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High-resolution (HR) MRI is critical in assisting the doctor's diagnosis and image-guided treatment but is highly time-consuming and costly to acquire. Therefore, deep learning-based super-resolution reconstruction (SRR) has been investigated to generate super-resolution images from low-resolution (LR) images. Training such neural networks requires authentic HR and LR image pairs, which are difficult to acquire due to patient movement during and between the acquisitions of LR and HR images. Rigid movements of hard tissues can be corrected with image registration. In contrast, the alignment of deformed soft tissues is challenging, making it impractical to train neural networks with authentic HR and LR image pairs. Existing studies in the literature focused on SRR using authentic HR images and down-sampled synthetic LR images. Yet, the difference in degradation representations between synthetic and authentic LR images suppresses the quality of SRR from authentic LR images. In this work, we propose a novel Unsupervised Degradation Adaptation Network (UDEAN) to mitigate this problem. Our network consists of the degradation learning network and the SRR network. The degradation learning network down-samples the HR images by addressing the degradation representation of the misaligned or unpaired LR images. The SRR network learns the mapping from the down-sampled HR images to the original ones. Experimental results show that our method outperforms state-of-the-art networks and can potentially be applied in real clinical settings.

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Networking:IFIP International Conferences on Networking。 Explanation:國(guo)際網(wang)絡會(hui)議(yi)。 Publisher:IFIP。 SIT:

Interactive segmentation has recently been explored to effectively and efficiently harvest high-quality segmentation masks by iteratively incorporating user hints. While iterative in nature, most existing interactive segmentation methods tend to ignore the dynamics of successive interactions and take each interaction independently. We here propose to model iterative interactive image segmentation with a Markov decision process (MDP) and solve it with reinforcement learning (RL) where each voxel is treated as an agent. Considering the large exploration space for voxel-wise prediction and the dependence among neighboring voxels for the segmentation tasks, multi-agent reinforcement learning is adopted, where the voxel-level policy is shared among agents. Considering that boundary voxels are more important for segmentation, we further introduce a boundary-aware reward, which consists of a global reward in the form of relative cross-entropy gain, to update the policy in a constrained direction, and a boundary reward in the form of relative weight, to emphasize the correctness of boundary predictions. To combine the advantages of different types of interactions, i.e., simple and efficient for point-clicking, and stable and robust for scribbles, we propose a supervoxel-clicking based interaction design. Experimental results on four benchmark datasets have shown that the proposed method significantly outperforms the state-of-the-arts, with the advantage of fewer interactions, higher accuracy, and enhanced robustness.

Existing real-world video super-resolution (VSR) methods focus on designing a general degradation pipeline for open-domain videos while ignoring data intrinsic characteristics which strongly limit their performance when applying to some specific domains (e.g. animation videos). In this paper, we thoroughly explore the characteristics of animation videos and leverage the rich priors in real-world animation data for a more practical animation VSR model. In particular, we propose a multi-scale Vector-Quantized Degradation model for animation video Super-Resolution (VQD-SR) to decompose the local details from global structures and transfer the degradation priors in real-world animation videos to a learned vector-quantized codebook for degradation modeling. A rich-content Real Animation Low-quality (RAL) video dataset is collected for extracting the priors. We further propose a data enhancement strategy for high-resolution (HR) training videos based on our observation that existing HR videos are mostly collected from the Web which contains conspicuous compression artifacts. The proposed strategy is valid to lift the upper bound of animation VSR performance, regardless of the specific VSR model. Experimental results demonstrate the superiority of the proposed VQD-SR over state-of-the-art methods, through extensive quantitative and qualitative evaluations of the latest animation video super-resolution benchmark.

With numerous medical tasks, the performance of deep models has recently experienced considerable improvements. These models are often adept learners. Yet, their intricate architectural design and high computational complexity make deploying them in clinical settings challenging, particularly with devices with limited resources. To deal with this issue, Knowledge Distillation (KD) has been proposed as a compression method and an acceleration technology. KD is an efficient learning strategy that can transfer knowledge from a burdensome model (i.e., teacher model) to a lightweight model (i.e., student model). Hence we can obtain a compact model with low parameters with preserving the teacher's performance. Therefore, we develop a KD-based deep model for prostate MRI segmentation in this work by combining features-based distillation with Kullback-Leibler divergence, Lovasz, and Dice losses. We further demonstrate its effectiveness by applying two compression procedures: 1) distilling knowledge to a student model from a single well-trained teacher, and 2) since most of the medical applications have a small dataset, we train multiple teachers that each one trained with a small set of images to learn an adaptive student model as close to the teachers as possible considering the desired accuracy and fast inference time. Extensive experiments were conducted on a public multi-site prostate tumor dataset, showing that the proposed adaptation KD strategy improves the dice similarity score by 9%, outperforming all tested well-established baseline models.

Robust segmentation of infant brain MRI across multiple ages, modalities, and sites remains challenging due to the intrinsic heterogeneity caused by different MRI scanners, vendors, or acquisition sequences, as well as varying stages of neurodevelopment. To address this challenge, previous studies have explored domain adaptation (DA) algorithms from various perspectives, including feature alignment, entropy minimization, contrast synthesis (style transfer), and pseudo-labeling. This paper introduces a novel framework called MAPSeg (Masked Autoencoding and Pseudo-labelling Segmentation) to address the challenges of cross-age, cross-modality, and cross-site segmentation of subcortical regions in infant brain MRI. Utilizing 3D masked autoencoding as well as masked pseudo-labeling, the model is able to jointly learn from labeled source domain data and unlabeled target domain data. We evaluated our framework on expert-annotated datasets acquired from different ages and sites. MAPSeg consistently outperformed other methods, including previous state-of-the-art supervised baselines, domain generalization, and domain adaptation frameworks in segmenting subcortical regions regardless of age, modality, or acquisition site. The code and pretrained encoder will be publicly available at //github.com/XuzheZ/MAPSeg

