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Image segmentation plays an essential role in nuclei image analysis. Recently, the segment anything model has made a significant breakthrough in such tasks. However, the current model exists two major issues for cell segmentation: (1) the image encoder of the segment anything model involves a large number of parameters. Retraining or even fine-tuning the model still requires expensive computational resources. (2) in point prompt mode, points are sampled from the center of the ground truth and more than one set of points is expected to achieve reliable performance, which is not efficient for practical applications. In this paper, a single-point prompt network is proposed for nuclei image segmentation, called SPPNet. We replace the original image encoder with a lightweight vision transformer. Also, an effective convolutional block is added in parallel to extract the low-level semantic information from the image and compensate for the performance degradation due to the small image encoder. We propose a new point-sampling method based on the Gaussian kernel. The proposed model is evaluated on the MoNuSeg-2018 dataset. The result demonstrated that SPPNet outperforms existing U-shape architectures and shows faster convergence in training. Compared to the segment anything model, SPPNet shows roughly 20 times faster inference, with 1/70 parameters and computational cost. Particularly, only one set of points is required in both the training and inference phases, which is more reasonable for clinical applications. The code for our work and more technical details can be found at //github.com/xq141839/SPPNet.

We propose Boundary-RL, a novel weakly supervised segmentation method that utilises only patch-level labels for training. We envision the segmentation as a boundary detection problem, rather than a pixel-level classification as in previous works. This outlook on segmentation may allow for boundary delineation under challenging scenarios such as where noise artefacts may be present within the region-of-interest (ROI) boundaries, where traditional pixel-level classification-based weakly supervised methods may not be able to effectively segment the ROI. Particularly of interest, ultrasound images, where intensity values represent acoustic impedance differences between boundaries, may also benefit from the boundary delineation approach. Our method uses reinforcement learning to train a controller function to localise boundaries of ROIs using a reward derived from a pre-trained boundary-presence classifier. The classifier indicates when an object boundary is encountered within a patch, as the controller modifies the patch location in a sequential Markov decision process. The classifier itself is trained using only binary patch-level labels of object presence, which are the only labels used during training of the entire boundary delineation framework, and serves as a weak signal to inform the boundary delineation. The use of a controller function ensures that a sliding window over the entire image is not necessary. It also prevents possible false-positive or -negative cases by minimising number of patches passed to the boundary-presence classifier. We evaluate our proposed approach for a clinically relevant task of prostate gland segmentation on trans-rectal ultrasound images. We show improved performance compared to other tested weakly supervised methods, using the same labels e.g., multiple instance learning.

Federated Learning (FL) is a promising approach enabling multiple clients to train Deep Neural Networks (DNNs) collaboratively without sharing their local training data. However, FL is susceptible to backdoor (or targeted poisoning) attacks. These attacks are initiated by malicious clients who seek to compromise the learning process by introducing specific behaviors into the learned model that can be triggered by carefully crafted inputs. Existing FL safeguards have various limitations: They are restricted to specific data distributions or reduce the global model accuracy due to excluding benign models or adding noise, are vulnerable to adaptive defense-aware adversaries, or require the server to access local models, allowing data inference attacks. This paper presents a novel defense mechanism, CrowdGuard, that effectively mitigates backdoor attacks in FL and overcomes the deficiencies of existing techniques. It leverages clients' feedback on individual models, analyzes the behavior of neurons in hidden layers, and eliminates poisoned models through an iterative pruning scheme. CrowdGuard employs a server-located stacked clustering scheme to enhance its resilience to rogue client feedback. The evaluation results demonstrate that CrowdGuard achieves a 100% True-Positive-Rate and True-Negative-Rate across various scenarios, including IID and non-IID data distributions. Additionally, CrowdGuard withstands adaptive adversaries while preserving the original performance of protected models. To ensure confidentiality, CrowdGuard uses a secure and privacy-preserving architecture leveraging Trusted Execution Environments (TEEs) on both client and server sides.

Building artificial intelligence (AI) systems on top of a set of foundation models (FMs) is becoming a new paradigm in AI research. Their representative and generative abilities learnt from vast amounts of data can be easily adapted and transferred to a wide range of downstream tasks without extra training from scratch. However, leveraging FMs in cross-modal generation remains under-researched when audio modality is involved. On the other hand, automatically generating semantically-relevant sound from visual input is an important problem in cross-modal generation studies. To solve this vision-to-audio (V2A) generation problem, existing methods tend to design and build complex systems from scratch using modestly sized datasets. In this paper, we propose a lightweight solution to this problem by leveraging foundation models, specifically CLIP, CLAP, and AudioLDM. We first investigate the domain gap between the latent space of the visual CLIP and the auditory CLAP models. Then we propose a simple yet effective mapper mechanism (V2A-Mapper) to bridge the domain gap by translating the visual input between CLIP and CLAP spaces. Conditioned on the translated CLAP embedding, pretrained audio generative FM AudioLDM is adopted to produce high-fidelity and visually-aligned sound. Compared to previous approaches, our method only requires a quick training of the V2A-Mapper. We further analyze and conduct extensive experiments on the choice of the V2A-Mapper and show that a generative mapper is better at fidelity and variability (FD) while a regression mapper is slightly better at relevance (CS). Both objective and subjective evaluation on two V2A datasets demonstrate the superiority of our proposed method compared to current state-of-the-art approaches - trained with 86% fewer parameters but achieving 53% and 19% improvement in FD and CS, respectively.

