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A large fraction of total healthcare expenditure occurs due to end-of-life (EOL) care, which means it is important to study the problem of more carefully incentivizing necessary versus unnecessary EOL care because this has the potential to reduce overall healthcare spending. This paper introduces a principal-agent model that integrates a mixed payment system of fee-for-service and pay-for-performance in order to analyze whether it is possible to better align healthcare provider incentives with patient outcomes and cost-efficiency in EOL care. The primary contributions are to derive optimal contracts for EOL care payments using a principal-agent framework under three separate models for the healthcare provider, where each model considers a different level of risk tolerance for the provider. We derive these optimal contracts by converting the underlying principal-agent models from a bilevel optimization problem into a single-level optimization problem that can be analytically solved. Our results are demonstrated using a simulation where an optimal contract is used to price intracranial pressure monitoring for traumatic brain injuries.

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Learning from Demonstration allows robots to mimic human actions. However, these methods do not model constraints crucial to ensure safety of the learned skill. Moreover, even when explicitly modelling constraints, they rely on the assumption of a known cost function, which limits their practical usability for task with unknown cost. In this work we propose a two-step optimization process that allow to estimate cost and constraints by decoupling the learning of cost functions from the identification of unknown constraints within the demonstrated trajectories. Initially, we identify the cost function by isolating the effect of constraints on parts of the demonstrations. Subsequently, a constraint leaning method is used to identify the unknown constraints. Our approach is validated both on simulated trajectories and a real robotic manipulation task. Our experiments show the impact that incorrect cost estimation has on the learned constraints and illustrate how the proposed method is able to infer unknown constraints, such as obstacles, from demonstrated trajectories without any initial knowledge of the cost.

Human infants learn language while interacting with their environment in which their caregivers may describe the objects and actions they perform. Similar to human infants, artificial agents can learn language while interacting with their environment. In this work, first, we present a neural model that bidirectionally binds robot actions and their language descriptions in a simple object manipulation scenario. Building on our previous Paired Variational Autoencoders (PVAE) model, we demonstrate the superiority of the variational autoencoder over standard autoencoders by experimenting with cubes of different colours, and by enabling the production of alternative vocabularies. Additional experiments show that the model's channel-separated visual feature extraction module can cope with objects of different shapes. Next, we introduce PVAE-BERT, which equips the model with a pretrained large-scale language model, i.e., Bidirectional Encoder Representations from Transformers (BERT), enabling the model to go beyond comprehending only the predefined descriptions that the network has been trained on; the recognition of action descriptions generalises to unconstrained natural language as the model becomes capable of understanding unlimited variations of the same descriptions. Our experiments suggest that using a pretrained language model as the language encoder allows our approach to scale up for real-world scenarios with instructions from human users.

In real-world scenarios, objects often require repositioning and reorientation before they can be grasped, a process known as pre-grasp manipulation. Learning universal dexterous functional pre-grasp manipulation requires precise control over the relative position, orientation, and contact between the hand and object while generalizing to diverse dynamic scenarios with varying objects and goal poses. To address this challenge, we propose a teacher-student learning approach that utilizes a novel mutual reward, incentivizing agents to optimize three key criteria jointly. Additionally, we introduce a pipeline that employs a mixture-of-experts strategy to learn diverse manipulation policies, followed by a diffusion policy to capture complex action distributions from these experts. Our method achieves a success rate of 72.6\% across more than 30 object categories by leveraging extrinsic dexterity and adjusting from feedback.

Understanding the causal impact of medical interventions is essential in healthcare research, especially through randomized controlled trials (RCTs). Despite their prominence, challenges arise due to discrepancies between treatment allocation and actual intake, influenced by various factors like patient non-adherence or procedural errors. This paper focuses on the Complier Average Causal Effect (CACE), crucial for evaluating treatment efficacy among compliant patients. Existing methodologies often rely on assumptions such as exclusion restriction and monotonicity, which can be problematic in practice. We propose a novel approach, leveraging supervised learning architectures, to estimate CACE without depending on these assumptions. Our method involves a two-step process: first estimating compliance probabilities for patients, then using these probabilities to estimate two nuisance components relevant to CACE calculation. Building upon the principal ignorability assumption, we introduce four root-n consistent, asymptotically normal, CACE estimators, and prove that the underlying mixtures of experts' nuisance components are identifiable. Our causal framework allows our estimation procedures to enjoy reduced mean squared errors when exclusion restriction or monotonicity assumptions hold. Through simulations and application to a breastfeeding promotion RCT, we demonstrate the method's performance and applicability.

We present P2PL, a practical multi-device peer-to-peer deep learning algorithm that, unlike the federated learning paradigm, does not require coordination from edge servers or the cloud. This makes P2PL well-suited for the sheer scale of beyond-5G computing environments like smart cities that otherwise create range, latency, bandwidth, and single point of failure issues for federated approaches. P2PL introduces max norm synchronization to catalyze training, retains on-device deep model training to preserve privacy, and leverages local inter-device communication to implement distributed consensus. Each device iteratively alternates between two phases: 1) on-device learning and 2) peer-to-peer cooperation where they combine model parameters with nearby devices. We empirically show that all participating devices achieve the same test performance attained by federated and centralized training -- even with 100 devices and relaxed singly stochastic consensus weights. We extend these experimental results to settings with diverse network topologies, sparse and intermittent communication, and non-IID data distributions.

