Remote medical diagnosis has emerged as a critical and indispensable technique in practical medical systems, where medical data are required to be efficiently compressed and transmitted for diagnosis by either professional doctors or intelligent diagnosis devices. In this process, a large amount of redundant content irrelevant to the diagnosis is subjected to high-fidelity coding, leading to unnecessary transmission costs. To mitigate this, we propose diagnosis-oriented medical image compression, a special semantic compression task designed for medical scenarios, targeting to reduce the compression cost without compromising the diagnosis accuracy. However, collecting sufficient medical data to optimize such a compression system is significantly expensive and challenging due to privacy issues and the lack of professional annotation. In this study, we propose DMIC, the first efficient transfer learning-based codec, for diagnosis-oriented medical image compression, which can be effectively optimized with only few-shot annotated medical examples, by reusing the knowledge in the existing reinforcement learning-based task-driven semantic coding framework, i.e., HRLVSC [1]. Concretely, we focus on tuning only the partial parameters of the policy network for bit allocation within HRLVSC, which enables it to adapt to the medical images. In this work, we validate our DMIC with the typical medical task, Coronary Artery Segmentation. Extensive experiments have demonstrated that our DMIC can achieve 47.594%BD-Rate savings compared to the HEVC anchor, by tuning only the A2C module (2.7% parameters) of the policy network with only 1 medical sample.
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Most convolutional neural network (CNN) based methods for skin cancer classification obtain their results using only dermatological images. Although good classification results have been shown, more accurate results can be achieved by considering the patient's metadata, which is valuable clinical information for dermatologists. Current methods only use the simple joint fusion structure (FS) and fusion modules (FMs) for the multi-modal classification methods, there still is room to increase the accuracy by exploring more advanced FS and FM. Therefore, in this paper, we design a new fusion method that combines dermatological images (dermoscopy images or clinical images) and patient metadata for skin cancer classification from the perspectives of FS and FM. First, we propose a joint-individual fusion (JIF) structure that learns the shared features of multi-modality data and preserves specific features simultaneously. Second, we introduce a fusion attention (FA) module that enhances the most relevant image and metadata features based on both the self and mutual attention mechanism to support the decision-making pipeline. We compare the proposed JIF-MMFA method with other state-of-the-art fusion methods on three different public datasets. The results show that our JIF-MMFA method improves the classification results for all tested CNN backbones and performs better than the other fusion methods on the three public datasets, demonstrating our method's effectiveness and robustness
Face clustering tasks can learn hierarchical semantic information from large-scale data, which has the potential to help facilitate face recognition. However, there are few works on this problem. This paper explores it by proposing a joint optimization task of label classification and supervised contrastive clustering to introduce the cluster knowledge to the traditional face recognition task in two ways. We first extend ArcFace with a cluster-guided angular margin to adjust the within-class feature distribution according to the hard level of face clustering. Secondly, we propose a supervised contrastive clustering approach to pull the features to the cluster center and propose the cluster-aligning procedure to align the cluster center and the learnable class center in the classifier for joint training. Finally, extensive qualitative and quantitative experiments on popular facial benchmarks demonstrate the effectiveness of our paradigm and its superiority over the existing approaches to face recognition.
Extractive question answering (QA) systems can enable physicians and researchers to query medical records, a foundational capability for designing clinical studies and understanding patient medical history. However, building these systems typically requires expert-annotated QA pairs. Large language models (LLMs), which can perform extractive QA, depend on high quality data in their prompts, specialized for the application domain. We introduce a novel approach, XAIQA, for generating synthetic QA pairs at scale from data naturally available in electronic health records. Our method uses the idea of a classification model explainer to generate questions and answers about medical concepts corresponding to medical codes. In an expert evaluation with two physicians, our method identifies $2.2\times$ more semantic matches and $3.8\times$ more clinical abbreviations than two popular approaches that use sentence transformers to create QA pairs. In an ML evaluation, adding our QA pairs improves performance of GPT-4 as an extractive QA model, including on difficult questions. In both the expert and ML evaluations, we examine trade-offs between our method and sentence transformers for QA pair generation depending on question difficulty.
Horizontal gene transfer inference approaches are usually based on gene sequences: parametric methods search for patterns that deviate from a particular genomic signature, while phylogenetic methods use sequences to reconstruct the gene and species trees. However, it is well-known that sequences have difficulty identifying ancient transfers since mutations have enough time to erase all evidence of such events. In this work, we ask whether character-based methods can predict gene transfers. Their advantage over sequences is that homologous genes can have low DNA similarity, but still have retained enough important common motifs that allow them to have common character traits, for instance the same functional or expression profile. A phylogeny that has two separate clades that acquired the same character independently might indicate the presence of a transfer even in the absence of sequence similarity. We introduce perfect transfer networks, which are phylogenetic networks that can explain the character diversity of a set of taxa under the assumption that characters have unique births, and that once a character is gained it is rarely lost. Examples of such traits include transposable elements, biochemical markers and emergence of organelles, just to name a few. We study the differences between our model and two similar models: perfect phylogenetic networks and ancestral recombination networks. Our goals are to initiate a study on the structural and algorithmic properties of perfect transfer networks. We then show that in polynomial time, one can decide whether a given network is a valid explanation for a set of taxa, and show how, for a given tree, one can add transfer edges to it so that it explains a set of taxa. We finally provide lower and upper bounds on the number of transfers required to explain a set of taxa, in the worst case.
