Medical image segmentation aims to delineate the anatomical or pathological structures of interest, playing a crucial role in clinical diagnosis. A substantial amount of high-quality annotated data is crucial for constructing high-precision deep segmentation models. However, medical annotation is highly cumbersome and time-consuming, especially for medical videos or 3D volumes, due to the huge labeling space and poor inter-frame consistency. Recently, a fundamental task named Moving Object Segmentation (MOS) has made significant advancements in natural images. Its objective is to delineate moving objects from the background within image sequences, requiring only minimal annotations. In this paper, we propose the first foundation model, named iMOS, for MOS in medical images. Extensive experiments on a large multi-modal medical dataset validate the effectiveness of the proposed iMOS. Specifically, with the annotation of only a small number of images in the sequence, iMOS can achieve satisfactory tracking and segmentation performance of moving objects throughout the entire sequence in bi-directions. We hope that the proposed iMOS can help accelerate the annotation speed of experts, and boost the development of medical foundation models.
The problem of Novel Class Discovery (NCD) consists in extracting knowledge from a labeled set of known classes to accurately partition an unlabeled set of novel classes. While NCD has recently received a lot of attention from the community, it is often solved on computer vision problems and under unrealistic conditions. In particular, the number of novel classes is usually assumed to be known in advance, and their labels are sometimes used to tune hyperparameters. Methods that rely on these assumptions are not applicable in real-world scenarios. In this work, we focus on solving NCD in tabular data when no prior knowledge of the novel classes is available. To this end, we propose to tune the hyperparameters of NCD methods by adapting the $k$-fold cross-validation process and hiding some of the known classes in each fold. Since we have found that methods with too many hyperparameters are likely to overfit these hidden classes, we define a simple deep NCD model. This method is composed of only the essential elements necessary for the NCD problem and performs impressively well under realistic conditions. Furthermore, we find that the latent space of this method can be used to reliably estimate the number of novel classes. Additionally, we adapt two unsupervised clustering algorithms ($k$-means and Spectral Clustering) to leverage the knowledge of the known classes. Extensive experiments are conducted on 7 tabular datasets and demonstrate the effectiveness of the proposed method and hyperparameter tuning process, and show that the NCD problem can be solved without relying on knowledge from the novel classes.
The detection of heterogeneous mental disorders based on brain readouts remains challenging due to the complexity of symptoms and the absence of reliable biomarkers. This paper introduces CAM (Cortical Anomaly Detection through Masked Image Modeling), a novel self-supervised framework designed for the unsupervised detection of complex brain disorders using cortical surface features. We employ this framework for the detection of individuals on the psychotic spectrum and demonstrate its capabilities compared to state-ofthe-art methods, achieving an AUC of 0.696 for Schizoaffective and 0.769 for Schizophreniform, without the need for any labels. Furthermore, the analysis of atypical cortical regions includes Pars Triangularis and several frontal areas, often implicated in schizophrenia, provide further confidence in our approach. Altogether, we demonstrate a scalable approach for anomaly detection of complex brain disorders based on cortical abnormalities.
Knowledge distillation (KD) emerges as a promising yet challenging technique for compressing deep neural networks, aiming to transfer extensive learning representations from proficient and computationally intensive teacher models to compact student models. However, current KD methods for super-resolution (SR) models have limited performance and restricted applications, since the characteristics of SR tasks are overlooked. In this paper, we put forth an approach from the perspective of effective data utilization, namely, the Data Upcycling Knowledge Distillation (DUKD), which facilitates the student model by the prior knowledge the teacher provided through the upcycled in-domain data derived from the input images. Besides, for the first time, we realize the label consistency regularization in KD for SR models, which is implemented by the paired invertible data augmentations. It constrains the training process of KD and leads to better generalization capability of the student model. The DUKD, due to its versatility, can be applied across a broad spectrum of teacher-student architectures (e.g., CNN and Transformer models) and SR tasks, such as single image SR, real-world SR, and SR quantization, and is in parallel with other compression techniques. Comprehensive experiments on diverse benchmarks demonstrate that the DUKD method significantly outperforms previous art.
Optimal transport aims to learn a mapping of sources to targets by minimizing the cost, which is typically defined as a function of distance. The solution to this problem consists of straight line segments optimally connecting sources to targets, and it does not exhibit branching. These optimal solutions are in stark contrast with both natural, and man-made transportation networks, where branching structures are prevalent. Here we discuss a fast heuristic branching method for optimal transport in networks, and we provide several applications.
