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Given its status as a classic problem and its importance to both theoreticians and practitioners, edit distance provides an excellent lens through which to understand how the theoretical analysis of algorithms impacts practical implementations. From an applied perspective, the goals of theoretical analysis are to predict the empirical performance of an algorithm and to serve as a yardstick to design novel algorithms that perform well in practice. In this paper, we systematically survey the types of theoretical analysis techniques that have been applied to edit distance and evaluate the extent to which each one has achieved these two goals. These techniques include traditional worst-case analysis, worst-case analysis parametrized by edit distance or entropy or compressibility, average-case analysis, semi-random models, and advice-based models. We find that the track record is mixed. On one hand, two algorithms widely used in practice have been born out of theoretical analysis and their empirical performance is captured well by theoretical predictions. On the other hand, all the algorithms developed using theoretical analysis as a yardstick since then have not had any practical relevance. We conclude by discussing the remaining open problems and how they can be tackled.

Adaptive and intelligent user interfaces have been proposed as a critical component of a successful extended reality (XR) system. In particular, a predictive system can make inferences about a user and provide them with task-relevant recommendations or adaptations. However, we believe such adaptive interfaces should carefully consider the overall \emph{cost} of interactions to better address uncertainty of predictions. In this position paper, we discuss a computational approach to adapt XR interfaces, with the goal of improving user experience and performance. Our novel model, applied to menu selection tasks, simulates user interactions by considering both cognitive and motor costs. In contrast to greedy algorithms that adapt based on predictions alone, our model holistically accounts for costs and benefits of adaptations towards adapting the interface and providing optimal recommendations to the user.

Adverse events are a serious issue in drug development and many prediction methods using machine learning have been developed. The random split cross-validation is the de facto standard for model building and evaluation in machine learning, but care should be taken in adverse event prediction because this approach tends to be overoptimistic compared with the real-world situation. The time split, which uses the time axis, is considered suitable for real-world prediction. However, the differences in model performance obtained using the time and random splits are not fully understood. To understand the differences, we compared the model performance between the time and random splits using eight types of compound information as input, eight adverse events as targets, and six machine learning algorithms. The random split showed higher area under the curve values than did the time split for six of eight targets. The chemical spaces of the training and test datasets of the time split were similar, suggesting that the concept of applicability domain is insufficient to explain the differences derived from the splitting. The area under the curve differences were smaller for the protein interaction than for the other datasets. Subsequent detailed analyses suggested the danger of confounding in the use of knowledge-based information in the time split. These findings indicate the importance of understanding the differences between the time and random splits in adverse event prediction and suggest that appropriate use of the splitting strategies and interpretation of results are necessary for the real-world prediction of adverse events.

The past few years have witnessed an increasing interest in improving the perception performance of LiDARs on autonomous vehicles. While most of the existing works focus on developing new deep learning algorithms or model architectures, we study the problem from the physical design perspective, i.e., how different placements of multiple LiDARs influence the learning-based perception. To this end, we introduce an easy-to-compute information-theoretic surrogate metric to quantitatively and fast evaluate LiDAR placement for 3D detection of different types of objects. We also present a new data collection, detection model training and evaluation framework in the realistic CARLA simulator to evaluate disparate multi-LiDAR configurations. Using several prevalent placements inspired by the designs of self-driving companies, we show the correlation between our surrogate metric and object detection performance of different representative algorithms on KITTI through extensive experiments, validating the effectiveness of our LiDAR placement evaluation approach. Our results show that sensor placement is non-negligible in 3D point cloud-based object detection, which will contribute up to 10% performance discrepancy in terms of average precision in challenging 3D object detection settings. We believe that this is one of the first studies to quantitatively investigate the influence of LiDAR placement on perception performance.

