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Deformable image registration is an essential approach for medical image analysis.This paper introduces MambaMorph, an innovative multi-modality deformable registration network, specifically designed for Magnetic Resonance (MR) and Computed Tomography (CT) image alignment. MambaMorph stands out with its Mamba-based registration module and a contrastive feature learning approach, addressing the prevalent challenges in multi-modality registration. The network leverages Mamba blocks for efficient long-range modeling and high-dimensional data processing, coupled with a feature extractor that learns fine-grained features for enhanced registration accuracy. Experimental results showcase MambaMorph's superior performance over existing methods in MR-CT registration, underlining its potential in clinical applications. This work underscores the significance of feature learning in multi-modality registration and positions MambaMorph as a trailblazing solution in this field. The code for MambaMorph is available at: //github.com/Guo-Stone/MambaMorph.

Existing learning-based solutions to medical image segmentation have two important shortcomings. First, for most new segmentation task, a new model has to be trained or fine-tuned. This requires extensive resources and machine learning expertise, and is therefore often infeasible for medical researchers and clinicians. Second, most existing segmentation methods produce a single deterministic segmentation mask for a given image. In practice however, there is often considerable uncertainty about what constitutes the correct segmentation, and different expert annotators will often segment the same image differently. We tackle both of these problems with Tyche, a model that uses a context set to generate stochastic predictions for previously unseen tasks without the need to retrain. Tyche differs from other in-context segmentation methods in two important ways. (1) We introduce a novel convolution block architecture that enables interactions among predictions. (2) We introduce in-context test-time augmentation, a new mechanism to provide prediction stochasticity. When combined with appropriate model design and loss functions, Tyche can predict a set of plausible diverse segmentation candidates for new or unseen medical images and segmentation tasks without the need to retrain.

This work explores an emerging security threat against deep neural networks (DNNs) based image classification, i.e., backdoor attack. In this scenario, the attacker aims to inject a backdoor into the model by manipulating training data, such that the backdoor could be activated by a particular trigger and bootstraps the model to make a target prediction at inference. Currently, most existing data poisoning-based attacks struggle to achieve success at low poisoning ratios, increasing the risk of being defended by defense methods. In this paper, we propose a novel frequency-based backdoor attack via Wavelet Packet Decomposition (WPD), WPD decomposes the original image signal to a spectrogram that contains frequency information with different semantic meanings. We leverage WPD to statistically analyze the frequency distribution of the dataset to infer the key frequency regions the DNNs would focus on, and the trigger information is only injected into the key frequency regions. Our method mainly includes three parts: 1) the selection of the poisoning frequency regions in spectrogram; 2) trigger generation; 3) the generation of the poisoned dataset. Our method is stealthy and precise, evidenced by the 98.12% Attack Success Rate (ASR) on CIFAR-10 with the extremely low poisoning ratio 0.004% (i.e., only 2 poisoned samples among 50,000 training samples) and can bypass most existing defense methods. Besides, we also provide visualization analyses to explain why our method works.

In this paper, we present a novel deep image clustering approach termed PICI, which enforces the partial information discrimination and the cross-level interaction in a joint learning framework. In particular, we leverage a Transformer encoder as the backbone, through which the masked image modeling with two paralleled augmented views is formulated. After deriving the class tokens from the masked images by the Transformer encoder, three partial information learning modules are further incorporated, including the PISD module for training the auto-encoder via masked image reconstruction, the PICD module for employing two levels of contrastive learning, and the CLI module for mutual interaction between the instance-level and cluster-level subspaces. Extensive experiments have been conducted on six real-world image datasets, which demononstrate the superior clustering performance of the proposed PICI approach over the state-of-the-art deep clustering approaches. The source code is available at //github.com/Regan-Zhang/PICI.

Recent medical image reconstruction techniques focus on generating high-quality medical images suitable for clinical use at the lowest possible cost and with the fewest possible adverse effects on patients. Recent works have shown significant promise for reconstructing MR images from sparsely sampled k-space data using deep learning. In this work, we propose a technique that rapidly estimates deep neural networks directly at reconstruction time by fitting them on small adaptively estimated neighborhoods of a training set. In brief, our algorithm alternates between searching for neighbors in a data set that are similar to the test reconstruction, and training a local network on these neighbors followed by updating the test reconstruction. Because our reconstruction model is learned on a dataset that is in some sense similar to the image being reconstructed rather than being fit on a large, diverse training set, it is more adaptive to new scans. It can also handle changes in training sets and flexible scan settings, while being relatively fast. Our approach, dubbed LONDN-MRI, was validated on multiple data sets using deep unrolled reconstruction networks. Reconstructions were performed at four fold and eight fold undersampling of k-space with 1D variable-density random phase-encode undersampling masks. Our results demonstrate that our proposed locally-trained method produces higher-quality reconstructions compared to models trained globally on larger datasets as well as other scan-adaptive methods.

