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The recent success of large language models (LLMs) has paved the way for their adoption in the high-stakes domain of healthcare. Specifically, the application of LLMs in patient-trial matching, which involves assessing patient eligibility against clinical trial's nuanced inclusion and exclusion criteria, has shown promise. Recent research has shown that GPT-3.5, a widely recognized LLM developed by OpenAI, can outperform existing methods with minimal 'variable engineering' by simply comparing clinical trial information against patient summaries. However, there are significant challenges associated with using closed-source proprietary LLMs like GPT-3.5 in practical healthcare applications, such as cost, privacy and reproducibility concerns. To address these issues, this study presents the first systematic examination of the efficacy of both proprietary (GPT-3.5, and GPT-4) and open-source LLMs (LLAMA 7B,13B, and 70B) for the task of patient-trial matching. Employing a multifaceted evaluation framework, we conducted extensive automated and human-centric assessments coupled with a detailed error analysis for each model. To enhance the adaptability of open-source LLMs, we have created a specialized synthetic dataset utilizing GPT-4, enabling effective fine-tuning under constrained data conditions. Our findings reveal that open-source LLMs, when fine-tuned on this limited and synthetic dataset, demonstrate performance parity with their proprietary counterparts. This presents a massive opportunity for their deployment in real-world healthcare applications. To foster further research and applications in this field, we release both the annotated evaluation dataset along with the fine-tuned LLM -- Trial-LLAMA -- for public use.

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大(da)(da)語(yu)(yu)言(yan)(yan)模(mo)型(xing)是基于海量文(wen)本(ben)(ben)(ben)數據訓(xun)練的(de)深(shen)度(du)學(xue)習模(mo)型(xing)。它(ta)不僅(jin)能(neng)(neng)(neng)夠生(sheng)成自然語(yu)(yu)言(yan)(yan)文(wen)本(ben)(ben)(ben),還能(neng)(neng)(neng)夠深(shen)入理(li)解(jie)文(wen)本(ben)(ben)(ben)含義,處理(li)各種自然語(yu)(yu)言(yan)(yan)任務,如文(wen)本(ben)(ben)(ben)摘要(yao)、問答、翻(fan)譯(yi)等(deng)。2023年,大(da)(da)語(yu)(yu)言(yan)(yan)模(mo)型(xing)及(ji)其(qi)在人(ren)工智(zhi)能(neng)(neng)(neng)領(ling)域(yu)的(de)應(ying)(ying)用已成為全球科(ke)技研究的(de)熱(re)點(dian),其(qi)在規模(mo)上的(de)增長尤為引人(ren)注目,參數量已從最初的(de)十幾(ji)億躍升到如今(jin)的(de)一萬億。參數量的(de)提(ti)升使得模(mo)型(xing)能(neng)(neng)(neng)夠更加精細地捕捉(zhuo)人(ren)類(lei)語(yu)(yu)言(yan)(yan)微妙之處,更加深(shen)入地理(li)解(jie)人(ren)類(lei)語(yu)(yu)言(yan)(yan)的(de)復(fu)雜性(xing)。在過去的(de)一年里,大(da)(da)語(yu)(yu)言(yan)(yan)模(mo)型(xing)在吸納新知識、分解(jie)復(fu)雜任務以及(ji)圖文(wen)對齊(qi)等(deng)多方面(mian)都有顯著提(ti)升。隨(sui)著技術的(de)不斷(duan)成熟,它(ta)將不斷(duan)拓展(zhan)其(qi)應(ying)(ying)用范(fan)圍(wei),為人(ren)類(lei)提(ti)供更加智(zhi)能(neng)(neng)(neng)化和個性(xing)化的(de)服務,進一步改善人(ren)們的(de)生(sheng)活和生(sheng)產方式。

The study of reinforcement learning from human feedback (RLHF) has gained prominence in recent years due to its role in the development of LLMs. Neuroscience research shows that human responses to stimuli are known to depend on partially-observed "internal states." Unfortunately current models of RLHF do not take take this into consideration. Moreover most RLHF models do not account for intermediate feedback, which is gaining importance in empirical work and can help improve both sample complexity and alignment. To address these limitations, we model RLHF as reinforcement learning with partially observed reward-states (PORRL). We show reductions from the the two dominant forms of human feedback in RLHF - cardinal and dueling feedback to PORRL. For cardinal feedback, we develop generic statistically efficient algorithms and instantiate them to present POR-UCRL and POR-UCBVI. For dueling feedback, we show that a naive reduction to cardinal feedback fails to achieve sublinear dueling regret. We then present the first explicit reduction that converts guarantees for cardinal regret to dueling regret. We show that our models and guarantees in both settings generalize and extend existing ones. Finally, we identify a recursive structure on our model that could improve the statistical and computational tractability of PORRL, giving examples from past work on RLHF as well as learning perfect reward machines, which PORRL subsumes.