Fact-centric question answering (QA) often requires access to multiple, heterogeneous, information sources. By jointly considering several sources like a knowledge base (KB), a text collection, and tables from the web, QA systems can enhance their answer coverage and confidence. However, existing QA benchmarks are mostly constructed with a single source of knowledge in mind. This limits capabilities of these benchmarks to fairly evaluate QA systems that can tap into more than one information repository. To bridge this gap, we release CompMix, a crowdsourced QA benchmark which naturally demands the integration of a mixture of input sources. CompMix has a total of 9,410 questions, and features several complex intents like joins and temporal conditions. Evaluation of a range of QA systems on CompMix highlights the need for further research on leveraging information from heterogeneous sources.

The current 3D human pose estimators face challenges in adapting to new datasets due to the scarcity of 2D-3D pose pairs in target domain training sets. We present the \textit{Multi-Hypothesis \textbf{P}ose \textbf{Syn}thesis \textbf{D}omain \textbf{A}daptation} (\textbf{PoSynDA}) framework to overcome this issue without extensive target domain annotation. Utilizing a diffusion-centric structure, PoSynDA simulates the 3D pose distribution in the target domain, filling the data diversity gap. By incorporating a multi-hypothesis network, it creates diverse pose hypotheses and aligns them with the target domain. Target-specific source augmentation obtains the target domain distribution data from the source domain by decoupling the scale and position parameters. The teacher-student paradigm and low-rank adaptation further refine the process. PoSynDA demonstrates competitive performance on benchmarks, such as Human3.6M, MPI-INF-3DHP, and 3DPW, even comparable with the target-trained MixSTE model~\cite{zhang2022mixste}. This work paves the way for the practical application of 3D human pose estimation. The code is available at //github.com/hbing-l/PoSynDA.

We introduce a Self-supervised Contrastive Representation Learning Approach for Time Series Anomaly Detection (CARLA), an innovative end-to-end self-supervised framework carefully developed to identify anomalous patterns in both univariate and multivariate time series data. By taking advantage of contrastive representation learning, We introduce an innovative end-to-end self-supervised deep learning framework carefully developed to identify anomalous patterns in both univariate and multivariate time series data. By taking advantage of contrastive representation learning, CARLA effectively generates robust representations for time series windows. It achieves this by 1) learning similar representations for temporally close windows and dissimilar representations for windows and their equivalent anomalous windows and 2) employing a self-supervised approach to classify normal/anomalous representations of windows based on their nearest/furthest neighbours in the representation space. Most of the existing models focus on learning normal behaviour. The normal boundary is often tightly defined, which can result in slight deviations being classified as anomalies, resulting in a high false positive rate and limited ability to generalise normal patterns. CARLA's contrastive learning methodology promotes the production of highly consistent and discriminative predictions, thereby empowering us to adeptly address the inherent challenges associated with anomaly detection in time series data. Through extensive experimentation on 7 standard real-world time series anomaly detection benchmark datasets, CARLA demonstrates F1 and AU-PR superior to existing state-of-the-art results. Our research highlights the immense potential of contrastive representation learning in advancing the field of time series anomaly detection, thus paving the way for novel applications and in-depth exploration in this domain.

The Spiking Neural Network (SNN) has attracted more and more attention recently. It adopts binary spike signals to transmit information. Benefitting from the information passing paradigm of SNNs, the multiplications of activations and weights can be replaced by additions, which are more energy-efficient. However, its "Hard Reset" mechanism for the firing activity would ignore the difference among membrane potentials when the membrane potential is above the firing threshold, causing information loss. Meanwhile, quantifying the membrane potential to 0/1 spikes at the firing instants will inevitably introduce the quantization error thus bringing about information loss too. To address these problems, we propose to use the "Soft Reset" mechanism for the supervised training-based SNNs, which will drive the membrane potential to a dynamic reset potential according to its magnitude, and Membrane Potential Rectifier (MPR) to reduce the quantization error via redistributing the membrane potential to a range close to the spikes. Results show that the SNNs with the "Soft Reset" mechanism and MPR outperform their vanilla counterparts on both static and dynamic datasets.

We present Emu, a system that semantically enhances multilingual sentence embeddings. Our framework fine-tunes pre-trained multilingual sentence embeddings using two main components: a semantic classifier and a language discriminator. The semantic classifier improves the semantic similarity of related sentences, whereas the language discriminator enhances the multilinguality of the embeddings via multilingual adversarial training. Our experimental results based on several language pairs show that our specialized embeddings outperform the state-of-the-art multilingual sentence embedding model on the task of cross-lingual intent classification using only monolingual labeled data.

We propose a novel single shot object detection network named Detection with Enriched Semantics (DES). Our motivation is to enrich the semantics of object detection features within a typical deep detector, by a semantic segmentation branch and a global activation module. The segmentation branch is supervised by weak segmentation ground-truth, i.e., no extra annotation is required. In conjunction with that, we employ a global activation module which learns relationship between channels and object classes in a self-supervised manner. Comprehensive experimental results on both PASCAL VOC and MS COCO detection datasets demonstrate the effectiveness of the proposed method. In particular, with a VGG16 based DES, we achieve an mAP of 81.7 on VOC2007 test and an mAP of 32.8 on COCO test-dev with an inference speed of 31.5 milliseconds per image on a Titan Xp GPU. With a lower resolution version, we achieve an mAP of 79.7 on VOC2007 with an inference speed of 13.0 milliseconds per image.