Alzheimer's disease (AD), as a progressive brain disease, affects cognition, memory, and behavior. Similarly, limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently defined common neurodegenerative disease that mimics the clinical symptoms of AD. At present, the risk factors implicated in LATE and those distinguishing LATE from AD are largely unknown. We leveraged an integrated feature selection-based algorithmic approach, to identify important factors differentiating subjects with LATE and/or AD from Control on significantly imbalanced data. We analyzed two datasets ROSMAP and NACC and discovered that alcohol consumption was a top lifestyle and environmental factor linked with LATE and AD and their associations were differential. In particular, we identified a specific subpopulation consisting of APOE e4 carriers. We found that, for this subpopulation, light-to-moderate alcohol intake was a protective factor against both AD and LATE, but its protective role against AD appeared stronger than LATE. The codes for our algorithms are available at //github.com/xinxingwu-uk/PFV.
Although online handwriting verification has made great progress recently, the verification performances are still far behind the real usage owing to the small scale of the datasets as well as the limited biometric mediums. Therefore, this paper proposes a new handwriting verification benchmark dataset named Multimodal Signature and Digit String (MSDS), which consists of two subsets: MSDS-ChS (Chinese Signatures) and MSDS-TDS (Token Digit Strings), contributed by 402 users, with 20 genuine samples and 20 skilled forgeries per user per subset. MSDS-ChS consists of handwritten Chinese signatures, which, to the best of our knowledge, is the largest publicly available Chinese signature dataset for handwriting verification, at least eight times larger than existing online datasets. Meanwhile, MSDS-TDS consists of handwritten Token Digit Strings, i.e, the actual phone numbers of users, which have not been explored yet. Extensive experiments with different baselines are respectively conducted for MSDS-ChS and MSDS-TDS. Surprisingly, verification performances of state-of-the-art methods on MSDS-TDS are generally better than those on MSDS-ChS, which indicates that the handwritten Token Digit String could be a more effective biometric than handwritten Chinese signature. This is a promising discovery that could inspire us to explore new biometric traits. The MSDS dataset is available at //github.com/HCIILAB/MSDS.
Concerns about the reproducibility of deep learning research are more prominent than ever, with no clear solution in sight. The relevance of machine learning research can only be improved if we also employ empirical rigor that incorporates reproducibility guidelines, especially so in the medical imaging field. The Medical Imaging with Deep Learning (MIDL) conference has made advancements in this direction by advocating open access, and recently also recommending authors to make their code public - both aspects being adopted by the majority of the conference submissions. This helps the reproducibility of the methods, however, there is currently little or no support for further evaluation of these supplementary material, making them vulnerable to poor quality, which affects the impact of the entire submission. We have evaluated all accepted full paper submissions to MIDL between 2018 and 2022 using established, but slightly adjusted guidelines on reproducibility and the quality of the public repositories. The evaluations show that publishing repositories and using public datasets are becoming more popular, which helps traceability, but the quality of the repositories has not improved over the years, leaving room for improvement in every aspect of designing repositories. Merely 22% of all submissions contain a repository that were deemed repeatable using our evaluations. From the commonly encountered issues during the evaluations, we propose a set of guidelines for machine learning-related research for medical imaging applications, adjusted specifically for future submissions to MIDL.
Autonomous robotic systems operating in human environments must understand their surroundings to make accurate and safe decisions. In crowded human scenes with close-up human-robot interaction and robot navigation, a deep understanding requires reasoning about human motion and body dynamics over time with human body pose estimation and tracking. However, existing datasets either do not provide pose annotations or include scene types unrelated to robotic applications. Many datasets also lack the diversity of poses and occlusions found in crowded human scenes. To address this limitation we introduce JRDB-Pose, a large-scale dataset and benchmark for multi-person pose estimation and tracking using videos captured from a social navigation robot. The dataset contains challenge scenes with crowded indoor and outdoor locations and a diverse range of scales and occlusion types. JRDB-Pose provides human pose annotations with per-keypoint occlusion labels and track IDs consistent across the scene. A public evaluation server is made available for fair evaluation on a held-out test set. JRDB-Pose is available at //jrdb.erc.monash.edu/ .
The objective of this work is to develop a speaker recognition model to be used in diverse scenarios. We hypothesise that two components should be adequately configured to build such a model. First, adequate architecture would be required. We explore several recent state-of-the-art models, including ECAPA-TDNN and MFA-Conformer, as well as other baselines. Second, a massive amount of data would be required. We investigate several new training data configurations combining a few existing datasets. The most extensive configuration includes over 87k speakers' 10.22k hours of speech. Four evaluation protocols are adopted to measure how the trained model performs in diverse scenarios. Through experiments, we find that MFA-Conformer with the least inductive bias generalises the best. We also show that training with proposed large data configurations gives better performance. A boost in generalisation is observed, where the average performance on four evaluation protocols improves by more than 20%. In addition, we also demonstrate that these models' performances can improve even further when increasing capacity.
