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A profound gap persists between artificial intelligence (AI) and clinical practice in medicine, primarily due to the lack of rigorous and cost-effective evaluation methodologies. State-of-the-art and state-of-the-practice AI model evaluations are limited to laboratory studies on medical datasets or direct clinical trials with no or solely patient-centered controls. Moreover, the crucial role of clinicians in collaborating with AI, pivotal for determining its impact on clinical practice, is often overlooked. For the first time, we emphasize the critical necessity for rigorous and cost-effective evaluation methodologies for AI models in clinical practice, featuring patient/clinician-centered (dual-centered) AI randomized controlled trials (DC-AI RCTs) and virtual clinician-based in-silico trials (VC-MedAI) as an effective proxy for DC-AI RCTs. Leveraging 7500 diagnosis records from two-phase inaugural DC-AI RCTs across 14 medical centers with 125 clinicians, our results demonstrate the necessity of DC-AI RCTs and the effectiveness of VC-MedAI. Notably, VC-MedAI performs comparably to human clinicians, replicating insights and conclusions from prospective DC-AI RCTs. We envision DC-AI RCTs and VC-MedAI as pivotal advancements, presenting innovative and transformative evaluation methodologies for AI models in clinical practice, offering a preclinical-like setting mirroring conventional medicine, and reshaping development paradigms in a cost-effective and fast-iterative manner. Chinese Clinical Trial Registration: ChiCTR2400086816.

Language models achieve impressive results in tasks involving complex multistep reasoning, but scaling these capabilities further traditionally requires expensive collection of more annotated data. In this work, we explore the potential of improving the capabilities of language models without new data, merely using automated feedback to the validity of their predictions in arithmetic reasoning (self-training). We find that models can substantially improve in both single-round (offline) and online self-training. In the offline setting, supervised methods are able to deliver gains comparable to preference optimization, but in online self-training, preference optimization shows to largely outperform supervised training thanks to superior stability and robustness on unseen types of problems.

Learning continually from a stream of non-i.i.d. data is an open challenge in deep learning, even more so when working in resource-constrained environments such as embedded devices. Visual models that are continually updated through supervised learning are often prone to overfitting, catastrophic forgetting, and biased representations. On the other hand, large language models contain knowledge about multiple concepts and their relations, which can foster a more robust, informed and coherent learning process. This work proposes Continual Visual Mapping (CVM), an approach that continually ground vision representations to a knowledge space extracted from a fixed Language model. Specifically, CVM continually trains a small and efficient visual model to map its representations into a conceptual space established by a fixed Large Language Model. Due to their smaller nature, CVM can be used when directly adapting large visual pre-trained models is unfeasible due to computational or data constraints. CVM overcome state-of-the-art continual learning methods on five benchmarks and offers a promising avenue for addressing generalization capabilities in continual learning, even in computationally constrained devices.

Pairwise likelihood offers a useful approximation to the full likelihood function for covariance estimation in high-dimensional context. It simplifies high-dimensional dependencies by combining marginal bivariate likelihood objects, thereby making estimation more manageable. In certain models, including the Gaussian model, both pairwise and full likelihoods are known to be maximized by the same parameter values, thus retaining optimal statistical efficiency, when the number of variables is fixed. Leveraging this insight, we introduce the estimation of sparse high-dimensional covariance matrices by maximizing a truncated version of the pairwise likelihood function, which focuses on pairwise terms corresponding to nonzero covariance elements. To achieve a meaningful truncation, we propose to minimize the discrepancy between pairwise and full likelihood scores plus an L1-penalty discouraging the inclusion of uninformative terms. Differently from other regularization approaches, our method selects whole pairwise likelihood objects rather than individual covariance parameters, thus retaining the inherent unbiasedness of the pairwise likelihood estimating equations. This selection procedure is shown to have the selection consistency property as the covariance dimension increases exponentially fast. As a result, the implied pairwise likelihood estimator is consistent and converges to the oracle maximum likelihood estimator that assumes knowledge of nonzero covariance entries.

Diffusion models have demonstrated their effectiveness across various generative tasks. However, when applied to medical image segmentation, these models encounter several challenges, including significant resource and time requirements. They also necessitate a multi-step reverse process and multiple samples to produce reliable predictions. To address these challenges, we introduce the first latent diffusion segmentation model, named SDSeg, built upon stable diffusion (SD). SDSeg incorporates a straightforward latent estimation strategy to facilitate a single-step reverse process and utilizes latent fusion concatenation to remove the necessity for multiple samples. Extensive experiments indicate that SDSeg surpasses existing state-of-the-art methods on five benchmark datasets featuring diverse imaging modalities. Remarkably, SDSeg is capable of generating stable predictions with a solitary reverse step and sample, epitomizing the model's stability as implied by its name. The code is available at //github.com/lin-tianyu/Stable-Diffusion-Seg

