One of the fundamental challenges in drawing causal inferences from observational studies is that the assumption of no unmeasured confounding is not testable from observed data. Therefore, assessing sensitivity to this assumption's violation is important to obtain valid causal conclusions in observational studies. Although several sensitivity analysis frameworks are available in the casual inference literature, very few of them are applicable to observational studies with multivalued treatments. To address this issue, we propose a sensitivity analysis framework for performing sensitivity analysis in multivalued treatment settings. Within this framework, a general class of additive causal estimands has been proposed. We demonstrate that the estimation of the causal estimands under the proposed sensitivity model can be performed very efficiently. Simulation results show that the proposed framework performs well in terms of bias of the point estimates and coverage of the confidence intervals when there is sufficient overlap in the covariate distributions. We illustrate the application of our proposed method by conducting an observational study that estimates the causal effect of fish consumption on blood mercury levels.
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Machine teaching often involves the creation of an optimal (typically minimal) dataset to help a model (referred to as the `student') achieve specific goals given by a teacher. While abundant in the continuous domain, the studies on the effectiveness of machine teaching in the discrete domain are relatively limited. This paper focuses on machine teaching in the discrete domain, specifically on manipulating student models' predictions based on the goals of teachers via changing the training data efficiently. We formulate this task as a combinatorial optimization problem and solve it by proposing an iterative searching algorithm. Our algorithm demonstrates significant numerical merit in the scenarios where a teacher attempts at correcting erroneous predictions to improve the student's models, or maliciously manipulating the model to misclassify some specific samples to the target class aligned with his personal profits. Experimental results show that our proposed algorithm can have superior performance in effectively and efficiently manipulating the predictions of the model, surpassing conventional baselines.
A comprehensive understanding of the organizational principles in the human brain requires, among other factors, well-quantifiable descriptors of nerve fiber architecture. Three-dimensional polarized light imaging (3D-PLI) is a microscopic imaging technique that enables insights into the fine-grained organization of myelinated nerve fibers with high resolution. Descriptors characterizing the fiber architecture observed in 3D-PLI would enable downstream analysis tasks such as multimodal correlation studies, clustering, and mapping. However, best practices for observer-independent characterization of fiber architecture in 3D-PLI are not yet available. To this end, we propose the application of a fully data-driven approach to characterize nerve fiber architecture in 3D-PLI images using self-supervised representation learning. We introduce a 3D-Context Contrastive Learning (CL-3D) objective that utilizes the spatial neighborhood of texture examples across histological brain sections of a 3D reconstructed volume to sample positive pairs for contrastive learning. We combine this sampling strategy with specifically designed image augmentations to gain robustness to typical variations in 3D-PLI parameter maps. The approach is demonstrated for the 3D reconstructed occipital lobe of a vervet monkey brain. We show that extracted features are highly sensitive to different configurations of nerve fibers, yet robust to variations between consecutive brain sections arising from histological processing. We demonstrate their practical applicability for retrieving clusters of homogeneous fiber architecture and performing data mining for interactively selected templates of specific components of fiber architecture such as U-fibers.
Sequential neural posterior estimation (SNPE) techniques have been recently proposed for dealing with simulation-based models with intractable likelihoods. They are devoted to learning the posterior from adaptively proposed simulations using neural network-based conditional density estimators. As a SNPE technique, the automatic posterior transformation (APT) method proposed by Greenberg et al. (2019) performs notably and scales to high dimensional data. However, the APT method bears the computation of an expectation of the logarithm of an intractable normalizing constant, i.e., a nested expectation. Although atomic APT was proposed to solve this by discretizing the normalizing constant, it remains challenging to analyze the convergence of learning. In this paper, we propose a nested APT method to estimate the involved nested expectation instead. This facilitates establishing the convergence analysis. Since the nested estimators for the loss function and its gradient are biased, we make use of unbiased multi-level Monte Carlo (MLMC) estimators for debiasing. To further reduce the excessive variance of the unbiased estimators, this paper also develops some truncated MLMC estimators by taking account of the trade-off between the bias and the average cost. Numerical experiments for approximating complex posteriors with multimodal in moderate dimensions are provided.
In continual RL, the environment of a reinforcement learning (RL) agent undergoes change. A successful system should appropriately balance the conflicting requirements of retaining agent performance on already learned tasks, stability, whilst learning new tasks, plasticity. The first-in-first-out buffer is commonly used to enhance learning in such settings but requires significant memory. We explore the application of an augmentation to this buffer which alleviates the memory constraints, and use it with a world model model-based reinforcement learning algorithm, to evaluate its effectiveness in facilitating continual learning. We evaluate the effectiveness of our method in Procgen and Atari RL benchmarks and show that the distribution matching augmentation to the replay-buffer used in the context of latent world models can successfully prevent catastrophic forgetting with significantly reduced computational overhead. Yet, we also find such a solution to not be entirely infallible, and other failure modes such as the opposite -- lacking plasticity and being unable to learn a new task -- to be a potential limitation in continual learning systems.
