Frontotemporal dementia and Alzheimer's disease are two common forms of dementia and are easily misdiagnosed as each other due to their similar pattern of clinical symptoms. Differentiating between the two dementia types is crucial for determining disease-specific intervention and treatment. Recent development of Deep-learning-based approaches in the field of medical image computing are delivering some of the best performance for many binary classification tasks, although its application in differential diagnosis, such as neuroimage-based differentiation for multiple types of dementia, has not been explored. In this study, a novel framework was proposed by using the Generative Adversarial Network technique to distinguish FTD, AD and normal control subjects, using volumetric features extracted at coarse-to-fine structural scales from Magnetic Resonance Imaging scans. Experiments of 10-folds cross-validation on 1,954 images achieved high accuracy. With the proposed framework, we have demonstrated that the combination of multi-scale structural features and synthetic data augmentation based on generative adversarial network can improve the performance of challenging tasks such as differentiating Dementia sub-types.
Due to its powerful capability of representation learning and high-efficiency computation, deep hashing has made significant progress in large-scale image retrieval. However, deep hashing networks are vulnerable to adversarial examples, which is a practical secure problem but seldom studied in hashing-based retrieval field. In this paper, we propose a novel prototype-supervised adversarial network (ProS-GAN), which formulates a flexible generative architecture for efficient and effective targeted hashing attack. To the best of our knowledge, this is the first generation-based method to attack deep hashing networks. Generally, our proposed framework consists of three parts, i.e., a PrototypeNet, a generator, and a discriminator. Specifically, the designed PrototypeNet embeds the target label into the semantic representation and learns the prototype code as the category-level representative of the target label. Moreover, the semantic representation and the original image are jointly fed into the generator for a flexible targeted attack. Particularly, the prototype code is adopted to supervise the generator to construct the targeted adversarial example by minimizing the Hamming distance between the hash code of the adversarial example and the prototype code. Furthermore, the generator is against the discriminator to simultaneously encourage the adversarial examples visually realistic and the semantic representation informative. Extensive experiments verify that the proposed framework can efficiently produce adversarial examples with better targeted attack performance and transferability over state-of-the-art targeted attack methods of deep hashing. The related codes could be available at //github.com/xunguangwang/ProS-GAN .
Recent advances in maximizing mutual information (MI) between the source and target have demonstrated its effectiveness in text generation. However, previous works paid little attention to modeling the backward network of MI (i.e., dependency from the target to the source), which is crucial to the tightness of the variational information maximization lower bound. In this paper, we propose Adversarial Mutual Information (AMI): a text generation framework which is formed as a novel saddle point (min-max) optimization aiming to identify joint interactions between the source and target. Within this framework, the forward and backward networks are able to iteratively promote or demote each other's generated instances by comparing the real and synthetic data distributions. We also develop a latent noise sampling strategy that leverages random variations at the high-level semantic space to enhance the long term dependency in the generation process. Extensive experiments based on different text generation tasks demonstrate that the proposed AMI framework can significantly outperform several strong baselines, and we also show that AMI has potential to lead to a tighter lower bound of maximum mutual information for the variational information maximization problem.
Sufficient supervised information is crucial for any machine learning models to boost performance. However, labeling data is expensive and sometimes difficult to obtain. Active learning is an approach to acquire annotations for data from a human oracle by selecting informative samples with a high probability to enhance performance. In recent emerging studies, a generative adversarial network (GAN) has been integrated with active learning to generate good candidates to be presented to the oracle. In this paper, we propose a novel model that is able to obtain labels for data in a cheaper manner without the need to query an oracle. In the model, a novel reward for each sample is devised to measure the degree of uncertainty, which is obtained from a classifier trained with existing labeled data. This reward is used to guide a conditional GAN to generate informative samples with a higher probability for a certain label. With extensive evaluations, we have confirmed the effectiveness of the model, showing that the generated samples are capable of improving the classification performance in popular image classification tasks.
In this paper, we describe how to apply image-to-image translation techniques to medical blood smear data to generate new data samples and meaningfully increase small datasets. Specifically, given the segmentation mask of the microscopy image, we are able to generate photorealistic images of blood cells which are further used alongside real data during the network training for segmentation and object detection tasks. This image data generation approach is based on conditional generative adversarial networks which have proven capabilities to high-quality image synthesis. In addition to synthesizing blood images, we synthesize segmentation mask as well which leads to a diverse variety of generated samples. The effectiveness of the technique is thoroughly analyzed and quantified through a number of experiments on a manually collected and annotated dataset of blood smear taken under a microscope.
