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Multiplex immunofluorescence (mIF) imaging technology facilitates the study of the tumour microenvironment in cancer patients. Due to the capabilities of this emerging bioimaging technique, it is possible to statistically analyse, for example, the co-varying location and functions of multiple different types of immune cells. Complex spatial relationships between different immune cells have been shown to correlate with patient outcomes and may reveal new pathways for targeted immunotherapy treatments. This tutorial reviews methods and procedures relating to spatial point patterns for complex data analysis. We consider tissue cells as a realisation of a spatial point process for each patient. We focus on proper functional descriptors for each observation and techniques that allow us to obtain information about inter-patient variation. Ovarian cancer is the deadliest gynaecological malignancy and can resist chemotherapy treatment effective in cancers. We use a dataset of high-grade serous ovarian cancer samples from 51 patients. We examine the immune cell composition (T cells, B cells, macrophages) within tumours and additional information such as cell classification (tumour or stroma) and other patient clinical characteristics. Our analyses, supported by reproducible software, apply to other digital pathology datasets.

Generative AI has made significant strides, yet concerns about the accuracy and reliability of its outputs continue to grow. Such inaccuracies can have serious consequences such as inaccurate decision-making, the spread of false information, privacy violations, legal liabilities, and more. Although efforts to address these risks are underway, including explainable AI and responsible AI practices such as transparency, privacy protection, bias mitigation, and social and environmental responsibility, misinformation caused by generative AI will remain a significant challenge. We propose that verifying the outputs of generative AI from a data management perspective is an emerging issue for generative AI. This involves analyzing the underlying data from multi-modal data lakes, including text files, tables, and knowledge graphs, and assessing its quality and consistency. By doing so, we can establish a stronger foundation for evaluating the outputs of generative AI models. Such an approach can ensure the correctness of generative AI, promote transparency, and enable decision-making with greater confidence. Our vision is to promote the development of verifiable generative AI and contribute to a more trustworthy and responsible use of AI.

Background: A good search strategy is essential for a successful systematic literature study. Historically, database searches have been the norm, which has later been complemented with snowball searches. Our conjecture is that we can perform even better searches if combining the two search approaches, referred to as a hybrid search strategy. Objective: Our main objective was to compare and evaluate a hybrid search strategy. Furthermore, we compared some alternative hybrid search strategies to assess whether it was possible to identify more cost-efficient ways of searching for relevant primary studies. Method: To compare and evaluate the hybrid search strategy, we replicated an SLR on industry-academia collaboration in software engineering. The SLR used a more traditional approach to searching for relevant articles for an SLR, while the replication was conducted using a hybrid search strategy. Results: In our evaluation, the hybrid search strategy was superior in identifying relevant primary studies. It identified 30 percent more primary studies and even more when focusing only on peer-reviewed articles. To embrace individual viewpoints when assessing research articles and minimise the risk of missing primary studies, we introduced two new concepts, wild cards and borderline articles, when conducting systematic literature studies. Conclusions: The hybrid search strategy is a strong contender for being used when conducting systematic literature studies. Furthermore, alternative hybrid search strategies may be viable if selected wisely in relation to the start set for snowballing. Finally, the two new concepts were judged as essential to cater for different individual judgements and to minimise the risk of excluding primary studies that ought to be included.

Elevator systems are one kind of Cyber-Physical Systems (CPSs), and as such, test cases are usually complex and long in time. This is mainly because realistic test scenarios are employed (e.g., for testing elevator dispatching algorithms, typically a full day of passengers traveling through a system of elevators is used). However, in such a context, when needing to reproduce a failure, it is of high benefit to provide the minimal test input to the software developers. This way, analyzing and trying to localize the root-cause of the failure is easier and more agile. Delta debugging has been found to be an efficient technique to reduce failure-inducing test inputs. In this paper, we enhance this technique by first monitoring the environment at which the CPS operates as well as its physical states. With the monitored information, we search for stable states of the CPS during the execution of the simulation. In a second step, we use such identified stable states to help the delta debugging algorithm isolate the failure-inducing test inputs more efficiently. We report our experience of applying our approach into an industrial elevator dispatching algorithm. An empirical evaluation carried out with real operational data from a real installation of elevators suggests that the proposed environment-wise delta debugging algorithm is between 1.3 to 1.8 times faster than the traditional delta debugging, while producing a larger reduction in the failure-inducing test inputs. The results provided by the different implemented delta debugging algorithm versions are qualitatively assessed with domain experts. This assessment provides new insights and lessons learned, such as, potential applications of the delta debugging algorithm beyond debugging.

Alzheimer's disease (AD) cannot be reversed, but early diagnosis will significantly benefit patients' medical treatment and care. In recent works, AD diagnosis has the primary assumption that all categories are known a prior -- a closed-set classification problem, which contrasts with the open-set recognition problem. This assumption hinders the application of the model in natural clinical settings. Although many open-set recognition technologies have been proposed in other fields, they are challenging to use for AD diagnosis directly since 1) AD is a degenerative disease of the nervous system with similar symptoms at each stage, and it is difficult to distinguish from its pre-state, and 2) diversified strategies for AD diagnosis are challenging to model uniformly. In this work, inspired by the concerns of clinicians during diagnosis, we propose an open-set recognition model, OpenAPMax, based on the anomaly pattern to address AD diagnosis in real-world settings. OpenAPMax first obtains the abnormal pattern of each patient relative to each known category through statistics or a literature search, clusters the patients' abnormal pattern, and finally, uses extreme value theory (EVT) to model the distance between each patient's abnormal pattern and the center of their category and modify the classification probability. We evaluate the performance of the proposed method with recent open-set recognition, where we obtain state-of-the-art results.