As the capabilities of Large Language Models (LLMs) in healthcare and medicine continue to advance, there is a growing need for competitive open-source models that can safeguard public interest. With the increasing availability of highly competitive open base models, the impact of continued pre-training is increasingly uncertain. In this work, we explore the role of instruct tuning, model merging, alignment, red teaming and advanced inference schemes, as means to improve current open models. To that end, we introduce the Aloe family, a set of open medical LLMs highly competitive within its scale range. Aloe models are trained on the current best base models (Mistral, LLaMA 3), using a new custom dataset which combines public data sources improved with synthetic Chain of Thought (CoT). Aloe models undergo an alignment phase, becoming one of the first few policy-aligned open healthcare LLM using Direct Preference Optimization, setting a new standard for ethical performance in healthcare LLMs. Model evaluation expands to include various bias and toxicity datasets, a dedicated red teaming effort, and a much-needed risk assessment for healthcare LLMs. Finally, to explore the limits of current LLMs in inference, we study several advanced prompt engineering strategies to boost performance across benchmarks, yielding state-of-the-art results for open healthcare 7B LLMs, unprecedented at this scale.

Decision-making algorithms are being used in important decisions, such as who should be enrolled in health care programs and be hired. Even though these systems are currently deployed in high-stakes scenarios, many of them cannot explain their decisions. This limitation has prompted the Explainable Artificial Intelligence (XAI) initiative, which aims to make algorithms explainable to comply with legal requirements, promote trust, and maintain accountability. This paper questions whether and to what extent explainability can help solve the responsibility issues posed by autonomous AI systems. We suggest that XAI systems that provide post-hoc explanations could be seen as blameworthy agents, obscuring the responsibility of developers in the decision-making process. Furthermore, we argue that XAI could result in incorrect attributions of responsibility to vulnerable stakeholders, such as those who are subjected to algorithmic decisions (i.e., patients), due to a misguided perception that they have control over explainable algorithms. This conflict between explainability and accountability can be exacerbated if designers choose to use algorithms and patients as moral and legal scapegoats. We conclude with a set of recommendations for how to approach this tension in the socio-technical process of algorithmic decision-making and a defense of hard regulation to prevent designers from escaping responsibility.

Despite the recent progress in deep learning, most approaches still go for a silo-like solution, focusing on learning each task in isolation: training a separate neural network for each individual task. Many real-world problems, however, call for a multi-modal approach and, therefore, for multi-tasking models. Multi-task learning (MTL) aims to leverage useful information across tasks to improve the generalization capability of a model. This thesis is concerned with multi-task learning in the context of computer vision. First, we review existing approaches for MTL. Next, we propose several methods that tackle important aspects of multi-task learning. The proposed methods are evaluated on various benchmarks. The results show several advances in the state-of-the-art of multi-task learning. Finally, we discuss several possibilities for future work.

We consider the problem of explaining the predictions of graph neural networks (GNNs), which otherwise are considered as black boxes. Existing methods invariably focus on explaining the importance of graph nodes or edges but ignore the substructures of graphs, which are more intuitive and human-intelligible. In this work, we propose a novel method, known as SubgraphX, to explain GNNs by identifying important subgraphs. Given a trained GNN model and an input graph, our SubgraphX explains its predictions by efficiently exploring different subgraphs with Monte Carlo tree search. To make the tree search more effective, we propose to use Shapley values as a measure of subgraph importance, which can also capture the interactions among different subgraphs. To expedite computations, we propose efficient approximation schemes to compute Shapley values for graph data. Our work represents the first attempt to explain GNNs via identifying subgraphs explicitly and directly. Experimental results show that our SubgraphX achieves significantly improved explanations, while keeping computations at a reasonable level.

Human doctors with well-structured medical knowledge can diagnose a disease merely via a few conversations with patients about symptoms. In contrast, existing knowledge-grounded dialogue systems often require a large number of dialogue instances to learn as they fail to capture the correlations between different diseases and neglect the diagnostic experience shared among them. To address this issue, we propose a more natural and practical paradigm, i.e., low-resource medical dialogue generation, which can transfer the diagnostic experience from source diseases to target ones with a handful of data for adaptation. It is capitalized on a commonsense knowledge graph to characterize the prior disease-symptom relations. Besides, we develop a Graph-Evolving Meta-Learning (GEML) framework that learns to evolve the commonsense graph for reasoning disease-symptom correlations in a new disease, which effectively alleviates the needs of a large number of dialogues. More importantly, by dynamically evolving disease-symptom graphs, GEML also well addresses the real-world challenges that the disease-symptom correlations of each disease may vary or evolve along with more diagnostic cases. Extensive experiment results on the CMDD dataset and our newly-collected Chunyu dataset testify the superiority of our approach over state-of-the-art approaches. Besides, our GEML can generate an enriched dialogue-sensitive knowledge graph in an online manner, which could benefit other tasks grounded on knowledge graph.

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