The application of data-intensive automatic speech recognition (ASR) technologies to dysarthric and elderly adult speech is confronted by their mismatch against healthy and nonaged voices, data scarcity and large speaker-level variability. To this end, this paper proposes two novel data-efficient methods to learn homogeneous dysarthric and elderly speaker-level features for rapid, on-the-fly test-time adaptation of DNN/TDNN and Conformer ASR models. These include: 1) speaker-level variance-regularized spectral basis embedding (VR-SBE) features that exploit a special regularization term to enforce homogeneity of speaker features in adaptation; and 2) feature-based learning hidden unit contributions (f-LHUC) transforms that are conditioned on VR-SBE features. Experiments are conducted on four tasks across two languages: the English UASpeech and TORGO dysarthric speech datasets, the English DementiaBank Pitt and Cantonese JCCOCC MoCA elderly speech corpora. The proposed on-the-fly speaker adaptation techniques consistently outperform baseline iVector and xVector adaptation by statistically significant word or character error rate reductions up to 5.32% absolute (18.57% relative) and batch-mode LHUC speaker adaptation by 2.24% absolute (9.20% relative), while operating with real-time factors speeding up to 33.6 times against xVectors during adaptation. The efficacy of the proposed adaptation techniques is demonstrated in a comparison against current ASR technologies including SSL pre-trained systems on UASpeech, where our best system produces a state-of-the-art WER of 23.33%. Analyses show VR-SBE features and f-LHUC transforms are insensitive to speaker-level data quantity in testtime adaptation. T-SNE visualization reveals they have stronger speaker-level homogeneity than baseline iVectors, xVectors and batch-mode LHUC transforms.

Causal inference has shown potential in enhancing the predictive accuracy, fairness, robustness, and explainability of Natural Language Processing (NLP) models by capturing causal relationships among variables. The emergence of generative Large Language Models (LLMs) has significantly impacted various NLP domains, particularly through their advanced reasoning capabilities. This survey focuses on evaluating and improving LLMs from a causal view in the following areas: understanding and improving the LLMs' reasoning capacity, addressing fairness and safety issues in LLMs, complementing LLMs with explanations, and handling multimodality. Meanwhile, LLMs' strong reasoning capacities can in turn contribute to the field of causal inference by aiding causal relationship discovery and causal effect estimations. This review explores the interplay between causal inference frameworks and LLMs from both perspectives, emphasizing their collective potential to further the development of more advanced and equitable artificial intelligence systems.

The rapid development of deep learning has made a great progress in segmentation, one of the fundamental tasks of computer vision. However, the current segmentation algorithms mostly rely on the availability of pixel-level annotations, which are often expensive, tedious, and laborious. To alleviate this burden, the past years have witnessed an increasing attention in building label-efficient, deep-learning-based segmentation algorithms. This paper offers a comprehensive review on label-efficient segmentation methods. To this end, we first develop a taxonomy to organize these methods according to the supervision provided by different types of weak labels (including no supervision, coarse supervision, incomplete supervision and noisy supervision) and supplemented by the types of segmentation problems (including semantic segmentation, instance segmentation and panoptic segmentation). Next, we summarize the existing label-efficient segmentation methods from a unified perspective that discusses an important question: how to bridge the gap between weak supervision and dense prediction -- the current methods are mostly based on heuristic priors, such as cross-pixel similarity, cross-label constraint, cross-view consistency, cross-image relation, etc. Finally, we share our opinions about the future research directions for label-efficient deep segmentation.

Ensembles over neural network weights trained from different random initialization, known as deep ensembles, achieve state-of-the-art accuracy and calibration. The recently introduced batch ensembles provide a drop-in replacement that is more parameter efficient. In this paper, we design ensembles not only over weights, but over hyperparameters to improve the state of the art in both settings. For best performance independent of budget, we propose hyper-deep ensembles, a simple procedure that involves a random search over different hyperparameters, themselves stratified across multiple random initializations. Its strong performance highlights the benefit of combining models with both weight and hyperparameter diversity. We further propose a parameter efficient version, hyper-batch ensembles, which builds on the layer structure of batch ensembles and self-tuning networks. The computational and memory costs of our method are notably lower than typical ensembles. On image classification tasks, with MLP, LeNet, and Wide ResNet 28-10 architectures, our methodology improves upon both deep and batch ensembles.

Detecting carried objects is one of the requirements for developing systems to reason about activities involving people and objects. We present an approach to detect carried objects from a single video frame with a novel method that incorporates features from multiple scales. Initially, a foreground mask in a video frame is segmented into multi-scale superpixels. Then the human-like regions in the segmented area are identified by matching a set of extracted features from superpixels against learned features in a codebook. A carried object probability map is generated using the complement of the matching probabilities of superpixels to human-like regions and background information. A group of superpixels with high carried object probability and strong edge support is then merged to obtain the shape of the carried object. We applied our method to two challenging datasets, and results show that our method is competitive with or better than the state-of-the-art.