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Patient monitoring in intensive care units, although assisted by biosensors, needs continuous supervision of staff. To reduce the burden on staff members, IT infrastructures are built to record monitoring data and develop clinical decision support systems. These systems, however, are vulnerable to artifacts (e.g. muscle movement due to ongoing treatment), which are often indistinguishable from real and potentially dangerous signals. Video recordings could facilitate the reliable classification of biosignals using object detection (OD) methods to find sources of unwanted artifacts. Due to privacy restrictions, only blurred videos can be stored, which severely impairs the possibility to detect clinically relevant events such as interventions or changes in patient status with standard OD methods. Hence, new kinds of approaches are necessary that exploit every kind of available information due to the reduced information content of blurred footage and that are at the same time easily implementable within the IT infrastructure of a normal hospital. In this paper, we propose a new method for exploiting information in the temporal succession of video frames. To be efficiently implementable using off-the-shelf object detectors that comply with given hardware constraints, we repurpose the image color channels to account for temporal consistency, leading to an improved detection rate of the object classes. Our method outperforms a standard YOLOv5 baseline model by +1.7% [email protected] while also training over ten times faster on our proprietary dataset. We conclude that this approach has shown effectiveness in the preliminary experiments and holds potential for more general video OD in the future.

The large-scale vision-language models (e.g., CLIP) are leveraged by different methods to detect unseen objects. However, most of these works require additional captions or images for training, which is not feasible in the context of zero-shot detection. In contrast, the distillation-based method is an extra-data-free method, but it has its limitations. Specifically, existing work creates distillation regions that are biased to the base categories, which limits the distillation of novel category information and harms the distillation efficiency. Furthermore, directly using the raw feature from CLIP for distillation neglects the domain gap between the training data of CLIP and the detection datasets, which makes it difficult to learn the mapping from the image region to the vision-language feature space - an essential component for detecting unseen objects. As a result, existing distillation-based methods require an excessively long training schedule. To solve these problems, we propose Efficient feature distillation for Zero-Shot Detection (EZSD). Firstly, EZSD adapts the CLIP's feature space to the target detection domain by re-normalizing CLIP to bridge the domain gap; Secondly, EZSD uses CLIP to generate distillation proposals with potential novel instances, to avoid the distillation being overly biased to the base categories. Finally, EZSD takes advantage of semantic meaning for regression to further improve the model performance. As a result, EZSD achieves state-of-the-art performance in the COCO zero-shot benchmark with a much shorter training schedule and outperforms previous work by 4% in LVIS overall setting with 1/10 training time.

Text-to-image diffusion models have advanced towards more controllable generation via supporting various image conditions (e.g., depth map) beyond text. However, these models are learned based on the premise of perfect alignment between the text and image conditions. If this alignment is not satisfied, the final output could be either dominated by one condition, or ambiguity may arise, failing to meet user expectations. To address this issue, we present a training-free approach called "Decompose and Realign'' to further improve the controllability of existing models when provided with partially aligned conditions. The ``Decompose'' phase separates conditions based on pair relationships, computing scores individually for each pair. This ensures that each pair no longer has conflicting conditions. The "Realign'' phase aligns these independently calculated scores via a cross-attention mechanism to avoid new conflicts when combing them back. Both qualitative and quantitative results demonstrate the effectiveness of our approach in handling unaligned conditions, which performs favorably against recent methods and more importantly adds flexibility to the controllable image generation process.

Deep Learning (DL) models tend to perform poorly when the data comes from a distribution different from the training one. In critical applications such as medical imaging, out-of-distribution (OOD) detection helps to identify such data samples, increasing the model's reliability. Recent works have developed DL-based OOD detection that achieves promising results on 2D medical images. However, scaling most of these approaches on 3D images is computationally intractable. Furthermore, the current 3D solutions struggle to achieve acceptable results in detecting even synthetic OOD samples. Such limited performance might indicate that DL often inefficiently embeds large volumetric images. We argue that using the intensity histogram of the original CT or MRI scan as embedding is descriptive enough to run OOD detection. Therefore, we propose a histogram-based method that requires no DL and achieves almost perfect results in this domain. Our proposal is supported two-fold. We evaluate the performance on the publicly available datasets, where our method scores 1.0 AUROC in most setups. And we score second in the Medical Out-of-Distribution challenge without fine-tuning and exploiting task-specific knowledge. Carefully discussing the limitations, we conclude that our method solves the sample-level OOD detection on 3D medical images in the current setting.