In hypothesis testing problems, taking samples sequentially and stopping opportunistically to make the inference greatly enhances the reliability. The design of the stopping and inference policy, however, critically relies on the knowledge of the underlying distribution of each hypothesis. When the knowledge of distributions, say, $P_0$ and $P_1$ in the binary-hypothesis case, is replaced by empirically observed statistics from the respective distributions, the gain of sequentiality is less understood when subject to universality constraints. In this work, the gap is mended by a unified study on sequentiality in the universal binary classification problem. We propose a unified framework where the universality constraints are set on the expected stopping time as well as the type-I error exponent. The type-I error exponent is required to achieve a pre-set distribution-dependent constraint $\lambda(P_0,P_1)$ for all $P_0,P_1$. The framework is employed to investigate a semi-sequential and a fully-sequential setup, so that fair comparison can be made with the fixed-length setup. The optimal type-II error exponents in different setups are characterized when the function $\lambda$ satisfies mild continuity conditions. The benefit of sequentiality is shown by comparing the semi-sequential, the fully-sequential, and the fixed-length cases in representative examples of $\lambda$. Conditions under which sequentiality eradicates the trade-off between error exponents are also derived.
We present an approach to outsourcing of training neural networks while preserving data confidentiality from malicious parties. We use fully homomorphic encryption to build a unified training approach that works on encrypted data and learns quantized neural network models. The data can be horizontally or vertically split between multiple parties, enabling collaboration on confidential data. We train logistic regression and multi-layer perceptrons on several datasets.
Dialogue systems controlled by predefined or rule-based scenarios derived from counseling techniques, such as cognitive behavioral therapy (CBT), play an important role in mental health apps. Despite the need for responsible responses, it is conceivable that using the newly emerging LLMs to generate contextually relevant utterances will enhance these apps. In this study, we construct dialogue modules based on a CBT scenario focused on conventional Socratic questioning using two kinds of LLMs: a Transformer-based dialogue model further trained with a social media empathetic counseling dataset, provided by Osaka Prefecture (OsakaED), and GPT-4, a state-of-the art LLM created by OpenAI. By comparing systems that use LLM-generated responses with those that do not, we investigate the impact of generated responses on subjective evaluations such as mood change, cognitive change, and dialogue quality (e.g., empathy). As a result, no notable improvements are observed when using the OsakaED model. When using GPT-4, the amount of mood change, empathy, and other dialogue qualities improve significantly. Results suggest that GPT-4 possesses a high counseling ability. However, they also indicate that even when using a dialogue model trained with a human counseling dataset, it does not necessarily yield better outcomes compared to scenario-based dialogues. While presenting LLM-generated responses, including GPT-4, and having them interact directly with users in real-life mental health care services may raise ethical issues, it is still possible for human professionals to produce example responses or response templates using LLMs in advance in systems that use rules, scenarios, or example responses.
The attribution of question answering is to provide citations for supporting generated statements, and has attracted wide research attention. The current methods for automatically evaluating the attribution, which are often based on Large Language Models (LLMs), are still inadequate, particularly in recognizing subtle differences between attributions, and complex relationships between citations and statements. To compare these attribution evaluation methods and develop new ones, we introduce a set of fine-grained categories (i.e., supportive, insufficient, contradictory and irrelevant) for measuring the attribution, and develop a Complex Attributed Question Answering (CAQA) benchmark by leveraging knowledge graphs (KGs) for automatically generating attributions of different categories to question-answer pairs. Our analysis reveals that existing evaluators perform poorly under fine-grained attribution settings and exhibit weaknesses in complex citation-statement reasoning. Our CAQA benchmark, validated with human annotations, emerges as a promising tool for selecting and developing LLM attribution evaluators.
Emotion recognition in conversation (ERC) aims to detect the emotion label for each utterance. Motivated by recent studies which have proven that feeding training examples in a meaningful order rather than considering them randomly can boost the performance of models, we propose an ERC-oriented hybrid curriculum learning framework. Our framework consists of two curricula: (1) conversation-level curriculum (CC); and (2) utterance-level curriculum (UC). In CC, we construct a difficulty measurer based on "emotion shift" frequency within a conversation, then the conversations are scheduled in an "easy to hard" schema according to the difficulty score returned by the difficulty measurer. For UC, it is implemented from an emotion-similarity perspective, which progressively strengthens the model's ability in identifying the confusing emotions. With the proposed model-agnostic hybrid curriculum learning strategy, we observe significant performance boosts over a wide range of existing ERC models and we are able to achieve new state-of-the-art results on four public ERC datasets.
Incompleteness is a common problem for existing knowledge graphs (KGs), and the completion of KG which aims to predict links between entities is challenging. Most existing KG completion methods only consider the direct relation between nodes and ignore the relation paths which contain useful information for link prediction. Recently, a few methods take relation paths into consideration but pay less attention to the order of relations in paths which is important for reasoning. In addition, these path-based models always ignore nonlinear contributions of path features for link prediction. To solve these problems, we propose a novel KG completion method named OPTransE. Instead of embedding both entities of a relation into the same latent space as in previous methods, we project the head entity and the tail entity of each relation into different spaces to guarantee the order of relations in the path. Meanwhile, we adopt a pooling strategy to extract nonlinear and complex features of different paths to further improve the performance of link prediction. Experimental results on two benchmark datasets show that the proposed model OPTransE performs better than state-of-the-art methods.
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