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Motivated by the pressing challenges in the digital twin development for biomanufacturing process, we introduce an adjoint sensitivity analysis (SA) approach to expedite the learning of mechanistic model parameters. In this paper, we consider enzymatic stochastic reaction networks representing a multi-scale bioprocess mechanistic model that allows us to integrate disparate data from diverse production processes and leverage the information from existing macro-kinetic and genome-scale models. To support forward prediction and backward reasoning, we develop a convergent adjoint SA algorithm studying how the perturbations of model parameters and inputs (e.g., initial state) propagate through enzymatic reaction networks and impact on output trajectory predictions. This SA can provide a sample efficient and interpretable way to assess the sensitivities between inputs and outputs accounting for their causal dependencies. Our empirical study underscores the resilience of these sensitivities and illuminates a deeper comprehension of the regulatory mechanisms behind bioprocess through sensitivities.

Inspired by the great potential of Large Language Models (LLMs) for solving complex coding tasks, in this paper, we propose a novel approach, named Code2API, to automatically perform APIzation for Stack Overflow code snippets. Code2API does not require additional model training or any manual crafting rules and can be easily deployed on personal computers without relying on other external tools. Specifically, Code2API guides the LLMs through well-designed prompts to generate well-formed APIs for given code snippets. To elicit knowledge and logical reasoning from LLMs, we used chain-of-thought (CoT) reasoning and few-shot in-context learning, which can help the LLMs fully understand the APIzation task and solve it step by step in a manner similar to a developer. Our evaluations show that Code2API achieves a remarkable accuracy in identifying method parameters (65%) and return statements (66%) equivalent to human-generated ones, surpassing the current state-of-the-art approach, APIzator, by 15.0% and 16.5% respectively. Moreover, compared with APIzator, our user study demonstrates that Code2API exhibits superior performance in generating meaningful method names, even surpassing the human-level performance, and developers are more willing to use APIs generated by our approach, highlighting the applicability of our tool in practice. Finally, we successfully extend our framework to the Python dataset, achieving a comparable performance with Java, which verifies the generalizability of our tool.

In this paper, we leverage a foundational principle of analog electronic circuitry, Kirchhoff's current and voltage laws, to introduce a distinctive class of neural network models termed KirchhoffNet. Essentially, KirchhoffNet is an analog circuit that can function as a neural network, utilizing its initial node voltages as the neural network input and the node voltages at a specific time point as the output. The evolution of node voltages within the specified time is dictated by learnable parameters on the edges connecting nodes. We demonstrate that KirchhoffNet is governed by a set of ordinary differential equations (ODEs), and notably, even in the absence of traditional layers (such as convolution layers), it attains state-of-the-art performances across diverse and complex machine learning tasks. Most importantly, KirchhoffNet can be potentially implemented as a low-power analog integrated circuit, leading to an appealing property -- irrespective of the number of parameters within a KirchhoffNet, its on-chip forward calculation can always be completed within a short time. This characteristic makes KirchhoffNet a promising and fundamental paradigm for implementing large-scale neural networks, opening a new avenue in analog neural networks for AI.

In this work, we introduce Brain Latent Progression (BrLP), a novel spatiotemporal disease progression model based on latent diffusion. BrLP is designed to predict the evolution of diseases at the individual level on 3D brain MRIs. Existing deep generative models developed for this task are primarily data-driven and face challenges in learning disease progressions. BrLP addresses these challenges by incorporating prior knowledge from disease models to enhance the accuracy of predictions. To implement this, we propose to integrate an auxiliary model that infers volumetric changes in various brain regions. Additionally, we introduce Latent Average Stabilization (LAS), a novel technique to improve spatiotemporal consistency of the predicted progression. BrLP is trained and evaluated on a large dataset comprising 11,730 T1-weighted brain MRIs from 2,805 subjects, collected from three publicly available, longitudinal Alzheimer's Disease (AD) studies. In our experiments, we compare the MRI scans generated by BrLP with the actual follow-up MRIs available from the subjects, in both cross-sectional and longitudinal settings. BrLP demonstrates significant improvements over existing methods, with an increase of 22% in volumetric accuracy across AD-related brain regions and 43% in image similarity to the ground-truth scans. The ability of BrLP to generate conditioned 3D scans at the subject level, along with the novelty of integrating prior knowledge to enhance accuracy, represents a significant advancement in disease progression modeling, opening new avenues for precision medicine. The code of BrLP is available at the following link: //github.com/LemuelPuglisi/BrLP.

