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Generative artificial intelligence (AI) has brought revolutionary innovations in various fields, including medicine. However, it also exhibits limitations. In response, retrieval-augmented generation (RAG) provides a potential solution, enabling models to generate more accurate contents by leveraging the retrieval of external knowledge. With the rapid advancement of generative AI, RAG can pave the way for connecting this transformative technology with medical applications and is expected to bring innovations in equity, reliability, and personalization to health care.

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醫學人工智能AIM(Artificial Intelligence in Medicine)雜志發表了多學科領域的原創文章,涉及醫學中的人工智能理論和實踐,以醫學為導向的人類生物學和衛生保健。醫學中的人工智能可以被描述為與研究、項目和應用相關的科學學科,旨在通過基于知識或數據密集型的計算機解決方案支持基于決策的醫療任務,最終支持和改善人類護理提供者的性能。 官網地址:

Recently, Kirkpatrick et al. [ALT 2019] and Fallat et al. [JMLR 2023] introduced non-clashing teaching and showed it is the most efficient machine teaching model satisfying the Goldman-Mathias collusion-avoidance criterion. A teaching map $T$ for a concept class $\mathcal{C}$ assigns a (teaching) set $T(C)$ of examples to each concept $C \in \mathcal{C}$. A teaching map is non-clashing if no pair of concepts are consistent with the union of their teaching sets. The size of a non-clashing teaching map (NCTM) $T$ is the maximum size of a teaching set $T(C)$, $C \in \mathcal{C}$. The non-clashing teaching dimension NCTD$(\mathcal{C})$ of $\mathcal{C}$ is the minimum size of an NCTM for $\mathcal{C}$. NCTM$^+$ and NCTD$^+(\mathcal{C})$ are defined analogously, except the teacher may only use positive examples. We study NCTMs and NCTM$^+$s for the concept class $\mathcal{B}(G)$ consisting of all balls of a graph $G$. We show that the associated decision problem B-NCTD$^+$ for NCTD$^+$ is NP-complete in split, co-bipartite, and bipartite graphs. Surprisingly, we even prove that, unless the ETH fails, B-NCTD$^+$ does not admit an algorithm running in time $2^{2^{o(\text{vc})}}\cdot n^{O(1)}$, nor a kernelization algorithm outputting a kernel with $2^{o(\text{vc})}$ vertices, where vc is the vertex cover number of $G$. We complement these lower bounds with matching upper bounds. These are extremely rare results: it is only the second problem in NP to admit such a tight double-exponential lower bound parameterized by vc, and only one of very few problems to admit such an ETH-based conditional lower bound on the number of vertices in a kernel. For trees, interval graphs, cycles, and trees of cycles, we derive NCTM$^+$s or NCTMs for $\mathcal{B}(G)$ of size proportional to its VC-dimension, and for Gromov-hyperbolic graphs, we design an approximate NCTM$^+$ of size 2.

The Internet of Things (IoT) is a communication scheme which allows various objects to exchange several types of information, enabling functions such as home automation, production management, healthcare, etc. In addition, energy-harvesting (EH) technology is considered for IoT environment in order to reduce the need for management and enhance maintainability. Moreover, since environments considering outdoor elements such as pedestrians, vehicles and drones have been on the rise recently, it is important to consider mobility when designing an IoT network management scheme. However, calculating the optimal relaying topology is considered as an NP-hard problem, and finishing computation for mobility environment before the channel status changes is important to prevent delayed calculation results. In this article, our objective is to calculate a sub-optimal relaying topology for stationary and mobile system within reasonable computation time. To achieve our objective, we validate an iterative balancing time slot allocation algorithm introduced in the previous study, and propose a guided-mutation genetic algorithm (GMGA) that modulates the mutation rate based on the channel status for rational exploration. Additionally, we propose a mobility-aware iterative relaying topology algorithm, which calculates relaying topology in a mobility environment using an inheritance of the sub-optimal relaying topology calculations. Simulation results verify that our proposed scheme effectively solves formulated IoT network problems compared to other conventional schemes, and also effectively handles IoT environments including mobility in terms of minimum rate budget and computation time.

Some imitation learning methods combine behavioural cloning with self-supervision to infer actions from state pairs. However, most rely on a large number of expert trajectories to increase generalisation and human intervention to capture key aspects of the problem, such as domain constraints. In this paper, we propose Continuous Imitation Learning from Observation (CILO), a new method augmenting imitation learning with two important features: (i) exploration, allowing for more diverse state transitions, requiring less expert trajectories and resulting in fewer training iterations; and (ii) path signatures, allowing for automatic encoding of constraints, through the creation of non-parametric representations of agents and expert trajectories. We compared CILO with a baseline and two leading imitation learning methods in five environments. It had the best overall performance of all methods in all environments, outperforming the expert in two of them.

