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This paper presents a computationally feasible method to compute rigorous bounds on the interval-generalisation of regression analysis to account for epistemic uncertainty in the output variables. The new iterative method uses machine learning algorithms to fit an imprecise regression model to data that consist of intervals rather than point values. The method is based on a single-layer interval neural network which can be trained to produce an interval prediction. It seeks parameters for the optimal model that minimizes the mean squared error between the actual and predicted interval values of the dependent variable using a first-order gradient-based optimization and interval analysis computations to model the measurement imprecision of the data. An additional extension to a multi-layer neural network is also presented. We consider the explanatory variables to be precise point values, but the measured dependent values are characterized by interval bounds without any probabilistic information. The proposed iterative method estimates the lower and upper bounds of the expectation region, which is an envelope of all possible precise regression lines obtained by ordinary regression analysis based on any configuration of real-valued points from the respective y-intervals and their x-values.

Recent studies have demonstrated the superiority of deep learning in medical image analysis, especially in cell instance segmentation, a fundamental step for many biological studies. However, the excellent performance of the neural networks requires training on large, unbiased dataset and annotations, which is labor-intensive and expertise-demanding. This paper presents an end-to-end framework to automatically detect and segment NeuN stained neuronal cells on histological images using only point annotations. Unlike traditional nuclei segmentation with point annotation, we propose using point annotation and binary segmentation to synthesize pixel-level annotations. The synthetic masks are used as the ground truth to train the neural network, a U-Net-like architecture with a state-of-the-art network, EfficientNet, as the encoder. Validation results show the superiority of our model compared to other recent methods. In addition, we investigated multiple post-processing schemes and proposed an original strategy to convert the probability map into segmented instances using ultimate erosion and dynamic reconstruction. This approach is easy to configure and outperforms other classical post-processing techniques. This work aims to develop a robust and efficient framework for analyzing neurons using optical microscopic data, which can be used in preclinical biological studies and, more specifically, in the context of neurodegenerative diseases.

Existing textual adversarial attacks usually utilize the gradient or prediction confidence to generate adversarial examples, making it hard to be deployed in real-world applications. To this end, we consider a rarely investigated but more rigorous setting, namely hard-label attack, in which the attacker can only access the prediction label. In particular, we find we can learn the importance of different words via the change on prediction label caused by word substitutions on the adversarial examples. Based on this observation, we propose a novel adversarial attack, termed Text Hard-label attacker (TextHacker). TextHacker randomly perturbs lots of words to craft an adversarial example. Then, TextHacker adopts a hybrid local search algorithm with the estimation of word importance from the attack history to minimize the adversarial perturbation. Extensive evaluations for text classification and textual entailment show that TextHacker significantly outperforms existing hard-label attacks regarding the attack performance as well as adversary quality.

Reasoning over natural language is a challenging problem in NLP. In this work, we focus on proof generation: Given a hypothesis and a set of supporting facts, the model generates a proof tree indicating how to derive the hypothesis from supporting facts. Compared to generating the entire proof in one shot, stepwise generation can better exploit the compositionality and generalize to longer proofs but has achieved limited success on real-world data. Existing stepwise methods struggle to generate proof steps that are both logically valid and relevant to the hypothesis. Instead, they tend to hallucinate invalid steps given the hypothesis. In this paper, we present a novel stepwise method, NLProofS (Natural Language Proof Search), which learns to generate relevant steps conditioning on the hypothesis. At the core of our approach, we train an independent verifier to check the validity of the proof steps to prevent hallucination. Instead of generating steps greedily, we search for proofs maximizing a global proof score judged by the verifier. NLProofS achieves state-of-the-art performance on EntailmentBank and RuleTaker. Specifically, it improves the correctness of predicted proofs from 27.7% to 33.3% in the distractor setting of EntailmentBank, demonstrating the effectiveness of NLProofS in generating challenging human-authored proofs.

In solving multi-modal, multi-objective optimization problems (MMOPs), the objective is not only to find a good representation of the Pareto-optimal front (PF) in the objective space but also to find all equivalent Pareto-optimal subsets (PSS) in the variable space. Such problems are practically relevant when a decision maker (DM) is interested in identifying alternative designs with similar performance. There has been significant research interest in recent years to develop efficient algorithms to deal with MMOPs. However, the existing algorithms still require prohibitive number of function evaluations (often in several thousands) to deal with problems involving as low as two objectives and two variables. The algorithms are typically embedded with sophisticated, customized mechanisms that require additional parameters to manage the diversity and convergence in the variable and the objective spaces. In this letter, we introduce a steady-state evolutionary algorithm for solving MMOPs, with a simple design and no additional userdefined parameters that need tuning compared to a standard EA. We report its performance on 21 MMOPs from various test suites that are widely used for benchmarking using a low computational budget of 1000 function evaluations. The performance of the proposed algorithm is compared with six state-of-the-art algorithms (MO Ring PSO SCD, DN-NSGAII, TriMOEA-TA&R, CPDEA, MMOEA/DC and MMEA-WI). The proposed algorithm exhibits significantly better performance than the above algorithms based on the established metrics including IGDX, PSP and IGD. We hope this study would encourage design of simple, efficient and generalized algorithms to improve its uptake for practical applications.

