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We study the sparse phase retrieval problem, which aims to recover a sparse signal from a limited number of phaseless measurements. Existing algorithms for sparse phase retrieval primarily rely on first-order methods with linear convergence rate. In this paper, we propose an efficient second-order algorithm based on Newton projection, which maintains the same per-iteration computational complexity as popular first-order methods. The proposed algorithm is theoretically guaranteed to converge to the ground truth (up to a global sign) at a quadratic convergence rate after at most $O\big(\log (\Vert \mathbf{x}^{\natural} \, \Vert /x_{\min}^{\natural})\big)$ iterations, provided a sample complexity of $O(s^2\log n)$, where $\mathbf{x}^{\natural} \in \mathbb{R}^n$ represents an $s$-sparse ground truth signal. Numerical experiments demonstrate that our algorithm not only outperforms state-of-the-art methods in terms of achieving a significantly faster convergence rate, but also excels in attaining a higher success rate for exact signal recovery from noise-free measurements and providing enhanced signal reconstruction in noisy scenarios.

With the growing imbalance between limited medical resources and escalating demands, AI-based clinical tasks have become paramount. Medication recommendation, as a sub-domain, aims to amalgamate longitudinal patient history with medical knowledge, assisting physicians in prescribing safer and more accurate medication combinations. Existing methods overlook the inherent long-tail distribution in medical data, lacking balanced representation between head and tail data, which leads to sub-optimal model performance. To address this challenge, we introduce StratMed, a model that incorporates an innovative relevance stratification mechanism. It harmonizes discrepancies in data long-tail distribution and strikes a balance between the safety and accuracy of medication combinations. Specifically, we first construct a pre-training method using deep learning networks to obtain entity representation. After that, we design a pyramid-like data stratification method to obtain more generalized entity relationships by reinforcing the features of unpopular entities. Based on this relationship, we designed two graph structures to express medication precision and safety at the same level to obtain visit representations. Finally, the patient's historical clinical information is fitted to generate medication combinations for the current health condition. Experiments on the MIMIC-III dataset demonstrate that our method has outperformed current state-of-the-art methods in four evaluation metrics (including safety and accuracy).

The recurrent neural network and its variants have shown great success in processing sequences in recent years. However, this deep neural network has not aroused much attention in anomaly detection through predictively process monitoring. Furthermore, the traditional statistic models work on assumptions and hypothesis tests, while neural network (NN) models do not need that many assumptions. This flexibility enables NN models to work efficiently on data with time-varying variability, a common inherent aspect of data in practice. This paper explores the ability of the recurrent neural network structure to monitor processes and proposes a control chart based on long short-term memory (LSTM) prediction intervals for data with time-varying variability. The simulation studies provide empirical evidence that the proposed model outperforms other NN-based predictive monitoring methods for mean shift detection. The proposed method is also applied to time series sensor data, which confirms that the proposed method is an effective technique for detecting abnormalities.

Surrogate variables in electronic health records (EHR) and biobank data play an important role in biomedical studies due to the scarcity or absence of chart-reviewed gold standard labels. We develop a novel approach named SASH for {\bf S}urrogate-{\bf A}ssisted and data-{\bf S}hielding {\bf H}igh-dimensional integrative regression. It is a semi-supervised approach that efficiently leverages sizable unlabeled samples with error-prone EHR surrogate outcomes from multiple local sites, to improve the learning accuracy of the small gold-labeled data. {To facilitate stable and efficient knowledge extraction from the surrogates, our method first obtains a preliminary supervised estimator, and then uses it to assist training a regularized single index model (SIM) for the surrogates. Interestingly, through a chain of convex and properly penalized sparse regressions that approximate the SIM loss with bias-correction, our method avoids the local minima issue of the SIM training, and fully eliminates the impact of the preliminary estimator's large error. In addition, it protects individual-level information through summary-statistics-based data aggregation across the local sites, leveraging a similar idea of bias-corrected approximation for SIM.} Through simulation studies, we demonstrate that our method outperforms existing approaches on finite samples. Finally, we apply our method to develop a high dimensional genetic risk model for type II diabetes using large-scale data sets from UK and Mass General Brigham biobanks, where only a small fraction of subjects in one site has been labeled via chart reviewing.

Diagnostic investigation has an important role in risk stratification and clinical decision making of patients with suspected and documented Coronary Artery Disease (CAD). However, the majority of existing tools are primarily focused on the selection of gatekeeper tests, whereas only a handful of systems contain information regarding the downstream testing or treatment. We propose a multi-task deep learning model to support risk stratification and down-stream test selection for patients undergoing Coronary Computed Tomography Angiography (CCTA). The analysis included 14,021 patients who underwent CCTA between 2006 and 2017. Our novel multitask deep learning framework extends the state-of-the art Perceiver model to deal with real-world CCTA report data. Our model achieved an Area Under the receiver operating characteristic Curve (AUC) of 0.76 in CAD risk stratification, and 0.72 AUC in predicting downstream tests. Our proposed deep learning model can accurately estimate the likelihood of CAD and provide recommended downstream tests based on prior CCTA data. In clinical practice, the utilization of such an approach could bring a paradigm shift in risk stratification and downstream management. Despite significant progress using deep learning models for tabular data, they do not outperform gradient boosting decision trees, and further research is required in this area. However, neural networks appear to benefit more readily from multi-task learning than tree-based models. This could offset the shortcomings of using single task learning approach when working with tabular data.

Cognitive diagnosis aims to diagnose students' knowledge proficiencies based on their response scores on exam questions, which is the basis of many domains such as computerized adaptive testing. Existing cognitive diagnosis models (CDMs) follow a proficiency-response paradigm, which views diagnostic results as learnable embeddings that are the cause of students' responses and learns the diagnostic results through optimization. However, such a paradigm can easily lead to unidentifiable diagnostic results and the explainability overfitting problem, which is harmful to the quantification of students' learning performance. To address these problems, we propose a novel identifiable cognitive diagnosis framework. Specifically, we first propose a flexible diagnostic module which directly diagnose identifiable and explainable examinee traits and question features from response logs. Next, we leverage a general predictive module to reconstruct response logs from the diagnostic results to ensure the preciseness of the latter. We furthermore propose an implementation of the framework, i.e., ID-CDM, to demonstrate the availability of the former. Finally, we demonstrate the identifiability, explainability and preciseness of diagnostic results of ID-CDM through experiments on four public real-world datasets.

Despite recent advances in the field of explainability, much remains unknown about the algorithms that neural networks learn to represent. Recent work has attempted to understand trained models by decomposing them into functional circuits (Csord\'as et al., 2020; Lepori et al., 2023). To advance this research, we developed NeuroSurgeon, a python library that can be used to discover and manipulate subnetworks within models in the Huggingface Transformers library (Wolf et al., 2019). NeuroSurgeon is freely available at //github.com/mlepori1/NeuroSurgeon.

Pneumonia remains a significant cause of child mortality, particularly in developing countries where resources and expertise are limited. The automated detection of Pneumonia can greatly assist in addressing this challenge. In this research, an XOR based Particle Swarm Optimization (PSO) is proposed to select deep features from the second last layer of a RegNet model, aiming to improve the accuracy of the CNN model on Pneumonia detection. The proposed XOR PSO algorithm offers simplicity by incorporating just one hyperparameter for initialization, and each iteration requires minimal computation time. Moreover, it achieves a balance between exploration and exploitation, leading to convergence on a suitable solution. By extracting 163 features, an impressive accuracy level of 98% was attained which demonstrates comparable accuracy to previous PSO-based methods. The source code of the proposed method is available in the GitHub repository.

Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.