The increasing rate at which scientific knowledge is discovered and health claims shared online has highlighted the importance of developing efficient fact-checking systems for scientific claims. The usual setting for this task in the literature assumes that the documents containing the evidence for claims are already provided and annotated or contained in a limited corpus. This renders the systems unrealistic for real-world settings where knowledge sources with potentially millions of documents need to be queried to find relevant evidence. In this paper, we perform an array of experiments to test the performance of open-domain claim verification systems. We test the final verdict prediction of systems on four datasets of biomedical and health claims in different settings. While keeping the pipeline's evidence selection and verdict prediction parts constant, document retrieval is performed over three common knowledge sources (PubMed, Wikipedia, Google) and using two different information retrieval techniques. We show that PubMed works better with specialized biomedical claims, while Wikipedia is more suited for everyday health concerns. Likewise, BM25 excels in retrieval precision, while semantic search in recall of relevant evidence. We discuss the results, outline frequent retrieval patterns and challenges, and provide promising future directions.

The power of large language models (LLMs) has been demonstrated through numerous data and computing resources. However, the application of language models on mobile devices is facing huge challenge on the computation and memory costs, that is, tiny language models with high performance are urgently required. Limited by the highly complex training process, there are many details for optimizing language models that are seldom studied carefully. In this study, based on a tiny language model with 1B parameters, we carefully design a series of empirical study to analyze the effect of each component. Three perspectives are mainly discussed, i.e., neural architecture, parameter initialization, and optimization strategy. Several design formulas are empirically proved especially effective for tiny language models, including tokenizer compression, architecture tweaking, parameter inheritance and multiple-round training. Then we train PanGu-$\pi$-1B Pro and PanGu-$\pi$-1.5B Pro on 1.6T multilingual corpora, following the established formulas. Experimental results demonstrate the improved optimization and architecture yield a notable average improvement of 8.87 on benchmark evaluation sets for PanGu-$\pi$-1B Pro. Besides, PanGu-$\pi$-1.5B Pro surpasses a range of SOTA models with larger model sizes, validating its superior performance. The code will be released soon (//github.com/YuchuanTian/RethinkTinyLM).

This research explores strategies for steering the output of large language models (LLMs) towards specific styles, such as sentiment, emotion, or writing style, by adding style vectors to the activations of hidden layers during text generation. We show that style vectors can be simply computed from recorded layer activations for input texts in a specific style in contrast to more complex training-based approaches. Through a series of experiments, we demonstrate the effectiveness of activation engineering using such style vectors to influence the style of generated text in a nuanced and parameterisable way, distinguishing it from prompt engineering. The presented research constitutes a significant step towards developing more adaptive and effective AI-empowered interactive systems.

Artificial intelligence (AI) in healthcare, especially in medical imaging, faces challenges due to data scarcity and privacy concerns. Addressing these, we introduce Med-DDPM, a diffusion model designed for 3D semantic brain MRI synthesis. This model effectively tackles data scarcity and privacy issues by integrating semantic conditioning. This involves the channel-wise concatenation of a conditioning image to the model input, enabling control in image generation. Med-DDPM demonstrates superior stability and performance compared to existing 3D brain imaging synthesis methods. It generates diverse, anatomically coherent images with high visual fidelity. In terms of dice score accuracy in the tumor segmentation task, Med-DDPM achieves 0.6207, close to the 0.6531 accuracy of real images, and outperforms baseline models. Combined with real images, it further increases segmentation accuracy to 0.6675, showing the potential of our proposed method for data augmentation. This model represents the first use of a diffusion model in 3D semantic brain MRI synthesis, producing high-quality images. Its semantic conditioning feature also shows potential for image anonymization in biomedical imaging, addressing data and privacy issues. We provide the code and model weights for Med-DDPM on our GitHub repository (//github.com/mobaidoctor/med-ddpm/) to support reproducibility.

