Unpaired image-to-image translation has been applied successfully to natural images but has received very little attention for manifold-valued data such as in diffusion tensor imaging (DTI). The non-Euclidean nature of DTI prevents current generative adversarial networks (GANs) from generating plausible images and has mainly limited their application to diffusion MRI scalar maps, such as fractional anisotropy (FA) or mean diffusivity (MD). Even if these scalar maps are clinically useful, they mostly ignore fiber orientations and therefore have limited applications for analyzing brain fibers. Here, we propose a manifold-aware CycleGAN that learns the generation of high-resolution DTI from unpaired T1w images. We formulate the objective as a Wasserstein distance minimization problem of data distributions on a Riemannian manifold of symmetric positive definite 3x3 matrices SPD(3), using adversarial and cycle-consistency losses. To ensure that the generated diffusion tensors lie on the SPD(3) manifold, we exploit the theoretical properties of the exponential and logarithm maps of the Log-Euclidean metric. We demonstrate that, unlike standard GANs, our method is able to generate realistic high-resolution DTI that can be used to compute diffusion-based metrics and potentially run fiber tractography algorithms. To evaluate our model's performance, we compute the cosine similarity between the generated tensors principal orientation and their ground-truth orientation, the mean squared error (MSE) of their derived FA values and the Log-Euclidean distance between the tensors. We demonstrate that our method produces 2.5 times better FA MSE than a standard CycleGAN and up to 30% better cosine similarity than a manifold-aware Wasserstein GAN while synthesizing sharp high-resolution DTI.
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Recently, adaptive inference is gaining increasing attention due to its high computational efficiency. Different from existing works, which mainly exploit architecture redundancy for adaptive network design, in this paper, we focus on spatial redundancy of input samples, and propose a novel Resolution Adaptive Network (RANet). Our motivation is that low-resolution representations can be sufficient for classifying "easy" samples containing canonical objects, while high-resolution features are curial for recognizing some "hard" ones. In RANet, input images are first routed to a lightweight sub-network that efficiently extracts coarse feature maps, and samples with high confident predictions will exit early from the sub-network. The high-resolution paths are only activated for those "hard" samples whose previous predictions are unreliable. By adaptively processing the features in varying resolutions, the proposed RANet can significantly improve its computational efficiency. Experiments on three classification benchmark tasks (CIFAR-10, CIFAR-100 and ImageNet) demonstrate the effectiveness of the proposed model in both anytime prediction setting and budgeted batch classification setting.
In this work, we study the problem of training deep networks for semantic image segmentation using only a fraction of annotated images, which may significantly reduce human annotation efforts. Particularly, we propose a strategy that exploits the unpaired image style transfer capabilities of CycleGAN in semi-supervised segmentation. Unlike recent works using adversarial learning for semi-supervised segmentation, we enforce cycle consistency to learn a bidirectional mapping between unpaired images and segmentation masks. This adds an unsupervised regularization effect that boosts the segmentation performance when annotated data is limited. Experiments on three different public segmentation benchmarks (PASCAL VOC 2012, Cityscapes and ACDC) demonstrate the effectiveness of the proposed method. The proposed model achieves 2-4% of improvement with respect to the baseline and outperforms recent approaches for this task, particularly in low labeled data regime.
Despite recent progress in generative image modeling, successfully generating high-resolution, diverse samples from complex datasets such as ImageNet remains an elusive goal. To this end, we train Generative Adversarial Networks at the largest scale yet attempted, and study the instabilities specific to such scale. We find that applying orthogonal regularization to the generator renders it amenable to a simple "truncation trick", allowing fine control over the trade-off between sample fidelity and variety by truncating the latent space. Our modifications lead to models which set the new state of the art in class-conditional image synthesis. When trained on ImageNet at 128x128 resolution, our models (BigGANs) achieve an Inception Score (IS) of 166.3 and Frechet Inception Distance (FID) of 9.6, improving over the previous best IS of 52.52 and FID of 18.65.
We present a new method for synthesizing high-resolution photo-realistic images from semantic label maps using conditional generative adversarial networks (conditional GANs). Conditional GANs have enabled a variety of applications, but the results are often limited to low-resolution and still far from realistic. In this work, we generate 2048x1024 visually appealing results with a novel adversarial loss, as well as new multi-scale generator and discriminator architectures. Furthermore, we extend our framework to interactive visual manipulation with two additional features. First, we incorporate object instance segmentation information, which enables object manipulations such as removing/adding objects and changing the object category. Second, we propose a method to generate diverse results given the same input, allowing users to edit the object appearance interactively. Human opinion studies demonstrate that our method significantly outperforms existing methods, advancing both the quality and the resolution of deep image synthesis and editing.
