Current unsupervised anomaly localization approaches rely on generative models to learn the distribution of normal images, which is later used to identify potential anomalous regions derived from errors on the reconstructed images. However, a main limitation of nearly all prior literature is the need of employing anomalous images to set a class-specific threshold to locate the anomalies. This limits their usability in realistic scenarios, where only normal data is typically accessible. Despite this major drawback, only a handful of works have addressed this limitation, by integrating supervision on attention maps during training. In this work, we propose a novel formulation that does not require accessing images with abnormalities to define the threshold. Furthermore, and in contrast to very recent work, the proposed constraint is formulated in a more principled manner, leveraging well-known knowledge in constrained optimization. In particular, the equality constraint on the attention maps in prior work is replaced by an inequality constraint, which allows more flexibility. In addition, to address the limitations of penalty-based functions we employ an extension of the popular log-barrier methods to handle the constraint. Comprehensive experiments on the popular BRATS'19 dataset demonstrate that the proposed approach substantially outperforms relevant literature, establishing new state-of-the-art results for unsupervised lesion segmentation.
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We consider the question: how can you sample good negative examples for contrastive learning? We argue that, as with metric learning, learning contrastive representations benefits from hard negative samples (i.e., points that are difficult to distinguish from an anchor point). The key challenge toward using hard negatives is that contrastive methods must remain unsupervised, making it infeasible to adopt existing negative sampling strategies that use label information. In response, we develop a new class of unsupervised methods for selecting hard negative samples where the user can control the amount of hardness. A limiting case of this sampling results in a representation that tightly clusters each class, and pushes different classes as far apart as possible. The proposed method improves downstream performance across multiple modalities, requires only few additional lines of code to implement, and introduces no computational overhead.
A key requirement for the success of supervised deep learning is a large labeled dataset - a condition that is difficult to meet in medical image analysis. Self-supervised learning (SSL) can help in this regard by providing a strategy to pre-train a neural network with unlabeled data, followed by fine-tuning for a downstream task with limited annotations. Contrastive learning, a particular variant of SSL, is a powerful technique for learning image-level representations. In this work, we propose strategies for extending the contrastive learning framework for segmentation of volumetric medical images in the semi-supervised setting with limited annotations, by leveraging domain-specific and problem-specific cues. Specifically, we propose (1) novel contrasting strategies that leverage structural similarity across volumetric medical images (domain-specific cue) and (2) a local version of the contrastive loss to learn distinctive representations of local regions that are useful for per-pixel segmentation (problem-specific cue). We carry out an extensive evaluation on three Magnetic Resonance Imaging (MRI) datasets. In the limited annotation setting, the proposed method yields substantial improvements compared to other self-supervision and semi-supervised learning techniques. When combined with a simple data augmentation technique, the proposed method reaches within 8% of benchmark performance using only two labeled MRI volumes for training, corresponding to only 4% (for ACDC) of the training data used to train the benchmark.
In this paper, we aim to improve the performance of semantic image segmentation in a semi-supervised setting in which training is effectuated with a reduced set of annotated images and additional non-annotated images. We present a method based on an ensemble of deep segmentation models. Each model is trained on a subset of the annotated data, and uses the non-annotated images to exchange information with the other models, similar to co-training. Even if each model learns on the same non-annotated images, diversity is preserved with the use of adversarial samples. Our results show that this ability to simultaneously train models, which exchange knowledge while preserving diversity, leads to state-of-the-art results on two challenging medical image datasets.
Despite much success, deep learning generally does not perform well with small labeled training sets. In these scenarios, data augmentation has shown much promise in alleviating the need for more labeled data, but it so far has mostly been applied in supervised settings and achieved limited gains. In this work, we propose to apply data augmentation to unlabeled data in a semi-supervised learning setting. Our method, named Unsupervised Data Augmentation or UDA, encourages the model predictions to be consistent between an unlabeled example and an augmented unlabeled example. Unlike previous methods that use random noise such as Gaussian noise or dropout noise, UDA has a small twist in that it makes use of harder and more realistic noise generated by state-of-the-art data augmentation methods. This small twist leads to substantial improvements on six language tasks and three vision tasks even when the labeled set is extremely small. For example, on the IMDb text classification dataset, with only 20 labeled examples, UDA achieves an error rate of 4.20, outperforming the state-of-the-art model trained on 25,000 labeled examples. On standard semi-supervised learning benchmarks CIFAR-10 and SVHN, UDA outperforms all previous approaches and achieves an error rate of 2.7% on CIFAR-10 with only 4,000 examples and an error rate of 2.85% on SVHN with only 250 examples, nearly matching the performance of models trained on the full sets which are one or two orders of magnitude larger. UDA also works well on large-scale datasets such as ImageNet. When trained with 10% of the labeled set, UDA improves the top-1/top-5 accuracy from 55.1/77.3% to 68.7/88.5%. For the full ImageNet with 1.3M extra unlabeled data, UDA further pushes the performance from 78.3/94.4% to 79.0/94.5%.
Biomedical image segmentation is an important task in many medical applications. Segmentation methods based on convolutional neural networks attain state-of-the-art accuracy; however, they typically rely on supervised training with large labeled datasets. Labeling datasets of medical images requires significant expertise and time, and is infeasible at large scales. To tackle the lack of labeled data, researchers use techniques such as hand-engineered preprocessing steps, hand-tuned architectures, and data augmentation. However, these techniques involve costly engineering efforts, and are typically dataset-specific. We present an automated data augmentation method for medical images. We demonstrate our method on the task of segmenting magnetic resonance imaging (MRI) brain scans, focusing on the one-shot segmentation scenario -- a practical challenge in many medical applications. Our method requires only a single segmented scan, and leverages other unlabeled scans in a semi-supervised approach. We learn a model of transforms from the images, and use the model along with the labeled example to synthesize additional labeled training examples for supervised segmentation. Each transform is comprised of a spatial deformation field and an intensity change, enabling the synthesis of complex effects such as variations in anatomy and image acquisition procedures. Augmenting the training of a supervised segmenter with these new examples provides significant improvements over state-of-the-art methods for one-shot biomedical image segmentation. Our code is available at //github.com/xamyzhao/brainstorm.