The goal of cryptocurrencies is decentralization. In principle, all currencies have equal status. Unlike traditional stock markets, there is no default currency of denomination (fiat), thus the trading pairs can be set freely. However, it is impractical to set up a trading market between every two currencies. In order to control management costs and ensure sufficient liquidity, we must give priority to covering those large-volume trading pairs and ensure that all coins are reachable. We note that this is an optimization problem. Its particularity lies in: 1) the trading volume between most (>99.5%) possible trading pairs cannot be directly observed. 2) It satisfies the connectivity constraint, that is, all currencies are guaranteed to be tradable. To solve this problem, we use a two-stage process: 1) Fill in missing values based on a regularized, truncated eigenvalue decomposition, where the regularization term is used to control what extent missing values should be limited to zero. 2) Search for the optimal trading pairs, based on a branch and bound process, with heuristic search and pruning strategies. The experimental results show that: 1) If the number of denominated coins is not limited, we will get a more decentralized trading pair settings, which advocates the establishment of trading pairs directly between large currency pairs. 2) There is a certain room for optimization in all exchanges. The setting of inappropriate trading pairs is mainly caused by subjectively setting small coins to quote, or failing to track emerging big coins in time. 3) Too few trading pairs will lead to low coverage; too many trading pairs will need to be adjusted with markets frequently. Exchanges should consider striking an appropriate balance between them.
Variable selection is crucial for sparse modeling in this age of big data. Missing values are common in data, and make variable selection more complicated. The approach of multiple imputation (MI) results in multiply imputed datasets for missing values, and has been widely applied in various variable selection procedures. However, directly performing variable selection on the whole MI data or bootstrapped MI data may not be worthy in terms of computation cost. To fast identify the active variables in the linear regression model, we propose the adaptive grafting procedure with three pooling rules on MI data. The proposed methods proceed iteratively, which starts from finding the active variables based on the complete case subset and then expand the working data matrix with both the number of active variables and available observations. A comprehensive simulation study shows the selection accuracy in different aspects and computational efficiency of the proposed methods. Two real-life examples illustrate the strength of the proposed methods.
Missing data imputation (MDI) is crucial when dealing with tabular datasets across various domains. Autoencoders can be trained to reconstruct missing values, and graph autoencoders (GAE) can additionally consider similar patterns in the dataset when imputing new values for a given instance. However, previously proposed GAEs suffer from scalability issues, requiring the user to define a similarity metric among patterns to build the graph connectivity beforehand. In this paper, we leverage recent progress in latent graph imputation to propose a novel EdGe Generation Graph AutoEncoder (EGG-GAE) for missing data imputation that overcomes these two drawbacks. EGG-GAE works on randomly sampled mini-batches of the input data (hence scaling to larger datasets), and it automatically infers the best connectivity across the mini-batch for each architecture layer. We also experiment with several extensions, including an ensemble strategy for inference and the inclusion of what we call prototype nodes, obtaining significant improvements, both in terms of imputation error and final downstream accuracy, across multiple benchmarks and baselines.
The time and effort involved in hand-designing deep neural networks is immense. This has prompted the development of Neural Architecture Search (NAS) techniques to automate this design. However, NAS algorithms tend to be slow and expensive; they need to train vast numbers of candidate networks to inform the search process. This could be alleviated if we could partially predict a network's trained accuracy from its initial state. In this work, we examine the overlap of activations between datapoints in untrained networks and motivate how this can give a measure which is usefully indicative of a network's trained performance. We incorporate this measure into a simple algorithm that allows us to search for powerful networks without any training in a matter of seconds on a single GPU, and verify its effectiveness on NAS-Bench-101, NAS-Bench-201, NATS-Bench, and Network Design Spaces. Our approach can be readily combined with more expensive search methods; we examine a simple adaptation of regularised evolutionary search. Code for reproducing our experiments is available at //github.com/BayesWatch/nas-without-training.
Behaviors of the synthetic characters in current military simulations are limited since they are generally generated by rule-based and reactive computational models with minimal intelligence. Such computational models cannot adapt to reflect the experience of the characters, resulting in brittle intelligence for even the most effective behavior models devised via costly and labor-intensive processes. Observation-based behavior model adaptation that leverages machine learning and the experience of synthetic entities in combination with appropriate prior knowledge can address the issues in the existing computational behavior models to create a better training experience in military training simulations. In this paper, we introduce a framework that aims to create autonomous synthetic characters that can perform coherent sequences of believable behavior while being aware of human trainees and their needs within a training simulation. This framework brings together three mutually complementary components. The first component is a Unity-based simulation environment - Rapid Integration and Development Environment (RIDE) - supporting One World Terrain (OWT) models and capable of running and supporting machine learning experiments. The second is Shiva, a novel multi-agent reinforcement and imitation learning framework that can interface with a variety of simulation environments, and that can additionally utilize a variety of learning algorithms. The final component is the Sigma Cognitive Architecture that will augment the behavior models with symbolic and probabilistic reasoning capabilities. We have successfully created proof-of-concept behavior models leveraging this framework on realistic terrain as an essential step towards bringing machine learning into military simulations.
This paper aims at revisiting Graph Convolutional Neural Networks by bridging the gap between spectral and spatial design of graph convolutions. We theoretically demonstrate some equivalence of the graph convolution process regardless it is designed in the spatial or the spectral domain. The obtained general framework allows to lead a spectral analysis of the most popular ConvGNNs, explaining their performance and showing their limits. Moreover, the proposed framework is used to design new convolutions in spectral domain with a custom frequency profile while applying them in the spatial domain. We also propose a generalization of the depthwise separable convolution framework for graph convolutional networks, what allows to decrease the total number of trainable parameters by keeping the capacity of the model. To the best of our knowledge, such a framework has never been used in the GNNs literature. Our proposals are evaluated on both transductive and inductive graph learning problems. Obtained results show the relevance of the proposed method and provide one of the first experimental evidence of transferability of spectral filter coefficients from one graph to another. Our source codes are publicly available at: //github.com/balcilar/Spectral-Designed-Graph-Convolutions