Mixture models are useful in a wide array of applications to identify subpopulations in noisy overlapping distributions. For example, in multiplexed immunofluorescence (mIF), cell image intensities represent expression levels and the cell populations are a noisy mixture of expressed and unexpressed cells. Among mixture models, the gamma mixture model has the strength of being flexible in fitting skewed strictly positive data that occur in many biological measurements. However, the current estimation method uses numerical optimization within the expectation maximization algorithm and is computationally expensive. This makes it infeasible to be applied across many large data sets, as is necessary in mIF data. Powered by a recently developed closed-form estimator for the gamma distribution, we propose a closed-form gamma mixture model that is not only more computationally efficient, but can also incorporate constraints from known biological information to the fitted distribution. We derive the closed-form estimators for the gamma mixture model and use simulations to demonstrate that our model produces comparable results with the current model with significantly less time, and is excellent in constrained model fitting.
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Targets are essential in problems such as object tracking in cluttered or textureless environments, camera (and multi-sensor) calibration tasks, and simultaneous localization and mapping (SLAM). Target shapes for these tasks typically are symmetric (square, rectangular, or circular) and work well for structured, dense sensor data such as pixel arrays (i.e., image). However, symmetric shapes lead to pose ambiguity when using sparse sensor data such as LiDAR point clouds and suffer from the quantization uncertainty of the LiDAR. This paper introduces the concept of optimizing target shape to remove pose ambiguity for LiDAR point clouds. A target is designed to induce large gradients at edge points under rotation and translation relative to the LiDAR to ameliorate the quantization uncertainty associated with point cloud sparseness. Moreover, given a target shape, we present a means that leverages the target's geometry to estimate the target's vertices while globally estimating the pose. Both the simulation and the experimental results (verified by a motion capture system) confirm that by using the optimal shape and the global solver, we achieve centimeter error in translation and a few degrees in rotation even when a partially illuminated target is placed 30 meters away. All the implementations and datasets are available at //github.com/UMich-BipedLab/optimal_shape_global_pose_estimation.
This paper develops a new approach to post-selection inference for screening high-dimensional predictors of survival outcomes. Post-selection inference for right-censored outcome data has been investigated in the literature, but much remains to be done to make the methods both reliable and computationally-scalable in high-dimensions. Machine learning tools are commonly used to provide {\it predictions} of survival outcomes, but the estimated effect of a selected predictor suffers from confirmation bias unless the selection is taken into account. The new approach involves construction of semi-parametrically efficient estimators of the linear association between the predictors and the survival outcome, which are used to build a test statistic for detecting the presence of an association between any of the predictors and the outcome. Further, a stabilization technique reminiscent of bagging allows a normal calibration for the resulting test statistic, which enables the construction of confidence intervals for the maximal association between predictors and the outcome and also greatly reduces computational cost. Theoretical results show that this testing procedure is valid even when the number of predictors grows superpolynomially with sample size, and our simulations support that this asymptotic guarantee is indicative the performance of the test at moderate sample sizes. The new approach is applied to the problem of identifying patterns in viral gene expression associated with the potency of an antiviral drug.
In Gaussian graphical models, the likelihood equations must typically be solved iteratively, for example by iterative proportional scaling. However, this method may not scale well to models with many variables because it involves repeated inversion of large matrices. We present a version of the algorithm which avoids these inversions, resulting in increased speed, in particular when graphs are sparse.
In the field of finance, insurance, and system reliability, etc., it is often of interest to measure the dependence among variables by modeling a multivariate distribution using a copula. The copula models with parametric assumptions are easy to estimate but can be highly biased when such assumptions are false, while the empirical copulas are non-smooth and often not genuine copula making the inference about dependence challenging in practice. As a compromise, the empirical Bernstein copula provides a smooth estimator but the estimation of tuning parameters remains elusive. In this paper, by using the so-called empirical checkerboard copula we build a hierarchical empirical Bayes model that enables the estimation of a smooth copula function for arbitrary dimensions. The proposed estimator based on the multivariate Bernstein polynomials is itself a genuine copula and the selection of its dimension-varying degrees is data-dependent. We also show that the proposed copula estimator provides a more accurate estimate of several multivariate dependence measures which can be obtained in closed form. We investigate the asymptotic and finite-sample performance of the proposed estimator and compare it with some nonparametric estimators through simulation studies. An application to portfolio risk management is presented along with a quantification of estimation uncertainty.