The Health Index (HI) is crucial for evaluating system health, aiding tasks like anomaly detection and predicting remaining useful life for systems demanding high safety and reliability. Tight monitoring is crucial for achieving high precision at a lower cost, with applications such as spray coating. Obtaining HI labels in real-world applications is often cost-prohibitive, requiring continuous, precise health measurements. Therefore, it is more convenient to leverage run-to failure datasets that may provide potential indications of machine wear condition, making it necessary to apply semi-supervised tools for HI construction. In this study, we adapt the Deep Semi-supervised Anomaly Detection (DeepSAD) method for HI construction. We use the DeepSAD embedding as a condition indicators to address interpretability challenges and sensitivity to system-specific factors. Then, we introduce a diversity loss to enrich condition indicators. We employ an alternating projection algorithm with isotonic constraints to transform the DeepSAD embedding into a normalized HI with an increasing trend. Validation on the PHME 2010 milling dataset, a recognized benchmark with ground truth HIs demonstrates meaningful HIs estimations. Our methodology is then applied to monitor wear states of thermal spray coatings using high-frequency voltage. Our contributions create opportunities for more accessible and reliable HI estimation, particularly in cases where obtaining ground truth HI labels is unfeasible.
Knowledge distillation (KD) emerges as a promising yet challenging technique for compressing deep neural networks, aiming to transfer extensive learning representations from proficient and computationally intensive teacher models to compact student models. However, current KD methods for super-resolution (SR) models have limited performance and restricted applications, since the characteristics of SR tasks are overlooked. In this paper, we put forth an approach from the perspective of effective data utilization, namely, the Data Upcycling Knowledge Distillation (DUKD), which facilitates the student model by the prior knowledge the teacher provided through the upcycled in-domain data derived from the input images. Besides, for the first time, we realize the label consistency regularization in KD for SR models, which is implemented by the paired invertible data augmentations. It constrains the training process of KD and leads to better generalization capability of the student model. The DUKD, due to its versatility, can be applied across a broad spectrum of teacher-student architectures (e.g., CNN and Transformer models) and SR tasks, such as single image SR, real-world SR, and SR quantization, and is in parallel with other compression techniques. Comprehensive experiments on diverse benchmarks demonstrate that the DUKD method significantly outperforms previous art.
Interpretability methods are critical components for examining and exploring deep neural networks (DNN), as well as increasing our understanding of and trust in them. Vision transformers (ViT), which can be trained to state-of-the-art performance with a self-supervised learning (SSL) training method, provide built-in attention maps (AM). While AMs can provide high-quality semantic segmentation of input images, they do not account for any signal coming from a downstream classifier. We introduce class-discriminative attention maps (CDAM), a novel post-hoc explanation method that is highly sensitive to the target class. Our method essentially scales attention scores by how relevant the corresponding tokens are for the predictions of a classifier head. Alternative to classifier outputs, CDAM can also explain a user-defined concept by targeting similarity measures in the latent space of the ViT. This allows for explanations of arbitrary concepts, defined by the user through a few sample images. We investigate the operating characteristics of CDAM in comparison with relevance propagation (RP) and token ablation maps (TAM), an alternative to pixel occlusion methods. CDAM is highly class-discriminative and semantically relevant, while providing implicit regularization of relevance scores. PyTorch implementation: \url{//github.com/lenbrocki/CDAM} Web live demo: \url{//cdam.informatism.com/}
Heterogeneous graph neural networks (HGNNs) as an emerging technique have shown superior capacity of dealing with heterogeneous information network (HIN). However, most HGNNs follow a semi-supervised learning manner, which notably limits their wide use in reality since labels are usually scarce in real applications. Recently, contrastive learning, a self-supervised method, becomes one of the most exciting learning paradigms and shows great potential when there are no labels. In this paper, we study the problem of self-supervised HGNNs and propose a novel co-contrastive learning mechanism for HGNNs, named HeCo. Different from traditional contrastive learning which only focuses on contrasting positive and negative samples, HeCo employs cross-viewcontrastive mechanism. Specifically, two views of a HIN (network schema and meta-path views) are proposed to learn node embeddings, so as to capture both of local and high-order structures simultaneously. Then the cross-view contrastive learning, as well as a view mask mechanism, is proposed, which is able to extract the positive and negative embeddings from two views. This enables the two views to collaboratively supervise each other and finally learn high-level node embeddings. Moreover, two extensions of HeCo are designed to generate harder negative samples with high quality, which further boosts the performance of HeCo. Extensive experiments conducted on a variety of real-world networks show the superior performance of the proposed methods over the state-of-the-arts.
Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.
Applying artificial intelligence techniques in medical imaging is one of the most promising areas in medicine. However, most of the recent success in this area highly relies on large amounts of carefully annotated data, whereas annotating medical images is a costly process. In this paper, we propose a novel method, called FocalMix, which, to the best of our knowledge, is the first to leverage recent advances in semi-supervised learning (SSL) for 3D medical image detection. We conducted extensive experiments on two widely used datasets for lung nodule detection, LUNA16 and NLST. Results show that our proposed SSL methods can achieve a substantial improvement of up to 17.3% over state-of-the-art supervised learning approaches with 400 unlabeled CT scans.
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