The current fabrication and assembly of fluidic circuits for soft robots relies heavily on manual processes; as the complexity of fluidic circuits increases, manual assembly becomes increasingly arduous, error-prone, and timeconsuming. We introduce a software tool that generates printable fluidic networks automatically. We provide a library of fluidic logic elements that are easily 3D printed from thermoplastic polyurethanes using Fused Deposition Modeling only. Our software tool and component library allow the development of arbitrary soft digital circuits. We demonstrate a variable frequency ring oscillator and a full adder. The simplicity of our approach using FDM printers only, democratizes fluidic circuit implementation beyond specialized laboratories. Our software is available on GitHub (//github.com/roboticmaterialsgroup/FluidLogic).
Medical image segmentation plays a crucial role in various healthcare applications, enabling accurate diagnosis, treatment planning, and disease monitoring. In recent years, Vision Transformers (ViTs) have emerged as a promising technique for addressing the challenges in medical image segmentation. In medical images, structures are usually highly interconnected and globally distributed. ViTs utilize their multi-scale attention mechanism to model the long-range relationships in the images. However, they do lack image-related inductive bias and translational invariance, potentially impacting their performance. Recently, researchers have come up with various ViT-based approaches that incorporate CNNs in their architectures, known as Hybrid Vision Transformers (HVTs) to capture local correlation in addition to the global information in the images. This survey paper provides a detailed review of the recent advancements in ViTs and HVTs for medical image segmentation. Along with the categorization of ViT and HVT-based medical image segmentation approaches we also present a detailed overview of their real-time applications in several medical image modalities. This survey may serve as a valuable resource for researchers, healthcare practitioners, and students in understanding the state-of-the-art approaches for ViT-based medical image segmentation.
The substantial computational cost of high-fidelity models in numerical hemodynamics has, so far, relegated their use mainly to offline treatment planning. New breakthroughs in data-driven architectures and optimization techniques for fast surrogate modeling provide an exciting opportunity to overcome these limitations, enabling the use of such technology for time-critical decisions. We discuss an application to the repair of multiple stenosis in peripheral pulmonary artery disease through either transcatheter pulmonary artery rehabilitation or surgery, where it is of interest to achieve desired pressures and flows at specific locations in the pulmonary artery tree, while minimizing the risk for the patient. Since different degrees of success can be achieved in practice during treatment, we formulate the problem in probability, and solve it through a sample-based approach. We propose a new offline-online pipeline for probabilsitic real-time treatment planning which combines offline assimilation of boundary conditions, model reduction, and training dataset generation with online estimation of marginal probabilities, possibly conditioned on the degree of augmentation observed in already repaired lesions. Moreover, we propose a new approach for the parametrization of arbitrarily shaped vascular repairs through iterative corrections of a zero-dimensional approximant. We demonstrate this pipeline for a diseased model of the pulmonary artery tree available through the Vascular Model Repository.
Online Continual Learning (CL) solves the problem of learning the ever-emerging new classification tasks from a continuous data stream. Unlike its offline counterpart, in online CL, the training data can only be seen once. Most existing online CL research regards catastrophic forgetting (i.e., model stability) as almost the only challenge. In this paper, we argue that the model's capability to acquire new knowledge (i.e., model plasticity) is another challenge in online CL. While replay-based strategies have been shown to be effective in alleviating catastrophic forgetting, there is a notable gap in research attention toward improving model plasticity. To this end, we propose Collaborative Continual Learning (CCL), a collaborative learning based strategy to improve the model's capability in acquiring new concepts. Additionally, we introduce Distillation Chain (DC), a novel collaborative learning scheme to boost the training of the models. We adapted CCL-DC to existing representative online CL works. Extensive experiments demonstrate that even if the learners are well-trained with state-of-the-art online CL methods, our strategy can still improve model plasticity dramatically, and thereby improve the overall performance by a large margin.
We introduce a framework for solving a class of parabolic partial differential equations on triangle mesh surfaces, including the Hamilton-Jacobi equation and the Fokker-Planck equation. PDE in this class often have nonlinear or stiff terms that cannot be resolved with standard methods on curved triangle meshes. To address this challenge, we leverage a splitting integrator combined with a convex optimization step to solve these PDE. Our machinery can be used to compute entropic approximation of optimal transport distances on geometric domains, overcoming the numerical limitations of the state-of-the-art method. In addition, we demonstrate the versatility of our method on a number of linear and nonlinear PDE that appear in diffusion and front propagation tasks in geometry processing.
Many important tasks of large-scale recommender systems can be naturally cast as testing multiple linear forms for noisy matrix completion. These problems, however, present unique challenges because of the subtle bias-and-variance tradeoff of and an intricate dependence among the estimated entries induced by the low-rank structure. In this paper, we develop a general approach to overcome these difficulties by introducing new statistics for individual tests with sharp asymptotics both marginally and jointly, and utilizing them to control the false discovery rate (FDR) via a data splitting and symmetric aggregation scheme. We show that valid FDR control can be achieved with guaranteed power under nearly optimal sample size requirements using the proposed methodology. Extensive numerical simulations and real data examples are also presented to further illustrate its practical merits.