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Medical image segmentation aims to delineate the anatomical or pathological structures of interest, playing a crucial role in clinical diagnosis. A substantial amount of high-quality annotated data is crucial for constructing high-precision deep segmentation models. However, medical annotation is highly cumbersome and time-consuming, especially for medical videos or 3D volumes, due to the huge labeling space and poor inter-frame consistency. Recently, a fundamental task named Moving Object Segmentation (MOS) has made significant advancements in natural images. Its objective is to delineate moving objects from the background within image sequences, requiring only minimal annotations. In this paper, we propose the first foundation model, named iMOS, for MOS in medical images. Extensive experiments on a large multi-modal medical dataset validate the effectiveness of the proposed iMOS. Specifically, with the annotation of only a small number of images in the sequence, iMOS can achieve satisfactory tracking and segmentation performance of moving objects throughout the entire sequence in bi-directions. We hope that the proposed iMOS can help accelerate the annotation speed of experts, and boost the development of medical foundation models.

The brain-inspired Spiking Neural Networks (SNNs) have garnered considerable research interest due to their superior performance and energy efficiency in processing temporal signals. Recently, a novel multi-compartment spiking neuron model, namely the Two-Compartment LIF (TC-LIF) model, has been proposed and exhibited a remarkable capacity for sequential modelling. However, training the TC-LIF model presents challenges stemming from the large memory consumption and the issue of gradient vanishing associated with the Backpropagation Through Time (BPTT) algorithm. To address these challenges, online learning methodologies emerge as a promising solution. Yet, to date, the application of online learning methods in SNNs has been predominantly confined to simplified Leaky Integrate-and-Fire (LIF) neuron models. In this paper, we present a novel online learning method specifically tailored for networks of TC-LIF neurons. Additionally, we propose a refined TC-LIF neuron model called Adaptive TC-LIF, which is carefully designed to enhance temporal information integration in online learning scenarios. Extensive experiments, conducted on various sequential benchmarks, demonstrate that our approach successfully preserves the superior sequential modeling capabilities of the TC-LIF neuron while incorporating the training efficiency and hardware friendliness of online learning. As a result, it offers a multitude of opportunities to leverage neuromorphic solutions for processing temporal signals.

Punctuation restoration plays an essential role in the post-processing procedure of automatic speech recognition, but model efficiency is a key requirement for this task. To that end, we present EfficientPunct, an ensemble method with a multimodal time-delay neural network that outperforms the current best model by 1.0 F1 points, using less than a tenth of its inference network parameters. We streamline a speech recognizer to efficiently output hidden layer acoustic embeddings for punctuation restoration, as well as BERT to extract meaningful text embeddings. By using forced alignment and temporal convolutions, we eliminate the need for attention-based fusion, greatly increasing computational efficiency and raising performance. EfficientPunct sets a new state of the art with an ensemble that weights BERT's purely language-based predictions slightly more than the multimodal network's predictions. Our code is available at //github.com/lxy-peter/EfficientPunct.

Reduced-order models (ROMs) allow for the simulation of blood flow in patient-specific vasculatures without the high computational cost and wait time associated with traditional computational fluid dynamics (CFD) models. Unfortunately, due to the simplifications made in their formulations, ROMs can suffer from significantly reduced accuracy. One common simplifying assumption is the continuity of static or total pressure over vascular junctions. In many cases, this assumption has been shown to introduce significant error. We propose a model to account for this pressure difference, with the ultimate goal of increasing the accuracy of cardiovascular ROMs. Our model successfully uses a structure common in existing ROMs in conjunction with machine-learning techniques to predict the pressure difference over a vascular bifurcation. We analyze the performance of our model on steady and transient flows, testing it on three bifurcation cohorts representing three different bifurcation geometric types. We also compare the efficacy of different machine-learning techniques and two different model modalities.

The performance of stochastic gradient descent (SGD), which is the simplest first-order optimizer for training deep neural networks, depends on not only the learning rate but also the batch size. They both affect the number of iterations and the stochastic first-order oracle (SFO) complexity needed for training. In particular, the previous numerical results indicated that, for SGD using a constant learning rate, the number of iterations needed for training decreases when the batch size increases, and the SFO complexity needed for training is minimized at a critical batch size and that it increases once the batch size exceeds that size. Here, we study the relationship between batch size and the iteration and SFO complexities needed for nonconvex optimization in deep learning with SGD using constant or decaying learning rates and show that SGD using the critical batch size minimizes the SFO complexity. We also provide numerical comparisons of SGD with the existing first-order optimizers and show the usefulness of SGD using a critical batch size. Moreover, we show that measured critical batch sizes are close to the sizes estimated from our theoretical results.

