Clinical texts, such as admission notes, discharge summaries, and progress notes, contain rich and valuable information that can be used for various clinical outcome prediction tasks. However, applying large language models, such as BERT-based models, to clinical texts poses two major challenges: the limitation of input length and the diversity of data sources. This paper proposes a novel method to preserve the knowledge of long clinical texts using aggregated ensembles of large language models. Unlike previous studies which use model ensembling or text aggregation methods separately, we combine ensemble learning with text aggregation and train multiple large language models on two clinical outcome tasks: mortality prediction and length of stay prediction. We show that our method can achieve better results than baselines, ensembling, and aggregation individually, and can improve the performance of large language models while handling long inputs and diverse datasets. We conduct extensive experiments on the admission notes from the MIMIC-III clinical database by combining multiple unstructured and high-dimensional datasets, demonstrating our method's effectiveness and superiority over existing approaches. We also provide a comprehensive analysis and discussion of our results, highlighting our method's applications and limitations for future research in the domain of clinical healthcare. The results and analysis of this study is supportive of our method assisting in clinical healthcare systems by enabling clinical decision-making with robust performance overcoming the challenges of long text inputs and varied datasets.
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Neural networks excel at discovering statistical patterns in high-dimensional data sets. In practice, higher-order cumulants, which quantify the non-Gaussian correlations between three or more variables, are particularly important for the performance of neural networks. But how efficient are neural networks at extracting features from higher-order cumulants? We study this question in the spiked cumulant model, where the statistician needs to recover a privileged direction or "spike" from the order-$p\ge 4$ cumulants of~$d$-dimensional inputs. We first characterise the fundamental statistical and computational limits of recovering the spike by analysing the number of samples~$n$ required to strongly distinguish between inputs from the spiked cumulant model and isotropic Gaussian inputs. We find that statistical distinguishability requires $n\gtrsim d$ samples, while distinguishing the two distributions in polynomial time requires $n \gtrsim d^2$ samples for a wide class of algorithms, i.e. those covered by the low-degree conjecture. These results suggest the existence of a wide statistical-to-computational gap in this problem. Numerical experiments show that neural networks learn to distinguish the two distributions with quadratic sample complexity, while "lazy" methods like random features are not better than random guessing in this regime. Our results show that neural networks extract information from higher-order correlations in the spiked cumulant model efficiently, and reveal a large gap in the amount of data required by neural networks and random features to learn from higher-order cumulants.
Error bounds are derived for sampling and estimation using a discretization of an intrinsically defined Langevin diffusion with invariant measure $d\mu_\phi \propto e^{-\phi} \mathrm{dvol}_g $ on a compact Riemannian manifold. Two estimators of linear functionals of $\mu_\phi $ based on the discretized Markov process are considered: a time-averaging estimator based on a single trajectory and an ensemble-averaging estimator based on multiple independent trajectories. Imposing no restrictions beyond a nominal level of smoothness on $\phi$, first-order error bounds, in discretization step size, on the bias and variances of both estimators are derived. The order of error matches the optimal rate in Euclidean and flat spaces, and leads to a first-order bound on distance between the invariant measure $\mu_\phi$ and a stationary measure of the discretized Markov process. Generality of the proof techniques, which exploit links between two partial differential equations and the semigroup of operators corresponding to the Langevin diffusion, renders them amenable for the study of a more general class of sampling algorithms related to the Langevin diffusion. Conditions for extending analysis to the case of non-compact manifolds are discussed. Numerical illustrations with distributions, log-concave and otherwise, on the manifolds of positive and negative curvature elucidate on the derived bounds and demonstrate practical utility of the sampling algorithm.
This paper presents the first application of the direct parametrisation method for invariant manifolds to a fully coupled multiphysics problem involving the nonlinear vibrations of deformable structures subjected to an electrostatic field. The formulation proposed is intended for model order reduction of electrostatically actuated resonating Micro-Electro-Mechanical Systems (MEMS). The continuous problem is first rewritten in a manner that can be directly handled by the parametrisation method, which relies upon automated asymptotic expansions. A new mixed fully Lagrangian formulation is thus proposed which contains only explicit polynomial nonlinearities, which is then discretised in the framework of finite element procedures. Validation is performed on the classical parallel plate configuration, where different formulations using either the general framework, or an approximation of the electrostatic field due to the geometric configuration selected, are compared. Reduced-order models along these formulations are also compared to full-order simulations operated with a time integration approach. Numerical results show a remarkable performance both in terms of accuracy and wealth of nonlinear effects that can be accounted for. In particular, the transition from hardening to softening behaviour of the primary resonance while increasing the constant voltage component of the electric actuation, is recovered. Secondary resonances leading to superharmonic and parametric resonances are also investigated with the reduced-order model.
Text normalization is a crucial technology for low-resource languages which lack rigid spelling conventions or that have undergone multiple spelling reforms. Low-resource text normalization has so far relied upon hand-crafted rules, which are perceived to be more data efficient than neural methods. In this paper we examine the case of text normalization for Ligurian, an endangered Romance language. We collect 4,394 Ligurian sentences paired with their normalized versions, as well as the first open source monolingual corpus for Ligurian. We show that, in spite of the small amounts of data available, a compact transformer-based model can be trained to achieve very low error rates by the use of backtranslation and appropriate tokenization.
