In the last years, social media has gained an unprecedented amount of attention, playing a pivotal role in shaping the contemporary landscape of communication and connection. However, Coordinated Inhautentic Behaviour (CIB), defined as orchestrated efforts by entities to deceive or mislead users about their identity and intentions, has emerged as a tactic to exploit the online discourse. In this study, we quantify the efficacy of CIB tactics by defining a general framework for evaluating the influence of a subset of nodes in a directed tree. We design two algorithms that provide optimal and greedy post-hoc placement strategies that lead to maximising the configuration influence. We then consider cascades from information spreading on Twitter to compare the observed behaviour with our algorithms. The results show that, according to our model, coordinated accounts are quite inefficient in terms of their network influence, thus suggesting that they may play a less pivotal role than expected. Moreover, the causes of these poor results may be found in two separate aspects: a bad placement strategy and a scarcity of resources.
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Colocalization analyses assess whether two traits are affected by the same or distinct causal genetic variants in a single gene region. A class of Bayesian colocalization tests are now routinely used in practice; for example, for genetic analyses in drug development pipelines. In this work, we consider an alternative frequentist approach to colocalization testing that examines the proportionality of genetic associations with each trait. The proportional colocalization approach uses markedly different assumptions to Bayesian colocalization tests, and therefore can provide valuable complementary evidence in cases where Bayesian colocalization results are inconclusive or sensitive to priors. We propose a novel conditional test of proportional colocalization, prop-coloc-cond, that aims to account for the uncertainty in variant selection, in order to recover accurate type I error control. The test can be implemented straightforwardly, requiring only summary data on genetic associations. Simulation evidence and an empirical investigation into GLP1R gene expression demonstrates how tests of proportional colocalization can offer important insights in conjunction with Bayesian colocalization tests.
Lax-Wendroff Flux Reconstruction (LWFR) is a single-stage, high order, quadrature free method for solving hyperbolic conservation laws. This work extends the LWFR scheme to solve conservation laws on curvilinear meshes with adaptive mesh refinement (AMR). The scheme uses a subcell based blending limiter to perform shock capturing and exploits the same subcell structure to obtain admissibility preservation on curvilinear meshes. It is proven that the proposed extension of LWFR scheme to curvilinear grids preserves constant solution (free stream preservation) under the standard metric identities. For curvilinear meshes, linear Fourier stability analysis cannot be used to obtain an optimal CFL number. Thus, an embedded-error based time step computation method is proposed for LWFR method which reduces fine-tuning process required to select a stable CFL number using the wave speed based time step computation. The developments are tested on compressible Euler's equations, validating the blending limiter, admissibility preservation, AMR algorithm, curvilinear meshes and error based time stepping.
The discharge summary is a one of critical documents in the patient journey, encompassing all events experienced during hospitalization, including multiple visits, medications, tests, surgery/procedures, and admissions/discharge. Providing a summary of the patient's progress is crucial, as it significantly influences future care and planning. Consequently, clinicians face the laborious and resource-intensive task of manually collecting, organizing, and combining all the necessary data for a discharge summary. Therefore, we propose "NOTE", which stands for "Notable generation Of patient Text summaries through an Efficient approach based on direct preference optimization". NOTE is based on Medical Information Mart for Intensive Care- III dataset and summarizes a single hospitalization of a patient. Patient events are sequentially combined and used to generate a discharge summary for each hospitalization. In the present circumstances, large language models' application programming interfaces (LLMs' APIs) are widely available, but importing and exporting medical data presents significant challenges due to privacy protection policies in healthcare institutions. Moreover, to ensure optimal performance, it is essential to implement a lightweight model for internal server or program within the hospital. Therefore, we utilized DPO and parameter efficient fine tuning (PEFT) techniques to apply a fine-tuning method that guarantees superior performance. To demonstrate the practical application of the developed NOTE, we provide a webpage-based demonstration software. In the future, we will aim to deploy the software available for actual use by clinicians in hospital. NOTE can be utilized to generate various summaries not only discharge summaries but also throughout a patient's journey, thereby alleviating the labor-intensive workload of clinicians and aiming for increased efficiency.
We provide full theoretical guarantees for the convergence behaviour of diffusion-based generative models under the assumption of strongly log-concave data distributions while our approximating class of functions used for score estimation is made of Lipschitz continuous functions. We demonstrate via a motivating example, sampling from a Gaussian distribution with unknown mean, the powerfulness of our approach. In this case, explicit estimates are provided for the associated optimization problem, i.e. score approximation, while these are combined with the corresponding sampling estimates. As a result, we obtain the best known upper bound estimates in terms of key quantities of interest, such as the dimension and rates of convergence, for the Wasserstein-2 distance between the data distribution (Gaussian with unknown mean) and our sampling algorithm. Beyond the motivating example and in order to allow for the use of a diverse range of stochastic optimizers, we present our results using an $L^2$-accurate score estimation assumption, which crucially is formed under an expectation with respect to the stochastic optimizer and our novel auxiliary process that uses only known information. This approach yields the best known convergence rate for our sampling algorithm.
