The development of closed-loop systems for glycemia control in type I diabetes relies heavily on simulated patients. Improving the performances and adaptability of these close-loops raises the risk of over-fitting the simulator. This may have dire consequences, especially in unusual cases which were not faithfully-if at all-captured by the simulator. To address this, we propose to use offline RL agents, trained on real patient data, to perform the glycemia control. To further improve the performances, we propose an end-to-end personalization pipeline, which leverages offline-policy evaluation methods to remove altogether the need of a simulator, while still enabling an estimation of clinically relevant metrics for diabetes.
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Hyperspectral 3D imaging aims to acquire both depth and spectral information of a scene. However, existing methods are either prohibitively expensive and bulky or compromise on spectral and depth accuracy. In this work, we present Dispersed Structured Light (DSL), a cost-effective and compact method for accurate hyperspectral 3D imaging. DSL modifies a traditional projector-camera system by placing a sub-millimeter thick diffraction grating film front of the projector. The grating disperses structured light based on light wavelength. To utilize the dispersed structured light, we devise a model for dispersive projection image formation and a per-pixel hyperspectral 3D reconstruction method. We validate DSL by instantiating a compact experimental prototype. DSL achieves spectral accuracy of 18.8nm full-width half-maximum (FWHM) and depth error of 1mm. We demonstrate that DSL outperforms prior work on practical hyperspectral 3D imaging. DSL promises accurate and practical hyperspectral 3D imaging for diverse application domains, including computer vision and graphics, cultural heritage, geology, and biology.
Object instances in remote sensing images often distribute with multi-orientations, varying scales, and dense distribution. These issues bring challenges to end-to-end oriented object detectors including multi-scale features alignment and a large number of queries. To address these limitations, we propose an end-to-end oriented detector equipped with an efficient decoder, which incorporates two technologies, Rotated RoI attention (RRoI attention) and Selective Distinct Queries (SDQ). Specifically, RRoI attention effectively focuses on oriented regions of interest through a cross-attention mechanism and aligns multi-scale features. SDQ collects queries from intermediate decoder layers and then filters similar queries to obtain distinct queries. The proposed SDQ can facilitate the optimization of one-to-one label assignment, without introducing redundant initial queries or extra auxiliary branches. Extensive experiments on five datasets demonstrate the effectiveness of our method. Notably, our method achieves state-of-the-art performance on DIOR-R (67.31% mAP), DOTA-v1.5 (67.43% mAP), and DOTA-v2.0 (53.28% mAP) with the ResNet50 backbone.
Text-to-image (T2I) models have recently experienced rapid development, achieving astonishing performance in terms of fidelity and textual alignment capabilities. However, given a long paragraph (up to 512 words), these generation models still struggle to achieve strong alignment and are unable to generate images depicting complex scenes. In this paper, we introduce an information-enriched diffusion model for paragraph-to-image generation task, termed ParaDiffusion, which delves into the transference of the extensive semantic comprehension capabilities of large language models to the task of image generation. At its core is using a large language model (e.g., Llama V2) to encode long-form text, followed by fine-tuning with LORA to alignthe text-image feature spaces in the generation task. To facilitate the training of long-text semantic alignment, we also curated a high-quality paragraph-image pair dataset, namely ParaImage. This dataset contains a small amount of high-quality, meticulously annotated data, and a large-scale synthetic dataset with long text descriptions being generated using a vision-language model. Experiments demonstrate that ParaDiffusion outperforms state-of-the-art models (SD XL, DeepFloyd IF) on ViLG-300 and ParaPrompts, achieving up to 15% and 45% human voting rate improvements for visual appeal and text faithfulness, respectively. The code and dataset will be released to foster community research on long-text alignment.
We investigate the molecular gene expressions studies and public databases for disease modelling using Probabilistic Graphical Models and Bayesian Inference. A case study on Spinal Muscle Atrophy Genome-Wide Association Study results is modelled and analyzed. The genes up and down-regulated in two stages of the disease development are linked to prior knowledge published in the public domain and co-expressions network is created and analyzed. The Molecular Pathways triggered by these genes are identified. The Bayesian inference posteriors distributions are estimated using a variational analytical algorithm and a Markov chain Monte Carlo sampling algorithm. Assumptions, limitations and possible future work are concluded.
