The diagnostic value of biopsies is highly dependent on the placement of needles. Robotic trajectory guidance has been shown to improve needle positioning, but feedback for real-time navigation is limited. Haptic display of needle tip forces can provide rich feedback for needle navigation by enabling localization of tissue structures along the insertion path. We present a collaborative robotic biopsy system that combines trajectory guidance with kinesthetic feedback to assist the physician in needle placement. The robot aligns the needle while the insertion is performed in collaboration with a medical expert who controls the needle position on site. We present a needle design that senses forces at the needle tip based on optical coherence tomography and machine learning for real-time data processing. Our robotic setup allows operators to sense deep tissue interfaces independent of frictional forces to improve needle placement relative to a desired target structure. We first evaluate needle tip force sensing in ex-vivo tissue in a phantom study. We characterize the tip forces during insertions with constant velocity and demonstrate the ability to detect tissue interfaces in a collaborative user study. Participants are able to detect 91% of ex-vivo tissue interfaces based on needle tip force feedback alone. Finally, we demonstrate that even smaller, deep target structures can be accurately sampled by performing post-mortem in situ biopsies of the pancreas.
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Inverse propensity weighting (IPW) is a popular method for estimating treatment effects from observational data. However, its correctness relies on the untestable (and frequently implausible) assumption that all confounders have been measured. This paper introduces a robust sensitivity analysis for IPW that estimates the range of treatment effects compatible with a given amount of unobserved confounding. The estimated range converges to the narrowest possible interval (under the given assumptions) that must contain the true treatment effect. Our proposal is a refinement of the influential sensitivity analysis by Zhao, Small, and Bhattacharya (2019), which we show gives bounds that are too wide even asymptotically. This analysis is based on new partial identification results for Tan (2006)'s marginal sensitivity model.
Many material properties are manifested in the morphological appearance and characterized with microscopic image, such as scanning electron microscopy (SEM). Polymer miscibility is a key physical quantity of polymer material and commonly and intuitively judged by SEM images. However, human observation and judgement for the images is time-consuming, labor-intensive and hard to be quantified. Computer image recognition with machine learning method can make up the defects of artificial judging, giving accurate and quantitative judgement. We achieve automatic miscibility recognition utilizing convolution neural network and transfer learning method, and the model obtains up to 94% accuracy. We also put forward a quantitative criterion for polymer miscibility with this model. The proposed method can be widely applied to the quantitative characterization of the microstructure and properties of various materials.
Matching problems with group-fairness constraints and diversity constraints have numerous applications such as in allocation problems, committee selection, school choice, etc. Moreover, online matching problems have lots of applications in ad allocations and other e-commerce problems like product recommendation in digital marketing. We study two problems involving assigning {\em items} to {\em platforms}, where items belong to various {\em groups} depending on their attributes; the set of items are available offline and the platforms arrive online. In the first problem, we study online matchings with {\em proportional fairness constraints}. Here, each platform on arrival should either be assigned a set of items in which the fraction of items from each group is within specified bounds or be assigned no items; the goal is to assign items to platforms in order to maximize the number of items assigned to platforms. In the second problem, we study online matchings with {\em diversity constraints}, i.e. for each platform, absolute lower bounds are specified for each group. Each platform on arrival should either be assigned a set of items that satisfy these bounds or be assigned no items; the goal is to maximize the set of platforms that get matched. We study approximation algorithms and hardness results for these problems. The technical core of our proofs is a new connection between these problems and the problem of matchings in hypergraphs. Our experimental evaluation shows the performance of our algorithms on real-world and synthetic datasets exceeds our theoretical guarantees.
Online auction scenarios, such as bidding searches on advertising platforms, often require bidders to participate repeatedly in auctions for the same or similar items. We design an algorithm for adaptive automatic bidding in repeated auctions in which the seller and other bidders also update their strategies. We apply and improve the opponent modeling algorithm to allow bidders to learn optimal bidding strategies in this multiagent reinforcement learning environment. The algorithm uses almost no private information about the opponent or restrictions on the strategy space, so it can be extended to multiple scenarios. Our algorithm improves the utility compared to both static bidding strategies and dynamic learning strategies. We hope the application of opponent modeling in auctions will promote the research of automatic bidding strategies in online auctions and the design of non-incentive compatible auction mechanisms.
Recent diffusion probabilistic models (DPMs) have shown remarkable abilities of generated content, however, they often suffer from complex forward processes, resulting in inefficient solutions for the reversed process and prolonged sampling times. In this paper, we aim to address the aforementioned challenges by focusing on the diffusion process itself that we propose to decouple the intricate diffusion process into two comparatively simpler process to improve the generative efficacy and speed. In particular, we present a novel diffusion paradigm named DDM (Decoupled Diffusion Models) based on the Ito diffusion process, in which the image distribution is approximated by an explicit transition probability while the noise path is controlled by the standard Wiener process. We find that decoupling the diffusion process reduces the learning difficulty and the explicit transition probability improves the generative speed significantly. We prove a new training objective for DPM, which enables the model to learn to predict the noise and image components separately. Moreover, given the novel forward diffusion equation, we derive the reverse denoising formula of DDM that naturally supports fewer steps of generation without ordinary differential equation (ODE) based accelerators. Our experiments demonstrate that DDM outperforms previous DPMs by a large margin in fewer function evaluations setting and gets comparable performances in long function evaluations setting. We also show that our framework can be applied to image-conditioned generation and high-resolution image synthesis, and that it can generate high-quality images with only 10 function evaluations.
Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from using traditional methods to infer potential causal structures from observational data to the field of pattern recognition involved in deep learning. The rapid accumulation of massive data promotes the emergence of causal search methods with brilliant scalability. Existing summaries of causal discovery methods mainly focus on traditional methods based on constraints, scores and FCMs, there is a lack of perfect sorting and elaboration for deep learning-based methods, also lacking some considers and exploration of causal discovery methods from the perspective of variable paradigms. Therefore, we divide the possible causal discovery tasks into three types according to the variable paradigm and give the definitions of the three tasks respectively, define and instantiate the relevant datasets for each task and the final causal model constructed at the same time, then reviews the main existing causal discovery methods for different tasks. Finally, we propose some roadmaps from different perspectives for the current research gaps in the field of causal discovery and point out future research directions.
Spectral clustering (SC) is a popular clustering technique to find strongly connected communities on a graph. SC can be used in Graph Neural Networks (GNNs) to implement pooling operations that aggregate nodes belonging to the same cluster. However, the eigendecomposition of the Laplacian is expensive and, since clustering results are graph-specific, pooling methods based on SC must perform a new optimization for each new sample. In this paper, we propose a graph clustering approach that addresses these limitations of SC. We formulate a continuous relaxation of the normalized minCUT problem and train a GNN to compute cluster assignments that minimize this objective. Our GNN-based implementation is differentiable, does not require to compute the spectral decomposition, and learns a clustering function that can be quickly evaluated on out-of-sample graphs. From the proposed clustering method, we design a graph pooling operator that overcomes some important limitations of state-of-the-art graph pooling techniques and achieves the best performance in several supervised and unsupervised tasks.
Pre-trained deep neural network language models such as ELMo, GPT, BERT and XLNet have recently achieved state-of-the-art performance on a variety of language understanding tasks. However, their size makes them impractical for a number of scenarios, especially on mobile and edge devices. In particular, the input word embedding matrix accounts for a significant proportion of the model's memory footprint, due to the large input vocabulary and embedding dimensions. Knowledge distillation techniques have had success at compressing large neural network models, but they are ineffective at yielding student models with vocabularies different from the original teacher models. We introduce a novel knowledge distillation technique for training a student model with a significantly smaller vocabulary as well as lower embedding and hidden state dimensions. Specifically, we employ a dual-training mechanism that trains the teacher and student models simultaneously to obtain optimal word embeddings for the student vocabulary. We combine this approach with learning shared projection matrices that transfer layer-wise knowledge from the teacher model to the student model. Our method is able to compress the BERT_BASE model by more than 60x, with only a minor drop in downstream task metrics, resulting in a language model with a footprint of under 7MB. Experimental results also demonstrate higher compression efficiency and accuracy when compared with other state-of-the-art compression techniques.
Object detection typically assumes that training and test data are drawn from an identical distribution, which, however, does not always hold in practice. Such a distribution mismatch will lead to a significant performance drop. In this work, we aim to improve the cross-domain robustness of object detection. We tackle the domain shift on two levels: 1) the image-level shift, such as image style, illumination, etc, and 2) the instance-level shift, such as object appearance, size, etc. We build our approach based on the recent state-of-the-art Faster R-CNN model, and design two domain adaptation components, on image level and instance level, to reduce the domain discrepancy. The two domain adaptation components are based on H-divergence theory, and are implemented by learning a domain classifier in adversarial training manner. The domain classifiers on different levels are further reinforced with a consistency regularization to learn a domain-invariant region proposal network (RPN) in the Faster R-CNN model. We evaluate our newly proposed approach using multiple datasets including Cityscapes, KITTI, SIM10K, etc. The results demonstrate the effectiveness of our proposed approach for robust object detection in various domain shift scenarios.
Deep neural networks (DNNs) have been found to be vulnerable to adversarial examples resulting from adding small-magnitude perturbations to inputs. Such adversarial examples can mislead DNNs to produce adversary-selected results. Different attack strategies have been proposed to generate adversarial examples, but how to produce them with high perceptual quality and more efficiently requires more research efforts. In this paper, we propose AdvGAN to generate adversarial examples with generative adversarial networks (GANs), which can learn and approximate the distribution of original instances. For AdvGAN, once the generator is trained, it can generate adversarial perturbations efficiently for any instance, so as to potentially accelerate adversarial training as defenses. We apply AdvGAN in both semi-whitebox and black-box attack settings. In semi-whitebox attacks, there is no need to access the original target model after the generator is trained, in contrast to traditional white-box attacks. In black-box attacks, we dynamically train a distilled model for the black-box model and optimize the generator accordingly. Adversarial examples generated by AdvGAN on different target models have high attack success rate under state-of-the-art defenses compared to other attacks. Our attack has placed the first with 92.76% accuracy on a public MNIST black-box attack challenge.
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