Unpaired image-to-image translation is the problem of mapping an image in the source domain to one in the target domain, without requiring corresponding image pairs. To ensure the translated images are realistically plausible, recent works, such as Cycle-GAN, demands this mapping to be invertible. While, this requirement demonstrates promising results when the domains are unimodal, its performance is unpredictable in a multi-modal scenario such as in an image segmentation task. This is because, invertibility does not necessarily enforce semantic correctness. To this end, we present a semantically-consistent GAN framework, dubbed Sem-GAN, in which the semantics are defined by the class identities of image segments in the source domain as produced by a semantic segmentation algorithm. Our proposed framework includes consistency constraints on the translation task that, together with the GAN loss and the cycle-constraints, enforces that the images when translated will inherit the appearances of the target domain, while (approximately) maintaining their identities from the source domain. We present experiments on several image-to-image translation tasks and demonstrate that Sem-GAN improves the quality of the translated images significantly, sometimes by more than 20% on the FCN score. Further, we show that semantic segmentation models, trained with synthetic images translated via Sem-GAN, leads to significantly better segmentation results than other variants.
The per-pixel cross-entropy loss (CEL) has been widely used in structured output prediction tasks as a spatial extension of generic image classification. However, its i.i.d. assumption neglects the structural regularity present in natural images. Various attempts have been made to incorporate structural reasoning mostly through structure priors in a cooperative way where co-occuring patterns are encouraged. We, on the other hand, approach this problem from an opposing angle and propose a new framework for training such structured prediction networks via an adversarial process, in which we train a structure analyzer that provides the supervisory signals, the adversarial structure matching loss (ASML). The structure analyzer is trained to maximize ASML, or to exaggerate recurring structural mistakes usually among co-occurring patterns. On the contrary, the structured output prediction network is trained to reduce those mistakes and is thus enabled to distinguish fine-grained structures. As a result, training structured output prediction networks using ASML reduces contextual confusion among objects and improves boundary localization. We demonstrate that ASML outperforms its counterpart CEL especially in context and boundary aspects on figure-ground segmentation and semantic segmentation tasks with various base architectures, such as FCN, U-Net, DeepLab, and PSPNet.
Generative Adversarial Networks (GANs) convergence in a high-resolution setting with a computational constrain of GPU memory capacity (from 12GB to 24 GB) has been beset with difficulty due to the known lack of convergence rate stability. In order to boost network convergence of DCGAN (Deep Convolutional Generative Adversarial Networks) and achieve good-looking high-resolution results we propose a new layered network structure, HDCGAN, that incorporates current state-of-the-art techniques for this effect. A novel dataset, Curt\'o Zarza (CZ), containing human faces from different ethnical groups in a wide variety of illumination conditions and image resolutions is introduced. CZ is enhanced with HDCGAN synthetic images, thus being the first GAN augmented face dataset. We conduct extensive experiments on CelebA and CZ.
Recent works showed that Generative Adversarial Networks (GANs) can be successfully applied in unsupervised domain adaptation, where, given a labeled source dataset and an unlabeled target dataset, the goal is to train powerful classifiers for the target samples. In particular, it was shown that a GAN objective function can be used to learn target features indistinguishable from the source ones. In this work, we extend this framework by (i) forcing the learned feature extractor to be domain-invariant, and (ii) training it through data augmentation in the feature space, namely performing feature augmentation. While data augmentation in the image space is a well established technique in deep learning, feature augmentation has not yet received the same level of attention. We accomplish it by means of a feature generator trained by playing the GAN minimax game against source features. Results show that both enforcing domain-invariance and performing feature augmentation lead to superior or comparable performance to state-of-the-art results in several unsupervised domain adaptation benchmarks.
Recent advances in 3D fully convolutional networks (FCN) have made it feasible to produce dense voxel-wise predictions of volumetric images. In this work, we show that a multi-class 3D FCN trained on manually labeled CT scans of several anatomical structures (ranging from the large organs to thin vessels) can achieve competitive segmentation results, while avoiding the need for handcrafting features or training class-specific models. To this end, we propose a two-stage, coarse-to-fine approach that will first use a 3D FCN to roughly define a candidate region, which will then be used as input to a second 3D FCN. This reduces the number of voxels the second FCN has to classify to ~10% and allows it to focus on more detailed segmentation of the organs and vessels. We utilize training and validation sets consisting of 331 clinical CT images and test our models on a completely unseen data collection acquired at a different hospital that includes 150 CT scans, targeting three anatomical organs (liver, spleen, and pancreas). In challenging organs such as the pancreas, our cascaded approach improves the mean Dice score from 68.5 to 82.2%, achieving the highest reported average score on this dataset. We compare with a 2D FCN method on a separate dataset of 240 CT scans with 18 classes and achieve a significantly higher performance in small organs and vessels. Furthermore, we explore fine-tuning our models to different datasets. Our experiments illustrate the promise and robustness of current 3D FCN based semantic segmentation of medical images, achieving state-of-the-art results. Our code and trained models are available for download: //github.com/holgerroth/3Dunet_abdomen_cascade.
We describe a new training methodology for generative adversarial networks. The key idea is to grow both the generator and discriminator progressively: starting from a low resolution, we add new layers that model increasingly fine details as training progresses. This both speeds the training up and greatly stabilizes it, allowing us to produce images of unprecedented quality, e.g., CelebA images at 1024^2. We also propose a simple way to increase the variation in generated images, and achieve a record inception score of 8.80 in unsupervised CIFAR10. Additionally, we describe several implementation details that are important for discouraging unhealthy competition between the generator and discriminator. Finally, we suggest a new metric for evaluating GAN results, both in terms of image quality and variation. As an additional contribution, we construct a higher-quality version of the CelebA dataset.
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