Thoracic diseases are very serious health problems that plague a large number of people. Chest X-ray is currently one of the most popular methods to diagnose thoracic diseases, playing an important role in the healthcare workflow. However, reading the chest X-ray images and giving an accurate diagnosis remain challenging tasks for expert radiologists. With the success of deep learning in computer vision, a growing number of deep neural network architectures were applied to chest X-ray image classification. However, most of the previous deep neural network classifiers were based on deterministic architectures which are usually very noise-sensitive and are likely to aggravate the overfitting issue. In this paper, to make a deep architecture more robust to noise and to reduce overfitting, we propose using deep generative classifiers to automatically diagnose thorax diseases from the chest X-ray images. Unlike the traditional deterministic classifier, a deep generative classifier has a distribution middle layer in the deep neural network. A sampling layer then draws a random sample from the distribution layer and input it to the following layer for classification. The classifier is generative because the class label is generated from samples of a related distribution. Through training the model with a certain amount of randomness, the deep generative classifiers are expected to be robust to noise and can reduce overfitting and then achieve good performances. We implemented our deep generative classifiers based on a number of well-known deterministic neural network architectures, and tested our models on the chest X-ray14 dataset. The results demonstrated the superiority of deep generative classifiers compared with the corresponding deep deterministic classifiers.
Network embedding has become a hot research topic recently which can provide low-dimensional feature representations for many machine learning applications. Current work focuses on either (1) whether the embedding is designed as an unsupervised learning task by explicitly preserving the structural connectivity in the network, or (2) whether the embedding is a by-product during the supervised learning of a specific discriminative task in a deep neural network. In this paper, we focus on bridging the gap of the two lines of the research. We propose to adapt the Generative Adversarial model to perform network embedding, in which the generator is trying to generate vertex pairs, while the discriminator tries to distinguish the generated vertex pairs from real connections (edges) in the network. Wasserstein-1 distance is adopted to train the generator to gain better stability. We develop three variations of models, including GANE which applies cosine similarity, GANE-O1 which preserves the first-order proximity, and GANE-O2 which tries to preserves the second-order proximity of the network in the low-dimensional embedded vector space. We later prove that GANE-O2 has the same objective function as GANE-O1 when negative sampling is applied to simplify the training process in GANE-O2. Experiments with real-world network datasets demonstrate that our models constantly outperform state-of-the-art solutions with significant improvements on precision in link prediction, as well as on visualizations and accuracy in clustering tasks.
Recently introduced generative adversarial network (GAN) has been shown numerous promising results to generate realistic samples. The essential task of GAN is to control the features of samples generated from a random distribution. While the current GAN structures, such as conditional GAN, successfully generate samples with desired major features, they often fail to produce detailed features that bring specific differences among samples. To overcome this limitation, here we propose a controllable GAN (ControlGAN) structure. By separating a feature classifier from a discriminator, the generator of ControlGAN is designed to learn generating synthetic samples with the specific detailed features. Evaluated with multiple image datasets, ControlGAN shows a power to generate improved samples with well-controlled features. Furthermore, we demonstrate that ControlGAN can generate intermediate features and opposite features for interpolated and extrapolated input labels that are not used in the training process. It implies that ControlGAN can significantly contribute to the variety of generated samples.
Person Re-identification (re-id) faces two major challenges: the lack of cross-view paired training data and learning discriminative identity-sensitive and view-invariant features in the presence of large pose variations. In this work, we address both problems by proposing a novel deep person image generation model for synthesizing realistic person images conditional on the pose. The model is based on a generative adversarial network (GAN) designed specifically for pose normalization in re-id, thus termed pose-normalization GAN (PN-GAN). With the synthesized images, we can learn a new type of deep re-id feature free of the influence of pose variations. We show that this feature is strong on its own and complementary to features learned with the original images. Importantly, under the transfer learning setting, we show that our model generalizes well to any new re-id dataset without the need for collecting any training data for model fine-tuning. The model thus has the potential to make re-id model truly scalable.
In this paper, we propose the Cross-Domain Adversarial Auto-Encoder (CDAAE) to address the problem of cross-domain image inference, generation and transformation. We make the assumption that images from different domains share the same latent code space for content, while having separate latent code space for style. The proposed framework can map cross-domain data to a latent code vector consisting of a content part and a style part. The latent code vector is matched with a prior distribution so that we can generate meaningful samples from any part of the prior space. Consequently, given a sample of one domain, our framework can generate various samples of the other domain with the same content of the input. This makes the proposed framework different from the current work of cross-domain transformation. Besides, the proposed framework can be trained with both labeled and unlabeled data, which makes it also suitable for domain adaptation. Experimental results on data sets SVHN, MNIST and CASIA show the proposed framework achieved visually appealing performance for image generation task. Besides, we also demonstrate the proposed method achieved superior results for domain adaptation. Code of our experiments is available in //github.com/luckycallor/CDAAE.
Domain Adaptation is an actively researched problem in Computer Vision. In this work, we propose an approach that leverages unsupervised data to bring the source and target distributions closer in a learned joint feature space. We accomplish this by inducing a symbiotic relationship between the learned embedding and a generative adversarial network. This is in contrast to methods which use the adversarial framework for realistic data generation and retraining deep models with such data. We demonstrate the strength and generality of our approach by performing experiments on three different tasks with varying levels of difficulty: (1) Digit classification (MNIST, SVHN and USPS datasets) (2) Object recognition using OFFICE dataset and (3) Domain adaptation from synthetic to real data. Our method achieves state-of-the art performance in most experimental settings and by far the only GAN-based method that has been shown to work well across different datasets such as OFFICE and DIGITS.