Brain tumors are the most common solid tumors and the leading cause of cancer-related death among children. Tumor segmentation is essential in surgical and treatment planning, and response assessment and monitoring. However, manual segmentation is time-consuming and has high inter-operator variability, underscoring the need for more efficient methods. We compared two deep learning-based 3D segmentation models, DeepMedic and nnU-Net, after training with pediatric-specific multi-institutional brain tumor data using based on multi-parametric MRI scans.Multi-parametric preoperative MRI scans of 339 pediatric patients (n=293 internal and n=46 external cohorts) with a variety of tumor subtypes, were preprocessed and manually segmented into four tumor subregions, i.e., enhancing tumor (ET), non-enhancing tumor (NET), cystic components (CC), and peritumoral edema (ED). After training, performance of the two models on internal and external test sets was evaluated using Dice scores, sensitivity, and Hausdorff distance with reference to ground truth manual segmentations. Dice score for nnU-Net internal test sets was (mean +/- SD (median)) 0.9+/-0.07 (0.94) for WT, 0.77+/-0.29 for ET, 0.66+/-0.32 for NET, 0.71+/-0.33 for CC, and 0.71+/-0.40 for ED, respectively. For DeepMedic the Dice scores were 0.82+/-0.16 for WT, 0.66+/-0.32 for ET, 0.48+/-0.27, for NET, 0.48+/-0.36 for CC, and 0.19+/-0.33 for ED, respectively. Dice scores were significantly higher for nnU-Net (p<=0.01). External validation of the trained nnU-Net model on the multi-institutional BraTS-PEDs 2023 dataset revealed high generalization capability in segmentation of whole tumor and tumor core with Dice scores of 0.87+/-0.13 (0.91) and 0.83+/-0.18 (0.89), respectively. Pediatric-specific data trained nnU-Net model is superior to DeepMedic for whole tumor and subregion segmentation of pediatric brain tumors.
Understanding the cortical organization of the human brain requires interpretable descriptors for distinct structural and functional imaging data. 3D polarized light imaging (3D-PLI) is an imaging modality for visualizing fiber architecture in postmortem brains with high resolution that also captures the presence of cell bodies, for example, to identify hippocampal subfields. The rich texture in 3D-PLI images, however, makes this modality particularly difficult to analyze and best practices for characterizing architectonic patterns still need to be established. In this work, we demonstrate a novel method to analyze the regional organization of the human hippocampus in 3D-PLI by combining recent advances in unfolding methods with deep texture features obtained using a self-supervised contrastive learning approach. We identify clusters in the representations that correspond well with classical descriptions of hippocampal subfields, lending validity to the developed methodology.
Chain-of-thought (CoT) advances the reasoning abilities of large language models (LLMs) and achieves superior performance in complex reasoning tasks. However, most CoT studies rely on carefully designed human-annotated rational chains to prompt LLMs, posing challenges for real-world applications where labeled data is available without rational chains. This paper proposes a new strategy, Automate-CoT (Automatic Prompt Augmentation and Selection with Chain-of-Thought), that can bypass human engineering of CoT by automatically augmenting rational chains from a small labeled dataset, and then pruning low-quality chains to construct a candidate pool of machine-generated rationale chains based on the labels. Finally, it selects the optimal combination of several rationale chains from the pool for CoT prompting by employing a variance-reduced policy gradient strategy to estimate the significance of each example. Automate-CoT enables a quick adaptation of the CoT technique to different tasks. Experimental results demonstrate the effectiveness of our method, where competitive results are achieved on arithmetic reasoning (+2.7%), commonsense reasoning (+3.4%), symbolic reasoning (+3.2%), and non-reasoning tasks (+2.5%). The code is available at //github.com/SHUMKASHUN/Automate-CoT.
We investigate the existence of fair and efficient allocations of indivisible chores to asymmetric agents who have unequal entitlements or weights. We consider the fairness notion of weighted envy-freeness up to one chore (wEF1) and the efficiency notion of Pareto-optimality (PO). The existence of EF1 and PO allocations of chores to symmetric agents is a major open problem in discrete fair division, and positive results are known only for certain structured instances. In this paper, we study this problem for a more general setting of asymmetric agents and show that an allocation that is wEF1 and PO exists and can be computed in polynomial time for instances with: - Three types of agents, where agents with the same type have identical preferences but can have different weights. - Two types of chores, where the chores can be partitioned into two sets, each containing copies of the same chore. For symmetric agents, our results establish that EF1 and PO allocations exist for three types of agents and also generalize known results for three agents, two types of agents, and two types of chores. Our algorithms use a weighted picking sequence algorithm as a subroutine; we expect this idea and our analysis to be of independent interest.
We analyze the statistical properties of generalized cross-validation (GCV) and leave-one-out cross-validation (LOOCV) applied to early-stopped gradient descent (GD) in high-dimensional least squares regression. We prove that GCV is generically inconsistent as an estimator of the prediction risk of early-stopped GD, even for a well-specified linear model with isotropic features. In contrast, we show that LOOCV converges uniformly along the GD trajectory to the prediction risk. Our theory requires only mild assumptions on the data distribution and does not require the underlying regression function to be linear. Furthermore, by leveraging the individual LOOCV errors, we construct consistent estimators for the entire prediction error distribution along the GD trajectory and consistent estimators for a wide class of error functionals. This in particular enables the construction of pathwise prediction intervals based on GD iterates that have asymptotically correct nominal coverage conditional on the training data.