The advent of foundation models has revolutionized the fields of natural language processing and computer vision, paving the way for their application in autonomous driving (AD). This survey presents a comprehensive review of more than 40 research papers, demonstrating the role of foundation models in enhancing AD. Large language models contribute to planning and simulation in AD, particularly through their proficiency in reasoning, code generation and translation. In parallel, vision foundation models are increasingly adapted for critical tasks such as 3D object detection and tracking, as well as creating realistic driving scenarios for simulation and testing. Multi-modal foundation models, integrating diverse inputs, exhibit exceptional visual understanding and spatial reasoning, crucial for end-to-end AD. This survey not only provides a structured taxonomy, categorizing foundation models based on their modalities and functionalities within the AD domain but also delves into the methods employed in current research. It identifies the gaps between existing foundation models and cutting-edge AD approaches, thereby charting future research directions and proposing a roadmap for bridging these gaps.

Pre-trained deep neural network language models such as ELMo, GPT, BERT and XLNet have recently achieved state-of-the-art performance on a variety of language understanding tasks. However, their size makes them impractical for a number of scenarios, especially on mobile and edge devices. In particular, the input word embedding matrix accounts for a significant proportion of the model's memory footprint, due to the large input vocabulary and embedding dimensions. Knowledge distillation techniques have had success at compressing large neural network models, but they are ineffective at yielding student models with vocabularies different from the original teacher models. We introduce a novel knowledge distillation technique for training a student model with a significantly smaller vocabulary as well as lower embedding and hidden state dimensions. Specifically, we employ a dual-training mechanism that trains the teacher and student models simultaneously to obtain optimal word embeddings for the student vocabulary. We combine this approach with learning shared projection matrices that transfer layer-wise knowledge from the teacher model to the student model. Our method is able to compress the BERT_BASE model by more than 60x, with only a minor drop in downstream task metrics, resulting in a language model with a footprint of under 7MB. Experimental results also demonstrate higher compression efficiency and accuracy when compared with other state-of-the-art compression techniques.

Graph neural networks (GNNs) are a popular class of machine learning models whose major advantage is their ability to incorporate a sparse and discrete dependency structure between data points. Unfortunately, GNNs can only be used when such a graph-structure is available. In practice, however, real-world graphs are often noisy and incomplete or might not be available at all. With this work, we propose to jointly learn the graph structure and the parameters of graph convolutional networks (GCNs) by approximately solving a bilevel program that learns a discrete probability distribution on the edges of the graph. This allows one to apply GCNs not only in scenarios where the given graph is incomplete or corrupted but also in those where a graph is not available. We conduct a series of experiments that analyze the behavior of the proposed method and demonstrate that it outperforms related methods by a significant margin.

Deep neural networks (DNNs) have been found to be vulnerable to adversarial examples resulting from adding small-magnitude perturbations to inputs. Such adversarial examples can mislead DNNs to produce adversary-selected results. Different attack strategies have been proposed to generate adversarial examples, but how to produce them with high perceptual quality and more efficiently requires more research efforts. In this paper, we propose AdvGAN to generate adversarial examples with generative adversarial networks (GANs), which can learn and approximate the distribution of original instances. For AdvGAN, once the generator is trained, it can generate adversarial perturbations efficiently for any instance, so as to potentially accelerate adversarial training as defenses. We apply AdvGAN in both semi-whitebox and black-box attack settings. In semi-whitebox attacks, there is no need to access the original target model after the generator is trained, in contrast to traditional white-box attacks. In black-box attacks, we dynamically train a distilled model for the black-box model and optimize the generator accordingly. Adversarial examples generated by AdvGAN on different target models have high attack success rate under state-of-the-art defenses compared to other attacks. Our attack has placed the first with 92.76% accuracy on a public MNIST black-box attack challenge.

Detecting carried objects is one of the requirements for developing systems to reason about activities involving people and objects. We present an approach to detect carried objects from a single video frame with a novel method that incorporates features from multiple scales. Initially, a foreground mask in a video frame is segmented into multi-scale superpixels. Then the human-like regions in the segmented area are identified by matching a set of extracted features from superpixels against learned features in a codebook. A carried object probability map is generated using the complement of the matching probabilities of superpixels to human-like regions and background information. A group of superpixels with high carried object probability and strong edge support is then merged to obtain the shape of the carried object. We applied our method to two challenging datasets, and results show that our method is competitive with or better than the state-of-the-art.

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