In this article we aim to obtain the Fisher Riemann geodesics for nonparametric families of probability densities as a weak limit of the parametric case with increasing number of parameters.
Spatio-temporal point process modelling of fires in Sicily exploring human and environmental factors
In 2023, Sicily faced an escalating issue of uncontrolled fires, necessitating a thorough investigation into their spatio-temporal dynamics. Our study addresses this concern through point process theory. Each wildfire is treated as a unique point in both space and time, allowing us to assess the influence of environmental and anthropogenic factors by fitting a spatio-temporal separable Poisson point process model, with a particular focus on the role of land usage. First, a spatial log-linear Poisson model is applied to investigate the influence of land use types on wildfire distribution, controlling for other environmental covariates. The results highlight the significant effect of human activities, altitude, and slope on spatial fire occurrence. Then, a Generalized Additive Model with Poisson-distributed response further explores the temporal dynamics of wildfire occurrences, confirming their dependence on various environmental variables, including the maximum daily temperature, wind speed, surface pressure, and total precipitation.
We consider the numerical behavior of the fixed-stress splitting method for coupled poromechanics as undrained regimes are approached. We explain that pressure stability is related to the splitting error of the scheme, not the fact that the discrete saddle point matrix never appears in the fixed-stress approach. This observation reconciles previous results regarding the pressure stability of the splitting method. Using examples of compositional poromechanics with application to geological CO$_2$ sequestration, we see that solutions obtained using the fixed-stress scheme with a low order finite element-finite volume discretization which is not inherently inf-sup stable can exhibit the same pressure oscillations obtained with the corresponding fully implicit scheme. Moreover, pressure jump stabilization can effectively remove these spurious oscillations in the fixed-stress setting, while also improving the efficiency of the scheme in terms of the number of iterations required at every time step to reach convergence.
In the realm of cost-sharing mechanisms, the vulnerability to Sybil strategies - also known as false-name strategies, where agents create fake identities to manipulate outcomes - has not yet been studied. In this paper, we delve into the details of different cost-sharing mechanisms proposed in the literature, highlighting their non-Sybil-resistant nature. Furthermore, we prove that a Sybil-proof cost-sharing mechanism for public excludable goods under mild conditions is at least $(n+1)/2-$approximate. This finding reveals an exponential increase in the worst-case social cost in environments where agents are restricted from using Sybil strategies. To circumvent these negative results, we introduce the concept of \textit{Sybil Welfare Invariant} mechanisms, where a mechanism does not decrease its welfare under Sybil-strategies when agents choose weak dominant strategies and have subjective prior beliefs over other players' actions. Finally, we prove that the Shapley value mechanism for symmetric and submodular cost functions holds this property, and so deduce that the worst-case social cost of this mechanism is the $n$th harmonic number $\mathcal H_n$ under equilibrium with Sybil strategies, matching the worst-case social cost bound for cost-sharing mechanisms. This finding suggests that any group of agents, each with private valuations, can fund public excludable goods both permissionless and anonymously, achieving efficiency comparable to that of permissioned and non-anonymous domains, even when the total number of participants is unknown.
While actors in a population can interact with anyone else freely, social relations significantly influence our inclination towards particular individuals. The consequence of such interactions, however, may also form the intensity of our relations established earlier. These dynamical processes are captured via a coevolutionary model staged in multiplex networks with two distinct layers. In a so-called relationship layer the weights of edges among players may change in time as a consequence of games played in the alternative interaction layer. As an reasonable assumption, bilateral cooperation confirms while mutual defection weakens these weight factors. Importantly, the fitness of a player, which basically determines the success of a strategy imitation, depends not only on the payoff collected from interactions, but also on the individual relationship index calculated from the mentioned weight factors of related edges. Within the framework of weak prisoner's dilemma situation we explore the potential outcomes of the mentioned coevolutionary process where we assume different topologies for relationship layer. We find that higher average degree of the relationship graph is more beneficial to maintain cooperation in regular graphs, but the randomness of links could be a decisive factor in harsh situations. Surprisingly, a stronger coupling between relationship index and fitness discourage the evolution of cooperation by weakening the direct consequence of a strategy change. To complete our study we also monitor how the distribution of relationship index vary and detect a strong relation between its polarization and the general cooperation level.
We show that a previously introduced key exchange based on a congruence-simple semiring action is not secure by providing an attack that reveals the shared key from the distributed public information for any of such semirings
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