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Population adjustment methods such as matching-adjusted indirect comparison (MAIC) are increasingly used to compare marginal treatment effects when there are cross-trial differences in effect modifiers and limited patient-level data. MAIC is sensitive to poor covariate overlap and cannot extrapolate beyond the observed covariate space. Current outcome regression-based alternatives can extrapolate but target a conditional treatment effect that is incompatible in the indirect comparison. When adjusting for covariates, one must integrate or average the conditional estimate over the population of interest to recover a compatible marginal treatment effect. We propose a marginalization method based on parametric G-computation that can be easily applied where the outcome regression is a generalized linear model or a Cox model. In addition, we introduce a novel general-purpose method based on multiple imputation, which we term multiple imputation marginalization (MIM) and is applicable to a wide range of models. Both methods can accommodate a Bayesian statistical framework, which naturally integrates the analysis into a probabilistic framework. A simulation study provides proof-of-principle for the methods and benchmarks their performance against MAIC and the conventional outcome regression. The marginalized outcome regression approaches achieve more precise and more accurate estimates than MAIC, particularly when covariate overlap is poor, and yield unbiased marginal treatment effect estimates under no failures of assumptions. Furthermore, the marginalized covariate-adjusted estimates provide greater precision and accuracy than the conditional estimates produced by the conventional outcome regression, which are systematically biased because the measure of effect is non-collapsible.

Estimating causal effects from observational data informs us about which factors are important in an autonomous system, and enables us to take better decisions. This is important because it has applications in selecting a treatment in medical systems or making better strategies in industries or making better policies for our government or even the society. Unavailability of complete data, coupled with high cardinality of data, makes this estimation task computationally intractable. Recently, a regression-based weighted estimator has been introduced that is capable of producing solution using bounded samples of a given problem. However, as the data dimension increases, the solution produced by the regression-based method degrades. Against this background, we introduce a neural network based estimator that improves the solution quality in case of non-linear and finitude of samples. Finally, our empirical evaluation illustrates a significant improvement of solution quality, up to around $55\%$, compared to the state-of-the-art estimators.

This work presents a new recursive robust filtering approach for feature-based 3D registration. Unlike the common state-of-the-art alignment algorithms, the proposed method has four advantages that have not yet occurred altogether in any previous solution. For instance, it is able to deal with inherent noise contaminating sensory data; it is robust to uncertainties caused by noisy feature localisation; it also combines the advantages of both (Formula presented.) and (Formula presented.) norms for a higher performance and a more prospective prevention of local minima. The result is an accurate and stable rigid body transformation. The latter enables a thorough control over the convergence regarding the alignment as well as a correct assessment of the quality of registration. The mathematical rationale behind the proposed approach is explained, and the results are validated on physical and synthetic data.

The idea of covariate balance is at the core of causal inference. Inverse propensity weights play a central role because they are the unique set of weights that balance the covariate distributions of different treatment groups. We discuss two broad approaches to estimating these weights: the more traditional one, which fits a propensity score model and then uses the reciprocal of the estimated propensity score to construct weights, and the balancing approach, which estimates the inverse propensity weights essentially by the method of moments, finding weights that achieve balance in the sample. We review ideas from the causal inference, sample surveys, and semiparametric estimation literatures, with particular attention to the role of balance as a sufficient condition for robust inference. We focus on the inverse propensity weighting and augmented inverse propensity weighting estimators for the average treatment effect given strong ignorability and consider generalizations for a broader class of problems including policy evaluation and the estimation of individualized treatment effects.

We propose novel compression algorithms to time-varying channel state information (CSI) for wireless communications. The proposed scheme combines (lossy) vector quantisation and (lossless) compression. First, the new vector quantisation technique is based on a class of parametrised companders applied on each component of the normalised vector. Our algorithm chooses a suitable compander in an intuitively simple way whenever empirical data are available. Then, we compress the quantised index sequences using a context-tree-based approach. Essentially, we update the estimate of the conditional distribution of the source at each instant and encode the current symbol with the estimated distribution. The algorithms have low complexity, are linear-time in both the spatial dimension and time duration, and can be implemented in an online fashion. We run simulations to demonstrate the effectiveness of the proposed algorithms in such scenarios.

