Bipolar Disorder (BD) is a psychiatric condition diagnosed by repetitive cycles of hypomania and depression. Since diagnosing BD relies on subjective behavioral assessments over a long period, a solid diagnosis based on objective criteria is not straightforward. The current study responded to the described obstacle by proposing a hybrid GAN-CNN model to diagnose BD from 3-D structural MRI Images (sMRI). The novelty of this study stems from diagnosing BD from sMRI samples rather than conventional datasets such as functional MRI (fMRI), electroencephalography (EEG), and behavioral symptoms while removing the data insufficiency usually encountered when dealing with sMRI samples. The impact of various augmentation ratios is also tested using 5-fold cross-validation. Based on the results, this study obtains an accuracy rate of 75.8%, a sensitivity of 60.3%, and a specificity of 82.5%, which are 3-5% higher than prior work while utilizing less than 6% sample counts. Next, it is demonstrated that a 2- D layer-based GAN generator can effectively reproduce complex 3D brain samples, a more straightforward technique than manual image processing. Lastly, the optimum augmentation threshold for the current study using 172 sMRI samples is 50%, showing the applicability of the described method for larger sMRI datasets. In conclusion, it is established that data augmentation using GAN improves the accuracy of the CNN classifier using sMRI samples, thus developing more reliable decision support systems to assist practitioners in identifying BD patients more reliably and in a shorter period
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Moving object segmentation (MOS) in dynamic scenes is challenging for autonomous driving, especially for sequences obtained from moving ego vehicles. Most state-of-the-art methods leverage motion cues obtained from optical flow maps. However, since these methods are often based on optical flows that are pre-computed from successive RGB frames, this neglects the temporal consideration of events occurring within inter-frame and limits the practicality of these methods in real-life situations. To address these limitations, we propose to exploit event cameras for better video understanding, which provide rich motion cues without relying on optical flow. To foster research in this area, we first introduce a novel large-scale dataset called DSEC-MOS for moving object segmentation from moving ego vehicles. Subsequently, we devise EmoFormer, a novel network able to exploit the event data. For this purpose, we fuse the event prior with spatial semantic maps to distinguish moving objects from the static background, adding another level of dense supervision around our object of interest - moving ones. Our proposed network relies only on event data for training but does not require event input during inference, making it directly comparable to frame-only methods in terms of efficiency and more widely usable in many application cases. An exhaustive comparison with 8 state-of-the-art video object segmentation methods highlights a significant performance improvement of our method over all other methods. Project Page: //github.com/ZZY-Zhou/DSEC-MOS.
Free Content Websites (FCWs) are a significant element of the Web, and realizing their use is essential. This study analyzes FCWs worldwide by studying how they correlate with different network sizes, cloud service providers, and countries, depending on the type of content they offer. Additionally, we compare these findings with those of premium content websites (PCWs). Our analysis concluded that FCWs correlate mainly with networks of medium size, which are associated with a higher concentration of malicious websites. Moreover, we found a strong correlation between PCWs, cloud, and country hosting patterns. At the same time, some correlations were also observed concerning FCWs but with distinct patterns contrasting each other for both types. Our investigation contributes to comprehending the FCW ecosystem through correlation analysis, and the indicative results point toward controlling the potential risks caused by these sites through adequate segregation and filtering due to their concentration.
We consider the problem of nonparametric estimation of the drift and diffusion coefficients of a Stochastic Differential Equation (SDE), based on $n$ independent replicates $\left\{X_i(t)\::\: t\in [0,1]\right\}_{1 \leq i \leq n}$, observed sparsely and irregularly on the unit interval, and subject to additive noise corruption. By sparse we intend to mean that the number of measurements per path can be arbitrary (as small as two), and remain constant with respect to $n$. We focus on time-inhomogeneous SDE of the form $dX_t = \mu(t)X_t^{\alpha}dt + \sigma(t)X_t^{\beta}dW_t$, where $\alpha \in \{0,1\}$ and $\beta \in \{0,1/2,1\}$, which includes prominent examples such as Brownian motion, Ornstein-Uhlenbeck process, geometric Brownian motion, and Brownian bridge. Our estimators are constructed by relating the local (drift/diffusion) parameters of the diffusion to their global parameters (mean/covariance, and their derivatives) by means of an apparently novel Partial Differential Equation (PDE). This allows us to use methods inspired by functional data analysis, and pool information across the sparsely measured paths. The methodology we develop is fully non-parametric and avoids any functional form specification on the time-dependency of either the drift function or the diffusion function. We establish almost sure uniform asymptotic convergence rates of the proposed estimators as the number of observed curves $n$ grows to infinity. Our rates are non-asymptotic in the number of measurements per path, explicitly reflecting how different sampling frequency might affect the speed of convergence. Our framework suggests possible further fruitful interactions between FDA and SDE methods in problems with replication.
