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Prior work applying semiparametric theory to causal inference has primarily focused on deriving estimators that exhibit statistical robustness under a prespecified causal model that permits identification of a desired causal parameter. However, a fundamental challenge is correct specification of such a model, which usually involves making untestable assumptions. Evidence factors is an approach to combining hypothesis tests of a common causal null hypothesis under two or more candidate causal models. Under certain conditions, this yields a test that is valid if at least one of the underlying models is correct, which is a form of causal robustness. We propose a method of combining semiparametric theory with evidence factors. We develop a causal null hypothesis test based on joint asymptotic normality of K asymptotically linear semiparametric estimators, where each estimator is based on a distinct identifying functional derived from each of K candidate causal models. We show that this test provides both statistical and causal robustness in the sense that it is valid if at least one of the K proposed causal models is correct, while also allowing for slower than parametric rates of convergence in estimating nuisance functions. We demonstrate the efficacy of our method via simulations and an application to the Framingham Heart Study.

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Mediation analysis is an important statistical tool in many research fields. Its aim is to investigate the mechanism along the causal pathway between an exposure and an outcome. The joint significance test is widely utilized as a prominent statistical approach for examining mediation effects in practical applications. Nevertheless, the limitation of this mediation testing method stems from its conservative Type I error, which reduces its statistical power and imposes certain constraints on its popularity and utility. The proposed solution to address this gap is the adaptive joint significance test for one mediator, a novel data-adaptive test for mediation effect that exhibits significant advancements compared to traditional joint significance test. The proposed method is designed to be user-friendly, eliminating the need for complicated procedures. We have derived explicit expressions for size and power, ensuring the theoretical validity of our approach. Furthermore, we extend the proposed adaptive joint significance tests for small-scale mediation hypotheses with family-wise error rate (FWER) control. Additionally, a novel adaptive Sobel-type approach is proposed for the estimation of confidence intervals for the mediation effects, demonstrating significant advancements over conventional Sobel's confidence intervals in terms of achieving desirable coverage probabilities. Our mediation testing and confidence intervals procedure is evaluated through comprehensive simulations, and compared with numerous existing approaches. Finally, we illustrate the usefulness of our method by analysing three real-world datasets with continuous, binary and time-to-event outcomes, respectively.

Counterfactual explanations (CFE) are methods that explain a machine learning model by giving an alternate class prediction of a data point with some minimal changes in its features. It helps the users to identify their data attributes that caused an undesirable prediction like a loan or credit card rejection. We describe an efficient and an actionable counterfactual (CF) generation method based on particle swarm optimization (PSO). We propose a simple objective function for the optimization of the instance-centric CF generation problem. The PSO brings in a lot of flexibility in terms of carrying out multi-objective optimization in large dimensions, capability for multiple CF generation, and setting box constraints or immutability of data attributes. An algorithm is proposed that incorporates these features and it enables greater control over the proximity and sparsity properties over the generated CFs. The proposed algorithm is evaluated with a set of action-ability metrics in real-world datasets, and the results were superior compared to that of the state-of-the-arts.

Inference of community structure in probabilistic graphical models may not be consistent with fairness constraints when nodes have demographic attributes. Certain demographics may be over-represented in some detected communities and under-represented in others. This paper defines a novel $\ell_1$-regularized pseudo-likelihood approach for fair graphical model selection. In particular, we assume there is some community or clustering structure in the true underlying graph, and we seek to learn a sparse undirected graph and its communities from the data such that demographic groups are fairly represented within the communities. In the case when the graph is known a priori, we provide a convex semidefinite programming approach for fair community detection. We establish the statistical consistency of the proposed method for both a Gaussian graphical model and an Ising model for, respectively, continuous and binary data, proving that our method can recover the graphs and their fair communities with high probability.

Achievability in information theory refers to demonstrating a coding strategy that accomplishes a prescribed performance benchmark for the underlying task. In quantum information theory, the crafted Hayashi-Nagaoka operator inequality is an essential technique in proving a wealth of one-shot achievability bounds since it effectively resembles a union bound in various problems. In this work, we show that the pretty-good measurement naturally plays a role as the union bound as well. A judicious application of it considerably simplifies the derivation of one-shot achievability for classical-quantum (c-q) channel coding via an elegant three-line proof. The proposed analysis enjoys the following favorable features. (i) The established one-shot bound admits a closed-form expression as in the celebrated Holevo-Helstrom Theorem. Namely, the error probability of sending $M$ messages through a c-q channel is upper bounded by the minimum error of distinguishing the joint channel input-output state against $(M-1)$ decoupled products states. (ii) Our bound directly yields asymptotic results in the large deviation, small deviation, and moderate deviation regimes in a unified manner. (iii) The coefficients incurred in applying the Hayashi-Nagaoka operator inequality are no longer needed. Hence, the derived one-shot bound sharpens existing results relying on the Hayashi-Nagaoka operator inequality. In particular, we obtain the tightest achievable $\epsilon$-one-shot capacity for c-q channel coding heretofore, improving the third-order coding rate in the asymptotic scenario. (iv) Our result holds for infinite-dimensional Hilbert space. (v) The proposed method applies to deriving one-shot achievability for classical data compression with quantum side information, entanglement-assisted classical communication over quantum channels, and various quantum network information-processing protocols.