The semiparametric estimation approach, which includes inverse-probability-weighted and doubly robust estimation using propensity scores, is a standard tool for marginal structural models basically used in causal inference, and is rapidly being extended and generalized in various directions. On the other hand, although model selection is indispensable in statistical analysis, information criterion for selecting an appropriate marginal structure has just started to be developed. In this paper, based on the original idea of the information criterion, we derive an AIC-type criterion. We define a risk function based on the Kullback-Leibler divergence as the cornerstone of the information criterion, and treat a general causal inference model that is not necessarily of the type represented as a linear model. The causal effects to be estimated are those in the general population, such as the average treatment effect on the treated or the average treatment effect on the untreated. In light of the fact that doubly robust estimation, which allows either the model of the assignment variable or the model of the outcome variable to be wrong, is attached importance in this field, we will make the information criterion itself doubly robust, so that either one of the two can be wrong and still be a mathematically valid criterion.

This work addresses testing the independence of two continuous and finite-dimensional random variables from the design of a data-driven partition. The empirical log-likelihood statistic is adopted to approximate the sufficient statistics of an oracle test against independence (that knows the two hypotheses). It is shown that approximating the sufficient statistics of the oracle test offers a learning criterion for designing a data-driven partition that connects with the problem of mutual information estimation. Applying these ideas in the context of a data-dependent tree-structured partition (TSP), we derive conditions on the TSP's parameters to achieve a strongly consistent distribution-free test of independence over the family of probabilities equipped with a density. Complementing this result, we present finite-length results that show our TSP scheme's capacity to detect the scenario of independence structurally with the data-driven partition as well as new sampling complexity bounds for this detection. Finally, some experimental analyses provide evidence regarding our scheme's advantage for testing independence compared with some strategies that do not use data-driven representations.

This paper focuses on the expected difference in borrower's repayment when there is a change in the lender's credit decisions. Classical estimators overlook the confounding effects and hence the estimation error can be magnificent. As such, we propose another approach to construct the estimators such that the error can be greatly reduced. The proposed estimators are shown to be unbiased, consistent, and robust through a combination of theoretical analysis and numerical testing. Moreover, we compare the power of estimating the causal quantities between the classical estimators and the proposed estimators. The comparison is tested across a wide range of models, including linear regression models, tree-based models, and neural network-based models, under different simulated datasets that exhibit different levels of causality, different degrees of nonlinearity, and different distributional properties. Most importantly, we apply our approaches to a large observational dataset provided by a global technology firm that operates in both the e-commerce and the lending business. We find that the relative reduction of estimation error is strikingly substantial if the causal effects are accounted for correctly.

The availability of large microarray data has led to a growing interest in biclustering methods in the past decade. Several algorithms have been proposed to identify subsets of genes and conditions according to different similarity measures and under varying constraints. In this paper we focus on the exclusive row biclustering problem for gene expression data sets, in which each row can only be a member of a single bicluster while columns can participate in multiple ones. This type of biclustering may be adequate, for example, for clustering groups of cancer patients where each patient (row) is expected to be carrying only a single type of cancer, while each cancer type is associated with multiple (and possibly overlapping) genes (columns). We present a novel method to identify these exclusive row biclusters through a combination of existing biclustering algorithms and combinatorial auction techniques. We devise an approach for tuning the threshold for our algorithm based on comparison to a null model in the spirit of the Gap statistic approach. We demonstrate our approach on both synthetic and real-world gene expression data and show its power in identifying large span non-overlapping rows sub matrices, while considering their unique nature. The Gap statistic approach succeeds in identifying appropriate thresholds in all our examples.

A social interaction is a social exchange between two or more individuals,where individuals modify and adjust their behaviors in response to their interaction partners. Our social interactions are one of most fundamental aspects of our lives and can profoundly affect our mood, both positively and negatively. With growing interest in virtual reality and avatar-mediated interactions,it is desirable to make these interactions natural and human like to promote positive effect in the interactions and applications such as intelligent tutoring systems, automated interview systems and e-learning. In this paper, we propose a method to generate facial behaviors for an agent. These behaviors include facial expressions and head pose and they are generated considering the users affective state. Our models learn semantically meaningful representations of the face and generate appropriate and temporally smooth facial behaviors in dyadic interactions.