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Cerebral blood flow and perfusion can be estimated using tracer dilution experiments. Accurate estimation of blood flow parameters is a crucial part of medical imaging for effective diagnosis and treatment. This study explores two themes: (i) the derivation of the gamma variate function as a response tracer infusion and (ii) the estimation of impulse and residue functions from tracer dilution curves parameters via the least squares method.

Adaptive experimental design (AED) methods are increasingly being used in industry as a tool to boost testing throughput or reduce experimentation cost relative to traditional A/B/N testing methods. However, the behavior and guarantees of such methods are not well-understood beyond idealized stationary settings. This paper shares lessons learned regarding the challenges of naively using AED systems in industrial settings where non-stationarity is prevalent, while also providing perspectives on the proper objectives and system specifications in such settings. We developed an AED framework for counterfactual inference based on these experiences, and tested it in a commercial environment.

Robotic manipulation in human environments is a challenging problem for researchers and industry alike. In particular, opening doors/drawers can be challenging for robots, as the size, shape, actuation and required force is variable. Because of this, it can be difficult to collect large real-world datasets and to benchmark different control algorithms on the same hardware. In this paper we present two automated testbeds, the Door Reset Mechanism (DORM) and Drawer Reset Mechanism (DWRM), for the purpose of real world testing and data collection. These devices are low-cost, are sensorized, operate with customized variable resistance, and come with open source software. Additionally, we provide a dataset of over 600 grasps using the DORM and DWRM. We use this dataset to highlight how much variability can exist even with the same trial on the same hardware. This data can also serve as a source for real-world noise in simulation environments.

Utilizing large-scale pretrained models is a well-known strategy to enhance performance on various target tasks. It is typically achieved through fine-tuning pretrained models on target tasks. However, na\"{\i}ve fine-tuning may not fully leverage knowledge embedded in pretrained models. In this study, we introduce a novel fine-tuning method, called stochastic cross-attention (StochCA), specific to Transformer architectures. This method modifies the Transformer's self-attention mechanism to selectively utilize knowledge from pretrained models during fine-tuning. Specifically, in each block, instead of self-attention, cross-attention is performed stochastically according to the predefined probability, where keys and values are extracted from the corresponding block of a pretrained model. By doing so, queries and channel-mixing multi-layer perceptron layers of a target model are fine-tuned to target tasks to learn how to effectively exploit rich representations of pretrained models. To verify the effectiveness of StochCA, extensive experiments are conducted on benchmarks in the areas of transfer learning and domain generalization, where the exploitation of pretrained models is critical. Our experimental results show the superiority of StochCA over state-of-the-art approaches in both areas. Furthermore, we demonstrate that StochCA is complementary to existing approaches, i.e., it can be combined with them to further improve performance. Our code is available at //github.com/daintlab/stochastic_cross_attention

Precise situational awareness is required for the safe decision-making of assisted and automated driving (AAD) functions. Panoptic segmentation is a promising perception technique to identify and categorise objects, impending hazards, and driveable space at a pixel level. While segmentation quality is generally associated with the quality of the camera data, a comprehensive understanding and modelling of this relationship are paramount for AAD system designers. Motivated by such a need, this work proposes a unifying pipeline to assess the robustness of panoptic segmentation models for AAD, correlating it with traditional image quality. The first step of the proposed pipeline involves generating degraded camera data that reflects real-world noise factors. To this end, 19 noise factors have been identified and implemented with 3 severity levels. Of these factors, this work proposes novel models for unfavourable light and snow. After applying the degradation models, three state-of-the-art CNN- and vision transformers (ViT)-based panoptic segmentation networks are used to analyse their robustness. The variations of the segmentation performance are then correlated to 8 selected image quality metrics. This research reveals that: 1) certain specific noise factors produce the highest impact on panoptic segmentation, i.e. droplets on lens and Gaussian noise; 2) the ViT-based panoptic segmentation backbones show better robustness to the considered noise factors; 3) some image quality metrics (i.e. LPIPS and CW-SSIM) correlate strongly with panoptic segmentation performance and therefore they can be used as predictive metrics for network performance.