Conceptual spaces represent entities in terms of their primitive semantic features. Such representations are highly valuable but they are notoriously difficult to learn, especially when it comes to modelling perceptual and subjective features. Distilling conceptual spaces from Large Language Models (LLMs) has recently emerged as a promising strategy. However, existing work has been limited to probing pre-trained LLMs using relatively simple zero-shot strategies. We focus in particular on the task of ranking entities according to a given conceptual space dimension. Unfortunately, we cannot directly fine-tune LLMs on this task, because ground truth rankings for conceptual space dimensions are rare. We therefore use more readily available features as training data and analyse whether the ranking capabilities of the resulting models transfer to perceptual and subjective features. We find that this is indeed the case, to some extent, but having perceptual and subjective features in the training data seems essential for achieving the best results. We furthermore find that pointwise ranking strategies are competitive against pairwise approaches, in defiance of common wisdom.

Traditional rigid endoscopes have challenges in flexibly treating tumors located deep in the brain, and low operability and fixed viewing angles limit its development. This study introduces a novel dual-segment flexible robotic endoscope MicroNeuro, designed to perform biopsies with dexterous surgical manipulation deep in the brain. Taking into account the uncertainty of the control model, an image-based visual servoing with online robot Jacobian estimation has been implemented to enhance motion accuracy. Furthermore, the application of model predictive control with constraints significantly bolsters the flexible robot's ability to adaptively track mobile objects and resist external interference. Experimental results underscore that the proposed control system enhances motion stability and precision. Phantom testing substantiates its considerable potential for deployment in neurosurgery.

Graph Convolutional Networks (GCNs) have been widely applied in various fields due to their significant power on processing graph-structured data. Typical GCN and its variants work under a homophily assumption (i.e., nodes with same class are prone to connect to each other), while ignoring the heterophily which exists in many real-world networks (i.e., nodes with different classes tend to form edges). Existing methods deal with heterophily by mainly aggregating higher-order neighborhoods or combing the immediate representations, which leads to noise and irrelevant information in the result. But these methods did not change the propagation mechanism which works under homophily assumption (that is a fundamental part of GCNs). This makes it difficult to distinguish the representation of nodes from different classes. To address this problem, in this paper we design a novel propagation mechanism, which can automatically change the propagation and aggregation process according to homophily or heterophily between node pairs. To adaptively learn the propagation process, we introduce two measurements of homophily degree between node pairs, which is learned based on topological and attribute information, respectively. Then we incorporate the learnable homophily degree into the graph convolution framework, which is trained in an end-to-end schema, enabling it to go beyond the assumption of homophily. More importantly, we theoretically prove that our model can constrain the similarity of representations between nodes according to their homophily degree. Experiments on seven real-world datasets demonstrate that this new approach outperforms the state-of-the-art methods under heterophily or low homophily, and gains competitive performance under homophily.

The dominating NLP paradigm of training a strong neural predictor to perform one task on a specific dataset has led to state-of-the-art performance in a variety of applications (eg. sentiment classification, span-prediction based question answering or machine translation). However, it builds upon the assumption that the data distribution is stationary, ie. that the data is sampled from a fixed distribution both at training and test time. This way of training is inconsistent with how we as humans are able to learn from and operate within a constantly changing stream of information. Moreover, it is ill-adapted to real-world use cases where the data distribution is expected to shift over the course of a model's lifetime. The first goal of this thesis is to characterize the different forms this shift can take in the context of natural language processing, and propose benchmarks and evaluation metrics to measure its effect on current deep learning architectures. We then proceed to take steps to mitigate the effect of distributional shift on NLP models. To this end, we develop methods based on parametric reformulations of the distributionally robust optimization framework. Empirically, we demonstrate that these approaches yield more robust models as demonstrated on a selection of realistic problems. In the third and final part of this thesis, we explore ways of efficiently adapting existing models to new domains or tasks. Our contribution to this topic takes inspiration from information geometry to derive a new gradient update rule which alleviate catastrophic forgetting issues during adaptation.

Multi-agent influence diagrams (MAIDs) are a popular form of graphical model that, for certain classes of games, have been shown to offer key complexity and explainability advantages over traditional extensive form game (EFG) representations. In this paper, we extend previous work on MAIDs by introducing the concept of a MAID subgame, as well as subgame perfect and trembling hand perfect equilibrium refinements. We then prove several equivalence results between MAIDs and EFGs. Finally, we describe an open source implementation for reasoning about MAIDs and computing their equilibria.