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Brain tumor growth is unique to each glioma patient and extends beyond what is visible in imaging scans, infiltrating surrounding brain tissue. Understanding these hidden patient-specific progressions is essential for effective therapies. Current treatment plans for brain tumors, such as radiotherapy, typically involve delineating a uniform margin around the visible tumor on pre-treatment scans to target this invisible tumor growth. This "one size fits all" approach is derived from population studies and often fails to account for the nuances of individual patient conditions. We present the GliODIL framework, which infers the full spatial distribution of tumor cell concentration from available multi-modal imaging, leveraging a Fisher-Kolmogorov type physics model to describe tumor growth. This is achieved through the newly introduced method of Optimizing the Discrete Loss (ODIL), where both data and physics-based constraints are softly assimilated into the solution. Our test dataset comprises 152 glioblastoma patients with pre-treatment imaging and post-treatment follow-ups for tumor recurrence monitoring. By blending data-driven techniques with physics-based constraints, GliODIL enhances recurrence prediction in radiotherapy planning, challenging traditional uniform margins and strict adherence to the Fisher-Kolmogorov partial differential equation (PDE) model, which is adapted for complex cases.

Inferential models have been proposed for valid and efficient prior-free probabilistic inference. As it gradually gained popularity, this theory is subject to further developments for practically challenging problems. This paper considers the many-normal-means problem with the means constrained to be in the neighborhood of each other, formally represented by a H\"older space. A new method, called partial conditioning, is proposed to generate valid and efficient marginal inference about the individual means. It is shown that the method outperforms both a fiducial-counterpart in terms of validity and a conservative-counterpart in terms of efficiency. We conclude the paper by remarking that a general theory of partial conditioning for inferential models deserves future development.

Robot swarms can effectively serve a variety of sensing and inspection applications. Certain inspection tasks require a binary classification decision. This work presents an experimental setup for a surface inspection task based on vibration sensing and studies a Bayesian two-outcome decision-making algorithm in a swarm of miniaturized wheeled robots. The robots are tasked with individually inspecting and collectively classifying a 1mx1m tiled surface consisting of vibrating and non-vibrating tiles based on the majority type of tiles. The robots sense vibrations using onboard IMUs and perform collision avoidance using a set of IR sensors. We develop a simulation and optimization framework leveraging the Webots robotic simulator and a Particle Swarm Optimization (PSO) method. We consider two existing information sharing strategies and propose a new one that allows the swarm to rapidly reach accurate classification decisions. We first find optimal parameters that allow efficient sampling in simulation and then evaluate our proposed strategy against the two existing ones using 100 randomized simulation and 10 real experiments. We find that our proposed method compels the swarm to make decisions at an accelerated rate, with an improvement of up to 20.52% in mean decision time at only 0.78% loss in accuracy.

This work presents a procedure to solve the Euler equations by explicitly updating, in a conservative manner, a generic thermodynamic variable such as temperature, pressure or entropy instead of the total energy. The presented procedure is valid for any equation of state and spatial discretization. When using complex equations of state such as Span-Wagner, choosing the temperature as the generic thermodynamic variable yields great reductions in the computational costs associated to thermodynamic evaluations. Results computed with a state of the art thermodynamic model are presented, and computational times are analyzed. Particular attention is dedicated to the conservation of total energy, the propagation speed of shock waves and jump conditions. The procedure is thoroughly tested using the Span-Wagner equation of state through the CoolProp thermodynamic library and the Van der Waals equation of state, both in the ideal and non-ideal compressible fluid-dynamics regimes, by comparing it to the standard total energy update and analytical solutions where available.

Many explainable AI (XAI) techniques strive for interpretability by providing concise salient information, such as sparse linear factors. However, users either only see inaccurate global explanations, or highly-varying local explanations. We propose to provide more detailed explanations by leveraging the human cognitive capacity to accumulate knowledge by incrementally receiving more details. Focusing on linear factor explanations (factors $\times$ values = outcome), we introduce Incremental XAI to automatically partition explanations for general and atypical instances by providing Base + Incremental factors to help users read and remember more faithful explanations. Memorability is improved by reusing base factors and reducing the number of factors shown in atypical cases. In modeling, formative, and summative user studies, we evaluated the faithfulness, memorability and understandability of Incremental XAI against baseline explanation methods. This work contributes towards more usable explanation that users can better ingrain to facilitate intuitive engagement with AI.

