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Recent advances in artificial intelligence (AI), in particular self-supervised learning of foundation models (FMs), are revolutionizing medical imaging and computational pathology (CPath). A constant challenge in the analysis of digital Whole Slide Images (WSIs) is the problem of aggregating tens of thousands of tile-level image embeddings to a slide-level representation. Due to the prevalent use of datasets created for genomic research, such as TCGA, for method development, the performance of these techniques on diagnostic slides from clinical practice has been inadequately explored. This study conducts a thorough benchmarking analysis of ten slide-level aggregation techniques across nine clinically relevant tasks, including diagnostic assessment, biomarker classification, and outcome prediction. The results yield following key insights: (1) Embeddings derived from domain-specific (histological images) FMs outperform those from generic ImageNet-based models across aggregation methods. (2) Spatial-aware aggregators enhance the performance significantly when using ImageNet pre-trained models but not when using FMs. (3) No single model excels in all tasks and spatially-aware models do not show general superiority as it would be expected. These findings underscore the need for more adaptable and universally applicable aggregation techniques, guiding future research towards tools that better meet the evolving needs of clinical-AI in pathology. The code used in this work is available at \url{//github.com/fuchs-lab-public/CPath_SABenchmark}.

Causal inference has recently garnered significant interest among recommender system (RS) researchers due to its ability to dissect cause-and-effect relationships and its broad applicability across multiple fields. It offers a framework to model the causality in recommender systems like confounding effects and deal with counterfactual problems such as offline policy evaluation and data augmentation. Although there are already some valuable surveys on causal recommendations, they typically classify approaches based on the practical issues faced in RS, a classification that may disperse and fragment the unified causal theories. Considering RS researchers' unfamiliarity with causality, it is necessary yet challenging to comprehensively review relevant studies from a coherent causal theoretical perspective, thereby facilitating a deeper integration of causal inference in RS. This survey provides a systematic review of up-to-date papers in this area from a causal theory standpoint and traces the evolutionary development of RS methods within the same causal strategy. Firstly, we introduce the fundamental concepts of causal inference as the basis of the following review. Subsequently, we propose a novel theory-driven taxonomy, categorizing existing methods based on the causal theory employed - namely, those based on the potential outcome framework, the structural causal model, and general counterfactuals. The review then delves into the technical details of how existing methods apply causal inference to address particular recommender issues. Finally, we highlight some promising directions for future research in this field. Representative papers and open-source resources will be progressively available at //github.com/Chrissie-Law/Causal-Inference-for-Recommendation.

Temporal reasoning (TR) is a critical component of artificial intelligence, encompassing understanding and processing temporal information and relationships between events. To discover and study the TR ability in Large Language Models (LLMs), various datasets have been constructed in different ways for evaluating various aspects of TR ability. Our work proposes a novel approach to design and develop a pipeline for constructing datasets to evaluate the TR ability of LLMs by leveraging random directed graph generation, LTL formula, and the NuSMV model checker. Based on the pipeline, we have also constructed a dataset as a benchmark, namely LTLBench, consisting of 2,000 TR challenges and evaluated six LLMs with it. Furthermore, we have conducted additional experiments to discover the impact of increasing the number of events and formula operators on the complexity of TR problems and the performance of LLMs. We have demonstrated that although LLMs exhibit some promise in handling TR challenges, they still struggle with complex TR. We expect this work can offer insights into TR ability in LLMs while also providing a valuable tool for future TR evaluations.

As intelligent robots like autonomous vehicles become increasingly deployed in the presence of people, the extent to which these systems should leverage model-based game-theoretic planners versus data-driven policies for safe, interaction-aware motion planning remains an open question. Existing dynamic game formulations assume all agents are task-driven and behave optimally. However, in reality, humans tend to deviate from the decisions prescribed by these models, and their behavior is better approximated under a noisy-rational paradigm. In this work, we investigate a principled methodology to blend a data-driven reference policy with an optimization-based game-theoretic policy. We formulate KLGame, an algorithm for solving non-cooperative dynamic game with Kullback-Leibler (KL) regularization with respect to a general, stochastic, and possibly multi-modal reference policy. Our method incorporates, for each decision maker, a tunable parameter that permits modulation between task-driven and data-driven behaviors. We propose an efficient algorithm for computing multi-modal approximate feedback Nash equilibrium strategies of KLGame in real time. Through a series of simulated and real-world autonomous driving scenarios, we demonstrate that KLGame policies can more effectively incorporate guidance from the reference policy and account for noisily-rational human behaviors versus non-regularized baselines. Website with additional information, videos, and code: //kl-games.github.io/.

In safety-critical robot planning or control, manually specifying safety constraints or learning them from demonstrations can be challenging. In this paper, we propose a certifiable alignment method for a robot to learn a safety constraint in its model predictive control (MPC) policy with human online directional feedback. To our knowledge, it is the first method to learn safety constraints from human feedback. The proposed method is based on an empirical observation: human directional feedback, when available, tends to guide the robot toward safer regions. The method only requires the direction of human feedback to update the learning hypothesis space. It is certifiable, providing an upper bound on the total number of human feedback in the case of successful learning of safety constraints, or declaring the misspecification of the hypothesis space, i.e., the true implicit safety constraint cannot be found within the specified hypothesis space. We evaluated the proposed method using numerical examples and user studies in two developed simulation games. Additionally, we implemented and tested the proposed method on a real-world Franka robot arm performing mobile water-pouring tasks in a user study. The simulation and experimental results demonstrate the efficacy and efficiency of our method, showing that it enables a robot to successfully learn safety constraints with a small handful (tens) of human directional corrections.