When subjected to a sudden, unanticipated threat, human groups characteristically self-organize to identify the threat, determine potential responses, and act to reduce its impact. Central to this process is the challenge of coordinating information sharing and response activity within a disrupted environment. In this paper, we consider coordination in the context of responses to the 2001 World Trade Center disaster. Using records of communications among 17 organizational units, we examine the mechanisms driving communication dynamics, with an emphasis on the emergence of coordinating roles. We employ relational event models (REMs) to identify the mechanisms shaping communications in each unit, finding a consistent pattern of behavior across units with very different characteristics. Using a simulation-based "knock-out" study, we also probe the importance of different mechanisms for hub formation. Our results suggest that, while preferential attachment and pre-disaster role structure generally contribute to the emergence of hub structure, temporally local conversational norms play a much larger role. We discuss broader implications for the role of microdynamics in driving macroscopic outcomes, and for the emergence of coordination in other settings.

The outbreak of the COVID-19 pandemic has deeply influenced the lifestyle of the general public and the healthcare system of the society. As a promising approach to address the emerging challenges caused by the epidemic of infectious diseases like COVID-19, Internet of Medical Things (IoMT) deployed in hospitals, clinics, and healthcare centers can save the diagnosis time and improve the efficiency of medical resources though privacy and security concerns of IoMT stall the wide adoption. In order to tackle the privacy, security, and interoperability issues of IoMT, we propose a framework of blockchain-enabled IoMT by introducing blockchain to incumbent IoMT systems. In this paper, we review the benefits of this architecture and illustrate the opportunities brought by blockchain-enabled IoMT. We also provide use cases of blockchain-enabled IoMT on fighting against the COVID-19 pandemic, including the prevention of infectious diseases, location sharing and contact tracing, and the supply chain of injectable medicines. We also outline future work in this area.

Frame-online speech enhancement systems in the short-time Fourier transform (STFT) domain usually have an algorithmic latency equal to the window size due to the use of the overlap-add algorithm in the inverse STFT (iSTFT). This algorithmic latency allows the enhancement models to leverage future contextual information up to a length equal to the window size. However, current frame-online systems only partially leverage this future information. To fully exploit this information, this study proposes an overlapped-frame prediction technique for deep learning based frame-online speech enhancement, where at each frame our deep neural network (DNN) predicts the current and several past frames that are necessary for overlap-add, instead of only predicting the current frame. In addition, we propose a novel loss function to account for the scale difference between predicted and oracle target signals. Evaluations results on a noisy-reverberant speech enhancement task show the effectiveness of the proposed algorithms.

During recent crises like COVID-19, microblogging platforms have become popular channels for affected people seeking assistance such as medical supplies and rescue operations from emergency responders and the public. Despite this common practice, the affordances of microblogging services for help-seeking during crises that needs immediate attention are not well understood. To fill this gap, we analyzed 8K posts from COVID-19 patients or caregivers requesting urgent medical assistance on Weibo, the largest microblogging site in China. Our mixed-methods analyses suggest that existing microblogging functions need to be improved in multiple aspects to sufficiently facilitate help-seeking in emergencies, including capabilities of search and tracking requests, ease of use, and privacy protection. We also find that people tend to stick to certain well-established functions for publishing requests, even after better alternatives emerge. These findings have implications for designing microblogging tools to better support help requesting and responding during crises.

Clustering is one of the most fundamental and wide-spread techniques in exploratory data analysis. Yet, the basic approach to clustering has not really changed: a practitioner hand-picks a task-specific clustering loss to optimize and fit the given data to reveal the underlying cluster structure. Some types of losses---such as k-means, or its non-linear version: kernelized k-means (centroid based), and DBSCAN (density based)---are popular choices due to their good empirical performance on a range of applications. Although every so often the clustering output using these standard losses fails to reveal the underlying structure, and the practitioner has to custom-design their own variation. In this work we take an intrinsically different approach to clustering: rather than fitting a dataset to a specific clustering loss, we train a recurrent model that learns how to cluster. The model uses as training pairs examples of datasets (as input) and its corresponding cluster identities (as output). By providing multiple types of training datasets as inputs, our model has the ability to generalize well on unseen datasets (new clustering tasks). Our experiments reveal that by training on simple synthetically generated datasets or on existing real datasets, we can achieve better clustering performance on unseen real-world datasets when compared with standard benchmark clustering techniques. Our meta clustering model works well even for small datasets where the usual deep learning models tend to perform worse.