We provide a compact data structure for representing polyominoes that supports neighborhood and visibility queries. Neighborhood queries concern reporting adjacent cells to a given cell, and visibility queries determine whether a straight line can be drawn within the polyomino that connects two specified cells. For an arbitrary small $\epsilon >0$, our data structure can encode a polyomino with $n$ cells in $(3+\epsilon)n + o(n)$ bits while supporting all queries in constant time. The space complexity can be improved to $3n+o(n)$, while supporting neighborhood queries in $\mathcal{O}(1)$ and visibility queries in $\mathcal{O}(t(n))$ for any arbitrary $t(n) \in \omega(1)$. Previous attempts at enumerating polyominoes have indicated that at least $2.00091n - o(n)$ bits are required to differentiate between distinct polyominoes, which shows our data structure is compact. In addition, we introduce a succinct data structure tailored for bar graphs, a specific subclass of polyominoes resembling histograms. We demonstrate that a bar graph comprising $n$ cells can be encoded using only $n + o(n)$ bits, enabling constant-time query processing. Meanwhile, $n-1$ bits are necessary to represent any bar graph, proving our data structure is succinct.
Out-of-distribution (OOD) detection methods often exploit auxiliary outliers to train model identifying OOD samples, especially discovering challenging outliers from auxiliary outliers dataset to improve OOD detection. However, they may still face limitations in effectively distinguishing between the most challenging OOD samples that are much like in-distribution (ID) data, i.e., ID-like samples. To this end, we propose a novel OOD detection framework that discovers ID-like outliers using CLIP from the vicinity space of the ID samples, thus helping to identify these most challenging OOD samples. Then a prompt learning framework is proposed that utilizes the identified ID-like outliers to further leverage the capabilities of CLIP for OOD detection. Benefiting from the powerful CLIP, we only need a small number of ID samples to learn the prompts of the model without exposing other auxiliary outlier datasets. By focusing on the most challenging ID-like OOD samples and elegantly exploiting the capabilities of CLIP, our method achieves superior few-shot learning performance on various real-world image datasets (e.g., in 4-shot OOD detection on the ImageNet-1k dataset, our method reduces the average FPR95 by 12.16% and improves the average AUROC by 2.76%, compared to state-of-the-art methods).
We introduce three notions of multivariate median bias, namely, rectilinear, Tukey, and orthant median bias. Each of these median biases is zero under a suitable notion of multivariate symmetry. We study the coverage probabilities of rectangular hull of $B$ independent multivariate estimators, with special attention to the number of estimators $B$ needed to ensure a miscoverage of at most $\alpha$. It is proved that for estimators with zero orthant median bias, we need $B\geq c\log_2(d/\alpha)$ for some constant $c > 0$. Finally, we show that there exists an asymptotically valid (non-trivial) confidence region for a multivariate parameter $\theta_0$ if and only if there exists a (non-trivial) estimator with an asymptotic orthant median bias of zero.
Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.
Object tracking is challenging as target objects often undergo drastic appearance changes over time. Recently, adaptive correlation filters have been successfully applied to object tracking. However, tracking algorithms relying on highly adaptive correlation filters are prone to drift due to noisy updates. Moreover, as these algorithms do not maintain long-term memory of target appearance, they cannot recover from tracking failures caused by heavy occlusion or target disappearance in the camera view. In this paper, we propose to learn multiple adaptive correlation filters with both long-term and short-term memory of target appearance for robust object tracking. First, we learn a kernelized correlation filter with an aggressive learning rate for locating target objects precisely. We take into account the appropriate size of surrounding context and the feature representations. Second, we learn a correlation filter over a feature pyramid centered at the estimated target position for predicting scale changes. Third, we learn a complementary correlation filter with a conservative learning rate to maintain long-term memory of target appearance. We use the output responses of this long-term filter to determine if tracking failure occurs. In the case of tracking failures, we apply an incrementally learned detector to recover the target position in a sliding window fashion. Extensive experimental results on large-scale benchmark datasets demonstrate that the proposed algorithm performs favorably against the state-of-the-art methods in terms of efficiency, accuracy, and robustness.
Visual Question Answering (VQA) models have struggled with counting objects in natural images so far. We identify a fundamental problem due to soft attention in these models as a cause. To circumvent this problem, we propose a neural network component that allows robust counting from object proposals. Experiments on a toy task show the effectiveness of this component and we obtain state-of-the-art accuracy on the number category of the VQA v2 dataset without negatively affecting other categories, even outperforming ensemble models with our single model. On a difficult balanced pair metric, the component gives a substantial improvement in counting over a strong baseline by 6.6%.
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