The increasing integration of intermittent renewable generation, especially at the distribution level,necessitates advanced planning and optimisation methodologies contingent on the knowledge of thegrid, specifically the admittance matrix capturing the topology and line parameters of an electricnetwork. However, a reliable estimate of the admittance matrix may either be missing or quicklybecome obsolete for temporally varying grids. In this work, we propose a data-driven identificationmethod utilising voltage and current measurements collected from micro-PMUs. More precisely,we first present a maximum likelihood approach and then move towards a Bayesian framework,leveraging the principles of maximum a posteriori estimation. In contrast with most existing con-tributions, our approach not only factors in measurement noise on both voltage and current data,but is also capable of exploiting available a priori information such as sparsity patterns and knownline parameters. Simulations conducted on benchmark cases demonstrate that, compared to otheralgorithms, our method can achieve significantly greater accuracy.
In this article we focus on dynamic network data which describe interactions among a fixed population through time. We model this data using the latent space framework, in which the probability of a connection forming is expressed as a function of low-dimensional latent coordinates associated with the nodes, and consider sequential estimation of model parameters via Sequential Monte Carlo (SMC) methods. In this setting, SMC is a natural candidate for estimation which offers greater scalability than existing approaches commonly considered in the literature, allows for estimates to be conveniently updated given additional observations and facilitates both online and offline inference. We present a novel approach to sequentially infer parameters of dynamic latent space network models by building on techniques from the high-dimensional SMC literature. Furthermore, we examine the scalability and performance of our approach via simulation, demonstrate the flexibility of our approach to model variants and analyse a real-world dataset describing classroom contacts.
Let $P$ be a bounded polyhedron defined as the intersection of the non-negative orthant ${\Bbb R}^n_+$ and an affine subspace of codimension $m$ in ${\Bbb R}^n$. We show that a simple and computationally efficient formula approximates the volume of $P$ within a factor of $\gamma^m$, where $\gamma >0$ is an absolute constant. The formula provides the best known estimate for the volume of transportation polytopes from a wide family.
Implicit probabilistic models are models defined naturally in terms of a sampling procedure and often induces a likelihood function that cannot be expressed explicitly. We develop a simple method for estimating parameters in implicit models that does not require knowledge of the form of the likelihood function or any derived quantities, but can be shown to be equivalent to maximizing likelihood under some conditions. Our result holds in the non-asymptotic parametric setting, where both the capacity of the model and the number of data examples are finite. We also demonstrate encouraging experimental results.
We propose a new method of estimation in topic models, that is not a variation on the existing simplex finding algorithms, and that estimates the number of topics K from the observed data. We derive new finite sample minimax lower bounds for the estimation of A, as well as new upper bounds for our proposed estimator. We describe the scenarios where our estimator is minimax adaptive. Our finite sample analysis is valid for any number of documents (n), individual document length (N_i), dictionary size (p) and number of topics (K), and both p and K are allowed to increase with n, a situation not handled well by previous analyses. We complement our theoretical results with a detailed simulation study. We illustrate that the new algorithm is faster and more accurate than the current ones, although we start out with a computational and theoretical disadvantage of not knowing the correct number of topics K, while we provide the competing methods with the correct value in our simulations.
We consider the task of learning the parameters of a {\em single} component of a mixture model, for the case when we are given {\em side information} about that component, we call this the "search problem" in mixture models. We would like to solve this with computational and sample complexity lower than solving the overall original problem, where one learns parameters of all components. Our main contributions are the development of a simple but general model for the notion of side information, and a corresponding simple matrix-based algorithm for solving the search problem in this general setting. We then specialize this model and algorithm to four common scenarios: Gaussian mixture models, LDA topic models, subspace clustering, and mixed linear regression. For each one of these we show that if (and only if) the side information is informative, we obtain parameter estimates with greater accuracy, and also improved computation complexity than existing moment based mixture model algorithms (e.g. tensor methods). We also illustrate several natural ways one can obtain such side information, for specific problem instances. Our experiments on real data sets (NY Times, Yelp, BSDS500) further demonstrate the practicality of our algorithms showing significant improvement in runtime and accuracy.
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