Deep Learning for Automatic Strain Quantification in Arrhythmogenic Right Ventricular Cardiomyopathy
Quantification of cardiac motion with cine Cardiac Magnetic Resonance Imaging (CMRI) is an integral part of arrhythmogenic right ventricular cardiomyopathy (ARVC) diagnosis. Yet, the expert evaluation of motion abnormalities with CMRI is a challenging task. To automatically assess cardiac motion, we register CMRIs from different time points of the cardiac cycle using Implicit Neural Representations (INRs) and perform a biomechanically informed regularization inspired by the myocardial incompressibility assumption. To enhance the registration performance, our method first rectifies the inter-slice misalignment inherent to CMRI by performing a rigid registration guided by the long-axis views, and then increases the through-plane resolution using an unsupervised deep learning super-resolution approach. Finally, we propose to synergically combine information from short-axis and 4-chamber long-axis views, along with an initialization to incorporate information from multiple cardiac time points. Thereafter, to quantify cardiac motion, we calculate global and segmental strain over a cardiac cycle and compute the peak strain. The evaluation of the method is performed on a dataset of cine CMRI scans from 47 ARVC patients and 67 controls. Our results show that inter-slice alignment and generation of super-resolved volumes combined with joint analysis of the two cardiac views, notably improves registration performance. Furthermore, the proposed initialization yields more physiologically plausible registrations. The significant differences in the peak strain, discerned between the ARVC patients and healthy controls suggest that automated motion quantification methods may assist in diagnosis and provide further understanding of disease-specific alterations of cardiac motion.
Mild Traumatic Brain Injury (mTBI) is a common and challenging condition to diagnose accurately. Timely and precise diagnosis is essential for effective treatment and improved patient outcomes. Traditional diagnostic methods for mTBI often have limitations in terms of accuracy and sensitivity. In this study, we introduce an innovative approach to enhance mTBI diagnosis using 3D Computed Tomography (CT) images and a metric learning technique trained with triplet loss. To address these challenges, we propose a Residual Triplet Convolutional Neural Network (RTCNN) model to distinguish between mTBI cases and healthy ones by embedding 3D CT scans into a feature space. The triplet loss function maximizes the margin between similar and dissimilar image pairs, optimizing feature representations. This facilitates better context placement of individual cases, aids informed decision-making, and has the potential to improve patient outcomes. Our RTCNN model shows promising performance in mTBI diagnosis, achieving an average accuracy of 94.3%, a sensitivity of 94.1%, and a specificity of 95.2%, as confirmed through a five-fold cross-validation. Importantly, when compared to the conventional Residual Convolutional Neural Network (RCNN) model, the RTCNN exhibits a significant improvement, showcasing a remarkable 22.5% increase in specificity, a notable 16.2% boost in accuracy, and an 11.3% enhancement in sensitivity. Moreover, RTCNN requires lower memory resources, making it not only highly effective but also resource-efficient in minimizing false positives while maximizing its diagnostic accuracy in distinguishing normal CT scans from mTBI cases. The quantitative performance metrics provided and utilization of occlusion sensitivity maps to visually explain the model's decision-making process further enhance the interpretability and transparency of our approach.
Pre-trained Foundation Models (PFMs) have ushered in a paradigm-shift in Artificial Intelligence, due to their ability to learn general-purpose representations that can be readily employed in a wide range of downstream tasks. While PFMs have been successfully adopted in various fields such as Natural Language Processing and Computer Vision, their capacity in handling geospatial data and answering urban questions remains limited. This can be attributed to the intrinsic heterogeneity of geospatial data, which encompasses different data types, including points, segments and regions, as well as multiple information modalities, such as a spatial position, visual characteristics and textual annotations. The proliferation of Volunteered Geographic Information initiatives, and the ever-increasing availability of open geospatial data sources, like OpenStreetMap, which is freely accessible globally, unveil a promising opportunity to bridge this gap. In this paper, we present CityFM, a self-supervised framework to train a foundation model within a selected geographical area of interest, such as a city. CityFM relies solely on open data from OSM, and produces multimodal representations of entities of different types, incorporating spatial, visual, and textual information. We analyse the entity representations generated using our foundation models from a qualitative perspective, and conduct quantitative experiments on road, building, and region-level downstream tasks. We compare its results to algorithms tailored specifically for the respective applications. In all the experiments, CityFM achieves performance superior to, or on par with, the baselines.