Emergency communication is critical but challenging after natural disasters when ground infrastructure is devastated. Unmanned aerial vehicles (UAVs) offer enormous potential for agile relief coordination in these scenarios. However, effectively leveraging UAV fleets poses additional challenges around security, privacy, and efficient collaboration across response agencies. This paper presents a robust blockchain-enabled framework to address these challenges by integrating a consortium blockchain model, smart contracts, and cryptographic techniques to securely coordinate UAV fleets for disaster response. Specifically, we make two key contributions: a consortium blockchain architecture for secure and private multi-agency coordination; and an optimized consensus protocol balancing efficiency and fault tolerance using a delegated proof of stake practical byzantine fault tolerance (DPoS-PBFT). Comprehensive simulations showcase the framework's ability to enhance transparency, automation, scalability, and cyber-attack resilience for UAV coordination in post-disaster networks.

With the incorporation of the UNet architecture, diffusion probabilistic models have become a dominant force in image generation tasks. One key design in UNet is the skip connections between the encoder and decoder blocks. Although skip connections have been shown to improve training stability and model performance, we reveal that such shortcuts can be a limiting factor for the complexity of the transformation. As the sampling steps decrease, the generation process and the role of the UNet get closer to the push-forward transformations from Gaussian distribution to the target, posing a challenge for the network's complexity. To address this challenge, we propose Skip-Tuning, a simple yet surprisingly effective training-free tuning method on the skip connections. Our method can achieve 100% FID improvement for pretrained EDM on ImageNet 64 with only 19 NFEs (1.75), breaking the limit of ODE samplers regardless of sampling steps. Surprisingly, the improvement persists when we increase the number of sampling steps and can even surpass the best result from EDM-2 (1.58) with only 39 NFEs (1.57). Comprehensive exploratory experiments are conducted to shed light on the surprising effectiveness. We observe that while Skip-Tuning increases the score-matching losses in the pixel space, the losses in the feature space are reduced, particularly at intermediate noise levels, which coincide with the most effective range accounting for image quality improvement.

Medical image segmentation is a fundamental and critical step in many image-guided clinical approaches. Recent success of deep learning-based segmentation methods usually relies on a large amount of labeled data, which is particularly difficult and costly to obtain especially in the medical imaging domain where only experts can provide reliable and accurate annotations. Semi-supervised learning has emerged as an appealing strategy and been widely applied to medical image segmentation tasks to train deep models with limited annotations. In this paper, we present a comprehensive review of recently proposed semi-supervised learning methods for medical image segmentation and summarized both the technical novelties and empirical results. Furthermore, we analyze and discuss the limitations and several unsolved problems of existing approaches. We hope this review could inspire the research community to explore solutions for this challenge and further promote the developments in medical image segmentation field.

The dominating NLP paradigm of training a strong neural predictor to perform one task on a specific dataset has led to state-of-the-art performance in a variety of applications (eg. sentiment classification, span-prediction based question answering or machine translation). However, it builds upon the assumption that the data distribution is stationary, ie. that the data is sampled from a fixed distribution both at training and test time. This way of training is inconsistent with how we as humans are able to learn from and operate within a constantly changing stream of information. Moreover, it is ill-adapted to real-world use cases where the data distribution is expected to shift over the course of a model's lifetime. The first goal of this thesis is to characterize the different forms this shift can take in the context of natural language processing, and propose benchmarks and evaluation metrics to measure its effect on current deep learning architectures. We then proceed to take steps to mitigate the effect of distributional shift on NLP models. To this end, we develop methods based on parametric reformulations of the distributionally robust optimization framework. Empirically, we demonstrate that these approaches yield more robust models as demonstrated on a selection of realistic problems. In the third and final part of this thesis, we explore ways of efficiently adapting existing models to new domains or tasks. Our contribution to this topic takes inspiration from information geometry to derive a new gradient update rule which alleviate catastrophic forgetting issues during adaptation.

Distant supervision can effectively label data for relation extraction, but suffers from the noise labeling problem. Recent works mainly perform soft bag-level noise reduction strategies to find the relatively better samples in a sentence bag, which is suboptimal compared with making a hard decision of false positive samples in sentence level. In this paper, we introduce an adversarial learning framework, which we named DSGAN, to learn a sentence-level true-positive generator. Inspired by Generative Adversarial Networks, we regard the positive samples generated by the generator as the negative samples to train the discriminator. The optimal generator is obtained until the discrimination ability of the discriminator has the greatest decline. We adopt the generator to filter distant supervision training dataset and redistribute the false positive instances into the negative set, in which way to provide a cleaned dataset for relation classification. The experimental results show that the proposed strategy significantly improves the performance of distant supervision relation extraction comparing to state-of-the-art systems.