Electroencephalogram (EEG) technology, particularly high-density EEG (HD EEG) devices, is widely used in fields such as neuroscience. HD EEG devices improve the spatial resolution of EEG by placing more electrodes on the scalp, meeting the requirements of clinical diagnostic applications such as epilepsy focus localization. However, this technique faces challenges such as high acquisition costs and limited usage scenarios. In this paper, spatio-temporal adaptive diffusion models (STADMs) are proposed to pioneer the use of diffusion models for achieving spatial SR reconstruction from low-resolution (LR, 64 channels or fewer) EEG to high-resolution (HR, 256 channels) EEG. Specifically, a spatio-temporal condition module is designed to extract the spatio-temporal features of LR EEG, which then serve as conditional inputs to guide the reverse denoising process of diffusion models. Additionally, a multi-scale Transformer denoising module is constructed to leverage multi-scale convolution blocks and cross-attention-based diffusion Transformer blocks for conditional guidance to generate subject-adaptive SR EEG. Experimental results demonstrate that the proposed method effectively enhances the spatial resolution of LR EEG and quantitatively outperforms existing methods. Furthermore, STADMs demonstrate their value by applying synthetic SR EEG to classification and source localization tasks of epilepsy patients, indicating their potential to significantly improve the spatial resolution of LR EEG.

Knowledge graphs represent factual knowledge about the world as relationships between concepts and are critical for intelligent decision making in enterprise applications. New knowledge is inferred from the existing facts in the knowledge graphs by encoding the concepts and relations into low-dimensional feature vector representations. The most effective representations for this task, called Knowledge Graph Embeddings (KGE), are learned through neural network architectures. Due to their impressive predictive performance, they are increasingly used in high-impact domains like healthcare, finance and education. However, are the black-box KGE models adversarially robust for use in domains with high stakes? This thesis argues that state-of-the-art KGE models are vulnerable to data poisoning attacks, that is, their predictive performance can be degraded by systematically crafted perturbations to the training knowledge graph. To support this argument, two novel data poisoning attacks are proposed that craft input deletions or additions at training time to subvert the learned model's performance at inference time. These adversarial attacks target the task of predicting the missing facts in knowledge graphs using KGE models, and the evaluation shows that the simpler attacks are competitive with or outperform the computationally expensive ones. The thesis contributions not only highlight and provide an opportunity to fix the security vulnerabilities of KGE models, but also help to understand the black-box predictive behaviour of KGE models.

Graph neural networks (GNNs) are a popular class of machine learning models whose major advantage is their ability to incorporate a sparse and discrete dependency structure between data points. Unfortunately, GNNs can only be used when such a graph-structure is available. In practice, however, real-world graphs are often noisy and incomplete or might not be available at all. With this work, we propose to jointly learn the graph structure and the parameters of graph convolutional networks (GCNs) by approximately solving a bilevel program that learns a discrete probability distribution on the edges of the graph. This allows one to apply GCNs not only in scenarios where the given graph is incomplete or corrupted but also in those where a graph is not available. We conduct a series of experiments that analyze the behavior of the proposed method and demonstrate that it outperforms related methods by a significant margin.

Named entity recognition (NER) is the task to identify text spans that mention named entities, and to classify them into predefined categories such as person, location, organization etc. NER serves as the basis for a variety of natural language applications such as question answering, text summarization, and machine translation. Although early NER systems are successful in producing decent recognition accuracy, they often require much human effort in carefully designing rules or features. In recent years, deep learning, empowered by continuous real-valued vector representations and semantic composition through nonlinear processing, has been employed in NER systems, yielding stat-of-the-art performance. In this paper, we provide a comprehensive review on existing deep learning techniques for NER. We first introduce NER resources, including tagged NER corpora and off-the-shelf NER tools. Then, we systematically categorize existing works based on a taxonomy along three axes: distributed representations for input, context encoder, and tag decoder. Next, we survey the most representative methods for recent applied techniques of deep learning in new NER problem settings and applications. Finally, we present readers with the challenges faced by NER systems and outline future directions in this area.

Detecting carried objects is one of the requirements for developing systems to reason about activities involving people and objects. We present an approach to detect carried objects from a single video frame with a novel method that incorporates features from multiple scales. Initially, a foreground mask in a video frame is segmented into multi-scale superpixels. Then the human-like regions in the segmented area are identified by matching a set of extracted features from superpixels against learned features in a codebook. A carried object probability map is generated using the complement of the matching probabilities of superpixels to human-like regions and background information. A group of superpixels with high carried object probability and strong edge support is then merged to obtain the shape of the carried object. We applied our method to two challenging datasets, and results show that our method is competitive with or better than the state-of-the-art.