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We consider the problem of solving a family of parametric mixed-integer linear optimization problems where some entries in the input data change. We introduce the concept of cutting-plane layer (CPL), i.e., a differentiable cutting-plane generator mapping the problem data and previous iterates to cutting planes. We propose a CPL implementation to generate split cuts, and by combining several CPLs, we devise a differentiable cutting-plane algorithm that exploits the repeated nature of parametric instances. In an offline phase, we train our algorithm by updating the internal parameters controlling the CPLs, thus altering cut generation. Once trained, our algorithm computes, with predictable execution times and a fixed number of cuts, solutions with low integrality gaps. Preliminary computational tests show that our algorithm generalizes on unseen instances and captures underlying parametric structures.

Edge-device collaboration has the potential to facilitate compute-intensive device pose tracking for resource-constrained mobile augmented reality (MAR) devices. In this paper, we devise a 3D map management scheme for edge-assisted MAR, wherein an edge server constructs and updates a 3D map of the physical environment by using the camera frames uploaded from an MAR device, to support local device pose tracking. Our objective is to minimize the uncertainty of device pose tracking by periodically selecting a proper set of uploaded camera frames and updating the 3D map. To cope with the dynamics of the uplink data rate and the user's pose, we formulate a Bayes-adaptive Markov decision process problem and propose a digital twin (DT)-based approach to solve the problem. First, a DT is designed as a data model to capture the time-varying uplink data rate, thereby supporting 3D map management. Second, utilizing extensive generated data provided by the DT, a model-based reinforcement learning algorithm is developed to manage the 3D map while adapting to these dynamics. Numerical results demonstrate that the designed DT outperforms Markov models in accurately capturing the time-varying uplink data rate, and our devised DT-based 3D map management scheme surpasses benchmark schemes in reducing device pose tracking uncertainty.

We investigate the so-called "MMSE conjecture" from Guo et al. (2011) which asserts that two distributions on the real line with the same entropy along the heat flow coincide up to translation and symmetry. Our approach follows the path breaking contribution Ledoux (1995) which gave algebraic representations of the derivatives of said entropy in terms of multivariate polynomials. The main contributions in this note are (i) we obtain the leading terms in the polynomials from Ledoux (1995), and (ii) we provide new conditions on the source distributions ensuring the MMSE conjecture holds. As illustrating examples, our findings cover the cases of uniform and Rademacher distributions, for which previous results in the literature were inapplicable.

When modeling a vector of risk variables, extreme scenarios are often of special interest. The peaks-over-thresholds method hinges on the notion that, asymptotically, the excesses over a vector of high thresholds follow a multivariate generalized Pareto distribution. However, existing literature has primarily concentrated on the setting when all risk variables are always large simultaneously. In reality, this assumption is often not met, especially in high dimensions. In response to this limitation, we study scenarios where distinct groups of risk variables may exhibit joint extremes while others do not. These discernible groups are derived from the angular measure inherent in the corresponding max-stable distribution, whence the term extreme direction. We explore such extreme directions within the framework of multivariate generalized Pareto distributions, with a focus on their probability density functions in relation to an appropriate dominating measure. Furthermore, we provide a stochastic construction that allows any prespecified set of risk groups to constitute the distribution's extreme directions. This construction takes the form of a smoothed max-linear model and accommodates the full spectrum of conceivable max-stable dependence structures. Additionally, we introduce a generic simulation algorithm tailored for multivariate generalized Pareto distributions, offering specific implementations for extensions of the logistic and H\"usler-Reiss families capable of carrying arbitrary extreme directions.

Distributed optimization has experienced a significant surge in interest due to its wide-ranging applications in distributed learning and adaptation. While various scenarios, such as shared-memory, local-memory, and consensus-based approaches, have been extensively studied in isolation, there remains a need for further exploration of their interconnections. This paper specifically concentrates on a scenario where agents collaborate toward a unified mission while potentially having distinct tasks. Each agent's actions can potentially impact other agents through interactions. Within this context, the objective for the agents is to optimize their local parameters based on the aggregate of local reward functions, where only local zeroth-order oracles are available. Notably, the learning process is asynchronous, meaning that agents update and query their zeroth-order oracles asynchronously while communicating with other agents subject to bounded but possibly random communication delays. This paper presents theoretical convergence analyses and establishes a convergence rate for the proposed approach. Furthermore, it addresses the relevant issue of deep learning-based resource allocation in communication networks and conducts numerical experiments in which agents, acting as transmitters, collaboratively train their individual (possibly unique) policies to maximize a common performance metric.

Black-box variational inference performance is sometimes hindered by the use of gradient estimators with high variance. This variance comes from two sources of randomness: Data subsampling and Monte Carlo sampling. While existing control variates only address Monte Carlo noise, and incremental gradient methods typically only address data subsampling, we propose a new "joint" control variate that jointly reduces variance from both sources of noise. This significantly reduces gradient variance, leading to faster optimization in several applications.

We introduce a semi-explicit time-stepping scheme of second order for linear poroelasticity satisfying a weak coupling condition. Here, semi-explicit means that the system, which needs to be solved in each step, decouples and hence improves the computational efficiency. The construction and the convergence proof are based on the connection to a differential equation with two time delays, namely one and two times the step size. Numerical experiments confirm the theoretical results and indicate the applicability to higher-order schemes.

Modern high-throughput sequencing assays efficiently capture not only gene expression and different levels of gene regulation but also a multitude of genome variants. Focused analysis of alternative alleles of variable sites at homologous chromosomes of the human genome reveals allele-specific gene expression and allele-specific gene regulation by assessing allelic imbalance of read counts at individual sites. Here we formally describe an advanced statistical framework for detecting the allelic imbalance in allelic read counts at single-nucleotide variants detected in diverse omics studies (ChIP-Seq, ATAC-Seq, DNase-Seq, CAGE-Seq, and others). MIXALIME accounts for copy-number variants and aneuploidy, reference read mapping bias, and provides several scoring models to balance between sensitivity and specificity when scoring data with varying levels of experimental noise-caused overdispersion.

We combine the recent relaxation approach with multiderivative Runge-Kutta methods to preserve conservation or dissipation of entropy functionals for ordinary and partial differential equations. Relaxation methods are minor modifications of explicit and implicit schemes, requiring only the solution of a single scalar equation per time step in addition to the baseline scheme. We demonstrate the robustness of the resulting methods for a range of test problems including the 3D compressible Euler equations. In particular, we point out improved error growth rates for certain entropy-conservative problems including nonlinear dispersive wave equations.

Graph-centric artificial intelligence (graph AI) has achieved remarkable success in modeling interacting systems prevalent in nature, from dynamical systems in biology to particle physics. The increasing heterogeneity of data calls for graph neural architectures that can combine multiple inductive biases. However, combining data from various sources is challenging because appropriate inductive bias may vary by data modality. Multimodal learning methods fuse multiple data modalities while leveraging cross-modal dependencies to address this challenge. Here, we survey 140 studies in graph-centric AI and realize that diverse data types are increasingly brought together using graphs and fed into sophisticated multimodal models. These models stratify into image-, language-, and knowledge-grounded multimodal learning. We put forward an algorithmic blueprint for multimodal graph learning based on this categorization. The blueprint serves as a way to group state-of-the-art architectures that treat multimodal data by choosing appropriately four different components. This effort can pave the way for standardizing the design of sophisticated multimodal architectures for highly complex real-world problems.