Although robust statistical estimators are less affected by outlying observations, their computation is usually more challenging. This is particularly the case in high-dimensional sparse settings. The availability of new optimization procedures, mainly developed in the computer science domain, offers new possibilities for the field of robust statistics. This paper investigates how such procedures can be used for robust sparse association estimators. The problem can be split into a robust estimation step followed by an optimization for the remaining decoupled, (bi-)convex problem. A combination of the augmented Lagrangian algorithm and adaptive gradient descent is implemented to also include suitable constraints for inducing sparsity. We provide results concerning the precision of the algorithm and show the advantages over existing algorithms in this context. High-dimensional empirical examples underline the usefulness of this procedure. Extensions to other robust sparse estimators are possible.

We consider a panel data analysis to examine the heterogeneity in treatment effects with respect to a pre-treatment covariate of interest in the staggered difference-in-differences setting of Callaway and Sant'Anna (2021). Under standard identification conditions, a doubly robust estimand conditional on the covariate identifies the group-time conditional average treatment effect given the covariate. Focusing on the case of a continuous covariate, we propose a three-step estimation procedure based on nonparametric local polynomial regressions and parametric estimation methods. Using uniformly valid distributional approximation results for empirical processes and multiplier bootstrapping, we develop doubly robust inference methods to construct uniform confidence bands for the group-time conditional average treatment effect function. The accompanying R package didhetero allows for easy implementation of the proposed methods.

The adaptive processing of structured data is a long-standing research topic in machine learning that investigates how to automatically learn a mapping from a structured input to outputs of various nature. Recently, there has been an increasing interest in the adaptive processing of graphs, which led to the development of different neural network-based methodologies. In this thesis, we take a different route and develop a Bayesian Deep Learning framework for graph learning. The dissertation begins with a review of the principles over which most of the methods in the field are built, followed by a study on graph classification reproducibility issues. We then proceed to bridge the basic ideas of deep learning for graphs with the Bayesian world, by building our deep architectures in an incremental fashion. This framework allows us to consider graphs with discrete and continuous edge features, producing unsupervised embeddings rich enough to reach the state of the art on several classification tasks. Our approach is also amenable to a Bayesian nonparametric extension that automatizes the choice of almost all model's hyper-parameters. Two real-world applications demonstrate the efficacy of deep learning for graphs. The first concerns the prediction of information-theoretic quantities for molecular simulations with supervised neural models. After that, we exploit our Bayesian models to solve a malware-classification task while being robust to intra-procedural code obfuscation techniques. We conclude the dissertation with an attempt to blend the best of the neural and Bayesian worlds together. The resulting hybrid model is able to predict multimodal distributions conditioned on input graphs, with the consequent ability to model stochasticity and uncertainty better than most works. Overall, we aim to provide a Bayesian perspective into the articulated research field of deep learning for graphs.

Dynamic programming (DP) solves a variety of structured combinatorial problems by iteratively breaking them down into smaller subproblems. In spite of their versatility, DP algorithms are usually non-differentiable, which hampers their use as a layer in neural networks trained by backpropagation. To address this issue, we propose to smooth the max operator in the dynamic programming recursion, using a strongly convex regularizer. This allows to relax both the optimal value and solution of the original combinatorial problem, and turns a broad class of DP algorithms into differentiable operators. Theoretically, we provide a new probabilistic perspective on backpropagating through these DP operators, and relate them to inference in graphical models. We derive two particular instantiations of our framework, a smoothed Viterbi algorithm for sequence prediction and a smoothed DTW algorithm for time-series alignment. We showcase these instantiations on two structured prediction tasks and on structured and sparse attention for neural machine translation.

Deep learning has yielded state-of-the-art performance on many natural language processing tasks including named entity recognition (NER). However, this typically requires large amounts of labeled data. In this work, we demonstrate that the amount of labeled training data can be drastically reduced when deep learning is combined with active learning. While active learning is sample-efficient, it can be computationally expensive since it requires iterative retraining. To speed this up, we introduce a lightweight architecture for NER, viz., the CNN-CNN-LSTM model consisting of convolutional character and word encoders and a long short term memory (LSTM) tag decoder. The model achieves nearly state-of-the-art performance on standard datasets for the task while being computationally much more efficient than best performing models. We carry out incremental active learning, during the training process, and are able to nearly match state-of-the-art performance with just 25\% of the original training data.

While existing machine learning models have achieved great success for sentiment classification, they typically do not explicitly capture sentiment-oriented word interaction, which can lead to poor results for fine-grained analysis at the snippet level (a phrase or sentence). Factorization Machine provides a possible approach to learning element-wise interaction for recommender systems, but they are not directly applicable to our task due to the inability to model contexts and word sequences. In this work, we develop two Position-aware Factorization Machines which consider word interaction, context and position information. Such information is jointly encoded in a set of sentiment-oriented word interaction vectors. Compared to traditional word embeddings, SWI vectors explicitly capture sentiment-oriented word interaction and simplify the parameter learning. Experimental results show that while they have comparable performance with state-of-the-art methods for document-level classification, they benefit the snippet/sentence-level sentiment analysis.

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