In multi-organ segmentation of abdominal CT scans, most existing fully supervised deep learning algorithms require lots of voxel-wise annotations, which are usually difficult, expensive, and slow to obtain. In comparison, massive unlabeled 3D CT volumes are usually easily accessible. Current mainstream works to address the semi-supervised biomedical image segmentation problem are mostly graph-based. By contrast, deep network based semi-supervised learning methods have not drawn much attention in this field. In this work, we propose Deep Multi-Planar Co-Training (DMPCT), whose contributions can be divided into two folds: 1) The deep model is learned in a co-training style which can mine consensus information from multiple planes like the sagittal, coronal, and axial planes; 2) Multi-planar fusion is applied to generate more reliable pseudo-labels, which alleviates the errors occurring in the pseudo-labels and thus can help to train better segmentation networks. Experiments are done on our newly collected large dataset with 100 unlabeled cases as well as 210 labeled cases where 16 anatomical structures are manually annotated by four radiologists and confirmed by a senior expert. The results suggest that DMPCT significantly outperforms the fully supervised method by more than 4% especially when only a small set of annotations is used.
Weak supervision, e.g., in the form of partial labels or image tags, is currently attracting significant attention in CNN segmentation as it can mitigate the lack of full and laborious pixel/voxel annotations. Enforcing high-order (global) inequality constraints on the network output, for instance, on the size of the target region, can leverage unlabeled data, guiding training with domain-specific knowledge. Inequality constraints are very flexible because they do not assume exact prior knowledge. However,constrained Lagrangian dual optimization has been largely avoided in deep networks, mainly for computational tractability reasons.To the best of our knowledge, the method of Pathak et al. is the only prior work that addresses deep CNNs with linear constraints in weakly supervised segmentation. It uses the constraints to synthesize fully-labeled training masks (proposals)from weak labels, mimicking full supervision and facilitating dual optimization.We propose to introduce a differentiable term, which enforces inequality constraints directly in the loss function, avoiding expensive Lagrangian dual iterates and proposal generation. From constrained-optimization perspective, our simple approach is not optimal as there is no guarantee that the constraints are satisfied. However, surprisingly,it yields substantially better results than the proposal-based constrained CNNs, while reducing the computational demand for training.In the context of cardiac images, we reached a segmentation performance close to full supervision using a fraction (0.1%) of the full ground-truth labels and image-level tags.While our experiments focused on basic linear constraints such as the target-region size and image tags, our framework can be easily extended to other non-linear constraints.Therefore, it has the potential to close the gap between weakly and fully supervised learning in semantic image segmentation.
Deep Convolutional Neural Networks have pushed the state-of-the art for semantic segmentation provided that a large amount of images together with pixel-wise annotations is available. Data collection is expensive and a solution to alleviate it is to use transfer learning. This reduces the amount of annotated data required for the network training but it does not get rid of this heavy processing step. We propose a method of transfer learning without annotations on the target task for datasets with redundant content and distinct pixel distributions. Our method takes advantage of the approximate content alignment of the images between two datasets when the approximation error prevents the reuse of annotation from one dataset to another. Given the annotations for only one dataset, we train a first network in a supervised manner. This network autonomously learns to generate deep data representations relevant to the semantic segmentation. Then the images in the new dataset, we train a new network to generate a deep data representation that matches the one from the first network on the previous dataset. The training consists in a regression between feature maps and does not require any annotations on the new dataset. We show that this method reaches performances similar to a classic transfer learning on the PASCAL VOC dataset with synthetic transformations.
Recent works showed that Generative Adversarial Networks (GANs) can be successfully applied in unsupervised domain adaptation, where, given a labeled source dataset and an unlabeled target dataset, the goal is to train powerful classifiers for the target samples. In particular, it was shown that a GAN objective function can be used to learn target features indistinguishable from the source ones. In this work, we extend this framework by (i) forcing the learned feature extractor to be domain-invariant, and (ii) training it through data augmentation in the feature space, namely performing feature augmentation. While data augmentation in the image space is a well established technique in deep learning, feature augmentation has not yet received the same level of attention. We accomplish it by means of a feature generator trained by playing the GAN minimax game against source features. Results show that both enforcing domain-invariance and performing feature augmentation lead to superior or comparable performance to state-of-the-art results in several unsupervised domain adaptation benchmarks.
This work presents a region-growing image segmentation approach based on superpixel decomposition. From an initial contour-constrained over-segmentation of the input image, the image segmentation is achieved by iteratively merging similar superpixels into regions. This approach raises two key issues: (1) how to compute the similarity between superpixels in order to perform accurate merging and (2) in which order those superpixels must be merged together. In this perspective, we firstly introduce a robust adaptive multi-scale superpixel similarity in which region comparisons are made both at content and common border level. Secondly, we propose a global merging strategy to efficiently guide the region merging process. Such strategy uses an adpative merging criterion to ensure that best region aggregations are given highest priorities. This allows to reach a final segmentation into consistent regions with strong boundary adherence. We perform experiments on the BSDS500 image dataset to highlight to which extent our method compares favorably against other well-known image segmentation algorithms. The obtained results demonstrate the promising potential of the proposed approach.
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