We propose a novel approach for generalizing the following rigid-body dynamics algorithms: Recursive Newton-Euler Algorithm, Articulated-Body Algorithm, and Extended-Force-Propagator Algorithm. The classic versions of these recursive algorithms require systems to have an open chain structure. Dealing with closed-chains has, conventionally, required different algorithms. In this paper, we demonstrate that the classic recursive algorithms can be modified to work for closed-chain mechanisms. The critical insight of our generalized algorithms is the clustering of bodies involved in local loop constraints. Clustering bodies enables loop constraints to be resolved locally, i.e., only when that group of bodies is encountered during a forward or backward pass. This local treatment avoids the need for large-scale matrix factorization. We provide self-contained derivations of the algorithms using familiar, physically meaningful concepts. Overall, our approach provides a foundation for simulating robotic systems with traditionally difficult-to-simulate designs, such as geared motors, differential drives, and four-bar mechanisms. The performance of our library of algorithms is validated numerically in C++ on various modern legged robots: the MIT Mini Cheetah, the MIT Humanoid, the UIUC Tello Humanoid, and a modified version of the JVRC-1 Humanoid. Our algorithms are shown to outperform state-of-the-art algorithms for computing constrained rigid-body dynamics.
Recent artificial intelligence (AI) systems have reached milestones in "grand challenges" ranging from Go to protein-folding. The capability to retrieve medical knowledge, reason over it, and answer medical questions comparably to physicians has long been viewed as one such grand challenge. Large language models (LLMs) have catalyzed significant progress in medical question answering; Med-PaLM was the first model to exceed a "passing" score in US Medical Licensing Examination (USMLE) style questions with a score of 67.2% on the MedQA dataset. However, this and other prior work suggested significant room for improvement, especially when models' answers were compared to clinicians' answers. Here we present Med-PaLM 2, which bridges these gaps by leveraging a combination of base LLM improvements (PaLM 2), medical domain finetuning, and prompting strategies including a novel ensemble refinement approach. Med-PaLM 2 scored up to 86.5% on the MedQA dataset, improving upon Med-PaLM by over 19% and setting a new state-of-the-art. We also observed performance approaching or exceeding state-of-the-art across MedMCQA, PubMedQA, and MMLU clinical topics datasets. We performed detailed human evaluations on long-form questions along multiple axes relevant to clinical applications. In pairwise comparative ranking of 1066 consumer medical questions, physicians preferred Med-PaLM 2 answers to those produced by physicians on eight of nine axes pertaining to clinical utility (p < 0.001). We also observed significant improvements compared to Med-PaLM on every evaluation axis (p < 0.001) on newly introduced datasets of 240 long-form "adversarial" questions to probe LLM limitations. While further studies are necessary to validate the efficacy of these models in real-world settings, these results highlight rapid progress towards physician-level performance in medical question answering.
We investigate the problem of automatically determining what type of shoe left an impression found at a crime scene. This recognition problem is made difficult by the variability in types of crime scene evidence (ranging from traces of dust or oil on hard surfaces to impressions made in soil) and the lack of comprehensive databases of shoe outsole tread patterns. We find that mid-level features extracted by pre-trained convolutional neural nets are surprisingly effective descriptors for this specialized domains. However, the choice of similarity measure for matching exemplars to a query image is essential to good performance. For matching multi-channel deep features, we propose the use of multi-channel normalized cross-correlation and analyze its effectiveness. Our proposed metric significantly improves performance in matching crime scene shoeprints to laboratory test impressions. We also show its effectiveness in other cross-domain image retrieval problems: matching facade images to segmentation labels and aerial photos to map images. Finally, we introduce a discriminatively trained variant and fine-tune our system through our proposed metric, obtaining state-of-the-art performance.
Visual Question Answering (VQA) models have struggled with counting objects in natural images so far. We identify a fundamental problem due to soft attention in these models as a cause. To circumvent this problem, we propose a neural network component that allows robust counting from object proposals. Experiments on a toy task show the effectiveness of this component and we obtain state-of-the-art accuracy on the number category of the VQA v2 dataset without negatively affecting other categories, even outperforming ensemble models with our single model. On a difficult balanced pair metric, the component gives a substantial improvement in counting over a strong baseline by 6.6%.
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