Inspired by Federated Learning, in this paper, we propose personal large models that are distilled from traditional large language models but more adaptive to local users' personal information such as education background and hobbies. We classify the large language models into three levels: the personal level, expert level and traditional level. The personal level models are adaptive to users' personal information. They encrypt the users' input and protect their privacy. The expert level models focus on merging specific knowledge such as finance, IT and art. The traditional models focus on the universal knowledge discovery and upgrading the expert models. In such classifications, the personal models directly interact with the user. For the whole system, the personal models have users' (encrypted) personal information. Moreover, such models must be small enough to be performed on personal computers or mobile devices. Finally, they also have to response in real-time for better user experience and produce high quality results. The proposed personal large models can be applied in a wide range of applications such as language and vision tasks.

In this paper, we proposed to apply meta learning approach for low-resource automatic speech recognition (ASR). We formulated ASR for different languages as different tasks, and meta-learned the initialization parameters from many pretraining languages to achieve fast adaptation on unseen target language, via recently proposed model-agnostic meta learning algorithm (MAML). We evaluated the proposed approach using six languages as pretraining tasks and four languages as target tasks. Preliminary results showed that the proposed method, MetaASR, significantly outperforms the state-of-the-art multitask pretraining approach on all target languages with different combinations of pretraining languages. In addition, since MAML's model-agnostic property, this paper also opens new research direction of applying meta learning to more speech-related applications.

In this paper, we propose Latent Relation Language Models (LRLMs), a class of language models that parameterizes the joint distribution over the words in a document and the entities that occur therein via knowledge graph relations. This model has a number of attractive properties: it not only improves language modeling performance, but is also able to annotate the posterior probability of entity spans for a given text through relations. Experiments demonstrate empirical improvements over both a word-based baseline language model and a previous approach that incorporates knowledge graph information. Qualitative analysis further demonstrates the proposed model's ability to learn to predict appropriate relations in context.

In this paper, we present an accurate and scalable approach to the face clustering task. We aim at grouping a set of faces by their potential identities. We formulate this task as a link prediction problem: a link exists between two faces if they are of the same identity. The key idea is that we find the local context in the feature space around an instance (face) contains rich information about the linkage relationship between this instance and its neighbors. By constructing sub-graphs around each instance as input data, which depict the local context, we utilize the graph convolution network (GCN) to perform reasoning and infer the likelihood of linkage between pairs in the sub-graphs. Experiments show that our method is more robust to the complex distribution of faces than conventional methods, yielding favorably comparable results to state-of-the-art methods on standard face clustering benchmarks, and is scalable to large datasets. Furthermore, we show that the proposed method does not need the number of clusters as prior, is aware of noises and outliers, and can be extended to a multi-view version for more accurate clustering accuracy.

In this paper, we introduce the Reinforced Mnemonic Reader for machine reading comprehension tasks, which enhances previous attentive readers in two aspects. First, a reattention mechanism is proposed to refine current attentions by directly accessing to past attentions that are temporally memorized in a multi-round alignment architecture, so as to avoid the problems of attention redundancy and attention deficiency. Second, a new optimization approach, called dynamic-critical reinforcement learning, is introduced to extend the standard supervised method. It always encourages to predict a more acceptable answer so as to address the convergence suppression problem occurred in traditional reinforcement learning algorithms. Extensive experiments on the Stanford Question Answering Dataset (SQuAD) show that our model achieves state-of-the-art results. Meanwhile, our model outperforms previous systems by over 6% in terms of both Exact Match and F1 metrics on two adversarial SQuAD datasets.

In this paper, we propose a conceptually simple and geometrically interpretable objective function, i.e. additive margin Softmax (AM-Softmax), for deep face verification. In general, the face verification task can be viewed as a metric learning problem, so learning large-margin face features whose intra-class variation is small and inter-class difference is large is of great importance in order to achieve good performance. Recently, Large-margin Softmax and Angular Softmax have been proposed to incorporate the angular margin in a multiplicative manner. In this work, we introduce a novel additive angular margin for the Softmax loss, which is intuitively appealing and more interpretable than the existing works. We also emphasize and discuss the importance of feature normalization in the paper. Most importantly, our experiments on LFW BLUFR and MegaFace show that our additive margin softmax loss consistently performs better than the current state-of-the-art methods using the same network architecture and training dataset. Our code has also been made available at //github.com/happynear/AMSoftmax