Robotic manipulation in human environments is a challenging problem for researchers and industry alike. In particular, opening doors/drawers can be challenging for robots, as the size, shape, actuation and required force is variable. Because of this, it can be difficult to collect large real-world datasets and to benchmark different control algorithms on the same hardware. In this paper we present two automated testbeds, the Door Reset Mechanism (DORM) and Drawer Reset Mechanism (DWRM), for the purpose of real world testing and data collection. These devices are low-cost, are sensorized, operate with customized variable resistance, and come with open source software. Additionally, we provide a dataset of over 600 grasps using the DORM and DWRM. We use this dataset to highlight how much variability can exist even with the same trial on the same hardware. This data can also serve as a source for real-world noise in simulation environments.
The brain-inspired Spiking Neural Networks (SNNs) have garnered considerable research interest due to their superior performance and energy efficiency in processing temporal signals. Recently, a novel multi-compartment spiking neuron model, namely the Two-Compartment LIF (TC-LIF) model, has been proposed and exhibited a remarkable capacity for sequential modelling. However, training the TC-LIF model presents challenges stemming from the large memory consumption and the issue of gradient vanishing associated with the Backpropagation Through Time (BPTT) algorithm. To address these challenges, online learning methodologies emerge as a promising solution. Yet, to date, the application of online learning methods in SNNs has been predominantly confined to simplified Leaky Integrate-and-Fire (LIF) neuron models. In this paper, we present a novel online learning method specifically tailored for networks of TC-LIF neurons. Additionally, we propose a refined TC-LIF neuron model called Adaptive TC-LIF, which is carefully designed to enhance temporal information integration in online learning scenarios. Extensive experiments, conducted on various sequential benchmarks, demonstrate that our approach successfully preserves the superior sequential modeling capabilities of the TC-LIF neuron while incorporating the training efficiency and hardware friendliness of online learning. As a result, it offers a multitude of opportunities to leverage neuromorphic solutions for processing temporal signals.
Many measures of human-robot trust have proliferated across the HRI research literature because each attempts to capture the factors that impact trust despite its many dimensions. None of the previous trust measures, however, address the systems of inequity and structures of power present in HRI research or attempt to counteract the systematic biases and potential harms caused by HRI systems. This position paper proposes a participatory and social justice-oriented approach for the design and evaluation of a trust measure. This proposed process would iteratively co-design the trust measure with the community for whom the HRI system is being created. The process would prioritize that community's needs and unique circumstances to produce a trust measure that accurately reflects the factors that impact their trust in a robot.
Large language models (LLMs) have made significant strides in reasoning capabilities, with ongoing efforts to refine their reasoning through self-correction. However, recent studies suggest that self-correction can be limited or even counterproductive without external accurate knowledge, raising questions about the limits and effectiveness of self-correction. In this paper, we aim to enhance LLM's self-checking capabilities by meticulously designing training data, thereby improving the accuracy of self-correction. We conduct a detailed analysis of error types in mathematical reasoning and develop a tailored prompt, termed "Step CoT Check". Then we construct a checking-correction dataset for training models. After integrating the original CoT data and checking-correction data for training, we observe that models could improve their self-checking capabilities, thereby enhancing their self-correction capacity and eliminating the need for external feedback or ground truth labels to ascertain the endpoint of correction. We compare the performance of models fine-tuned with the "Step CoT Check" prompt against those refined using other promps within the context of checking-correction data. The "Step CoT Check" outperforms the other two check formats in model with lager parameters, providing more precise feedback thus achieving a higher rate of correctness. For reproducibility, all the datasets and codes are provided in //github.com/bammt/Learn-to-check.
Large language models (LLMs) have strong capabilities in solving diverse natural language processing tasks. However, the safety and security issues of LLM systems have become the major obstacle to their widespread application. Many studies have extensively investigated risks in LLM systems and developed the corresponding mitigation strategies. Leading-edge enterprises such as OpenAI, Google, Meta, and Anthropic have also made lots of efforts on responsible LLMs. Therefore, there is a growing need to organize the existing studies and establish comprehensive taxonomies for the community. In this paper, we delve into four essential modules of an LLM system, including an input module for receiving prompts, a language model trained on extensive corpora, a toolchain module for development and deployment, and an output module for exporting LLM-generated content. Based on this, we propose a comprehensive taxonomy, which systematically analyzes potential risks associated with each module of an LLM system and discusses the corresponding mitigation strategies. Furthermore, we review prevalent benchmarks, aiming to facilitate the risk assessment of LLM systems. We hope that this paper can help LLM participants embrace a systematic perspective to build their responsible LLM systems.
Deep neural networks (DNNs) are successful in many computer vision tasks. However, the most accurate DNNs require millions of parameters and operations, making them energy, computation and memory intensive. This impedes the deployment of large DNNs in low-power devices with limited compute resources. Recent research improves DNN models by reducing the memory requirement, energy consumption, and number of operations without significantly decreasing the accuracy. This paper surveys the progress of low-power deep learning and computer vision, specifically in regards to inference, and discusses the methods for compacting and accelerating DNN models. The techniques can be divided into four major categories: (1) parameter quantization and pruning, (2) compressed convolutional filters and matrix factorization, (3) network architecture search, and (4) knowledge distillation. We analyze the accuracy, advantages, disadvantages, and potential solutions to the problems with the techniques in each category. We also discuss new evaluation metrics as a guideline for future research.