With the wide application of machine translation, the testing of Machine Translation Systems (MTSs) has attracted much attention. Recent works apply Metamorphic Testing (MT) to address the oracle problem in MTS testing. Existing MT methods for MTS generally follow the workflow of input transformation and output relation comparison, which generates a follow-up input sentence by mutating the source input and compares the source and follow-up output translations to detect translation errors, respectively. These methods use various input transformations to generate test case pairs and have successfully triggered numerous translation errors. However, they have limitations in performing fine-grained and rigorous output relation comparison and thus may report many false alarms and miss many true errors. In this paper, we propose a word closure-based output comparison method to address the limitations of the existing MTS MT methods. We first propose word closure as a new comparison unit, where each closure includes a group of correlated input and output words in the test case pair. Word closures suggest the linkages between the appropriate fragment in the source output translation and its counterpart in the follow-up output for comparison. Next, we compare the semantics on the level of word closure to identify the translation errors. In this way, we perform a fine-grained and rigorous semantic comparison for the outputs and thus realize more effective violation identification. We evaluate our method with the test cases generated by five existing input transformations and the translation outputs from three popular MTSs. Results show that our method significantly outperforms the existing works in violation identification by improving the precision and recall and achieving an average increase of 29.9% in F1 score. It also helps to increase the F1 score of translation error localization by 35.9%.

Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.

Emotion recognition in conversation (ERC) aims to detect the emotion label for each utterance. Motivated by recent studies which have proven that feeding training examples in a meaningful order rather than considering them randomly can boost the performance of models, we propose an ERC-oriented hybrid curriculum learning framework. Our framework consists of two curricula: (1) conversation-level curriculum (CC); and (2) utterance-level curriculum (UC). In CC, we construct a difficulty measurer based on "emotion shift" frequency within a conversation, then the conversations are scheduled in an "easy to hard" schema according to the difficulty score returned by the difficulty measurer. For UC, it is implemented from an emotion-similarity perspective, which progressively strengthens the model's ability in identifying the confusing emotions. With the proposed model-agnostic hybrid curriculum learning strategy, we observe significant performance boosts over a wide range of existing ERC models and we are able to achieve new state-of-the-art results on four public ERC datasets.

Recommender systems have been widely applied in different real-life scenarios to help us find useful information. Recently, Reinforcement Learning (RL) based recommender systems have become an emerging research topic. It often surpasses traditional recommendation models even most deep learning-based methods, owing to its interactive nature and autonomous learning ability. Nevertheless, there are various challenges of RL when applying in recommender systems. Toward this end, we firstly provide a thorough overview, comparisons, and summarization of RL approaches for five typical recommendation scenarios, following three main categories of RL: value-function, policy search, and Actor-Critic. Then, we systematically analyze the challenges and relevant solutions on the basis of existing literature. Finally, under discussion for open issues of RL and its limitations of recommendation, we highlight some potential research directions in this field.

Deep neural networks (DNNs) are successful in many computer vision tasks. However, the most accurate DNNs require millions of parameters and operations, making them energy, computation and memory intensive. This impedes the deployment of large DNNs in low-power devices with limited compute resources. Recent research improves DNN models by reducing the memory requirement, energy consumption, and number of operations without significantly decreasing the accuracy. This paper surveys the progress of low-power deep learning and computer vision, specifically in regards to inference, and discusses the methods for compacting and accelerating DNN models. The techniques can be divided into four major categories: (1) parameter quantization and pruning, (2) compressed convolutional filters and matrix factorization, (3) network architecture search, and (4) knowledge distillation. We analyze the accuracy, advantages, disadvantages, and potential solutions to the problems with the techniques in each category. We also discuss new evaluation metrics as a guideline for future research.

Applying artificial intelligence techniques in medical imaging is one of the most promising areas in medicine. However, most of the recent success in this area highly relies on large amounts of carefully annotated data, whereas annotating medical images is a costly process. In this paper, we propose a novel method, called FocalMix, which, to the best of our knowledge, is the first to leverage recent advances in semi-supervised learning (SSL) for 3D medical image detection. We conducted extensive experiments on two widely used datasets for lung nodule detection, LUNA16 and NLST. Results show that our proposed SSL methods can achieve a substantial improvement of up to 17.3% over state-of-the-art supervised learning approaches with 400 unlabeled CT scans.

With the advent of deep neural networks, learning-based approaches for 3D reconstruction have gained popularity. However, unlike for images, in 3D there is no canonical representation which is both computationally and memory efficient yet allows for representing high-resolution geometry of arbitrary topology. Many of the state-of-the-art learning-based 3D reconstruction approaches can hence only represent very coarse 3D geometry or are limited to a restricted domain. In this paper, we propose occupancy networks, a new representation for learning-based 3D reconstruction methods. Occupancy networks implicitly represent the 3D surface as the continuous decision boundary of a deep neural network classifier. In contrast to existing approaches, our representation encodes a description of the 3D output at infinite resolution without excessive memory footprint. We validate that our representation can efficiently encode 3D structure and can be inferred from various kinds of input. Our experiments demonstrate competitive results, both qualitatively and quantitatively, for the challenging tasks of 3D reconstruction from single images, noisy point clouds and coarse discrete voxel grids. We believe that occupancy networks will become a useful tool in a wide variety of learning-based 3D tasks.

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