Graph neural networks (GNNs) have drawn increasing attention in recent years and achieved remarkable performance in many graph-based tasks, especially in semi-supervised learning on graphs. However, most existing GNNs are based on the message-passing paradigm to iteratively aggregate neighborhood information in a single topology space. Despite their success, the expressive power of GNNs is limited by some drawbacks, such as inflexibility of message source expansion, negligence of node-level message output discrepancy, and restriction of single message space. To address these drawbacks, we present a novel message-passing paradigm, based on the properties of multi-step message source, node-specific message output, and multi-space message interaction. To verify its validity, we instantiate the new message-passing paradigm as a Dual-Perception Graph Neural Network (DPGNN), which applies a node-to-step attention mechanism to aggregate node-specific multi-step neighborhood information adaptively. Our proposed DPGNN can capture the structural neighborhood information and the feature-related information simultaneously for graph representation learning. Experimental results on six benchmark datasets with different topological structures demonstrate that our method outperforms the latest state-of-the-art models, which proves the superiority and versatility of our method. To our knowledge, we are the first to consider node-specific message passing in the GNNs.

Recently, neural networks have been widely used in e-commerce recommender systems, owing to the rapid development of deep learning. We formalize the recommender system as a sequential recommendation problem, intending to predict the next items that the user might be interacted with. Recent works usually give an overall embedding from a user's behavior sequence. However, a unified user embedding cannot reflect the user's multiple interests during a period. In this paper, we propose a novel controllable multi-interest framework for the sequential recommendation, called ComiRec. Our multi-interest module captures multiple interests from user behavior sequences, which can be exploited for retrieving candidate items from the large-scale item pool. These items are then fed into an aggregation module to obtain the overall recommendation. The aggregation module leverages a controllable factor to balance the recommendation accuracy and diversity. We conduct experiments for the sequential recommendation on two real-world datasets, Amazon and Taobao. Experimental results demonstrate that our framework achieves significant improvements over state-of-the-art models. Our framework has also been successfully deployed on the offline Alibaba distributed cloud platform.

Since deep neural networks were developed, they have made huge contributions to everyday lives. Machine learning provides more rational advice than humans are capable of in almost every aspect of daily life. However, despite this achievement, the design and training of neural networks are still challenging and unpredictable procedures. To lower the technical thresholds for common users, automated hyper-parameter optimization (HPO) has become a popular topic in both academic and industrial areas. This paper provides a review of the most essential topics on HPO. The first section introduces the key hyper-parameters related to model training and structure, and discusses their importance and methods to define the value range. Then, the research focuses on major optimization algorithms and their applicability, covering their efficiency and accuracy especially for deep learning networks. This study next reviews major services and toolkits for HPO, comparing their support for state-of-the-art searching algorithms, feasibility with major deep learning frameworks, and extensibility for new modules designed by users. The paper concludes with problems that exist when HPO is applied to deep learning, a comparison between optimization algorithms, and prominent approaches for model evaluation with limited computational resources.

In this paper, we adopt 3D Convolutional Neural Networks to segment volumetric medical images. Although deep neural networks have been proven to be very effective on many 2D vision tasks, it is still challenging to apply them to 3D tasks due to the limited amount of annotated 3D data and limited computational resources. We propose a novel 3D-based coarse-to-fine framework to effectively and efficiently tackle these challenges. The proposed 3D-based framework outperforms the 2D counterpart to a large margin since it can leverage the rich spatial infor- mation along all three axes. We conduct experiments on two datasets which include healthy and pathological pancreases respectively, and achieve the current state-of-the-art in terms of Dice-S{\o}rensen Coefficient (DSC). On the NIH pancreas segmentation dataset, we outperform the previous best by an average of over 2%, and the worst case is improved by 7% to reach almost 70%, which indicates the reliability of our framework in clinical applications.

In this paper, we focus on three problems in deep learning based medical image segmentation. Firstly, U-net, as a popular model for medical image segmentation, is difficult to train when convolutional layers increase even though a deeper network usually has a better generalization ability because of more learnable parameters. Secondly, the exponential ReLU (ELU), as an alternative of ReLU, is not much different from ReLU when the network of interest gets deep. Thirdly, the Dice loss, as one of the pervasive loss functions for medical image segmentation, is not effective when the prediction is close to ground truth and will cause oscillation during training. To address the aforementioned three problems, we propose and validate a deeper network that can fit medical image datasets that are usually small in the sample size. Meanwhile, we propose a new loss function to accelerate the learning process and a combination of different activation functions to improve the network performance. Our experimental results suggest that our network is comparable or superior to state-of-the-art methods.