As advancements in artificial intelligence (AI) propel progress in the life sciences, they may also enable the weaponisation and misuse of biological agents. This article differentiates two classes of AI tools that could pose such biosecurity risks: large language models (LLMs) and biological design tools (BDTs). LLMs, such as GPT-4 and its successors, might provide dual-use information and thus remove some barriers encountered by historical biological weapons efforts. As LLMs are turned into multi-modal lab assistants and autonomous science tools, this will increase their ability to support non-experts in performing laboratory work. Thus, LLMs may in particular lower barriers to biological misuse. In contrast, BDTs will expand the capabilities of sophisticated actors. Concretely, BDTs may enable the creation of pandemic pathogens substantially worse than anything seen to date and could enable forms of more predictable and targeted biological weapons. In combination, the convergence of LLMs and BDTs could raise the ceiling of harm from biological agents and could make them broadly accessible. A range of interventions would help to manage risks. Independent pre-release evaluations could help understand the capabilities of models and the effectiveness of safeguards. Options for differentiated access to such tools should be carefully weighed with the benefits of openly releasing systems. Lastly, essential for mitigating risks will be universal and enhanced screening of gene synthesis products.
We investigate the descriptive complexity of a class of neural networks with unrestricted topologies and piecewise polynomial activation functions. We consider the general scenario where the running time is unlimited and floating-point numbers are used for simulating reals. We characterize these neural networks with a rule-based logic for Boolean networks. In particular, we show that the sizes of the neural networks and the corresponding Boolean rule formulae are polynomially related. In fact, in the direction from Boolean rules to neural networks, the blow-up is only linear. We also analyze the delays in running times due to the translations. In the translation from neural networks to Boolean rules, the time delay is polylogarithmic in the neural network size and linear in time. In the converse translation, the time delay is linear in both factors. We also obtain translations between the rule-based logic for Boolean networks, the diamond-free fragment of modal substitution calculus and a class of recursive Boolean circuits where the number of input and output gates match.
Stabbing Planes (also known as Branch and Cut) is a proof system introduced very recently which, informally speaking, extends the DPLL method by branching on integer linear inequalities instead of single variables. The techniques known so far to prove size and depth lower bounds for Stabbing Planes are generalizations of those used for the Cutting Planes proof system. For size lower bounds these are established by monotone circuit arguments, while for depth these are found via communication complexity and protection. As such these bounds apply for lifted versions of combinatorial statements. Rank lower bounds for Cutting Planes are also obtained by geometric arguments called protection lemmas. In this work we introduce two new geometric approaches to prove size/depth lower bounds in Stabbing Planes working for any formula: (1) the antichain method, relying on Sperner's Theorem and (2) the covering method which uses results on essential coverings of the boolean cube by linear polynomials, which in turn relies on Alon's combinatorial Nullenstellensatz. We demonstrate their use on classes of combinatorial principles such as the Pigeonhole principle, the Tseitin contradictions and the Linear Ordering Principle. By the first method we prove almost linear size lower bounds and optimal logarithmic depth lower bounds for the Pigeonhole principle and analogous lower bounds for the Tseitin contradictions over the complete graph and for the Linear Ordering Principle. By the covering method we obtain a superlinear size lower bound and a logarithmic depth lower bound for Stabbing Planes proof of Tseitin contradictions over a grid graph.
Deep learning techniques have dominated the literature on aspect-based sentiment analysis (ABSA), achieving state-of-the-art performance. However, deep models generally suffer from spurious correlations between input features and output labels, which hurts the robustness and generalization capability by a large margin. In this paper, we propose to reduce spurious correlations for ABSA, via a novel Contrastive Variational Information Bottleneck framework (called CVIB). The proposed CVIB framework is composed of an original network and a self-pruned network, and these two networks are optimized simultaneously via contrastive learning. Concretely, we employ the Variational Information Bottleneck (VIB) principle to learn an informative and compressed network (self-pruned network) from the original network, which discards the superfluous patterns or spurious correlations between input features and prediction labels. Then, self-pruning contrastive learning is devised to pull together semantically similar positive pairs and push away dissimilar pairs, where the representations of the anchor learned by the original and self-pruned networks respectively are regarded as a positive pair while the representations of two different sentences within a mini-batch are treated as a negative pair. To verify the effectiveness of our CVIB method, we conduct extensive experiments on five benchmark ABSA datasets and the experimental results show that our approach achieves better performance than the strong competitors in terms of overall prediction performance, robustness, and generalization. Code and data to reproduce the results in this paper is available at: //github.com/shesshan/CVIB.
Incorporating prior knowledge into pre-trained language models has proven to be effective for knowledge-driven NLP tasks, such as entity typing and relation extraction. Current pre-training procedures usually inject external knowledge into models by using knowledge masking, knowledge fusion and knowledge replacement. However, factual information contained in the input sentences have not been fully mined, and the external knowledge for injecting have not been strictly checked. As a result, the context information cannot be fully exploited and extra noise will be introduced or the amount of knowledge injected is limited. To address these issues, we propose MLRIP, which modifies the knowledge masking strategies proposed by ERNIE-Baidu, and introduce a two-stage entity replacement strategy. Extensive experiments with comprehensive analyses illustrate the superiority of MLRIP over BERT-based models in military knowledge-driven NLP tasks.
Knowledge graphs (KGs) of real-world facts about entities and their relationships are useful resources for a variety of natural language processing tasks. However, because knowledge graphs are typically incomplete, it is useful to perform knowledge graph completion or link prediction, i.e. predict whether a relationship not in the knowledge graph is likely to be true. This paper serves as a comprehensive survey of embedding models of entities and relationships for knowledge graph completion, summarizing up-to-date experimental results on standard benchmark datasets and pointing out potential future research directions.
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