Successful unsupervised domain adaptation (UDA) is guaranteed only under strong assumptions such as covariate shift and overlap between input domains. The latter is often violated in high-dimensional applications such as image classification which, despite this challenge, continues to serve as inspiration and benchmark for algorithm development. In this work, we show that access to side information about examples from the source and target domains can help relax these assumptions and increase sample efficiency in learning, at the cost of collecting a richer variable set. We call this domain adaptation by learning using privileged information (DALUPI). Tailored for this task, we propose a simple two-stage learning algorithm inspired by our analysis and a practical end-to-end algorithm for multi-label image classification. In a suite of experiments, including an application to medical image analysis, we demonstrate that incorporating privileged information in learning can reduce errors in domain transfer compared to classical learning.

Most unsupervised domain adaptation (UDA) methods assume that labeled source images are available during model adaptation. However, this assumption is often infeasible owing to confidentiality issues or memory constraints on mobile devices. Some recently developed approaches do not require source images during adaptation, but they show limited performance on perturbed images. To address these problems, we propose a novel source-free UDA method that uses only a pre-trained source model and unlabeled target images. Our method captures the aleatoric uncertainty by incorporating data augmentation and trains the feature generator with two consistency objectives. The feature generator is encouraged to learn consistent visual features away from the decision boundaries of the head classifier. Thus, the adapted model becomes more robust to image perturbations. Inspired by self-supervised learning, our method promotes inter-space alignment between the prediction space and the feature space while incorporating intra-space consistency within the feature space to reduce the domain gap between the source and target domains. We also consider epistemic uncertainty to boost the model adaptation performance. Extensive experiments on popular UDA benchmark datasets demonstrate that the proposed source-free method is comparable or even superior to vanilla UDA methods. Moreover, the adapted models show more robust results when input images are perturbed.

A key requirement for the success of supervised deep learning is a large labeled dataset - a condition that is difficult to meet in medical image analysis. Self-supervised learning (SSL) can help in this regard by providing a strategy to pre-train a neural network with unlabeled data, followed by fine-tuning for a downstream task with limited annotations. Contrastive learning, a particular variant of SSL, is a powerful technique for learning image-level representations. In this work, we propose strategies for extending the contrastive learning framework for segmentation of volumetric medical images in the semi-supervised setting with limited annotations, by leveraging domain-specific and problem-specific cues. Specifically, we propose (1) novel contrasting strategies that leverage structural similarity across volumetric medical images (domain-specific cue) and (2) a local version of the contrastive loss to learn distinctive representations of local regions that are useful for per-pixel segmentation (problem-specific cue). We carry out an extensive evaluation on three Magnetic Resonance Imaging (MRI) datasets. In the limited annotation setting, the proposed method yields substantial improvements compared to other self-supervision and semi-supervised learning techniques. When combined with a simple data augmentation technique, the proposed method reaches within 8% of benchmark performance using only two labeled MRI volumes for training, corresponding to only 4% (for ACDC) of the training data used to train the benchmark.

We present CURL: Contrastive Unsupervised Representations for Reinforcement Learning. CURL extracts high-level features from raw pixels using contrastive learning and performs off-policy control on top of the extracted features. CURL outperforms prior pixel-based methods, both model-based and model-free, on complex tasks in the DeepMind Control Suite and Atari Games showing 1.9x and 1.6x performance gains at the 100K environment and interaction steps benchmarks respectively. On the DeepMind Control Suite, CURL is the first image-based algorithm to nearly match the sample-efficiency and performance of methods that use state-based features.

Convolutional neural networks (CNNs) have shown dramatic improvements in single image super-resolution (SISR) by using large-scale external samples. Despite their remarkable performance based on the external dataset, they cannot exploit internal information within a specific image. Another problem is that they are applicable only to the specific condition of data that they are supervised. For instance, the low-resolution (LR) image should be a "bicubic" downsampled noise-free image from a high-resolution (HR) one. To address both issues, zero-shot super-resolution (ZSSR) has been proposed for flexible internal learning. However, they require thousands of gradient updates, i.e., long inference time. In this paper, we present Meta-Transfer Learning for Zero-Shot Super-Resolution (MZSR), which leverages ZSSR. Precisely, it is based on finding a generic initial parameter that is suitable for internal learning. Thus, we can exploit both external and internal information, where one single gradient update can yield quite considerable results. (See Figure 1). With our method, the network can quickly adapt to a given image condition. In this respect, our method can be applied to a large spectrum of image conditions within a fast adaptation process.

Convolutional networks (ConvNets) have achieved great successes in various challenging vision tasks. However, the performance of ConvNets would degrade when encountering the domain shift. The domain adaptation is more significant while challenging in the field of biomedical image analysis, where cross-modality data have largely different distributions. Given that annotating the medical data is especially expensive, the supervised transfer learning approaches are not quite optimal. In this paper, we propose an unsupervised domain adaptation framework with adversarial learning for cross-modality biomedical image segmentations. Specifically, our model is based on a dilated fully convolutional network for pixel-wise prediction. Moreover, we build a plug-and-play domain adaptation module (DAM) to map the target input to features which are aligned with source domain feature space. A domain critic module (DCM) is set up for discriminating the feature space of both domains. We optimize the DAM and DCM via an adversarial loss without using any target domain label. Our proposed method is validated by adapting a ConvNet trained with MRI images to unpaired CT data for cardiac structures segmentations, and achieved very promising results.

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