We present DiffInfinite, a hierarchical diffusion model that generates arbitrarily large histological images while preserving long-range correlation structural information. Our approach first generates synthetic segmentation masks, subsequently used as conditions for the high-fidelity generative diffusion process. The proposed sampling method can be scaled up to any desired image size while only requiring small patches for fast training. Moreover, it can be parallelized more efficiently than previous large-content generation methods while avoiding tiling artefacts. The training leverages classifier-free guidance to augment a small, sparsely annotated dataset with unlabelled data. Our method alleviates unique challenges in histopathological imaging practice: large-scale information, costly manual annotation, and protective data handling. The biological plausibility of DiffInfinite data is validated in a survey by ten experienced pathologists as well as a downstream segmentation task. Furthermore, the model scores strongly on anti-copying metrics which is beneficial for the protection of patient data.

Recent advancements in large-scale text-to-image diffusion models have enabled many applications in image editing. However, none of these methods have been able to edit the layout of single existing images. To address this gap, we propose the first framework for layout editing of a single image while preserving its visual properties, thus allowing for continuous editing on a single image. Our approach is achieved through two key modules. First, to preserve the characteristics of multiple objects within an image, we disentangle the concepts of different objects and embed them into separate textual tokens using a novel method called masked textual inversion. Next, we propose a training-free optimization method to perform layout control for a pre-trained diffusion model, which allows us to regenerate images with learned concepts and align them with user-specified layouts. As the first framework to edit the layout of existing images, we demonstrate that our method is effective and outperforms other baselines that were modified to support this task. Our code will be freely available for public use upon acceptance.

Large multimodal language models (LMMs) have achieved significant success in general domains. However, due to the significant differences between medical images and text and general web content, the performance of LMMs in medical scenarios is limited. In ophthalmology, clinical diagnosis relies on multiple modalities of medical images, but unfortunately, multimodal ophthalmic large language models have not been explored to date. In this paper, we study and construct an ophthalmic large multimodal model. Firstly, we use fundus images as an entry point to build a disease assessment and diagnosis pipeline to achieve common ophthalmic disease diagnosis and lesion segmentation. Then, we establish a new ophthalmic multimodal instruction-following and dialogue fine-tuning dataset based on disease-related knowledge data and publicly available real-world medical dialogue. We introduce visual ability into the large language model to complete the ophthalmic large language and vision assistant (OphGLM). Our experimental results demonstrate that the OphGLM model performs exceptionally well, and it has the potential to revolutionize clinical applications in ophthalmology. The dataset, code, and models will be made publicly available at //github.com/ML-AILab/OphGLM.

Contrastive loss has been increasingly used in learning representations from multiple modalities. In the limit, the nature of the contrastive loss encourages modalities to exactly match each other in the latent space. Yet it remains an open question how the modality alignment affects the downstream task performance. In this paper, based on an information-theoretic argument, we first prove that exact modality alignment is sub-optimal in general for downstream prediction tasks. Hence we advocate that the key of better performance lies in meaningful latent modality structures instead of perfect modality alignment. To this end, we propose three general approaches to construct latent modality structures. Specifically, we design 1) a deep feature separation loss for intra-modality regularization; 2) a Brownian-bridge loss for inter-modality regularization; and 3) a geometric consistency loss for both intra- and inter-modality regularization. Extensive experiments are conducted on two popular multi-modal representation learning frameworks: the CLIP-based two-tower model and the ALBEF-based fusion model. We test our model on a variety of tasks including zero/few-shot image classification, image-text retrieval, visual question answering, visual reasoning, and visual entailment. Our method achieves consistent improvements over existing methods, demonstrating the effectiveness and generalizability of our proposed approach on latent modality structure regularization.

Benefit from the quick development of deep learning techniques, salient object detection has achieved remarkable progresses recently. However, there still exists following two major challenges that hinder its application in embedded devices, low resolution output and heavy model weight. To this end, this paper presents an accurate yet compact deep network for efficient salient object detection. More specifically, given a coarse saliency prediction in the deepest layer, we first employ residual learning to learn side-output residual features for saliency refinement, which can be achieved with very limited convolutional parameters while keep accuracy. Secondly, we further propose reverse attention to guide such side-output residual learning in a top-down manner. By erasing the current predicted salient regions from side-output features, the network can eventually explore the missing object parts and details which results in high resolution and accuracy. Experiments on six benchmark datasets demonstrate that the proposed approach compares favorably against state-of-the-art methods, and with advantages in terms of simplicity, efficiency (45 FPS) and model size (81 MB).