Artificial neural networks thrive in solving the classification problem for a particular rigid task, acquiring knowledge through generalized learning behaviour from a distinct training phase. The resulting network resembles a static entity of knowledge, with endeavours to extend this knowledge without targeting the original task resulting in a catastrophic forgetting. Continual learning shifts this paradigm towards networks that can continually accumulate knowledge over different tasks without the need to retrain from scratch. We focus on task incremental classification, where tasks arrive sequentially and are delineated by clear boundaries. Our main contributions concern 1) a taxonomy and extensive overview of the state-of-the-art, 2) a novel framework to continually determine the stability-plasticity trade-off of the continual learner, 3) a comprehensive experimental comparison of 11 state-of-the-art continual learning methods and 4 baselines. We empirically scrutinize method strengths and weaknesses on three benchmarks, considering Tiny Imagenet and large-scale unbalanced iNaturalist and a sequence of recognition datasets. We study the influence of model capacity, weight decay and dropout regularization, and the order in which the tasks are presented, and qualitatively compare methods in terms of required memory, computation time, and storage.

Deep Learning algorithms have achieved the state-of-the-art performance for Image Classification and have been used even in security-critical applications, such as biometric recognition systems and self-driving cars. However, recent works have shown those algorithms, which can even surpass the human capabilities, are vulnerable to adversarial examples. In Computer Vision, adversarial examples are images containing subtle perturbations generated by malicious optimization algorithms in order to fool classifiers. As an attempt to mitigate these vulnerabilities, numerous countermeasures have been constantly proposed in literature. Nevertheless, devising an efficient defense mechanism has proven to be a difficult task, since many approaches have already shown to be ineffective to adaptive attackers. Thus, this self-containing paper aims to provide all readerships with a review of the latest research progress on Adversarial Machine Learning in Image Classification, however with a defender's perspective. Here, novel taxonomies for categorizing adversarial attacks and defenses are introduced and discussions about the existence of adversarial examples are provided. Further, in contrast to exisiting surveys, it is also given relevant guidance that should be taken into consideration by researchers when devising and evaluating defenses. Finally, based on the reviewed literature, it is discussed some promising paths for future research.

Deep learning models on graphs have achieved remarkable performance in various graph analysis tasks, e.g., node classification, link prediction and graph clustering. However, they expose uncertainty and unreliability against the well-designed inputs, i.e., adversarial examples. Accordingly, various studies have emerged for both attack and defense addressed in different graph analysis tasks, leading to the arms race in graph adversarial learning. For instance, the attacker has poisoning and evasion attack, and the defense group correspondingly has preprocessing- and adversarial- based methods. Despite the booming works, there still lacks a unified problem definition and a comprehensive review. To bridge this gap, we investigate and summarize the existing works on graph adversarial learning tasks systemically. Specifically, we survey and unify the existing works w.r.t. attack and defense in graph analysis tasks, and give proper definitions and taxonomies at the same time. Besides, we emphasize the importance of related evaluation metrics, and investigate and summarize them comprehensively. Hopefully, our works can serve as a reference for the relevant researchers, thus providing assistance for their studies. More details of our works are available at //github.com/gitgiter/Graph-Adversarial-Learning.

Adversarial attacks to image classification systems present challenges to convolutional networks and opportunities for understanding them. This study suggests that adversarial perturbations on images lead to noise in the features constructed by these networks. Motivated by this observation, we develop new network architectures that increase adversarial robustness by performing feature denoising. Specifically, our networks contain blocks that denoise the features using non-local means or other filters; the entire networks are trained end-to-end. When combined with adversarial training, our feature denoising networks substantially improve the state-of-the-art in adversarial robustness in both white-box and black-box attack settings. On ImageNet, under 10-iteration PGD white-box attacks where prior art has 27.9% accuracy, our method achieves 55.7%; even under extreme 2000-iteration PGD white-box attacks, our method secures 42.6% accuracy. A network based on our method was ranked first in Competition on Adversarial Attacks and Defenses (CAAD) 2018 --- it achieved 50.6% classification accuracy on a secret, ImageNet-like test dataset against 48 unknown attackers, surpassing the runner-up approach by ~10%. Code and models will be made publicly available.

We introduce an effective model to overcome the problem of mode collapse when training Generative Adversarial Networks (GAN). Firstly, we propose a new generator objective that finds it better to tackle mode collapse. And, we apply an independent Autoencoders (AE) to constrain the generator and consider its reconstructed samples as "real" samples to slow down the convergence of discriminator that enables to reduce the gradient vanishing problem and stabilize the model. Secondly, from mappings between latent and data spaces provided by AE, we further regularize AE by the relative distance between the latent and data samples to explicitly prevent the generator falling into mode collapse setting. This idea comes when we find a new way to visualize the mode collapse on MNIST dataset. To the best of our knowledge, our method is the first to propose and apply successfully the relative distance of latent and data samples for stabilizing GAN. Thirdly, our proposed model, namely Generative Adversarial Autoencoder Networks (GAAN), is stable and has suffered from neither gradient vanishing nor mode collapse issues, as empirically demonstrated on synthetic, MNIST, MNIST-1K, CelebA and CIFAR-10 datasets. Experimental results show that our method can approximate well multi-modal distribution and achieve better results than state-of-the-art methods on these benchmark datasets. Our model implementation is published here: //github.com/tntrung/gaan