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Intraoperative ultrasound (iUS) imaging has the potential to improve surgical outcomes in brain surgery. However, its interpretation is challenging, even for expert neurosurgeons. In this work, we designed the first patient-specific framework that performs brain tumor segmentation in trackerless iUS. To disambiguate ultrasound imaging and adapt to the neurosurgeon's surgical objective, a patient-specific real-time network is trained using synthetic ultrasound data generated by simulating virtual iUS sweep acquisitions in pre-operative MR data. Extensive experiments performed in real ultrasound data demonstrate the effectiveness of the proposed approach, allowing for adapting to the surgeon's definition of surgical targets and outperforming non-patient-specific models, neurosurgeon experts, and high-end tracking systems. Our code is available at: \url{//github.com/ReubenDo/MHVAE-Seg}.

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The widespread application of Large Language Models (LLMs) across various tasks and fields has necessitated the alignment of these models with human values and preferences. Given various approaches of human value alignment, ranging from Reinforcement Learning with Human Feedback (RLHF), to constitutional learning, etc. there is an urgent need to understand the scope and nature of human values injected into these models before their release. There is also a need for model alignment without a costly large scale human annotation effort. We propose UniVaR, a high-dimensional representation of human value distributions in LLMs, orthogonal to model architecture and training data. Trained from the value-relevant output of eight multilingual LLMs and tested on the output from four multilingual LLMs, namely LlaMA2, ChatGPT, JAIS and Yi, we show that UniVaR is a powerful tool to compare the distribution of human values embedded in different LLMs with different langauge sources. Through UniVaR, we explore how different LLMs prioritize various values in different languages and cultures, shedding light on the complex interplay between human values and language modeling.

Structure-Based Drug Design (SBDD) focuses on generating valid ligands that strongly and specifically bind to a designated protein pocket. Several methods use machine learning for SBDD to generate these ligands in 3D space, conditioned on the structure of a desired protein pocket. Recently, diffusion models have shown success here by modeling the underlying distributions of atomic positions and types. While these methods are effective in considering the structural details of the protein pocket, they often fail to explicitly consider the binding affinity. Binding affinity characterizes how tightly the ligand binds to the protein pocket, and is measured by the change in free energy associated with the binding process. It is one of the most crucial metrics for benchmarking the effectiveness of the interaction between a ligand and protein pocket. To address this, we propose BADGER: Binding Affinity Diffusion Guidance with Enhanced Refinement. BADGER is a general guidance method to steer the diffusion sampling process towards improved protein-ligand binding, allowing us to adjust the distribution of the binding affinity between ligands and proteins. Our method is enabled by using a neural network (NN) to model the energy function, which is commonly approximated by AutoDock Vina (ADV). ADV's energy function is non-differentiable, and estimates the affinity based on the interactions between a ligand and target protein receptor. By using a NN as a differentiable energy function proxy, we utilize the gradient of our learned energy function as a guidance method on top of any trained diffusion model. We show that our method improves the binding affinity of generated ligands to their protein receptors by up to 60\%, significantly surpassing previous machine learning methods. We also show that our guidance method is flexible and can be easily applied to other diffusion-based SBDD frameworks.

Prompting Large Language Models (LLMs) has created new and interesting means for classifying textual data. While evaluating and remediating group fairness is a well-studied problem in classifier fairness literature, some classical approaches (e.g., regularization) do not carry over, and some new opportunities arise (e.g., prompt-based remediation). We measure fairness of LLM-based classifiers on a toxicity classification task, and empirically show that prompt-based classifiers may lead to unfair decisions. We introduce several remediation techniques and benchmark their fairness and performance trade-offs. We hope our work encourages more research on group fairness in LLM-based classifiers.

Combinatorial Optimization is crucial to numerous real-world applications, yet still presents challenges due to its (NP-)hard nature. Amongst existing approaches, heuristics often offer the best trade-off between quality and scalability, making them suitable for industrial use. While Reinforcement Learning (RL) offers a flexible framework for designing heuristics, its adoption over handcrafted heuristics remains incomplete within industrial solvers. Existing learned methods still lack the ability to adapt to specific instances and fully leverage the available computational budget. The current best methods either rely on a collection of pre-trained policies, or on data-inefficient fine-tuning; hence failing to fully utilize newly available information within the constraints of the budget. In response, we present MEMENTO, an RL approach that leverages memory to improve the adaptation of neural solvers at inference time. MEMENTO enables updating the action distribution dynamically based on the outcome of previous decisions. We validate its effectiveness on benchmark problems, in particular Traveling Salesman and Capacitated Vehicle Routing, demonstrating it can successfully be combined with standard methods to boost their performance under a given budget, both in and out-of-distribution, improving their performance on all 12 evaluated tasks.

