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Characterizing Enzyme function is an important requirement for predicting Enzyme-Substrate interactions. In this paper, we present a novel approach of applying Contrastive Multiview Coding to this problem to improve the performance of prediction. We present a method to leverage auxiliary data from an Enzymatic database like KEGG to learn the mutual information present in multiple views of enzyme-substrate reactions. We show that congruency in the multiple views of the reaction data can be used to improve prediction performance.

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Spatio-temporal representation learning is critical for video self-supervised representation. Recent approaches mainly use contrastive learning and pretext tasks. However, these approaches learn representation by discriminating sampled instances via feature similarity in the latent space while ignoring the intermediate state of the learned representations, which limits the overall performance. In this work, taking into account the degree of similarity of sampled instances as the intermediate state, we propose a novel pretext task - spatio-temporal overlap rate (STOR) prediction. It stems from the observation that humans are capable of discriminating the overlap rates of videos in space and time. This task encourages the model to discriminate the STOR of two generated samples to learn the representations. Moreover, we employ a joint optimization combining pretext tasks with contrastive learning to further enhance the spatio-temporal representation learning. We also study the mutual influence of each component in the proposed scheme. Extensive experiments demonstrate that our proposed STOR task can favor both contrastive learning and pretext tasks. The joint optimization scheme can significantly improve the spatio-temporal representation in video understanding. The code is available at //github.com/Katou2/CSTP.

With the explosive growth of information technology, multi-view graph data have become increasingly prevalent and valuable. Most existing multi-view clustering techniques either focus on the scenario of multiple graphs or multi-view attributes. In this paper, we propose a generic framework to cluster multi-view attributed graph data. Specifically, inspired by the success of contrastive learning, we propose multi-view contrastive graph clustering (MCGC) method to learn a consensus graph since the original graph could be noisy or incomplete and is not directly applicable. Our method composes of two key steps: we first filter out the undesirable high-frequency noise while preserving the graph geometric features via graph filtering and obtain a smooth representation of nodes; we then learn a consensus graph regularized by graph contrastive loss. Results on several benchmark datasets show the superiority of our method with respect to state-of-the-art approaches. In particular, our simple approach outperforms existing deep learning-based methods.

Self-supervised video representation methods typically focus on the representation of temporal attributes in videos. However, the role of stationary versus non-stationary attributes is less explored: Stationary features, which remain similar throughout the video, enable the prediction of video-level action classes. Non-stationary features, which represent temporally varying attributes, are more beneficial for downstream tasks involving more fine-grained temporal understanding, such as action segmentation. We argue that a single representation to capture both types of features is sub-optimal, and propose to decompose the representation space into stationary and non-stationary features via contrastive learning from long and short views, i.e. long video sequences and their shorter sub-sequences. Stationary features are shared between the short and long views, while non-stationary features aggregate the short views to match the corresponding long view. To empirically verify our approach, we demonstrate that our stationary features work particularly well on an action recognition downstream task, while our non-stationary features perform better on action segmentation. Furthermore, we analyse the learned representations and find that stationary features capture more temporally stable, static attributes, while non-stationary features encompass more temporally varying ones.

To date, most existing self-supervised learning methods are designed and optimized for image classification. These pre-trained models can be sub-optimal for dense prediction tasks due to the discrepancy between image-level prediction and pixel-level prediction. To fill this gap, we aim to design an effective, dense self-supervised learning method that directly works at the level of pixels (or local features) by taking into account the correspondence between local features. We present dense contrastive learning, which implements self-supervised learning by optimizing a pairwise contrastive (dis)similarity loss at the pixel level between two views of input images. Compared to the baseline method MoCo-v2, our method introduces negligible computation overhead (only <1% slower), but demonstrates consistently superior performance when transferring to downstream dense prediction tasks including object detection, semantic segmentation and instance segmentation; and outperforms the state-of-the-art methods by a large margin. Specifically, over the strong MoCo-v2 baseline, our method achieves significant improvements of 2.0% AP on PASCAL VOC object detection, 1.1% AP on COCO object detection, 0.9% AP on COCO instance segmentation, 3.0% mIoU on PASCAL VOC semantic segmentation and 1.8% mIoU on Cityscapes semantic segmentation. Code is available at: //git.io/AdelaiDet

MoCo is effective for unsupervised image representation learning. In this paper, we propose VideoMoCo for unsupervised video representation learning. Given a video sequence as an input sample, we improve the temporal feature representations of MoCo from two perspectives. First, we introduce a generator to drop out several frames from this sample temporally. The discriminator is then learned to encode similar feature representations regardless of frame removals. By adaptively dropping out different frames during training iterations of adversarial learning, we augment this input sample to train a temporally robust encoder. Second, we use temporal decay to model key attenuation in the memory queue when computing the contrastive loss. As the momentum encoder updates after keys enqueue, the representation ability of these keys degrades when we use the current input sample for contrastive learning. This degradation is reflected via temporal decay to attend the input sample to recent keys in the queue. As a result, we adapt MoCo to learn video representations without empirically designing pretext tasks. By empowering the temporal robustness of the encoder and modeling the temporal decay of the keys, our VideoMoCo improves MoCo temporally based on contrastive learning. Experiments on benchmark datasets including UCF101 and HMDB51 show that VideoMoCo stands as a state-of-the-art video representation learning method.