We investigate the role of uncertainty in decision-making problems with natural language as input. For such tasks, using Large Language Models as agents has become the norm. However, none of the recent approaches employ any additional phase for estimating the uncertainty the agent has about the world during the decision-making task. We focus on a fundamental decision-making framework with natural language as input, which is the one of contextual bandits, where the context information consists of text. As a representative of the approaches with no uncertainty estimation, we consider an LLM bandit with a greedy policy, which picks the action corresponding to the largest predicted reward. We compare this baseline to LLM bandits that make active use of uncertainty estimation by integrating the uncertainty in a Thompson Sampling policy. We employ different techniques for uncertainty estimation, such as Laplace Approximation, Dropout, and Epinets. We empirically show on real-world data that the greedy policy performs worse than the Thompson Sampling policies. These findings suggest that, while overlooked in the LLM literature, uncertainty plays a fundamental role in bandit tasks with LLMs.

Reinforcement learning in partially observed Markov decision processes (POMDPs) faces two challenges. (i) It often takes the full history to predict the future, which induces a sample complexity that scales exponentially with the horizon. (ii) The observation and state spaces are often continuous, which induces a sample complexity that scales exponentially with the extrinsic dimension. Addressing such challenges requires learning a minimal but sufficient representation of the observation and state histories by exploiting the structure of the POMDP. To this end, we propose a reinforcement learning algorithm named Embed to Control (ETC), which learns the representation at two levels while optimizing the policy.~(i) For each step, ETC learns to represent the state with a low-dimensional feature, which factorizes the transition kernel. (ii) Across multiple steps, ETC learns to represent the full history with a low-dimensional embedding, which assembles the per-step feature. We integrate (i) and (ii) in a unified framework that allows a variety of estimators (including maximum likelihood estimators and generative adversarial networks). For a class of POMDPs with a low-rank structure in the transition kernel, ETC attains an $O(1/\epsilon^2)$ sample complexity that scales polynomially with the horizon and the intrinsic dimension (that is, the rank). Here $\epsilon$ is the optimality gap. To our best knowledge, ETC is the first sample-efficient algorithm that bridges representation learning and policy optimization in POMDPs with infinite observation and state spaces.

Learning from demonstration is a proven technique to teach robots new skills. Data quality and quantity play a critical role in the performance of models trained using data collected from human demonstrations. In this paper we enhance an existing teleoperation data collection system with real-time haptic feedback to the human demonstrators; we observe improvements in the collected data throughput and in the performance of autonomous policies using models trained with the data. Our experimental testbed was a mobile manipulator robot that opened doors with latch handles. Evaluation of teleoperated data collection on eight real conference room doors found that adding haptic feedback improved data throughput by 6%. We additionally used the collected data to train six image-based deep imitation learning models, three with haptic feedback and three without it. These models were used to implement autonomous door-opening with the same type of robot used during data collection. A policy from a imitation learning model trained with data collected while the human demonstrators received haptic feedback performed on average 11% better than its counterpart trained with data collected without haptic feedback, indicating that haptic feedback provided during data collection resulted in improved autonomous policies.

In the era of generative artificial intelligence and the Internet of Things, while there is explosive growth in the volume of data and the associated need for processing, analysis, and storage, several new challenges are faced in identifying spurious and fake information and protecting the privacy of sensitive data. This has led to an increasing demand for more robust and resilient schemes for authentication, integrity protection, encryption, non-repudiation, and privacy-preservation of data. The chapters in this book present some of the state-of-the-art research works in the field of cryptography and security in computing and communications.

Diabetic Retinopathy (DR) stands as the leading cause of blindness globally, particularly affecting individuals between the ages of 20 and 70. This paper presents a Computer-Aided Diagnosis (CAD) system designed for the automatic classification of retinal images into five distinct classes: Normal, Mild, Moderate, Severe, and Proliferative Diabetic Retinopathy (PDR). The proposed system leverages Convolutional Neural Networks (CNNs) employing pre-trained deep learning models. Through the application of fine-tuning techniques, our model is trained on fundus images of diabetic retinopathy with resolutions of 350x350x3 and 224x224x3. Experimental results obtained on the Kaggle platform, utilizing resources comprising 4 CPUs, 17 GB RAM, and 1 GB Disk, demonstrate the efficacy of our approach. The achieved Area Under the Curve (AUC) values for CNN, MobileNet, VGG-16, InceptionV3, and InceptionResNetV2 models are 0.50, 0.70, 0.53, 0.63, and 0.69, respectively.