Accelerating iterative eigenvalue algorithms is often achieved by employing a spectral shifting strategy. Unfortunately, improved shifting typically leads to a smaller eigenvalue for the resulting shifted operator, which in turn results in a high condition number of the underlying solution matrix, posing a major challenge for iterative linear solvers. This paper introduces a two-level domain decomposition preconditioner that addresses this issue for the linear Schr\"odinger eigenvalue problem, even in the presence of a vanishing eigenvalue gap in non-uniform, expanding domains. Since the quasi-optimal shift, which is already available as the solution to a spectral cell problem, is required for the eigenvalue solver, it is logical to also use its associated eigenfunction as a generator to construct a coarse space. We analyze the resulting two-level additive Schwarz preconditioner and obtain a condition number bound that is independent of the domain's anisotropy, despite the need for only one basis function per subdomain for the coarse solver. Several numerical examples are presented to illustrate its flexibility and efficiency.

Magnetic Particle Imaging is an emerging imaging modality through which it is possible to detect tracers containing superparamagnetic nanoparticles. The exposure of the particles to dynamic magnetic fields generates a non-linear response that is used to locate the particles and produce an image of their distribution. The bounding box that can be covered by a single scan curve depends on the strength of the gradients of the magnetic fields applied, which is limited due to the risk of causing peripheral nerve stimulation (PNS) in the patients. To address this issue, multiple scans are performed. The scan data must be merged together to produce reconstructions of larger regions of interest. In this paper we propose a mathematical framework which can deal with rather general multi-patching scenarios including rigid transformations of the field of view (FoV), the specimen and of the scanner. We show the flexibility of this framework in a variety of different scanning scenarios. Moreover, we describe an iterative reconstruction algorithm that yields a reconstruction of the target distribution by minimizing a convex functional which includes positivity constraints and sparsity enforcing priors. We show its convergence to a minimizer and perform numerical experiments on simulated data.

Acoustic features play an important role in improving the quality of the synthesised speech. Currently, the Mel spectrogram is a widely employed acoustic feature in most acoustic models. However, due to the fine-grained loss caused by its Fourier transform process, the clarity of speech synthesised by Mel spectrogram is compromised in mutant signals. In order to obtain a more detailed Mel spectrogram, we propose a Mel spectrogram enhancement paradigm based on the continuous wavelet transform (CWT). This paradigm introduces an additional task: a more detailed wavelet spectrogram, which like the post-processing network takes as input the Mel spectrogram output by the decoder. We choose Tacotron2 and Fastspeech2 for experimental validation in order to test autoregressive (AR) and non-autoregressive (NAR) speech systems, respectively. The experimental results demonstrate that the speech synthesised using the model with the Mel spectrogram enhancement paradigm exhibits higher MOS, with an improvement of 0.14 and 0.09 compared to the baseline model, respectively. These findings provide some validation for the universality of the enhancement paradigm, as they demonstrate the success of the paradigm in different architectures.

Machine unlearning is an emerging technology that has come to attract widespread attention. A number of factors, including regulations and laws, privacy, and usability concerns, have resulted in this need to allow a trained model to forget some of its training data. Existing studies of machine unlearning mainly focus on unlearning requests that forget a cluster of instances or all instances from one class. While these approaches are effective in removing instances, they do not scale to scenarios where partial targets within an instance need to be forgotten. For example, one would like to only unlearn a person from all instances that simultaneously contain the person and other targets. Directly migrating instance-level unlearning to target-level unlearning will reduce the performance of the model after the unlearning process, or fail to erase information completely. To address these concerns, we have proposed a more effective and efficient unlearning scheme that focuses on removing partial targets from the model, which we name "target unlearning". Specifically, we first construct an essential graph data structure to describe the relationships between all important parameters that are selected based on the model explanation method. After that, we simultaneously filter parameters that are also important for the remaining targets and use the pruning-based unlearning method, which is a simple but effective solution to remove information about the target that needs to be forgotten. Experiments with different training models on various datasets demonstrate the effectiveness of the proposed approach.

Unmanned Aerial Vehicles (UAVs) have become increasingly popular in various applications, especially with the emergence of 6G systems and networks. However, their widespread adoption has also led to concerns regarding security vulnerabilities, making the development of reliable intrusion detection systems (IDS) essential for ensuring UAVs safety and mission success. This paper presents a new IDS for UAV networks. A binary-tuple representation was used for encoding class labels, along with a deep learning-based approach employed for classification. The proposed system enhances the intrusion detection by capturing complex class relationships and temporal network patterns. Moreover, a cross-correlation study between common features of different UAVs was conducted to discard correlated features that might mislead the classification of the proposed IDS. The full study was carried out using the UAV-IDS-2020 dataset, and we assessed the performance of the proposed IDS using different evaluation metrics. The experimental results highlighted the effectiveness of the proposed multiclass classifier model with an accuracy of 95%.

The problem of Multiple Object Tracking (MOT) consists in following the trajectory of different objects in a sequence, usually a video. In recent years, with the rise of Deep Learning, the algorithms that provide a solution to this problem have benefited from the representational power of deep models. This paper provides a comprehensive survey on works that employ Deep Learning models to solve the task of MOT on single-camera videos. Four main steps in MOT algorithms are identified, and an in-depth review of how Deep Learning was employed in each one of these stages is presented. A complete experimental comparison of the presented works on the three MOTChallenge datasets is also provided, identifying a number of similarities among the top-performing methods and presenting some possible future research directions.

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