimal paths, it asymptotically improves, for some $n,m,k$, the Ramaswamy-Orlin-Chakravarty's complexity $O\big(k(m+n\log n)\big)$ up to $O(m\alpha(n,m)+km)$.

The application of deep learning in cancer research, particularly in early diagnosis, case understanding, and treatment strategy design, emphasizes the need for high-quality data. Generative AI, especially Generative Adversarial Networks (GANs), has emerged as a leading solution to challenges like class imbalance, robust learning, and model training, while addressing issues stemming from patient privacy and the scarcity of real data. Despite their promise, GANs face several challenges, both inherent and specific to histopathology data. Inherent issues include training imbalance, mode collapse, linear learning from insufficient discriminator feedback, and hard boundary convergence due to stringent feedback. Histopathology data presents a unique challenge with its complex representation, high spatial resolution, and multiscale features. To address these challenges, we propose a framework consisting of two components. First, we introduce a contrastive learning-based Multistage Progressive Finetuning Siamese Neural Network (MFT-SNN) for assessing the similarity between histopathology patches. Second, we implement a Reinforcement Learning-based External Optimizer (RL-EO) within the GAN training loop, serving as a reward signal generator. The modified discriminator loss function incorporates a weighted reward, guiding the GAN to maximize this reward while minimizing loss. This approach offers an external optimization guide to the discriminator, preventing generator overfitting and ensuring smooth convergence. Our proposed solution has been benchmarked against state-of-the-art (SOTA) GANs and a Denoising Diffusion Probabilistic model, outperforming previous SOTA across various metrics, including FID score, KID score, Perceptual Path Length, and downstream classification tasks.

This paper deals with asymptotic errors, limit theorems for errors between numerical and exact solutions of stochastic differential equation (SDE) driven by one-dimensional fractional Brownian motion (fBm). The Euler-Maruyama, higher-order Milstein, and Crank-Nicolson schemes are among the most studied numerical schemes for SDE (fSDE) driven by fBm. Most previous studies of asymptotic errors have derived specific asymptotic errors for these schemes as main theorems or their corollary. Even in the one-dimensional case, the asymptotic error was not determined for the Milstein or the Crank-Nicolson method when the Hurst exponent is less than or equal to $1/3$ with a drift term. We obtained a new evaluation method for convergence and asymptotic errors. This evaluation method improves the conditions under which we can prove convergence of the numerical scheme and obtain the asymptotic error under the same conditions. We have completely determined the asymptotic error of the Milstein method for arbitrary orders. In addition, we have newly determined the asymptotic error of the Crank-Nicolson method for $1/4<H\leq 1/3$.

Methods for estimating heterogeneous treatment effects (HTE) from observational data have largely focused on continuous or binary outcomes, with less attention paid to survival outcomes and almost none to settings with competing risks. In this work, we develop censoring unbiased transformations (CUTs) for survival outcomes both with and without competing risks. After converting time-to-event outcomes using these CUTs, direct application of HTE learners for continuous outcomes yields consistent estimates of heterogeneous cumulative incidence effects, total effects, and separable direct effects. Our CUTs enable application of a much larger set of state of the art HTE learners for censored outcomes than had previously been available, especially in competing risks settings. We provide generic model-free learner-specific oracle inequalities bounding the finite-sample excess risk. The oracle efficiency results depend on the oracle selector and estimated nuisance functions from all steps involved in the transformation. We demonstrate the empirical performance of the proposed methods in simulation studies.

Recent contrastive representation learning methods rely on estimating mutual information (MI) between multiple views of an underlying context. E.g., we can derive multiple views of a given image by applying data augmentation, or we can split a sequence into views comprising the past and future of some step in the sequence. Contrastive lower bounds on MI are easy to optimize, but have a strong underestimation bias when estimating large amounts of MI. We propose decomposing the full MI estimation problem into a sum of smaller estimation problems by splitting one of the views into progressively more informed subviews and by applying the chain rule on MI between the decomposed views. This expression contains a sum of unconditional and conditional MI terms, each measuring modest chunks of the total MI, which facilitates approximation via contrastive bounds. To maximize the sum, we formulate a contrastive lower bound on the conditional MI which can be approximated efficiently. We refer to our general approach as Decomposed Estimation of Mutual Information (DEMI). We show that DEMI can capture a larger amount of MI than standard non-decomposed contrastive bounds in a synthetic setting, and learns better representations in a vision domain and for dialogue generation.

Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.

Graph neural networks (GNNs) are a popular class of machine learning models whose major advantage is their ability to incorporate a sparse and discrete dependency structure between data points. Unfortunately, GNNs can only be used when such a graph-structure is available. In practice, however, real-world graphs are often noisy and incomplete or might not be available at all. With this work, we propose to jointly learn the graph structure and the parameters of graph convolutional networks (GCNs) by approximately solving a bilevel program that learns a discrete probability distribution on the edges of the graph. This allows one to apply GCNs not only in scenarios where the given graph is incomplete or corrupted but also in those where a graph is not available. We conduct a series of experiments that analyze the behavior of the proposed method and demonstrate that it outperforms related methods by a significant margin.