Large language models(LLMs) have shown excellent text generation capabilities, but there is still much space for improvement in accuracy, sometimes with grammatical errors, semantic inaccuracies, and contextual incoherence, which seriously affect the reliability of the models. These problems may originate from the difficulties and limitations encountered in the pattern extraction stage of large language models. How to utilize the generative power of large language models to generate as many possible patterns that help solve problems and find the optimal patterns from them, so as to use patterns to guide large language models to generate good content, has become a current research hotspot. In this paper, we propose a pattern extraction and selection framework, PatternGPT, which generates rich patterns through the extraction ability of large language models and draws on the idea of federation learning, where multiple agents collaborate with each other to generate diverse patterns. High-quality patterns are selected by defining criteria and optimization algorithms to personalize the guidance of the model generation process. PatternGPT has the advantages of generating diverse and useful patterns, extending relevant knowledge, facilitating efficient pattern use and transfer, and optimizing the quality of generated results and user experience, which provides an effective method for optimizing the text generation capability of large language models and is expected to drive further development in the field of intelligent dialogue and content generation. It is expected to promote further development in the field of intelligent dialogue and content generation.

Edge computing facilitates low-latency services at the network's edge by distributing computation, communication, and storage resources within the geographic proximity of mobile and Internet-of-Things (IoT) devices. The recent advancement in Unmanned Aerial Vehicles (UAVs) technologies has opened new opportunities for edge computing in military operations, disaster response, or remote areas where traditional terrestrial networks are limited or unavailable. In such environments, UAVs can be deployed as aerial edge servers or relays to facilitate edge computing services. This form of computing is also known as UAV-enabled Edge Computing (UEC), which offers several unique benefits such as mobility, line-of-sight, flexibility, computational capability, and cost-efficiency. However, the resources on UAVs, edge servers, and IoT devices are typically very limited in the context of UEC. Efficient resource management is, therefore, a critical research challenge in UEC. In this article, we present a survey on the existing research in UEC from the resource management perspective. We identify a conceptual architecture, different types of collaborations, wireless communication models, research directions, key techniques and performance indicators for resource management in UEC. We also present a taxonomy of resource management in UEC. Finally, we identify and discuss some open research challenges that can stimulate future research directions for resource management in UEC.

Automated Driving Systems (ADS) have made great achievements in recent years thanks to the efforts from both academia and industry. A typical ADS is composed of multiple modules, including sensing, perception, planning and control, which brings together the latest advances in multiple domains. Despite these achievements, safety assurance of the systems is still of great significance, since the unsafe behavior of ADS can bring catastrophic consequences and unacceptable economic and social losses. Testing is an important approach to system validation for the deployment in practice; in the context of ADS, it is extremely challenging, due to the system complexity and multidisciplinarity. There has been a great deal of literature that focuses on the testing of ADS, and a number of surveys have also emerged to summarize the technical advances. However, most of these surveys focus on the system-level testing that is performed within software simulators, and thereby ignore the distinct features of individual modules. In this paper, we provide a comprehensive survey on the existing ADS testing literature, which takes into account both module-level and system-level testing. Specifically, we make the following contributions: (1) we build a threat model that reveals the potential safety threats for each module of an ADS; (2) we survey the module-level testing techniques for ADS and highlight the technical differences affected by the properties of the modules; (3) we also survey the system-level testing techniques, but we focus on empirical studies that take a bird's-eye view on the system, the problems due to the collaborations between modules, and the gaps between ADS testing in simulators and real world; (4) we identify the challenges and opportunities in ADS testing, which facilitates the future research in this field.

Autonomic computing investigates how systems can achieve (user) specified control outcomes on their own, without the intervention of a human operator. Autonomic computing fundamentals have been substantially influenced by those of control theory for closed and open-loop systems. In practice, complex systems may exhibit a number of concurrent and inter-dependent control loops. Despite research into autonomic models for managing computer resources, ranging from individual resources (e.g., web servers) to a resource ensemble (e.g., multiple resources within a data center), research into integrating Artificial Intelligence (AI) and Machine Learning (ML) to improve resource autonomy and performance at scale continues to be a fundamental challenge. The integration of AI/ML to achieve such autonomic and self-management of systems can be achieved at different levels of granularity, from full to human-in-the-loop automation. In this article, leading academics, researchers, practitioners, engineers, and scientists in the fields of cloud computing, AI/ML, and quantum computing join to discuss current research and potential future directions for these fields. Further, we discuss challenges and opportunities for leveraging AI and ML in next generation computing for emerging computing paradigms, including cloud, fog, edge, serverless and quantum computing environments.

Deep Learning (DL) is the most widely used tool in the contemporary field of computer vision. Its ability to accurately solve complex problems is employed in vision research to learn deep neural models for a variety of tasks, including security critical applications. However, it is now known that DL is vulnerable to adversarial attacks that can manipulate its predictions by introducing visually imperceptible perturbations in images and videos. Since the discovery of this phenomenon in 2013~[1], it has attracted significant attention of researchers from multiple sub-fields of machine intelligence. In [2], we reviewed the contributions made by the computer vision community in adversarial attacks on deep learning (and their defenses) until the advent of year 2018. Many of those contributions have inspired new directions in this area, which has matured significantly since witnessing the first generation methods. Hence, as a legacy sequel of [2], this literature review focuses on the advances in this area since 2018. To ensure authenticity, we mainly consider peer-reviewed contributions published in the prestigious sources of computer vision and machine learning research. Besides a comprehensive literature review, the article also provides concise definitions of technical terminologies for non-experts in this domain. Finally, this article discusses challenges and future outlook of this direction based on the literature reviewed herein and [2].