Change Point Detection techniques aim to capture changes in trends and sequences in time-series data to describe the underlying behaviour of the system. Detecting changes and anomalies in the web services, the trend of applications usage can provide valuable insight towards the system, however, many existing approaches are done in a supervised manner, requiring well-labelled data. As the amount of data produced and captured by sensors are growing rapidly, it is getting harder and even impossible to annotate the data. Therefore, coming up with a self-supervised solution is a necessity these days. In this work, we propose TSCP a novel self-supervised technique for temporal change point detection, based on representation learning with Temporal Convolutional Network (TCN). To the best of our knowledge, our proposed method is the first method which employs Contrastive Learning for prediction with the aim change point detection. Through extensive evaluations, we demonstrate that our method outperforms multiple state-of-the-art change point detection and anomaly detection baselines, including those adopting either unsupervised or semi-supervised approach. TSCP is shown to improve both non-Deep learning- and Deep learning-based methods by 0.28 and 0.12 in terms of average F1-score across three datasets.

Potential Drug-Drug Interaction(DDI) occurring while treating complex or co-existing diseases with drug combinations may cause changes in drugs' pharmacological activity. Therefore, DDI prediction has been an important task in the medical healthy machine learning community. Graph-based learning methods have recently aroused widespread interest and are proved to be a priority for this task. However, these methods are often limited to exploiting the inter-view drug molecular structure and ignoring the drug's intra-view interaction relationship, vital to capturing the complex DDI patterns. This study presents a new method, multi-view graph contrastive representation learning for drug-drug interaction prediction, MIRACLE for brevity, to capture inter-view molecule structure and intra-view interactions between molecules simultaneously. MIRACLE treats a DDI network as a multi-view graph where each node in the interaction graph itself is a drug molecular graph instance. We use GCN to encode DDI relationships and a bond-aware attentive message propagating method to capture drug molecular structure information in the MIRACLE learning stage. Also, we propose a novel unsupervised contrastive learning component to balance and integrate the multi-view information. Comprehensive experiments on multiple real datasets show that MIRACLE outperforms the state-of-the-art DDI prediction models consistently.

With the advent of deep learning, many dense prediction tasks, i.e. tasks that produce pixel-level predictions, have seen significant performance improvements. The typical approach is to learn these tasks in isolation, that is, a separate neural network is trained for each individual task. Yet, recent multi-task learning (MTL) techniques have shown promising results w.r.t. performance, computations and/or memory footprint, by jointly tackling multiple tasks through a learned shared representation. In this survey, we provide a well-rounded view on state-of-the-art deep learning approaches for MTL in computer vision, explicitly emphasizing on dense prediction tasks. Our contributions concern the following. First, we consider MTL from a network architecture point-of-view. We include an extensive overview and discuss the advantages/disadvantages of recent popular MTL models. Second, we examine various optimization methods to tackle the joint learning of multiple tasks. We summarize the qualitative elements of these works and explore their commonalities and differences. Finally, we provide an extensive experimental evaluation across a variety of dense prediction benchmarks to examine the pros and cons of the different methods, including both architectural and optimization based strategies.

While supervised learning has enabled great progress in many applications, unsupervised learning has not seen such widespread adoption, and remains an important and challenging endeavor for artificial intelligence. In this work, we propose a universal unsupervised learning approach to extract useful representations from high-dimensional data, which we call Contrastive Predictive Coding. The key insight of our model is to learn such representations by predicting the future in latent space by using powerful autoregressive models. We use a probabilistic contrastive loss which induces the latent space to capture information that is maximally useful to predict future samples. It also makes the model tractable by using negative sampling. While most prior work has focused on evaluating representations for a particular modality, we demonstrate that our approach is able to learn useful representations achieving strong performance on four distinct domains: speech, images, text and reinforcement learning in 3D environments.

To solve complex real-world problems with reinforcement learning, we cannot rely on manually specified reward functions. Instead, we can have humans communicate an objective to the agent directly. In this work, we combine two approaches to learning from human feedback: expert demonstrations and trajectory preferences. We train a deep neural network to model the reward function and use its predicted reward to train an DQN-based deep reinforcement learning agent on 9 Atari games. Our approach beats the imitation learning baseline in 7 games and achieves strictly superhuman performance on 2 games without using game rewards. Additionally, we investigate the goodness of fit of the reward model, present some reward hacking problems, and study the effects of noise in the human labels.

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